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- Trastuzumab_emtansine abstract "Trastuzumab emtansine (INN; in the United States, ado-trastuzumab emtansine, trade name Kadcyla) is an antibody-drug conjugate consisting of the monoclonal antibody trastuzumab (Herceptin) linked to the cytotoxic agent mertansine (DM1). Trastuzumab alone stops growth of cancer cells by binding to the HER2/neu receptor, whereas mertansine enters cells and destroys them by binding to tubulin. Because the monoclonal antibody targets HER2, and HER2 is only over-expressed in cancer cells, the conjugate delivers the toxin specifically to tumor cells. The conjugate is abbreviated T-DM1.In the EMILIA clinical trial of women with advanced HER2 positive breast cancer who were already resistant to trastuzumab alone, it improved survival by 5.8 months compared to the combination of lapatinib and capecitabine. Based on that trial, the U.S. Food and Drug Administration (FDA) approved marketing on February 22, 2013.Trastuzumab emtansine was developed by Genentech. The planned cost is expected to be $9,800 a month, or $94,000 for a typical course of treatment.".
- Trastuzumab_emtansine atcPrefix "L01".
- Trastuzumab_emtansine atcSuffix "XC14".
- Trastuzumab_emtansine casNumber "1018448-65-1".
- Trastuzumab_emtansine fdaUniiCode "SE2KH7T06F".
- Trastuzumab_emtansine thumbnail Trastuzumab_emtansine.svg?width=300.
- Trastuzumab_emtansine wikiPageExternalLink www.kadcyla.com.
- Trastuzumab_emtansine wikiPageID "30507233".
- Trastuzumab_emtansine wikiPageRevisionID "603986262".
- Trastuzumab_emtansine atcPrefix "L01".
- Trastuzumab_emtansine atcSuffix "XC14".
- Trastuzumab_emtansine bioavailability "N/A".
- Trastuzumab_emtansine casNumber "1018448".
- Trastuzumab_emtansine chemicalFormula "C6448H9948N1720O2012S44·n".
- Trastuzumab_emtansine chemspiderid "NA".
- Trastuzumab_emtansine eliminationHalfLife "345600.0".
- Trastuzumab_emtansine hasPhotoCollection Trastuzumab_emtansine.
- Trastuzumab_emtansine kegg "D09980".
- Trastuzumab_emtansine legalUs "Rx-only".
- Trastuzumab_emtansine mabType "mab".
- Trastuzumab_emtansine metabolism "Hepatic".
- Trastuzumab_emtansine molecularWeight "148.5".
- Trastuzumab_emtansine pregnancyUs "D".
- Trastuzumab_emtansine proteinBound "93.0".
- Trastuzumab_emtansine routesOfAdministration Intravenous_therapy.
- Trastuzumab_emtansine source "zu/o".
- Trastuzumab_emtansine tradename "Kadcyla".
- Trastuzumab_emtansine type "mab".
- Trastuzumab_emtansine unii "SE2KH7T06F".
- Trastuzumab_emtansine verifiedfields "changed".
- Trastuzumab_emtansine verifiedrevid "470612501".
- Trastuzumab_emtansine watchedfields "changed".
- Trastuzumab_emtansine width "300".
- Trastuzumab_emtansine subject Category:Monoclonal_antibodies_for_tumors.
- Trastuzumab_emtansine type Abstraction100002137.
- Trastuzumab_emtansine type Antibody115027189.
- Trastuzumab_emtansine type Chemical114806838.
- Trastuzumab_emtansine type Compound114818238.
- Trastuzumab_emtansine type Macromolecule114944888.
- Trastuzumab_emtansine type Material114580897.
- Trastuzumab_emtansine type Matter100020827.
- Trastuzumab_emtansine type Molecule114682133.
- Trastuzumab_emtansine type MonoclonalAntibodiesForTumors.
- Trastuzumab_emtansine type MonoclonalAntibody115029781.
- Trastuzumab_emtansine type OrganicCompound114727670.
- Trastuzumab_emtansine type Part113809207.
- Trastuzumab_emtansine type PhysicalEntity100001930.
- Trastuzumab_emtansine type Protein114728724.
- Trastuzumab_emtansine type Relation100031921.
- Trastuzumab_emtansine type Substance100019613.
- Trastuzumab_emtansine type Thing100002452.
- Trastuzumab_emtansine type Unit109465459.
- Trastuzumab_emtansine type Drug.
- Trastuzumab_emtansine type FunctionalSubstance.
- Trastuzumab_emtansine comment "Trastuzumab emtansine (INN; in the United States, ado-trastuzumab emtansine, trade name Kadcyla) is an antibody-drug conjugate consisting of the monoclonal antibody trastuzumab (Herceptin) linked to the cytotoxic agent mertansine (DM1). Trastuzumab alone stops growth of cancer cells by binding to the HER2/neu receptor, whereas mertansine enters cells and destroys them by binding to tubulin.".
- Trastuzumab_emtansine label "Trastuzumab emtansine".
- Trastuzumab_emtansine label "Trastuzumab emtansine".
- Trastuzumab_emtansine label "Trastuzumab emtansine".
- Trastuzumab_emtansine sameAs Trastuzumab_emtansine.
- Trastuzumab_emtansine sameAs Trastuzumab_emtansine.
- Trastuzumab_emtansine sameAs m.0g9t39y.
- Trastuzumab_emtansine sameAs Q3997863.
- Trastuzumab_emtansine sameAs Q3997863.
- Trastuzumab_emtansine sameAs Trastuzumab_emtansine.
- Trastuzumab_emtansine wasDerivedFrom Trastuzumab_emtansine?oldid=603986262.
- Trastuzumab_emtansine depiction Trastuzumab_emtansine.svg.
- Trastuzumab_emtansine homepage www.kadcyla.com.
- Trastuzumab_emtansine isPrimaryTopicOf Trastuzumab_emtansine.