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- Tiagabine abstract "Tiagabine (/taɪˈæɡəbiːn/ is an anti-convulsive medication produced by Cephalon and marketed under the brand name Gabitril. The drug was discovered at Novo Nordisk in Denmark in 1988 by a team of chemists and pharmacologists under the general direction of Dr. Claus Bræstrup. An article authored by Dr. Lars J. S. Knutsen describing the design, selection, pharmacology and synthesis of tiagabine was published in the Journal of Medicinal Chemistry in 1993, pulling together the work of the team at Novo Nordisk. The drug was co-developed with Abbott, in a 40/60 cost sharing deal, with Abbott paying a premium for licensing the IP from the Danish company.Abbott did initially embrace the drug enthusiastically after its US launch in 1998, and provided further clinical studies with the goal of gaining FDA approval for monotherapy in epilepsy. However, the senior management at Abbott drew back after realizing that the original deal with Novo would limit the company's financial gain from a monotherapy approval. After a period of co-promotion, Cephalon licensed Tiagabine from Abbott/Novo and now is the exclusive producer. The medication is also utilized in the treatment of panic disorder, as are a few other anticonvulsants.".
- Tiagabine atcPrefix "N03".
- Tiagabine atcSuffix "AG06".
- Tiagabine bioavailability "90.0".
- Tiagabine casNumber "115103-54-3".
- Tiagabine drugbank "DB00906".
- Tiagabine fdaUniiCode "Z80I64HMNP".
- Tiagabine iupacName "(R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl] piperidine-3-carboxylic acid".
- Tiagabine pubchem "60648".
- Tiagabine thumbnail Tiagabine-skeletal.svg?width=300.
- Tiagabine wikiPageExternalLink default.asp.
- Tiagabine wikiPageExternalLink abstract?CRETRY=1&SRETRY=0.
- Tiagabine wikiPageID "1636378".
- Tiagabine wikiPageRevisionID "598816565".
- Tiagabine atcPrefix "N03".
- Tiagabine atcSuffix "AG06".
- Tiagabine bioavailability "90.0".
- Tiagabine c "20".
- Tiagabine casNumber "115103".
- Tiagabine chembl "1027".
- Tiagabine chemspiderid "54661".
- Tiagabine drugbank "DB00906".
- Tiagabine eliminationHalfLife "-32400.0".
- Tiagabine excretion "Fecal and renal".
- Tiagabine h "25".
- Tiagabine hasPhotoCollection Tiagabine.
- Tiagabine inchi "1".
- Tiagabine inchikey "PBJUNZJWGZTSKL-MRXNPFEDBV".
- Tiagabine iupacName "-1".
- Tiagabine kegg "D08588".
- Tiagabine legalStatus "POM , ℞-only".
- Tiagabine medlineplus "a698014".
- Tiagabine metabolism "Hepatic".
- Tiagabine molecularWeight "375.55".
- Tiagabine n "1".
- Tiagabine o "2".
- Tiagabine pregnancyCategory "B3 , C".
- Tiagabine proteinBound "96.0".
- Tiagabine pubchem "60648".
- Tiagabine routesOfAdministration "Oral".
- Tiagabine s "2".
- Tiagabine smiles "O=C[C@H]1CNCC/C=Cc3sccc3C".
- Tiagabine stdinchi "1".
- Tiagabine stdinchikey "PBJUNZJWGZTSKL-MRXNPFEDSA-N".
- Tiagabine tradename "Gabitril".
- Tiagabine unii "Z80I64HMNP".
- Tiagabine verifiedrevid "470609936".
- Tiagabine subject Category:Anticonvulsants.
- Tiagabine subject Category:Carboxylic_acids.
- Tiagabine subject Category:GABA_reuptake_inhibitors.
- Tiagabine subject Category:Piperidines.
- Tiagabine subject Category:Thiophenes.
- Tiagabine type Agent114778436.
- Tiagabine type Anticonvulsant102718469.
- Tiagabine type Anticonvulsants.
- Tiagabine type CausalAgent100007347.
- Tiagabine type Drug103247620.
- Tiagabine type GABAReuptakeInhibitors.
- Tiagabine type Inhibitor114724436.
- Tiagabine type Matter100020827.
- Tiagabine type Medicine103740161.
- Tiagabine type PhysicalEntity100001930.
- Tiagabine type Substance100020090.
- Tiagabine type Drug.
- Tiagabine type DrugProduct.
- Tiagabine type FunctionalSubstance.
- Tiagabine comment "Tiagabine (/taɪˈæɡəbiːn/ is an anti-convulsive medication produced by Cephalon and marketed under the brand name Gabitril. The drug was discovered at Novo Nordisk in Denmark in 1988 by a team of chemists and pharmacologists under the general direction of Dr. Claus Bræstrup. An article authored by Dr. Lars J. S.".
- Tiagabine label "Tiagabin".
- Tiagabine label "Tiagabina".
- Tiagabine label "Tiagabina".
- Tiagabine label "Tiagabine".
- Tiagabine sameAs Tiagabin.
- Tiagabine sameAs Tiagabina.
- Tiagabine sameAs Tiagabina.
- Tiagabine sameAs m.05jjxg.
- Tiagabine sameAs Q907219.
- Tiagabine sameAs Q907219.
- Tiagabine sameAs tiagabine.
- Tiagabine sameAs DB00906.
- Tiagabine sameAs 5466.
- Tiagabine sameAs Tiagabine.
- Tiagabine wasDerivedFrom Tiagabine?oldid=598816565.
- Tiagabine depiction Tiagabine-skeletal.svg.
- Tiagabine isPrimaryTopicOf Tiagabine.