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- TCS-OX2-29 abstract "TCS-OX2-29 is an orexin antagonist. It was the first non-peptide antagonist developed that is selective for the orexin receptor subtype OX2, with an IC50 of 40nM and selectivity of around 250x for OX2 over OX1 receptors. Orexin antagonists are expected to be useful for the treatment of insomnia, with subtype-selective antagonists such as TCS-OX2-29 potentially offering more specificity of action compared to non-selective orexin antagonists like almorexant.".
- TCS-OX2-29 casNumber "372523-75-6".
- TCS-OX2-29 iupacName "(2S)-1-(3,4-Dihydro- 6,7-dimethoxy- 2(1H)-isoquinolinyl)- 3,3-dimethyl- 2-[(4-pyridinylmethyl)amino]- 1-butanone".
- TCS-OX2-29 pubchem "10408514".
- TCS-OX2-29 thumbnail TCSOX229_structure.png?width=300.
- TCS-OX2-29 wikiPageID "22229405".
- TCS-OX2-29 wikiPageRevisionID "554125316".
- TCS-OX2-29 c "23".
- TCS-OX2-29 casNumber "372523".
- TCS-OX2-29 h "31".
- TCS-OX2-29 hasPhotoCollection TCS-OX2-29.
- TCS-OX2-29 iupacName "-1".
- TCS-OX2-29 molecularWeight "397.509".
- TCS-OX2-29 n "3".
- TCS-OX2-29 o "3".
- TCS-OX2-29 pubchem "10408514".
- TCS-OX2-29 smiles "c3cnccc3CNCCNCCc2cc1OC".
- TCS-OX2-29 verifiedrevid "398756641".
- TCS-OX2-29 width "240".
- TCS-OX2-29 subject Category:Amides.
- TCS-OX2-29 subject Category:Orexin_antagonists.
- TCS-OX2-29 subject Category:Phenol_ethers.
- TCS-OX2-29 subject Category:Pyridines.
- TCS-OX2-29 subject Category:Sedatives.
- TCS-OX2-29 subject Category:Tetrahydroisoquinolines.
- TCS-OX2-29 type Drug.
- TCS-OX2-29 type DrugProduct.
- TCS-OX2-29 type FunctionalSubstance.
- TCS-OX2-29 comment "TCS-OX2-29 is an orexin antagonist. It was the first non-peptide antagonist developed that is selective for the orexin receptor subtype OX2, with an IC50 of 40nM and selectivity of around 250x for OX2 over OX1 receptors. Orexin antagonists are expected to be useful for the treatment of insomnia, with subtype-selective antagonists such as TCS-OX2-29 potentially offering more specificity of action compared to non-selective orexin antagonists like almorexant.".
- TCS-OX2-29 label "TCS-OX2-29".
- TCS-OX2-29 sameAs m.05q890b.
- TCS-OX2-29 sameAs Q12747053.
- TCS-OX2-29 sameAs Q12747053.
- TCS-OX2-29 wasDerivedFrom TCS-OX2-29?oldid=554125316.
- TCS-OX2-29 depiction TCSOX229_structure.png.
- TCS-OX2-29 isPrimaryTopicOf TCS-OX2-29.