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- ATryn abstract "ATryn is the brand name of the anticoagulant antithrombin manufactured by the Massachusetts-based U.S. company GTC Biotherapeutics. It is made from the milk of goats that have been genetically modified to produce human antithrombin, a plasma protein with anticoagulant properties. Microinjection was used to insert human antithrombin genes into the cell nucleus of their embryos. ATryn is the first medicine produced using genetically engineered animals. GTC states that one genetically modified goat can produce the same amount of antithrombin in a year as 90,000 blood donations. GTC chose goats for the process because they reproduce more rapidly than cattle and produce more protein than rabbits or mice.On February 6, 2009, ATryn was approved by the U.S. Food and Drug Administration (FDA) for treatment of patients with hereditary antithrombin deficiency who are undergoing surgical or childbirth procedures. Along with the approval from the FDA's pharmaceutical regulatory board, the Center for Veterinary Medicine of the FDA also approved the genetic makeup of the goats that are used to manufacture ATryn. GTC has the sole rights to sell ATryn in the United States, and the drug is available in the U.S. market. Earlier in 2006, the European Medicines Agency (EMEA) initially rejected and, after an appeal from GTC, approved the drug for use in the European Union countries.According to Tom Newberry, the spokesperson for GTC, the company plans to acquire additional approval for treatment of those with non-hereditary antithrombin deficiency.The Humane Society of the United States has said of the process used to manufacture ATryn, "It is a mechanistic use of animals that seems to perpetuate the notion of their being merely tools for human use rather than sentient creatures." However, the genetic change has no known ill-effects on the host animal.[citation needed]".
- ATryn wikiPageExternalLink rnd:2006029.
- ATryn wikiPageExternalLink atryn.htm.
- ATryn wikiPageExternalLink www.gtc-bio.com.
- ATryn wikiPageID "21436303".
- ATryn wikiPageRevisionID "547183049".
- ATryn hasPhotoCollection ATryn.
- ATryn subject Category:Anticoagulants.
- ATryn subject Category:Genetic_engineering.
- ATryn subject Category:Goats.
- ATryn type Agent114778436.
- ATryn type Animal100015388.
- ATryn type Anticoagulant102718259.
- ATryn type Anticoagulants.
- ATryn type Bovid102401031.
- ATryn type CausalAgent100007347.
- ATryn type Chordate101466257.
- ATryn type Drug103247620.
- ATryn type Even-toedUngulate102394477.
- ATryn type Goat102416519.
- ATryn type Goats.
- ATryn type LivingThing100004258.
- ATryn type Mammal101861778.
- ATryn type Matter100020827.
- ATryn type Medicine103740161.
- ATryn type Object100002684.
- ATryn type Organism100004475.
- ATryn type PhysicalEntity100001930.
- ATryn type Placental101886756.
- ATryn type Ruminant102399000.
- ATryn type Substance100020090.
- ATryn type Ungulate102370806.
- ATryn type Vertebrate101471682.
- ATryn type Whole100003553.
- ATryn comment "ATryn is the brand name of the anticoagulant antithrombin manufactured by the Massachusetts-based U.S. company GTC Biotherapeutics. It is made from the milk of goats that have been genetically modified to produce human antithrombin, a plasma protein with anticoagulant properties. Microinjection was used to insert human antithrombin genes into the cell nucleus of their embryos. ATryn is the first medicine produced using genetically engineered animals.".
- ATryn label "ATryn".
- ATryn label "ATryn".
- ATryn label "Atryn".
- ATryn sameAs ATryn.
- ATryn sameAs Atryn.
- ATryn sameAs m.05f6sgk.
- ATryn sameAs Q8183085.
- ATryn sameAs Q8183085.
- ATryn sameAs ATryn.
- ATryn wasDerivedFrom ATryn?oldid=547183049.
- ATryn homepage www.gtc-bio.com.
- ATryn isPrimaryTopicOf ATryn.