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- Temozolomide abstract "Temozolomide (brand names Temodar and Temodal and Temcad) is an oral chemotherapy drug. It is an alkylating agent used for the treatment of Grade IV astrocytoma — an aggressive brain tumor, also known as glioblastoma multiforme — as well as for treating melanoma, a form of skin cancer. Temozolomide is also indicated for relapsed Grade III anaplastic astrocytoma and not indicated for, but as of 2011 used to treat oligodendroglioma brain tumors in some countries, replacing the older (and less well tolerated) PCV (Procarbazine-Lomustine-Vincristine) regimen.The agent was developed by Malcolm Stevens and his team at Aston University in Birmingham, Temozolomide is a prodrug and an imidazotetrazine derivative of the alkylating agent dacarbazine. It has been available in the US since August 1999, and in other countries since the early 2000s.The therapeutic benefit of temozolomide depends on its ability to alkylate/methylate DNA, which most often occurs at the N-7 or O-6 positions of guanine residues. This methylation damages the DNA and triggers the death of tumor cells. However, some tumor cells are able to repair this type of DNA damage, and therefore diminish the therapeutic efficacy of temozolomide, by expressing a protein O6-alkylguanine DNA alkyltransferase (AGT) encoded in humans by the O-6-methylguanine-DNA methyltransferase (MGMT) gene. In some tumors, epigenetic silencing of the MGMT gene prevents the synthesis of this enzyme, and as a consequence such tumors are more sensitive to killing by temozolomide. Conversely, the presence of AGT protein in brain tumors predicts poor response to temozolomide and these patients receive little benefit from chemotherapy with temozolomide.".
- Temozolomide atcPrefix "L01".
- Temozolomide atcSuffix "AX03".
- Temozolomide casNumber "85622-93-1".
- Temozolomide chEBI "72564".
- Temozolomide drugbank "DB00853".
- Temozolomide fdaUniiCode "YF1K15M17Y".
- Temozolomide iupacName "4-methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide".
- Temozolomide pubchem "5394".
- Temozolomide thumbnail Temozolomide_structure.png?width=300.
- Temozolomide wikiPageExternalLink index.cfm?fuseaction=release.view&release=509.
- Temozolomide wikiPageExternalLink temozolomide.
- Temozolomide wikiPageID "30863182".
- Temozolomide wikiPageRevisionID "605101872".
- Temozolomide atcPrefix "L01".
- Temozolomide atcSuffix "AX03".
- Temozolomide c "6".
- Temozolomide casNumber "85622".
- Temozolomide chebi "72564".
- Temozolomide chembl "810".
- Temozolomide chemspiderid "5201".
- Temozolomide drugbank "DB00853".
- Temozolomide eliminationHalfLife "6480.0".
- Temozolomide h "6".
- Temozolomide hasPhotoCollection Temozolomide.
- Temozolomide image "Temozolomide-3D-spacefill.png".
- Temozolomide inchi "1".
- Temozolomide inchikey "BPEGJWRSRHCHSN-UHFFFAOYAN".
- Temozolomide iupacName "4".
- Temozolomide kegg "D06067".
- Temozolomide legalUs "Rx-only".
- Temozolomide licenceEu "Temodal".
- Temozolomide licenceUs "Temozolomide".
- Temozolomide medlineplus "a601250".
- Temozolomide metabolism "spontaneously hydrolyzed at physiologic pH to the active species, 3-methyl-imidazole-4-carboxamide and to temozolomide acid metabolite.".
- Temozolomide molecularWeight "194.151".
- Temozolomide n "6".
- Temozolomide o "2".
- Temozolomide pregnancyUs "D".
- Temozolomide proteinBound "15.0".
- Temozolomide pubchem "5394".
- Temozolomide routesOfAdministration "Oral, intravenous".
- Temozolomide smiles "O=CN".
- Temozolomide stdinchi "1".
- Temozolomide stdinchikey "BPEGJWRSRHCHSN-UHFFFAOYSA-N".
- Temozolomide tradename "Temodar, Temodal,Temcad".
- Temozolomide unii "YF1K15M17Y".
- Temozolomide verifiedfields "changed".
- Temozolomide verifiedrevid "477861554".
- Temozolomide watchedfields "changed".
- Temozolomide width "200".
- Temozolomide subject Category:Amides.
- Temozolomide subject Category:DNA_replication_inhibitors.
- Temozolomide subject Category:Fetotoxicants.
- Temozolomide subject Category:Lactams.
- Temozolomide subject Category:Prodrugs.
- Temozolomide subject Category:Schering-Plough.
- Temozolomide subject Category:Teratogens.
- Temozolomide type Abstraction100002137.
- Temozolomide type Amide114724264.
- Temozolomide type Amides.
- Temozolomide type Chemical114806838.
- Temozolomide type Compound114818238.
- Temozolomide type Material114580897.
- Temozolomide type Matter100020827.
- Temozolomide type OrganicCompound114727670.
- Temozolomide type Part113809207.
- Temozolomide type PhysicalEntity100001930.
- Temozolomide type Relation100031921.
- Temozolomide type Substance100019613.
- Temozolomide type Drug.
- Temozolomide type DrugProduct.
- Temozolomide type FunctionalSubstance.
- Temozolomide comment "Temozolomide (brand names Temodar and Temodal and Temcad) is an oral chemotherapy drug. It is an alkylating agent used for the treatment of Grade IV astrocytoma — an aggressive brain tumor, also known as glioblastoma multiforme — as well as for treating melanoma, a form of skin cancer.".
- Temozolomide label "Temozolomid".
- Temozolomide label "Temozolomid".
- Temozolomide label "Temozolomide".
- Temozolomide label "Temozolomide".
- Temozolomide label "Temozolomide".
- Temozolomide label "Témozolomide".
- Temozolomide label "Темозоломид".
- Temozolomide sameAs Temozolomid.
- Temozolomide sameAs Témozolomide.
- Temozolomide sameAs Temozolomide.
- Temozolomide sameAs Temozolomide.
- Temozolomide sameAs Temozolomid.
- Temozolomide sameAs m.060rrv.
- Temozolomide sameAs Q425088.
- Temozolomide sameAs Q425088.
- Temozolomide sameAs Temozolomide.
- Temozolomide sameAs DB00853.
- Temozolomide sameAs 5394.
- Temozolomide sameAs Temozolomide.
- Temozolomide wasDerivedFrom Temozolomide?oldid=605101872.
- Temozolomide depiction Temozolomide_structure.png.
- Temozolomide isPrimaryTopicOf Temozolomide.