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- Systemic_scleroderma abstract "Systemic sclerosis or systemic scleroderma is an autoimmune or connective tissue disease. It is characterized by thickening of the skin caused by accumulation of collagen, and by injuries to the smallest arteries. There are two overlapping forms. Limited cutaneous scleroderma is limited to the skin on the face, hands and feet. Diffuse cutaneous scleroderma covers more of the skin, and is at risk of progressing to the visceral organs, including the kidneys, heart, lungs and gastrointestinal tract are affected.Survival is determined by the severity of visceral disease. Prognosis is difficult to predict until the disease differentiates into recognizable subsets. Patients with limited cutaneous scleroderma have a good prognosis, with 10-year survival of 75%, although <10% develop pulmonary arterial hypertension after 10 to 20 years. Patients with diffuse cutaneous scleroderma have a 10-year survival of 55%. Death is most often from pulmonary, heart and kidney involvement, although survival has greatly improved with effective treatment for kidney failure. Immunosuppressive drugs are used, although glucocorticoids have limited application.Annual incidence is 19 per million, and prevalence is 19-75 per 100,000, with a female:male ratio of 3:1, and 8:1 in mid to late childbearing years. Incidence is twice as high among African Americans, and the Choctow Native Americans in Oklahoma have the highest prevalence in the world (469/100,000). There is some hereditary association, some suggestion of immune reaction (molecular mimicry) to a virus, and some cases caused by toxins.".
- Systemic_scleroderma diseasesdb "12845".
- Systemic_scleroderma emedicineSubject "derm".
- Systemic_scleroderma emedicineTopic "677".
- Systemic_scleroderma icd10 "M34".
- Systemic_scleroderma icd9 "710.1".
- Systemic_scleroderma medlineplus "000429".
- Systemic_scleroderma meshId "D012595".
- Systemic_scleroderma omim "181750".
- Systemic_scleroderma thumbnail Systemic_sclerosis_finger.jpg?width=300.
- Systemic_scleroderma wikiPageExternalLink systemic-sclerosis.html.
- Systemic_scleroderma wikiPageExternalLink scleroderma.jhmi.edu.
- Systemic_scleroderma wikiPageExternalLink www.jsdn.org.
- Systemic_scleroderma wikiPageExternalLink www.juvenile-scleroderma.com.
- Systemic_scleroderma wikiPageExternalLink www.raynauds.org.uk.
- Systemic_scleroderma wikiPageExternalLink index.html.
- Systemic_scleroderma wikiPageExternalLink www.scleroderma.org.
- Systemic_scleroderma wikiPageExternalLink www.sclerodermaaustralia.com.au.
- Systemic_scleroderma wikiPageExternalLink www.sclerodermaontario.ca.
- Systemic_scleroderma wikiPageExternalLink www.sclerodermaresearch.org.
- Systemic_scleroderma wikiPageExternalLink www.sclerodermasociety.co.uk.
- Systemic_scleroderma wikiPageID "26951".
- Systemic_scleroderma wikiPageRevisionID "605577976".
- Systemic_scleroderma caption "Clinical appearance of acrosclerotic piece-meal necrosis of the thumb in a patient with systemic sclerosis.".
- Systemic_scleroderma diseasesdb "12845".
- Systemic_scleroderma emedicinesubj "derm".
- Systemic_scleroderma emedicinetopic "677".
- Systemic_scleroderma hasPhotoCollection Systemic_scleroderma.
- Systemic_scleroderma icd "710.1".
- Systemic_scleroderma icd "M34".
- Systemic_scleroderma medlineplus "429".
- Systemic_scleroderma meshid "D012595".
- Systemic_scleroderma name "Systemic sclerosis".
- Systemic_scleroderma omim "181750".
- Systemic_scleroderma subject Category:Autoimmune_diseases.
- Systemic_scleroderma subject Category:Connective_tissue_diseases.
- Systemic_scleroderma subject Category:Diseases_involving_the_fasciae.
- Systemic_scleroderma subject Category:Mucinoses.
- Systemic_scleroderma subject Category:Systemic_connective_tissue_disorders.
- Systemic_scleroderma type Abstraction100002137.
- Systemic_scleroderma type Attribute100024264.
- Systemic_scleroderma type Condition113920835.
- Systemic_scleroderma type Disease114070360.
- Systemic_scleroderma type Disorder114052403.
- Systemic_scleroderma type IllHealth114052046.
- Systemic_scleroderma type Illness114061805.
- Systemic_scleroderma type PathologicalState114051917.
- Systemic_scleroderma type PhysicalCondition114034177.
- Systemic_scleroderma type State100024720.
- Systemic_scleroderma type SystemicConnectiveTissueDisorders.
- Systemic_scleroderma type Disease.
- Systemic_scleroderma type AilmentCondition.
- Systemic_scleroderma type Situation.
- Systemic_scleroderma comment "Systemic sclerosis or systemic scleroderma is an autoimmune or connective tissue disease. It is characterized by thickening of the skin caused by accumulation of collagen, and by injuries to the smallest arteries. There are two overlapping forms. Limited cutaneous scleroderma is limited to the skin on the face, hands and feet.".
- Systemic_scleroderma label "Sclérodermie systémique".
- Systemic_scleroderma label "Systemic scleroderma".
- Systemic_scleroderma label "Системная склеродермия".
- Systemic_scleroderma sameAs Sclérodermie_systémique.
- Systemic_scleroderma sameAs m.06pmx.
- Systemic_scleroderma sameAs Q5340515.
- Systemic_scleroderma sameAs Q5340515.
- Systemic_scleroderma sameAs Systemic_scleroderma.
- Systemic_scleroderma wasDerivedFrom Systemic_scleroderma?oldid=605577976.
- Systemic_scleroderma depiction Systemic_sclerosis_finger.jpg.
- Systemic_scleroderma isPrimaryTopicOf Systemic_scleroderma.
- Systemic_scleroderma name "Systemic sclerosis".