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- Tissue_factor abstract "Tissue factor, also called platelet tissue factor, factor III, thromboplastin, or CD142 is a protein present in subendothelial tissue and leukocytes necessary for the initiation of thrombin formation from the zymogen prothrombin.This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. In addition to the membrane-bound tissue factor, soluble form of tissue factor was also found which results from alternatively spliced tissue factor mRNA transcripts, in which exon 5 is absent and exon 4 is spliced directly to exon 6.".
- Tissue_factor entrezgene "2152".
- Tissue_factor wikiPageID "2967227".
- Tissue_factor wikiPageRevisionID "603655446".
- Tissue_factor hasPhotoCollection Tissue_factor.
- Tissue_factor requireManualInspection "no".
- Tissue_factor summaryText "This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described.".
- Tissue_factor updateCitations "yes".
- Tissue_factor updatePage "yes".
- Tissue_factor updateProteinBox "yes".
- Tissue_factor updateSummary "yes".
- Tissue_factor subject Category:Clusters_of_differentiation.
- Tissue_factor subject Category:Coagulation_system.
- Tissue_factor type Abstraction100002137.
- Tissue_factor type Agglomeration107959269.
- Tissue_factor type Bunch107959943.
- Tissue_factor type ClustersOfDifferentiation.
- Tissue_factor type Collection107951464.
- Tissue_factor type Group100031264.
- Tissue_factor type Biomolecule.
- Tissue_factor type Protein.
- Tissue_factor type BiologicalObject.
- Tissue_factor comment "Tissue factor, also called platelet tissue factor, factor III, thromboplastin, or CD142 is a protein present in subendothelial tissue and leukocytes necessary for the initiation of thrombin formation from the zymogen prothrombin.This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII.".
- Tissue_factor label "Facteur tissulaire".
- Tissue_factor label "Factor tisular".
- Tissue_factor label "Fator tissular".
- Tissue_factor label "Fattore tissutale".
- Tissue_factor label "Gewebefaktor".
- Tissue_factor label "Tissue factor".
- Tissue_factor label "Tromboplastine".
- Tissue_factor label "Tromboplastyna tkankowa".
- Tissue_factor label "Фактор свёртывания крови III".
- Tissue_factor sameAs Faktor_III.
- Tissue_factor sameAs Gewebefaktor.
- Tissue_factor sameAs Factor_tisular.
- Tissue_factor sameAs Facteur_tissulaire.
- Tissue_factor sameAs Trombokinase.
- Tissue_factor sameAs Fattore_tissutale.
- Tissue_factor sameAs Tromboplastine.
- Tissue_factor sameAs Tromboplastyna_tkankowa.
- Tissue_factor sameAs Fator_tissular.
- Tissue_factor sameAs m.08gnrl.
- Tissue_factor sameAs Q412841.
- Tissue_factor sameAs Q412841.
- Tissue_factor sameAs 19.
- Tissue_factor sameAs 2139.
- Tissue_factor sameAs 369.
- Tissue_factor sameAs Tissue_factor.
- Tissue_factor wasDerivedFrom Tissue_factor?oldid=603655446.
- Tissue_factor isPrimaryTopicOf Tissue_factor.