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- Synapsin abstract "The synapsins are a family of proteins that have long been implicated in the regulation of neurotransmitter release at synapses. Specifically, they are thought to be involved in regulating the number of synaptic vesicles available for release via exocytosis at any one time.Synapsins are present in invertebrates and vertebrates and are somewhat homologous across evaluated vertebrates.Current studies suggest the following hypothesis for the role of synapsin: synapsins bind synaptic vesicles to components of the cytoskeleton which prevents them from migrating to the presynaptic membrane and releasing transmitter. During an action potential, synapsins are phosphorylated by PKA (cAMP dependent protein kinase), releasing the synaptic vesicles and allowing them to move to the membrane and release their neurotransmitter.Gene knockout studies in mice (where the mouse is unable to produce synapsin) have had some surprising results. Mice lacking all three synapsins are prone to seizures, and experience learning defects. These results suggest that while synapsins are not essential for synaptic function, they do serve an important modulatory role. Conversely, studies using transgenic mice in which neuronal signaling is abolished in specific circuitries showed that synaptic activity regulates, but is not essential to maintain, the expression of these proteins.".
- Synapsin symbol "Synapsin".
- Synapsin symbol "Synapsin_C".
- Synapsin thumbnail PDB_1auv_EBI.jpg?width=300.
- Synapsin wikiPageID "1474305".
- Synapsin wikiPageRevisionID "593117679".
- Synapsin caption "Structure of the c domain of synapsin IA from bovine brain.".
- Synapsin hasPhotoCollection Synapsin.
- Synapsin interpro "IPR001359".
- Synapsin name "Synapsin, ATP binding domain".
- Synapsin name "Synapsin, N-terminal domain".
- Synapsin opmFamily "131".
- Synapsin opmProtein "1".
- Synapsin pdb ", , , , , ,".
- Synapsin pfam "PF02078".
- Synapsin pfam "PF02750".
- Synapsin prosite "PDOC00345".
- Synapsin scop "1".
- Synapsin symbol "Synapsin".
- Synapsin symbol "Synapsin_C".
- Synapsin subject Category:Animal_genes.
- Synapsin subject Category:Animal_proteins.
- Synapsin subject Category:Molecular_neuroscience.
- Synapsin subject Category:Peripheral_membrane_proteins.
- Synapsin type Abstraction100002137.
- Synapsin type Arrangement107938773.
- Synapsin type Chemical114806838.
- Synapsin type Compound114818238.
- Synapsin type Gene105436752.
- Synapsin type Genes.
- Synapsin type Group100031264.
- Synapsin type Macromolecule114944888.
- Synapsin type Material114580897.
- Synapsin type Matter100020827.
- Synapsin type Molecule114682133.
- Synapsin type Ordering108456993.
- Synapsin type OrganicCompound114727670.
- Synapsin type Part113809207.
- Synapsin type PeripheralMembraneProteins.
- Synapsin type PhysicalEntity100001930.
- Synapsin type Protein114728724.
- Synapsin type Proteins.
- Synapsin type Relation100031921.
- Synapsin type Sequence108459252.
- Synapsin type Series108457976.
- Synapsin type Substance100019613.
- Synapsin type Thing100002452.
- Synapsin type Unit109465459.
- Synapsin type Biomolecule.
- Synapsin type Protein.
- Synapsin type BiologicalObject.
- Synapsin comment "The synapsins are a family of proteins that have long been implicated in the regulation of neurotransmitter release at synapses.".
- Synapsin label "Synapsin".
- Synapsin label "Синапсины".
- Synapsin label "سينابسينات".
- Synapsin sameAs m.054cr6.
- Synapsin sameAs Q2062141.
- Synapsin sameAs Q2062141.
- Synapsin sameAs Synapsin.
- Synapsin wasDerivedFrom Synapsin?oldid=593117679.
- Synapsin depiction PDB_1auv_EBI.jpg.
- Synapsin isPrimaryTopicOf Synapsin.