Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Warfarin> ?p ?o. }
- Warfarin abstract "Warfarin (also known by the brand names Coumadin, Jantoven, Marevan, Uniwarfin) is an anticoagulant normally used in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migration elsewhere in the body respectively. Warfarin is commonly but incorrectly referred to as a blood thinner. It was initially introduced in 1948 as a pesticide against rats and mice and is still used for this purpose, although more potent poisons such as brodifacoum have since been developed. In the early 1950s, warfarin was found to be effective and relatively safe for preventing thrombosis and thromboembolism in many disorders. It was approved for use as a medication in 1954 and has remained popular ever since; warfarin is the most widely prescribed oral anticoagulant drug in North America.Despite its effectiveness, treatment with warfarin has several shortcomings. Many commonly used medications interact with warfarin, as do some foods (particularly leaf vegetable foods or "greens," since these typically contain large amounts of vitamin K1) and its activity has to be monitored by blood testing for the international normalized ratio (INR) to ensure an adequate yet safe dose is taken. A high INR predisposes to a high risk of bleeding, while an INR below the therapeutic target indicates that the dose of warfarin is insufficient to protect against thromboembolic events.Warfarin and related 4-hydroxycoumarin-containing molecules decrease blood coagulation by inhibiting vitamin K epoxide reductase, an enzyme that recycles oxidized vitamin K1 to its reduced form after it has participated in the carboxylation of several blood coagulation proteins, mainly prothrombin and factor VII. Despite being labeled a vitamin K antagonist, warfarin does not antagonize the action of vitamin K1, but rather antagonizes vitamin K1 recycling, depleting active vitamin K1. Thus, the pharmacologic action may always be reversed by fresh vitamin K1. When administered, these drugs do not anticoagulate blood immediately. Instead, onset of their effect requires about a day before remaining active clotting factors have had time to naturally disappear in metabolism, and the duration of action of a single dose of warfarin is 2 to 5 days. Reversal of warfarin's effect when it is discontinued or vitamin K1 is administered, requires a similar time.Warfarin is a synthetic derivative of dicoumarol, a 4-hydroxycoumarin-derived mycotoxin anticoagulant originally discovered in spoiled sweet clover-based animal feeds. Dicoumarol, in turn, is derived from coumarin, a sweet-smelling but coagulation-inactive chemical found naturally in "sweet" clover (to which it gives its odor and name), tonka beans (also known as "cumaru" from which coumarin's name derives) and many other plants. The name warfarin stems from its discovery at the University of Wisconsin, incorporating the acronym for the organization that funded the key research (WARF, for Wisconsin Alumni Research Foundation) and the ending -arin, indicating its link with coumarin.".
- Warfarin atcPrefix "B01".
- Warfarin atcSuffix "AA03".
- Warfarin bioavailability "79.0".
- Warfarin casNumber "81-81-2".
- Warfarin chEBI "10033".
- Warfarin drugbank "DB00682".
- Warfarin fdaUniiCode "5Q7ZVV76EI".
- Warfarin iupacName "(RS)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)- 2H-chromen-2-one".
- Warfarin pubchem "54678486".
- Warfarin thumbnail Warfarin2DACS.svg?width=300.
- Warfarin wikiPageExternalLink dpdirect.jsp?name=Warfarin.
- Warfarin wikiPageExternalLink 681.htm.
- Warfarin wikiPageExternalLink npgd0665.html.
- Warfarin wikiPageExternalLink ?ligand=RWF.
- Warfarin wikiPageExternalLink ?ligand=SWF.
- Warfarin wikiPageExternalLink e5.full.
- Warfarin wikiPageExternalLink index.jsp?cid=26&scid=34.
- Warfarin wikiPageID "238097".
- Warfarin wikiPageRevisionID "605371532".
- Warfarin atcPrefix "B01".
- Warfarin atcSuffix "AA03".
- Warfarin bioavailability "79".
- Warfarin c "19".
- Warfarin casNumber "81".
- Warfarin casNumberRef "I".
- Warfarin chebi "10033".
- Warfarin chembl "1464".
- Warfarin chemspiderid "10442445".
- Warfarin drugbank "DB00682".
- Warfarin eliminationHalfLife "-216000.0".
- Warfarin excretion Kidney.
- Warfarin h "16".
- Warfarin hasPhotoCollection Warfarin.
- Warfarin image "Warfarin3Dan.gif".
- Warfarin inchi "1".
- Warfarin iupacName "-4".
- Warfarin kegg "D08682".
- Warfarin legalAu "S4".
- Warfarin legalCa "Rx-only".
- Warfarin legalUk "POM".
- Warfarin legalUs "Rx-only".
- Warfarin licenceUs "Warfarin".
- Warfarin medlineplus "a682277".
- Warfarin metabolism "Hepatic: CYP2C9, 2C19, 2C8, 2C18, 1A2 and 3A4".
- Warfarin molecularWeight "308.33".
- Warfarin o "4".
- Warfarin pregnancyAu "D".
- Warfarin pregnancyUs "X".
- Warfarin proteinBound "99.0".
- Warfarin pubchem "54678486".
- Warfarin routesOfAdministration "Oral or intravenous".
- Warfarin smiles "CCCCc3ccccc3".
- Warfarin stdinchi "1".
- Warfarin stdinchikey "PJVWKTKQMONHTI-UHFFFAOYSA-N".
- Warfarin tradename "Coumadin, Jantoven, Marevan".
- Warfarin unii "5".
- Warfarin verifiedfields "changed".
- Warfarin verifiedrevid "460939157".
- Warfarin watchedfields "changed".
- Warfarin width "200".
- Warfarin width "250".
- Warfarin subject Category:Coumarin_drugs.
- Warfarin subject Category:Ketones.
- Warfarin subject Category:Rodenticides.
- Warfarin subject Category:Teratogens.
- Warfarin subject Category:Vitamin_K_antagonists.
- Warfarin type Drug.
- Warfarin type DrugProduct.
- Warfarin type FunctionalSubstance.
- Warfarin comment "Warfarin (also known by the brand names Coumadin, Jantoven, Marevan, Uniwarfin) is an anticoagulant normally used in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migration elsewhere in the body respectively. Warfarin is commonly but incorrectly referred to as a blood thinner.".
- Warfarin label "Coumaphène".
- Warfarin label "Varfarina".
- Warfarin label "Warfarin".
- Warfarin label "Warfarin".
- Warfarin label "Warfarin".
- Warfarin label "Warfarina".
- Warfarin label "Warfarine".
- Warfarin label "Warfaryna".
- Warfarin label "Варфарин".
- Warfarin label "وارفارين".
- Warfarin label "ワルファリン".
- Warfarin label "华法林".
- Warfarin sameAs Warfarin.
- Warfarin sameAs Warfarina.
- Warfarin sameAs Coumaphène.
- Warfarin sameAs Warfarin.
- Warfarin sameAs Warfarin.
- Warfarin sameAs ワルファリン.
- Warfarin sameAs 워파린.
- Warfarin sameAs Warfarine.
- Warfarin sameAs Warfaryna.
- Warfarin sameAs Varfarina.
- Warfarin sameAs m.01jjmt.
- Warfarin sameAs Q407431.
- Warfarin sameAs Q407431.
- Warfarin sameAs warfarin.
- Warfarin sameAs DB00682.
- Warfarin sameAs 6691.
- Warfarin wasDerivedFrom Warfarin?oldid=605371532.