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- Xaliproden abstract "Xaliproden (codenamed SR57746) is a drug which acts as a 5HT1A agonist. It has neurotrophic and neuroprotective effects in vitro, and has been proposed for use in the treatment of several neurodegenerative conditions including amyotrophic lateral sclerosis (ALS) and Alzheimer's disease.Development of xaliproden for these two indications was discontinued in 2007 following analysis of Phase III data. While the drug did show an effect on hippocampal volume (suggesting perhaps a slowing of cell loss), there was insufficient evidence for efficacy in counteracting Alzheimer's related cognitive decline. Similarly while there were some indicators of efficacy in ALS, including a small but clinically noteworthy effect on some functional parameters, the overall benefit did not reach statistical significance when results across several Phase III trials were averaged. Xaliproden remains under investigation for treatment of chemotherapy-induced peripheral neuropathy.".
- Xaliproden atcPrefix "N07".
- Xaliproden atcSuffix "XX03".
- Xaliproden casNumber "135354-02-8".
- Xaliproden fdaUniiCode "V8QL94KNQO".
- Xaliproden iupacName "1-[2-(2-naphthyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine".
- Xaliproden pubchem "128919".
- Xaliproden thumbnail Xaliproden.svg?width=300.
- Xaliproden wikiPageID "12499204".
- Xaliproden wikiPageRevisionID "580142168".
- Xaliproden atcPrefix "N07".
- Xaliproden atcSuffix "XX03".
- Xaliproden c "24".
- Xaliproden casNumber "135354".
- Xaliproden chemspiderid "114237".
- Xaliproden f "3".
- Xaliproden h "22".
- Xaliproden hasPhotoCollection Xaliproden.
- Xaliproden inchi "1".
- Xaliproden inchikey "WJJYZXPHLSLMGE-UHFFFAOYAV".
- Xaliproden iupacName "1".
- Xaliproden kegg "D06327".
- Xaliproden molecularWeight "381.433".
- Xaliproden n "1".
- Xaliproden pubchem "128919".
- Xaliproden smiles "FCc4ccccc4".
- Xaliproden stdinchi "1".
- Xaliproden stdinchikey "WJJYZXPHLSLMGE-UHFFFAOYSA-N".
- Xaliproden unii "V8QL94KNQO".
- Xaliproden verifiedfields "changed".
- Xaliproden verifiedrevid "447814729".
- Xaliproden watchedfields "changed".
- Xaliproden subject Category:Naphthalenes.
- Xaliproden subject Category:Organofluorides.
- Xaliproden subject Category:Pyridines.
- Xaliproden subject Category:Serotonin_receptor_agonists.
- Xaliproden type Abstraction100002137.
- Xaliproden type Base114618253.
- Xaliproden type Chemical114806838.
- Xaliproden type Compound114818238.
- Xaliproden type Hydrocarbon114911057.
- Xaliproden type Material114580897.
- Xaliproden type Matter100020827.
- Xaliproden type Naphthalene114958564.
- Xaliproden type Naphthalenes.
- Xaliproden type OrganicCompound114727670.
- Xaliproden type Part113809207.
- Xaliproden type PhysicalEntity100001930.
- Xaliproden type Pyridine114692510.
- Xaliproden type Pyridines.
- Xaliproden type Relation100031921.
- Xaliproden type Substance100019613.
- Xaliproden type Drug.
- Xaliproden type DrugProduct.
- Xaliproden type FunctionalSubstance.
- Xaliproden comment "Xaliproden (codenamed SR57746) is a drug which acts as a 5HT1A agonist. It has neurotrophic and neuroprotective effects in vitro, and has been proposed for use in the treatment of several neurodegenerative conditions including amyotrophic lateral sclerosis (ALS) and Alzheimer's disease.Development of xaliproden for these two indications was discontinued in 2007 following analysis of Phase III data.".
- Xaliproden label "Xaliproden".
- Xaliproden sameAs m.02w9421.
- Xaliproden sameAs Q12745720.
- Xaliproden sameAs Q12745720.
- Xaliproden sameAs Xaliproden.
- Xaliproden wasDerivedFrom Xaliproden?oldid=580142168.
- Xaliproden depiction Xaliproden.svg.
- Xaliproden isPrimaryTopicOf Xaliproden.