Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Torreyanic_acid> ?p ?o. }
Showing items 1 to 36 of
36
with 100 items per page.
- Torreyanic_acid abstract "Torreyanic acid is a dimeric quinone first isolated and by Lee et al. in 1996 from an endophyte, Pestalotisopsis microspora. This endophyte is likely the cause of the decline of Florida torreya (Torreya taxifolia), an endangered species that is related to the taxol-producing Taxus brevifolia. The natural product was found to be cytotoxic against 25 different human cancer cell lines with an average IC50 value of 9.4 µg/mL, ranging from 3.5 (NEC) to 45 (A549) µg/mL. Torreyanic acid was found to be 5-10 times more potent in cell lines sensitive to protein kinase C (PKC) agonists, 12-o-tetradecanoyl phorbol-13-acetate (TPA), and was shown to cause cell death via apoptosis. Torreyanic acid also promoted G1 arrest of G0 cynchronized cells at 1-5 µg/mL levels, depending on the cell line. It has been proposed that the eukaryotic translation initiation factor EIF-4a is a potential biochemical target for the natural compound.".
- Torreyanic_acid atcPrefix "none".
- Torreyanic_acid casNumber "176260-42-7".
- Torreyanic_acid iupacName "(2E,2'E)-4,4'-[(1aR,5R,5aS,7aS,8aR,10aS,11aS)-2,7,9,11-tetraoxo-5,13-dipentyl-1a,2,5a,6,7,8a,9,10-octahydro-10,6-(epoxymethano)bis[1]benzoxireno[3,4-d:3',4'-g]isochromene-7a,11a(5H,11H)-diyl]bis(2-met hylbut-2-enoic acid)".
- Torreyanic_acid thumbnail Torreyanic_acid.png?width=300.
- Torreyanic_acid wikiPageID "27670466".
- Torreyanic_acid wikiPageRevisionID "601396801".
- Torreyanic_acid atcPrefix "none".
- Torreyanic_acid c "38".
- Torreyanic_acid casNumber "176260".
- Torreyanic_acid chemspiderid "10307511".
- Torreyanic_acid h "44".
- Torreyanic_acid hasPhotoCollection Torreyanic_acid.
- Torreyanic_acid iupacName "-44".
- Torreyanic_acid molecularWeight "692.7488".
- Torreyanic_acid o "12".
- Torreyanic_acid smiles "CCCCC[C@@H]1[C@H]2C3CCCCCC".
- Torreyanic_acid stdinchi "1".
- Torreyanic_acid stdinchikey "DQBVXDMPCDAQGS-YOWCJFHESA-N".
- Torreyanic_acid verifiedfields "changed".
- Torreyanic_acid verifiedrevid "470625291".
- Torreyanic_acid watchedfields "changed".
- Torreyanic_acid width "171".
- Torreyanic_acid subject Category:Quinolones.
- Torreyanic_acid type Drug.
- Torreyanic_acid type FunctionalSubstance.
- Torreyanic_acid comment "Torreyanic acid is a dimeric quinone first isolated and by Lee et al. in 1996 from an endophyte, Pestalotisopsis microspora. This endophyte is likely the cause of the decline of Florida torreya (Torreya taxifolia), an endangered species that is related to the taxol-producing Taxus brevifolia. The natural product was found to be cytotoxic against 25 different human cancer cell lines with an average IC50 value of 9.4 µg/mL, ranging from 3.5 (NEC) to 45 (A549) µg/mL.".
- Torreyanic_acid label "Torreyanic acid".
- Torreyanic_acid label "Ácido torreyánico".
- Torreyanic_acid sameAs Ácido_torreyánico.
- Torreyanic_acid sameAs m.0c41qb1.
- Torreyanic_acid sameAs Q388948.
- Torreyanic_acid sameAs Q388948.
- Torreyanic_acid wasDerivedFrom Torreyanic_acid?oldid=601396801.
- Torreyanic_acid depiction Torreyanic_acid.png.
- Torreyanic_acid isPrimaryTopicOf Torreyanic_acid.