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- Terguride abstract "Terguride (INN) is a serotonin antagonist. It is used for the treatment of hyperprolactinemia. Terguride is an oral, potent antagonist of 5-HT2B and 5-HT2A (serotonin) receptors. Serotonin stimulates the proliferation of pulmonary artery smooth muscle cells, and induces fibrosis in the wall of pulmonary arteries. Together, this causes vascular remodeling and narrowing of the pulmonary arteries. These changes result in increased vascular resistance and PAH. Due to the potential anti-proliferative and anti-fibrotic activity of terguride, this potential medicine could offer the hope of achieving reversal of pulmonary artery vascular remodeling and attenuation of disease progression.In May 2008, terguride was granted orphan drug status for the treatment of pulmonary arterial hypertension.In May 2010 Pfizer purchased world-wide rights for the drug.".
- Terguride atcPrefix "G02".
- Terguride atcSuffix "CB06".
- Terguride casNumber "37686-84-3".
- Terguride fdaUniiCode "21OJT43Q88".
- Terguride iupacName "N,N-diethyl-N'-[(8α)-6-methylergolin-8-yl]urea".
- Terguride pubchem "443951".
- Terguride thumbnail Terguride.png?width=300.
- Terguride wikiPageID "18368829".
- Terguride wikiPageRevisionID "546624935".
- Terguride atcPrefix "G02".
- Terguride atcSuffix "CB06".
- Terguride c "20".
- Terguride casNumber "37686".
- Terguride h "28".
- Terguride hasPhotoCollection Terguride.
- Terguride iupacName "N,N-diethyl-N'-[-6-methylergolin-8-yl]urea".
- Terguride iupharLigand "56".
- Terguride kegg "D01348".
- Terguride legalStatus "Rx-only".
- Terguride molecularWeight "340.46".
- Terguride n "4".
- Terguride o "1".
- Terguride pubchem "443951".
- Terguride routesOfAdministration "Oral".
- Terguride smiles "CCNCN[C@H]1C[C@H]2[C@@H]NC".
- Terguride unii "21".
- Terguride verifiedrevid "437134889".
- Terguride subject Category:Dopamine_agonists.
- Terguride subject Category:Orphan_drugs.
- Terguride subject Category:Ureas.
- Terguride type Abstraction100002137.
- Terguride type Chemical114806838.
- Terguride type Compound114818238.
- Terguride type Material114580897.
- Terguride type Matter100020827.
- Terguride type OrganicCompound114727670.
- Terguride type Part113809207.
- Terguride type PhysicalEntity100001930.
- Terguride type Relation100031921.
- Terguride type Substance100019613.
- Terguride type Urea115085472.
- Terguride type Ureas.
- Terguride type Drug.
- Terguride type DrugProduct.
- Terguride type FunctionalSubstance.
- Terguride comment "Terguride (INN) is a serotonin antagonist. It is used for the treatment of hyperprolactinemia. Terguride is an oral, potent antagonist of 5-HT2B and 5-HT2A (serotonin) receptors. Serotonin stimulates the proliferation of pulmonary artery smooth muscle cells, and induces fibrosis in the wall of pulmonary arteries. Together, this causes vascular remodeling and narrowing of the pulmonary arteries. These changes result in increased vascular resistance and PAH.".
- Terguride label "Terguride".
- Terguride sameAs m.04dyybn.
- Terguride sameAs Q7702355.
- Terguride sameAs Q7702355.
- Terguride sameAs Terguride.
- Terguride wasDerivedFrom Terguride?oldid=546624935.
- Terguride depiction Terguride.png.
- Terguride isPrimaryTopicOf Terguride.