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- TDR_Targets abstract "The TDR Targets database is a bioinformatics project that seeks to exploit the availability of diverse genomic and chemical datasets to facilitate the identification and prioritization of drugs and drug targets in neglected disease pathogens. TDR in the name of the database stands from the popular abbreviation for a special programme within the World Health Organization, whose focus is Tropical Disease Research. The project was jumpstarted by funds from this programme (see Special Programme for Research and Training in Tropical Diseases), and the initial focus of the resource was on organisms/diseases of high priority for this Programme.The database functions both as a website, where researchers can look for information on targets or compounds of interest, or as a tool for prioritization of targets in whole genomes. When prioritizing genes, individual database queries are used to specify one or more desirable or undersirable criteria. The output of each query will be a set of genes (e.g. all genes that produce a lethal phenotype upon a genetic knockout); and different combinations of gene sets can be obtained using standard set operators (UNION, INTERSECTION, SUBTRACTION), including the possibility of weighting genes present in more than one set (this is particularly useful when calculating UNIONs). A number of prioritizations obtained with this tool have been published, demonstrating a number of use cases.The database currently hosts information for 11 bacterial and eukaryotic pathogens, and for > 800,000 bioactive compounds. Information integrated into the TDR Targets database comes from disparate data sources, and therefore cannot be considered a primary data repository.The database has seen 5 major releases since its launch in 2007, which coincided with expansion of pylogenetic coverage (e.g. inclusion of helminth genomes in release 2), incorporation of new functionalities (e.g. chemical similarity and substructure searches in release 4), and/or major data updates to keep the database in sync with upstream data providers.".
- TDR_Targets thumbnail Database.png?width=300.
- TDR_Targets title "TDR Targets".
- TDR_Targets wikiPageExternalLink tdrtargets.org.
- TDR_Targets wikiPageID "32616043".
- TDR_Targets wikiPageRevisionID "532091860".
- TDR_Targets author "Fernán Agüero, Santiago Carmona, María Paula Magariños, Dhanasekaran Shanmugam, Gregory Crowther, Stuart Ralph, David Roos, Wes Van Voorhis".
- TDR_Targets center National_University_of_General_San_Mart%C3%ADn.
- TDR_Targets center University_of_Pennsylvania.
- TDR_Targets center University_of_Washington.
- TDR_Targets curation "yes".
- TDR_Targets description "Chemogenomics resource for neglected diseases".
- TDR_Targets frequency "-2.36682E7".
- TDR_Targets hasPhotoCollection TDR_Targets.
- TDR_Targets laboratory "Laboratory of Genomics and Bioinformatics, UNSAM".
- TDR_Targets logo File:Database.png.
- TDR_Targets organism "Various".
- TDR_Targets pmid "Agüero et al.".
- TDR_Targets released "2007".
- TDR_Targets scope "Genomics, Medicinal Chemistry".
- TDR_Targets title "TDR Targets".
- TDR_Targets url tdrtargets.org.
- TDR_Targets version "5".
- TDR_Targets webapp "Perl MVC".
- TDR_Targets description "Chemogenomics resource for neglected diseases".
- TDR_Targets subject Category:Bioinformatics.
- TDR_Targets type BiologicalDatabase.
- TDR_Targets type Database.
- TDR_Targets type Work.
- TDR_Targets type CreativeWork.
- TDR_Targets type InformationEntity.
- TDR_Targets type InformationObject.
- TDR_Targets comment "The TDR Targets database is a bioinformatics project that seeks to exploit the availability of diverse genomic and chemical datasets to facilitate the identification and prioritization of drugs and drug targets in neglected disease pathogens. TDR in the name of the database stands from the popular abbreviation for a special programme within the World Health Organization, whose focus is Tropical Disease Research.".
- TDR_Targets label "TDR Targets".
- TDR_Targets sameAs m.0hgq_q3.
- TDR_Targets sameAs Q7669877.
- TDR_Targets sameAs Q7669877.
- TDR_Targets wasDerivedFrom TDR_Targets?oldid=532091860.
- TDR_Targets depiction Database.png.
- TDR_Targets homepage tdrtargets.org.
- TDR_Targets isPrimaryTopicOf TDR_Targets.