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- U-90042 abstract "U-90042 is a sedative and hypnotic drug used in scientific research. It has similar effects to sedative-hypnotic benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic. U-90042 is a GABAA agonist acting primarily at the α1, α3 and α6 subtypes, with a Ki of 7.8nM at α1, 9.5nM at α3 and 11.0nM at α6. It produces sedation and ataxia and prolongs sleeping time in mice, rats and monkeys, but does not produce amnesia and blocks the amnestic effect of diazepam, reflecting its different subtype affinity compared to benzodiazepine drugs. It was developed by a team at Novo Nordisk in the 1980s.".
- U-90042 casNumber "134516-99-7".
- U-90042 iupacName "11-Chloro-5-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-2,3-dihydrodiimidazo[1,2-c:1',5'-a]quinazoline".
- U-90042 pubchem "9928470".
- U-90042 thumbnail U-90042.png?width=300.
- U-90042 wikiPageID "18324309".
- U-90042 wikiPageRevisionID "570804015".
- U-90042 c "17".
- U-90042 casNumber "134516".
- U-90042 chemspiderid "8104103".
- U-90042 cl "1".
- U-90042 h "13".
- U-90042 hasPhotoCollection U-90042.
- U-90042 inchi "1".
- U-90042 inchikey "CLPSAAPUJUVQPP-UHFFFAOYAK".
- U-90042 iupacName "11".
- U-90042 molecularWeight "352.78".
- U-90042 n "6".
- U-90042 o "1".
- U-90042 pubchem "9928470".
- U-90042 smiles "ClC1=CC2=CN3C=NC=C3N6C2=NCC6".
- U-90042 stdinchi "1".
- U-90042 stdinchikey "CLPSAAPUJUVQPP-UHFFFAOYSA-N".
- U-90042 verifiedfields "changed".
- U-90042 verifiedrevid "448131874".
- U-90042 watchedfields "changed".
- U-90042 width "140".
- U-90042 subject Category:Cyclopropanes.
- U-90042 subject Category:Organochlorides.
- U-90042 subject Category:Oxadiazoles.
- U-90042 subject Category:Sedatives.
- U-90042 type Drug.
- U-90042 type DrugProduct.
- U-90042 type FunctionalSubstance.
- U-90042 comment "U-90042 is a sedative and hypnotic drug used in scientific research. It has similar effects to sedative-hypnotic benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic. U-90042 is a GABAA agonist acting primarily at the α1, α3 and α6 subtypes, with a Ki of 7.8nM at α1, 9.5nM at α3 and 11.0nM at α6.".
- U-90042 label "U-90042".
- U-90042 sameAs m.04cy166.
- U-90042 sameAs Q15410174.
- U-90042 sameAs Q15410174.
- U-90042 wasDerivedFrom U-90042?oldid=570804015.
- U-90042 depiction U-90042.png.
- U-90042 isPrimaryTopicOf U-90042.