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- Vpu abstract "Vpu is a protein that in HIV is encoded by the vpu gene. Vpu stands for "Viral Protein Unique". The Vpu gene is found exclusively in HIV-1 and some HIV-1-related simian immunodeficiency virus (SIV) isolates, such as SIVcpz, SIVgsn, and SIVmon, but not in HIV-2 or the majority of SIV isolates. Structural similarities between Vpu and another small viral protein, M2, encoded by influenza A virus were first noted soon after the discovery of Vpu. Since then, M2 has been shown to form cation-selective ion channels when expressed in Xenopus oocytes or mammalian cells and also when purified and reconstituted into planar lipid bilayers.The Vpu protein acts in the degradation of CD4 in the endoplasmic reticulum and in the enhancement of virion release from the plasma membrane of infected cells. Vpu induces the degradation of the CD4 viral receptor and therefore participates in the general downregulation of CD4 expression during the course of HIV infection. Vpu-mediated CD4 degradation is thought to prevent CD4-Env binding in the endoplasmic reticulum in order to facilitate proper Env assembly into virions. It is found in the membranes of infected cells, but not the virus particles themselves.".
- Vpu symbol "Vpu".
- Vpu thumbnail PDB_1pje_EBI.jpg?width=300.
- Vpu wikiPageID "17707387".
- Vpu wikiPageRevisionID "593290119".
- Vpu caption "structure of the channel-forming trans-membrane domain of virus protein "u" from HIV-1".
- Vpu chromosome "viral genome".
- Vpu entrezchromosome "NC_001802.1".
- Vpu entrezgene "155945".
- Vpu genlocEnd "5892".
- Vpu genlocStart "5570".
- Vpu hasPhotoCollection Vpu.
- Vpu interpro "IPR008187".
- Vpu name "Viral Protein Unique".
- Vpu name "Vpu".
- Vpu organism "HIV-1".
- Vpu pfam "PF00558".
- Vpu refseqprotein "NP_057855.1".
- Vpu scop "1".
- Vpu symbol "Vpu".
- Vpu symbol "vpu".
- Vpu taxid "11676".
- Vpu tcdb "1".
- Vpu uniprot "Q9WB91".
- Vpu subject AIDS.
- Vpu subject Category:Protein_domains.
- Vpu subject Category:Viral_proteins.
- Vpu type Abstraction100002137.
- Vpu type Chemical114806838.
- Vpu type Compound114818238.
- Vpu type Macromolecule114944888.
- Vpu type Material114580897.
- Vpu type Matter100020827.
- Vpu type Molecule114682133.
- Vpu type OrganicCompound114727670.
- Vpu type Part113809207.
- Vpu type PhysicalEntity100001930.
- Vpu type Protein114728724.
- Vpu type Relation100031921.
- Vpu type Substance100019613.
- Vpu type Thing100002452.
- Vpu type Unit109465459.
- Vpu type ViralProteins.
- Vpu type Biomolecule.
- Vpu type Protein.
- Vpu type BiologicalObject.
- Vpu comment "Vpu is a protein that in HIV is encoded by the vpu gene. Vpu stands for "Viral Protein Unique". The Vpu gene is found exclusively in HIV-1 and some HIV-1-related simian immunodeficiency virus (SIV) isolates, such as SIVcpz, SIVgsn, and SIVmon, but not in HIV-2 or the majority of SIV isolates. Structural similarities between Vpu and another small viral protein, M2, encoded by influenza A virus were first noted soon after the discovery of Vpu.".
- Vpu label "Vpu".
- Vpu sameAs m.05b6q1d.
- Vpu sameAs Q7942549.
- Vpu sameAs Q7942549.
- Vpu sameAs Vpu.
- Vpu wasDerivedFrom Vpu?oldid=593290119.
- Vpu depiction PDB_1pje_EBI.jpg.
- Vpu isPrimaryTopicOf Vpu.