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- Trace_amine abstract "Trace amines are an endogenous group of TAAR1 agonists that are structurally and metabolically related to classical monoamine neurotransmitters, such as dopamine, norepinephrine, and serotonin. Compared to the classical monoamines, they are present in trace concentrations. They are distributed heterogeneously throughout the mammalian brain and peripheral nervous tissues and exhibit high rates of metabolism. Although they can be synthesized within parent monoamine neurotransmitter systems, there is evidence that suggests that some of them may comprise their own independent neurotransmitter systems.Trace amines may play very significant roles in the coordination of biogenic monoamine-based synaptic physiology. At high concentrations, they have well-characterized presynaptic ‘‘amphetamine-like’’ effects on monoamine release, reuptake and biosynthesis; at lower concentrations, they possess postsynaptic modulatory effects that potentiate the activity of other neurotransmitters, particularly dopamine and serotonin. A family of G protein coupled receptors known as TAARs (trace amine associated receptors) has been characterized to be responsive to trace amines and structurally related psychoactive drugs, such as amphetamine, MDMA, LSD, and DMT. Like dopamine, noradrenaline, and serotonin, the trace amines have been implicated in a vast array of human disorders of affect and cognition, such as depression and schizophrenia.A thorough review of trace amines and trace amine-associated receptors that discusses the historical evolution of this research particularly well is that of Grandy.".
- Trace_amine wikiPageID "5552077".
- Trace_amine wikiPageRevisionID "606572612".
- Trace_amine align "right".
- Trace_amine caption "Phenethylaminergic trace amines and the catecholamines are derivatives of phenylalanine.".
- Trace_amine hasPhotoCollection Trace_amine.
- Trace_amine header "Metabolic pathway of phenylalanine".
- Trace_amine subject Category:Amines.
- Trace_amine subject Category:Amphetamine.
- Trace_amine subject Category:Neurochemistry.
- Trace_amine subject Category:Neurotransmitters.
- Trace_amine subject Category:TAAR1_agonists.
- Trace_amine type Abstraction100002137.
- Trace_amine type AliphaticCompound114601294.
- Trace_amine type Amine114739004.
- Trace_amine type Amines.
- Trace_amine type Chemical114806838.
- Trace_amine type Compound114818238.
- Trace_amine type Material114580897.
- Trace_amine type Matter100020827.
- Trace_amine type MethaneSeries114951377.
- Trace_amine type Neurochemical114807410.
- Trace_amine type Neurotransmitter114807558.
- Trace_amine type Neurotransmitters.
- Trace_amine type OrganicCompound114727670.
- Trace_amine type Part113809207.
- Trace_amine type PhysicalEntity100001930.
- Trace_amine type Relation100031921.
- Trace_amine type Substance100019613.
- Trace_amine comment "Trace amines are an endogenous group of TAAR1 agonists that are structurally and metabolically related to classical monoamine neurotransmitters, such as dopamine, norepinephrine, and serotonin. Compared to the classical monoamines, they are present in trace concentrations. They are distributed heterogeneously throughout the mammalian brain and peripheral nervous tissues and exhibit high rates of metabolism.".
- Trace_amine label "Amina traço".
- Trace_amine label "Spurenamine".
- Trace_amine label "Trace amine".
- Trace_amine label "痕量胺".
- Trace_amine sameAs Spurenamine.
- Trace_amine sameAs Amina_traço.
- Trace_amine sameAs m.0ds5wp.
- Trace_amine sameAs Q413778.
- Trace_amine sameAs Q413778.
- Trace_amine sameAs Trace_amine.
- Trace_amine wasDerivedFrom Trace_amine?oldid=606572612.
- Trace_amine isPrimaryTopicOf Trace_amine.