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- Strontium_ranelate abstract "Strontium ranelate, a strontium(II) salt of ranelic acid, is a medication for osteoporosis marketed as Protelos or Protos by Servier. On 13 May 2013, Servier released a Direct Healthcare Professional Communication which stated that important new restrictions for the use of Protelos are now in place, as randomised trials have shown an increased risk of myocardial infarction. Servier states that the use of Protelos is now restricted to treatment of severe osteoporosis in postmenopausal women at high risk for fracture. Studies indicate it can also slow the course of osteoarthritis of the knee. The drug is unusual in that it both increases deposition of new bone by osteoblasts and reduces the resorption of bone by osteoclasts. It is therefore promoted as a "dual action bone agent" (DABA).Also European Pharmacovigilance Risk Assessment Committee (PRAC) recommends restriction in the use of strontium ranelate, based on a routine benefit-risk assessment of the medicine, which included data showing an increased risk of heart problems, including heart attacks. On January 10, 2014 PRAC has recommended that Protelos/Osseor should no longer be used to treat osteoporosis (PRAC recommends suspending use of Protelos/Osseor).".
- Strontium_ranelate atcPrefix "M05".
- Strontium_ranelate atcSuffix "BX03".
- Strontium_ranelate bioavailability "25.0".
- Strontium_ranelate casNumber "135459-90-4".
- Strontium_ranelate iupacName "3-(2-oxido-2-oxoethyl)thiophene-2-carboxylate".
- Strontium_ranelate iupacName "distrontium 5-[bis(2-oxido-2-oxoethyl)amino]-4-cyano-".
- Strontium_ranelate pubchem "6918182".
- Strontium_ranelate thumbnail Strontium_ranelate.svg?width=300.
- Strontium_ranelate wikiPageExternalLink news_detail_002005.jsp&mid=WC0b01ac058004d5c1.
- Strontium_ranelate wikiPageExternalLink printerfriendlynews.php?newsid=132149.
- Strontium_ranelate wikiPageExternalLink www.protelos.com.
- Strontium_ranelate wikiPageID "10053205".
- Strontium_ranelate wikiPageRevisionID "603511277".
- Strontium_ranelate atcPrefix "M05".
- Strontium_ranelate atcSuffix "BX03".
- Strontium_ranelate bioavailability "25.0".
- Strontium_ranelate c "12".
- Strontium_ranelate casNumber "135459".
- Strontium_ranelate chemspiderid "5293393".
- Strontium_ranelate eliminationHalfLife "216000.0".
- Strontium_ranelate excretion "Renal and gastrointestinal. Plasma clearance is about 12 ml/min and renal clearance about 7 ml/min".
- Strontium_ranelate h "6".
- Strontium_ranelate hasPhotoCollection Strontium_ranelate.
- Strontium_ranelate image "Strontium ranelate 3D.png".
- Strontium_ranelate inchi "1".
- Strontium_ranelate inchikey "XXUZFRDUEGQHOV-XBHQNQODAM".
- Strontium_ranelate iupacName "3".
- Strontium_ranelate iupacName "distrontium 5-[bisamino]-4-cyano-".
- Strontium_ranelate legalUk "POM".
- Strontium_ranelate metabolism "As a divalent cation, strontium is not metabolised. Does not inhibit cytochrome P450 enzymes".
- Strontium_ranelate molecularWeight "513.491".
- Strontium_ranelate n "2".
- Strontium_ranelate o "8".
- Strontium_ranelate pregnancyCategory "Only intended for use in postmenopausal women, no data on exposed pregnancies. If strontium ranelate is used inadvertently during pregnancy, treatment must be stopped.".
- Strontium_ranelate proteinBound "25".
- Strontium_ranelate pubchem "6918182".
- Strontium_ranelate routesOfAdministration "Oral".
- Strontium_ranelate s "1".
- Strontium_ranelate smiles "[Sr+2].[Sr+2].O=CCNCC=O".
- Strontium_ranelate sr "2".
- Strontium_ranelate stdinchi "1".
- Strontium_ranelate stdinchikey "XXUZFRDUEGQHOV-UHFFFAOYSA-J".
- Strontium_ranelate verifiedfields "changed".
- Strontium_ranelate verifiedrevid "470471557".
- Strontium_ranelate subject Category:Drugs.
- Strontium_ranelate subject Category:Strontium_compounds.
- Strontium_ranelate type Abstraction100002137.
- Strontium_ranelate type Cognition100023271.
- Strontium_ranelate type Compound105870180.
- Strontium_ranelate type Concept105835747.
- Strontium_ranelate type Content105809192.
- Strontium_ranelate type Idea105833840.
- Strontium_ranelate type PsychologicalFeature100023100.
- Strontium_ranelate type StrontiumCompounds.
- Strontium_ranelate type Whole105869584.
- Strontium_ranelate type Drug.
- Strontium_ranelate type DrugProduct.
- Strontium_ranelate type FunctionalSubstance.
- Strontium_ranelate comment "Strontium ranelate, a strontium(II) salt of ranelic acid, is a medication for osteoporosis marketed as Protelos or Protos by Servier. On 13 May 2013, Servier released a Direct Healthcare Professional Communication which stated that important new restrictions for the use of Protelos are now in place, as randomised trials have shown an increased risk of myocardial infarction.".
- Strontium_ranelate label "Ranelato de estroncio".
- Strontium_ranelate label "Ranelato de estrôncio".
- Strontium_ranelate label "Ranelinian strontu".
- Strontium_ranelate label "Ranélate de strontium".
- Strontium_ranelate label "Strontium ranelate".
- Strontium_ranelate label "Strontiumranelaat".
- Strontium_ranelate label "Strontiumranelat".
- Strontium_ranelate label "Stronzio ranelato".
- Strontium_ranelate label "ラネル酸ストロンチウム".
- Strontium_ranelate sameAs Strontiumranelat.
- Strontium_ranelate sameAs Ranelato_de_estroncio.
- Strontium_ranelate sameAs Ranélate_de_strontium.
- Strontium_ranelate sameAs Stronzio_ranelato.
- Strontium_ranelate sameAs ラネル酸ストロンチウム.
- Strontium_ranelate sameAs Strontiumranelaat.
- Strontium_ranelate sameAs Ranelinian_strontu.
- Strontium_ranelate sameAs Ranelato_de_estrôncio.
- Strontium_ranelate sameAs m.0h14j7.
- Strontium_ranelate sameAs Q419215.
- Strontium_ranelate sameAs Q419215.
- Strontium_ranelate sameAs Strontium_ranelate.
- Strontium_ranelate wasDerivedFrom Strontium_ranelate?oldid=603511277.
- Strontium_ranelate depiction Strontium_ranelate.svg.
- Strontium_ranelate homepage www.protelos.com.
- Strontium_ranelate isPrimaryTopicOf Strontium_ranelate.