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- AB_toxin abstract "The AB toxins are two-component protein complexes secreted by a number of pathogenic bacteria. They can be classified as Type III toxins because they interfere with internal cell function. They are named AB toxins due to their components: the "A" component is usually the "active" portion, and the "B" component is usually the "binding" portion. The "A" subunit possesses enzyme activity, and is transferred to the host cell following a conformational change in the membrane-bound transport "B" subunit.Among the toxins produced by certain Clostridium spp. are the binary exotoxins. These proteins consist of two independent polypeptides, which correspond to the A/B subunit moieties. The enzyme component (A) enters the cell through endosomes produced by the oligomeric binding/translocation protein (B), and prevents actin polymerisation through ADP-ribosylation of monomeric G-actin.Members of the "A" binary toxin family include C. perfringens iota toxin Ia, C. botulinum C2 toxin CI, and Clostridium difficile ADP-ribosyltransferase . Other homologous proteins have been found in Clostridium spiroforme.Members of the "B" binary toxin family include the Bacillus anthracis protective antigen (PA) protein, most likely due to a common evolutionary ancestor. B. anthracis, a large Gram-positive spore-forming rod, is the causative agent of anthrax. Its two virulence factors are the poly-D-glutamate polypeptide capsule, and the actual anthrax exotoxin. The toxin comprises three factors: the protective antigen (PA); the oedema factor (EF); and the lethal factor (LF). Each is a thermolabile protein of ~80kDa. PA forms the "B" part of the exotoxin and allows passage of the "A" moiety (consisting of EF and LF) into target cells. PA protein forms the central part of the complete anthrax toxin, and translocates the B moiety into host cells after assembling as a heptamer in the membrane.The AB5 toxins are usually considered a type of AB toxin, characterized by B pentamers. Less commonly, the term "AB toxin" is used to emphasize the monomeric character of the B component.".
- AB_toxin symbol "ADPrib_exo_Tox".
- AB_toxin symbol "Binary_toxB".
- AB_toxin thumbnail PDB_1giq_EBI.jpg?width=300.
- AB_toxin wikiPageID "20681039".
- AB_toxin wikiPageRevisionID "589911365".
- AB_toxin caption "crystal structure of the anthrax toxin protective antigen heptameric prepore".
- AB_toxin caption "crystal structure of the enzymatic componet of iota-toxin from clostridium perfringens with nadh".
- AB_toxin hasPhotoCollection AB_toxin.
- AB_toxin interpro "IPR003540".
- AB_toxin interpro "IPR003896".
- AB_toxin name "ADPrib_exo_Tox".
- AB_toxin name "Binary_toxB".
- AB_toxin pfam "PF03495".
- AB_toxin pfam "PF03496".
- AB_toxin pfamClan "CL0084".
- AB_toxin scop "1".
- AB_toxin symbol "ADPrib_exo_Tox".
- AB_toxin symbol "Binary_toxB".
- AB_toxin tcdb "1".
- AB_toxin subject Category:Bacterial_toxins.
- AB_toxin subject Category:Protein_families.
- AB_toxin type Abstraction100002137.
- AB_toxin type Family108078020.
- AB_toxin type Group100031264.
- AB_toxin type Organization108008335.
- AB_toxin type ProteinFamilies.
- AB_toxin type SocialGroup107950920.
- AB_toxin type Unit108189659.
- AB_toxin type YagoLegalActor.
- AB_toxin type YagoLegalActorGeo.
- AB_toxin type YagoPermanentlyLocatedEntity.
- AB_toxin type Biomolecule.
- AB_toxin type Protein.
- AB_toxin type BiologicalObject.
- AB_toxin comment "The AB toxins are two-component protein complexes secreted by a number of pathogenic bacteria. They can be classified as Type III toxins because they interfere with internal cell function. They are named AB toxins due to their components: the "A" component is usually the "active" portion, and the "B" component is usually the "binding" portion.".
- AB_toxin label "AB toxin".
- AB_toxin sameAs m.051zfpy.
- AB_toxin sameAs Q4650462.
- AB_toxin sameAs Q4650462.
- AB_toxin sameAs AB_toxin.
- AB_toxin wasDerivedFrom AB_toxin?oldid=589911365.
- AB_toxin depiction PDB_1giq_EBI.jpg.
- AB_toxin isPrimaryTopicOf AB_toxin.