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- Zosuquidar abstract "Zosuquidar is a compound of antineoplastic drug candidates currently under development. It is now in "Phase 3" of clinical tests in the United States. Its action mechanism consists of the inhibition of P-glycoproteins; other drugs with this mechanism include tariquidar and laniquidar. P-glycoproteins are proteins whichconvert the energy derived from the hydrolysis of ATP to structural changes in protein molecules, in order to perform coupling, thus discharging medicine from cells. If P-glycoprotein coded with the MDR1 gene manifests itself in cancer cells, it discharges much of the antineoplastic drugs from the cells, making cancer cells medicine tolerant, and rendering antineoplastic drugs ineffective. This protein also manifests itself in normal organs not affected by the cancer (such as the liver, small intestine, and skin cells in blood vessels of the brain), and participates in the transportation of medicine. The compound zosuquidar inhibits this P-glycoprotein, causing the cancer cells to lose their medicine tolerance, and making antineoplastic drugs effective.".
- Zosuquidar atcPrefix "none".
- Zosuquidar casNumber "167354-41-8".
- Zosuquidar fdaUniiCode "AB5K82X98Y".
- Zosuquidar iupacName "(2R)-​1-​{4-​[(1aR,10bS)-​1,1-​difluoro-​1,1a,6,10b-​tetrahydrodibenzo​[a,e]​cyclopropa​[c]​[7]​annulen-​6-​yl}-​3-​(quinolin-​5-​yloxy)​propan-​2-​ol".
- Zosuquidar pubchem "153997".
- Zosuquidar thumbnail Zosuquidar.svg?width=300.
- Zosuquidar wikiPageID "1608293".
- Zosuquidar wikiPageRevisionID "589776153".
- Zosuquidar atcPrefix "none".
- Zosuquidar c "32".
- Zosuquidar casNumber "167354".
- Zosuquidar chembl "444172".
- Zosuquidar chemspiderid "24599682".
- Zosuquidar f "2".
- Zosuquidar h "31".
- Zosuquidar hasPhotoCollection Zosuquidar.
- Zosuquidar iupacName "-​1-​{4-​[-​1,1-​difluoro-​1,1a,6,10b-​tetrahydrodibenzo​[a,e]​cyclopropa​[c]​[7]​annulen-​6-​yl}-​3-​​propan-​2-​ol".
- Zosuquidar kegg "D06387".
- Zosuquidar molecularWeight "527.61".
- Zosuquidar n "3".
- Zosuquidar o "2".
- Zosuquidar pubchem "153997".
- Zosuquidar smiles "Cl.Cl.Cl.FC4[C@@H]3c1ccccc1CN5CCNC[C@@H]COc7c6cccnc6ccc7".
- Zosuquidar stdinchi "1".
- Zosuquidar stdinchikey "IHOVFYSQUDPMCN-DBEBIPAYSA-N".
- Zosuquidar unii "AB5K82X98Y".
- Zosuquidar verifiedfields "changed".
- Zosuquidar verifiedrevid "477869670".
- Zosuquidar width "250".
- Zosuquidar subject Category:Cyclopropanes.
- Zosuquidar subject Category:Experimental_cancer_drugs.
- Zosuquidar subject Category:Organofluorides.
- Zosuquidar subject Category:Piperazines.
- Zosuquidar subject Category:Quinolines.
- Zosuquidar type Agent114778436.
- Zosuquidar type Anesthetic102710766.
- Zosuquidar type Antineoplastic102722458.
- Zosuquidar type CausalAgent100007347.
- Zosuquidar type Cyclopropane103155661.
- Zosuquidar type Cyclopropanes.
- Zosuquidar type CytotoxicDrug103157987.
- Zosuquidar type Drug103247620.
- Zosuquidar type ExperimentalCancerDrugs.
- Zosuquidar type GeneralAnesthetic103433434.
- Zosuquidar type InhalationAnesthetic103570838.
- Zosuquidar type Matter100020827.
- Zosuquidar type Medicine103740161.
- Zosuquidar type PhysicalEntity100001930.
- Zosuquidar type Piperazine103946814.
- Zosuquidar type Piperazines.
- Zosuquidar type Substance100020090.
- Zosuquidar type Vermifuge104528630.
- Zosuquidar type Drug.
- Zosuquidar type DrugProduct.
- Zosuquidar type FunctionalSubstance.
- Zosuquidar comment "Zosuquidar is a compound of antineoplastic drug candidates currently under development. It is now in "Phase 3" of clinical tests in the United States. Its action mechanism consists of the inhibition of P-glycoproteins; other drugs with this mechanism include tariquidar and laniquidar. P-glycoproteins are proteins whichconvert the energy derived from the hydrolysis of ATP to structural changes in protein molecules, in order to perform coupling, thus discharging medicine from cells.".
- Zosuquidar label "Zosuquidar".
- Zosuquidar label "ゾスキダル".
- Zosuquidar sameAs ゾスキダル.
- Zosuquidar sameAs m.05g9jk.
- Zosuquidar sameAs Q8074586.
- Zosuquidar sameAs Q8074586.
- Zosuquidar sameAs Zosuquidar.
- Zosuquidar wasDerivedFrom Zosuquidar?oldid=589776153.
- Zosuquidar depiction Zosuquidar.svg.
- Zosuquidar isPrimaryTopicOf Zosuquidar.