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- TATA-binding_protein abstract "The TATA-binding protein (TBP) is a general transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene promoters. TBP, along with a variety of TBP-associated factors, make up the TFIID, a general transcription factor that in turn makes up part of the RNA polymerase II preinitiation complex. As one of the few proteins in the preinitiation complex that binds DNA in a sequence-specific manner, it helps position RNA polymerase II over the transcription start site of the gene. However, it is estimated that only 10-20% of human promoters have TATA boxes. Therefore, TBP is probably not the only protein involved in positioning RNA polymerase II.TBP is involved in DNA melting (double strand separation) by bending the DNA by 80° (the AT-rich sequence to which it binds facilitates easy melting). The TBP is an unusual protein in that it binds the minor groove using a β sheet.Another distinctive feature of TBP is a long string of glutamines in the N-terminus of the protein. This region modulates the DNA binding activity of the C-terminus, and modulation of DNA-binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease.".
- TATA-binding_protein entrezgene "6908".
- TATA-binding_protein symbol "TBP".
- TATA-binding_protein thumbnail PDB_1ngm_EBI.jpg?width=300.
- TATA-binding_protein wikiPageExternalLink framset.htm.
- TATA-binding_protein wikiPageExternalLink br.fcgi?book=gene&part=sca17.
- TATA-binding_protein wikiPageID "3233135".
- TATA-binding_protein wikiPageRevisionID "593128612".
- TATA-binding_protein caption "crystal structure of a yeast brf1-tbp-dna ternary complex".
- TATA-binding_protein hasPhotoCollection TATA-binding_protein.
- TATA-binding_protein interpro "IPR000814".
- TATA-binding_protein name "TBP".
- TATA-binding_protein pfam "PF00352".
- TATA-binding_protein pfamClan "CL0407".
- TATA-binding_protein prosite "PDOC00303".
- TATA-binding_protein scop "1".
- TATA-binding_protein symbol "TBP".
- TATA-binding_protein subject Category:Genes.
- TATA-binding_protein subject Category:Proteins.
- TATA-binding_protein subject Category:Transcription_factors.
- TATA-binding_protein type Abstraction100002137.
- TATA-binding_protein type Arrangement107938773.
- TATA-binding_protein type Beginning107290905.
- TATA-binding_protein type Cause107326557.
- TATA-binding_protein type Chemical114806838.
- TATA-binding_protein type Compound114818238.
- TATA-binding_protein type Event100029378.
- TATA-binding_protein type Factor107327805.
- TATA-binding_protein type Gene105436752.
- TATA-binding_protein type Genes.
- TATA-binding_protein type Group100031264.
- TATA-binding_protein type Happening107283608.
- TATA-binding_protein type Macromolecule114944888.
- TATA-binding_protein type Material114580897.
- TATA-binding_protein type Matter100020827.
- TATA-binding_protein type Molecule114682133.
- TATA-binding_protein type Ordering108456993.
- TATA-binding_protein type OrganicCompound114727670.
- TATA-binding_protein type Origin107323922.
- TATA-binding_protein type Part113809207.
- TATA-binding_protein type PhysicalEntity100001930.
- TATA-binding_protein type Protein114728724.
- TATA-binding_protein type Proteins.
- TATA-binding_protein type PsychologicalFeature100023100.
- TATA-binding_protein type Relation100031921.
- TATA-binding_protein type Sequence108459252.
- TATA-binding_protein type Series108457976.
- TATA-binding_protein type Substance100019613.
- TATA-binding_protein type Thing100002452.
- TATA-binding_protein type TranscriptionFactors.
- TATA-binding_protein type Unit109465459.
- TATA-binding_protein type YagoPermanentlyLocatedEntity.
- TATA-binding_protein type Biomolecule.
- TATA-binding_protein type Protein.
- TATA-binding_protein type BiologicalObject.
- TATA-binding_protein comment "The TATA-binding protein (TBP) is a general transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene promoters. TBP, along with a variety of TBP-associated factors, make up the TFIID, a general transcription factor that in turn makes up part of the RNA polymerase II preinitiation complex.".
- TATA-binding_protein label "Proteína de ligação TATA".
- TATA-binding_protein label "Proteína de unión a TATA".
- TATA-binding_protein label "TATA-binding protein".
- TATA-binding_protein label "TATA結合タンパク質".
- TATA-binding_protein label "Tata Binding Protein".
- TATA-binding_protein sameAs TATA_vazebný_protein.
- TATA-binding_protein sameAs Proteína_de_unión_a_TATA.
- TATA-binding_protein sameAs Tata_Binding_Protein.
- TATA-binding_protein sameAs TATA結合タンパク質.
- TATA-binding_protein sameAs Proteína_de_ligação_TATA.
- TATA-binding_protein sameAs m.09041g.
- TATA-binding_protein sameAs Q2480972.
- TATA-binding_protein sameAs Q2480972.
- TATA-binding_protein sameAs TATA-binding_protein.
- TATA-binding_protein wasDerivedFrom TATA-binding_protein?oldid=593128612.
- TATA-binding_protein depiction PDB_1ngm_EBI.jpg.
- TATA-binding_protein isPrimaryTopicOf TATA-binding_protein.