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- Trichostatin_A abstract "Trichostatin A (TSA) is an organic compound that serves as an antifungal antibiotic and selectively inhibits the class I and II mammalian histone deacetylase (HDAC) families of enzymes, but not class III HDACs (i.e., Sirtuins). TSA inhibits the eukaryotic cell cycle during the beginning of the growth stage. TSA can be used to alter gene expression by interfering with the removal of acetyl groups from histones (histone deacetylases, HDAC) and therefore altering the ability of DNA transcription factors to access the DNA molecules inside chromatin. It is a member of a larger class of histone deacetylase inhibitors (HDIs or HDACIs) that have a broad spectrum of epigenetic activities. Thus, TSA has some potential as an anti-cancer drug. One suggested mechanism is that TSA promotes the expression of apoptosis-related genes, leading to cancerous cells surviving at lower rates, thus slowing the progression of cancer. Other mechanisms may include the activity of HDIs to induce cell differentiation, thus acting to "mature" some of the de-differentiated cells found in tumors. HDIs have multiple effects on non-histone effector molecules, so the anti-cancer mechanisms are truly not understood at this time.TSA inhibits HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM.TSA represses IL (interleukin)-1β/LPS (lipopolysaccharide)/IFNγ (interferon γ)-induced nitric oxide synthase (NOS)2 expression in murine macrophage-like cells but increases LPS-stimulated NOS2 expression in murine N9 and primary rat microglial cells.However, there TSA has not been tested in clinical trials as of 2013-05-27.".
- Trichostatin_A atcPrefix "none".
- Trichostatin_A casNumber "58880-19-6".
- Trichostatin_A chEBI "46024".
- Trichostatin_A drugbank "DB04297".
- Trichostatin_A iupacName "7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide".
- Trichostatin_A pubchem "444732".
- Trichostatin_A thumbnail Trichostatin_A.svg?width=300.
- Trichostatin_A wikiPageExternalLink trichostatin_A-MSDS.htm.
- Trichostatin_A wikiPageID "3181579".
- Trichostatin_A wikiPageRevisionID "593215820".
- Trichostatin_A atcPrefix "none".
- Trichostatin_A c "17".
- Trichostatin_A casNumber "58880".
- Trichostatin_A chebi "46024".
- Trichostatin_A chembl "99".
- Trichostatin_A chemspiderid "392575".
- Trichostatin_A drugbank "DB04297".
- Trichostatin_A h "22".
- Trichostatin_A hasPhotoCollection Trichostatin_A.
- Trichostatin_A image "Trichostatin A 3D 1t64.png".
- Trichostatin_A inchi "1".
- Trichostatin_A inchikey "RTKIYFITIVXBLE-QEQCGCAPBF".
- Trichostatin_A iupacName "7".
- Trichostatin_A molecularWeight "302.37".
- Trichostatin_A n "2".
- Trichostatin_A o "3".
- Trichostatin_A pregnancyCategory "D—teratogenic".
- Trichostatin_A pubchem "444732".
- Trichostatin_A smiles "O=C\C=C\CC".
- Trichostatin_A stdinchi "1".
- Trichostatin_A stdinchikey "RTKIYFITIVXBLE-QEQCGCAPSA-N".
- Trichostatin_A verifiedfields "changed".
- Trichostatin_A verifiedrevid "470613588".
- Trichostatin_A subject Category:Anilines.
- Trichostatin_A subject Category:Antibiotics.
- Trichostatin_A subject Category:Aromatic_ketones.
- Trichostatin_A subject Category:Histone_deacetylase_inhibitors.
- Trichostatin_A subject Category:Hydroxamic_acids.
- Trichostatin_A type Abstraction100002137.
- Trichostatin_A type Acid114607521.
- Trichostatin_A type AliphaticCompound114601294.
- Trichostatin_A type Amine114739004.
- Trichostatin_A type Aniline114754505.
- Trichostatin_A type Anilines.
- Trichostatin_A type AromaticKetones.
- Trichostatin_A type Chemical114806838.
- Trichostatin_A type Compound114818238.
- Trichostatin_A type HydroxamicAcids.
- Trichostatin_A type Ketone114926294.
- Trichostatin_A type Material114580897.
- Trichostatin_A type Matter100020827.
- Trichostatin_A type MethaneSeries114951377.
- Trichostatin_A type OrganicCompound114727670.
- Trichostatin_A type Part113809207.
- Trichostatin_A type PhysicalEntity100001930.
- Trichostatin_A type Relation100031921.
- Trichostatin_A type Substance100019613.
- Trichostatin_A type Drug.
- Trichostatin_A type DrugProduct.
- Trichostatin_A type FunctionalSubstance.
- Trichostatin_A comment "Trichostatin A (TSA) is an organic compound that serves as an antifungal antibiotic and selectively inhibits the class I and II mammalian histone deacetylase (HDAC) families of enzymes, but not class III HDACs (i.e., Sirtuins). TSA inhibits the eukaryotic cell cycle during the beginning of the growth stage.".
- Trichostatin_A label "Trichostatin A".
- Trichostatin_A label "Trichostatin A".
- Trichostatin_A label "Trichostatyna A".
- Trichostatin_A label "トリコスタチンA".
- Trichostatin_A sameAs Trichostatin_A.
- Trichostatin_A sameAs トリコスタチンA.
- Trichostatin_A sameAs Trichostatyna_A.
- Trichostatin_A sameAs m.08xl13.
- Trichostatin_A sameAs Q425894.
- Trichostatin_A sameAs Q425894.
- Trichostatin_A sameAs Trichostatin_A.
- Trichostatin_A wasDerivedFrom Trichostatin_A?oldid=593215820.
- Trichostatin_A depiction Trichostatin_A.svg.
- Trichostatin_A isPrimaryTopicOf Trichostatin_A.