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- Telomerase abstract "Telomerase is a ribonucleoprotein that is an enzyme that adds DNA sequence repeats ("TTAGGG" in all vertebrates) to the 3' end of DNA strands in the telomere regions, which are found at the ends of eukaryotic chromosomes. This region of repeated nucleotide called telomeres contains noncoding DNA and hinders the loss of important DNA from chromosome ends. As a result, every time the chromosome is copied, only 100–200 nucleotides are lost, which causes no damage to the organism's DNA. Telomerase is a reverse transcriptase that carries its own RNA molecule, which is used as a template when it elongates telomeres, which are shortened after each replication cycle.The existence of a compensatory mechanism for telomere shortening was first predicted by Soviet biologist Alexey Olovnikov in 1973, who also suggested the telomere hypothesis of aging and the telomere's connections to cancer. Telomerase was discovered by Carol W. Greider and Elizabeth Blackburn in 1984 in the ciliate Tetrahymena. Together with Jack W. Szostak, Greider and Blackburn were awarded the 2009 Nobel Prize in Physiology or Medicine for their discovery.The role of telomeres and telomerase in cell aging and cancer was established by scientists at biotechnology company Geron with the cloning of the RNA and catalytic components of human telomerase and the development of a PCR- based assay for telomerase activity called the TRAP assay allowing for a survey of telomerase activity in multiple types of cancer.".
- Telomerase ecNumber "2.7.7.49".
- Telomerase thumbnail Tibolium_castaneum_TERT_structure.png?width=300.
- Telomerase wikiPageExternalLink telomerase.asu.edu.
- Telomerase wikiPageExternalLink elizabeth-blackburn-part-1.html.
- Telomerase wikiPageExternalLink telomerase_model.gif.
- Telomerase wikiPageID "273854".
- Telomerase wikiPageRevisionID "606434586".
- Telomerase caption "A conceptual diagram showing the protein component of telomerase in grey and the RNA component in yellow".
- Telomerase casNumber "9068".
- Telomerase ecNumber "2.7".
- Telomerase goCode "3967".
- Telomerase hasPhotoCollection Telomerase.
- Telomerase iubmbEcNumber "2".
- Telomerase name "RNA-directed RNA polymerase".
- Telomerase width "240".
- Telomerase subject Category:Ageing.
- Telomerase subject Category:Aging-related_enzymes.
- Telomerase subject Category:Aging-related_proteins.
- Telomerase subject Category:Anti-aging_substances.
- Telomerase subject Category:DNA_replication.
- Telomerase subject Category:EC_2.7.7.
- Telomerase subject Category:Gerontology.
- Telomerase subject Category:Senescence.
- Telomerase subject Category:Telomere-related_proteins.
- Telomerase subject Category:Telomeres.
- Telomerase type Biomolecule.
- Telomerase type Enzyme.
- Telomerase type BiologicalObject.
- Telomerase comment "Telomerase is a ribonucleoprotein that is an enzyme that adds DNA sequence repeats ("TTAGGG" in all vertebrates) to the 3' end of DNA strands in the telomere regions, which are found at the ends of eukaryotic chromosomes. This region of repeated nucleotide called telomeres contains noncoding DNA and hinders the loss of important DNA from chromosome ends. As a result, every time the chromosome is copied, only 100–200 nucleotides are lost, which causes no damage to the organism's DNA.".
- Telomerase label "Telomerasa".
- Telomerase label "Telomerase".
- Telomerase label "Telomerase".
- Telomerase label "Telomerase".
- Telomerase label "Telomerase".
- Telomerase label "Telomerasi".
- Telomerase label "Telomeraza".
- Telomerase label "Télomérase".
- Telomerase label "Теломераза".
- Telomerase label "テロメラーゼ".
- Telomerase label "端粒酶".
- Telomerase sameAs Telomeráza.
- Telomerase sameAs Telomerase.
- Telomerase sameAs Telomerasa.
- Telomerase sameAs Télomérase.
- Telomerase sameAs Telomerase.
- Telomerase sameAs Telomerasi.
- Telomerase sameAs テロメラーゼ.
- Telomerase sameAs 텔로머레이스.
- Telomerase sameAs Telomerase.
- Telomerase sameAs Telomeraza.
- Telomerase sameAs Telomerase.
- Telomerase sameAs m.01p28_.
- Telomerase sameAs Q331839.
- Telomerase sameAs Q331839.
- Telomerase wasDerivedFrom Telomerase?oldid=606434586.
- Telomerase depiction Tibolium_castaneum_TERT_structure.png.
- Telomerase isPrimaryTopicOf Telomerase.
- Telomerase name "RNA-directed RNA polymerase".