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- Survivin abstract "Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene. NCBI Reference Sequence: NG_029069.1Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. This has been shown by disruption of survivin induction pathways leading to increase in apoptosis and decrease in tumour growth. The survivin protein is expressed highly in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells. These data suggest survivin might provide a new target for cancer therapy that would discrimnate between transformed and normal cells. Survivin expression is also highly regulated by the cell cycle and is only expressed in the G2-M phase. It is known that survivin localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis. The molecular mechanisms of survivin regulation are still not well understood, but regulation of survivin seems to be linked to the p53 protein. It also is a direct target gene of the Wnt pathway and is upregulated by beta-catenin.".
- Survivin entrezgene "332".
- Survivin wikiPageExternalLink pmidlookup?view=long&pmid=16950794.
- Survivin wikiPageID "8310787".
- Survivin wikiPageRevisionID "599912951".
- Survivin hasPhotoCollection Survivin.
- Survivin requireManualInspection "no".
- Survivin updateCitations "yes".
- Survivin updatePage "yes".
- Survivin updateProteinBox "yes".
- Survivin updateSummary "no".
- Survivin subject Category:Gene_expression.
- Survivin subject Category:Oncology.
- Survivin type Biomolecule.
- Survivin type Protein.
- Survivin type BiologicalObject.
- Survivin comment "Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene. NCBI Reference Sequence: NG_029069.1Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death.".
- Survivin label "Survivin".
- Survivin label "Survivin".
- Survivin label "サバイビン".
- Survivin sameAs Survivin.
- Survivin sameAs サバイビン.
- Survivin sameAs m.026zyby.
- Survivin sameAs Q906904.
- Survivin sameAs Q906904.
- Survivin wasDerivedFrom Survivin?oldid=599912951.
- Survivin isPrimaryTopicOf Survivin.