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- ZD6126 abstract "ZD6126 is a vascular-targeting agent and a prodrug of N-acetylcolchinol, related to colchicine. It has shown promising results on tumors in mice.A phase I clinical trial identified gastrointestinal and cardiac effects as limiting dosing. Two phase II clinical trials were started investigating ZD6126 in metastatic renal cell carcinoma and metastatic colorectal cancer. ZD6126 was being investigated by AstraZeneca as a vascular disrupting agent (VDA). However, the trials were halted, after it became apparent that ZD6126 was too cardiotoxic at the required doses.".
- ZD6126 casNumber "219923-05-4".
- ZD6126 fdaUniiCode "GBO3S6M9W7".
- ZD6126 iupacName "Phosphoric acid mono-(5-acetylamino-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cyclohepten-3-yl) ester".
- ZD6126 pubchem "9896434".
- ZD6126 thumbnail ZD6126.png?width=300.
- ZD6126 wikiPageID "20689396".
- ZD6126 wikiPageRevisionID "590500588".
- ZD6126 alt "Ball-and-stick model".
- ZD6126 alt "Skeletal formula".
- ZD6126 c "20".
- ZD6126 casNumber "219923".
- ZD6126 chemspiderid "8072099".
- ZD6126 h "24".
- ZD6126 hasPhotoCollection ZD6126.
- ZD6126 image "ZD6126-3D-balls.png".
- ZD6126 inchi "1".
- ZD6126 inchikey "UGBMEXLBFDAOGL-INIZCTEOBQ".
- ZD6126 iupacName "Phosphoric acid mono- ester".
- ZD6126 molecularWeight "437.38".
- ZD6126 n "1".
- ZD6126 o "8".
- ZD6126 p "1".
- ZD6126 pubchem "9896434".
- ZD6126 smiles "CCN[C@H]1CCC2=CCOC".
- ZD6126 stdinchi "1".
- ZD6126 stdinchikey "UGBMEXLBFDAOGL-INIZCTEOSA-N".
- ZD6126 synonyms "ANG 453; AZD 6126; N-Acetylcolchicinol dihydrogenphosphate".
- ZD6126 unii "GBO3S6M9W7".
- ZD6126 verifiedfields "changed".
- ZD6126 verifiedrevid "450106830".
- ZD6126 watchedfields "changed".
- ZD6126 subject Category:Amides.
- ZD6126 subject Category:Experimental_cancer_drugs.
- ZD6126 subject Category:Phenol_ethers.
- ZD6126 type Drug.
- ZD6126 type DrugProduct.
- ZD6126 type FunctionalSubstance.
- ZD6126 comment "ZD6126 is a vascular-targeting agent and a prodrug of N-acetylcolchinol, related to colchicine. It has shown promising results on tumors in mice.A phase I clinical trial identified gastrointestinal and cardiac effects as limiting dosing. Two phase II clinical trials were started investigating ZD6126 in metastatic renal cell carcinoma and metastatic colorectal cancer. ZD6126 was being investigated by AstraZeneca as a vascular disrupting agent (VDA).".
- ZD6126 label "ZD6126".
- ZD6126 sameAs m.051vhvf.
- ZD6126 sameAs Q8062996.
- ZD6126 sameAs Q8062996.
- ZD6126 wasDerivedFrom ZD6126?oldid=590500588.
- ZD6126 depiction ZD6126.png.
- ZD6126 isPrimaryTopicOf ZD6126.