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- Allopregnanolone abstract "Allopregnanolone (3α-hydroxy-5α-pregnan-20-one or 3α,5α-tetrahydroprogesterone; also abbreviated as THP or THPROG) is a prototypic neurosteroid present in the blood and also the brain. It is a metabolite of progesterone and potent modulator of GABAA receptors. While allopregnanolone, like other GABAA receptor active neuro steroids such as allotetrahydrodeoxycorticosterone (3α,21-dihydroxy-5α-pregnan-20-one; THDOC), positively modulates all GABAA receptor isoforms, those isoforms containing δ-subunits exhibit greater magnitude potentiation. Allopregnanolone has pharmacological properties similar to other positive modulators of GABAA receptors, including anxiolytic and anticonvulsant activity.The biosynthesis of allopregnanolone starts with the converting of progesterone into 5α-dihydroprogesterone by 5α-reductase type I. After that, 3α-hydroxysteroid oxidoreductase isoenzymes (also referred to as 3α-hydroxysteroid dehydrogenase) converts this intermediate into allopregnanolone. Anxiety and depression are common side effects of 5α-reductase inhibitors such as finasteride and dutasteride, and they are believed to be caused, in part, by the prevention of the endogenous production of allopregnanolone.The 5β-epimer of this compound (pregnanolone; 3α-hydroxy-5β-pregnan-20-one) has similar properties to allopregnanolone, and the 3β-methyl analogue, ganaxolone, is under development to treat epilepsy and other conditions.Allopregnanolone may serve as an endogenous anticonvulsant and play a role in catamenial epilepsy.Allopregnanolone aids neurogenesis and has been found to reverse neuron proliferative deficit and cognitive deficits in mouse model of Alzheimer's disease.Allopregnanolone decreases the cue-induced reinstatement of extinguished cocaine seeking in rats.".
- Allopregnanolone iupacName "1-(3-hydroxy-10,13-dimethyl-".
- Allopregnanolone iupacName "1H-cyclopenta[a]".
- Allopregnanolone iupacName "2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-".
- Allopregnanolone iupacName "phenanthren-17-yl)ethanone".
- Allopregnanolone thumbnail Allopregnanolone.png?width=300.
- Allopregnanolone wikiPageID "10023726".
- Allopregnanolone wikiPageRevisionID "601537977".
- Allopregnanolone hasPhotoCollection Allopregnanolone.
- Allopregnanolone imagefile "Allopregnanolone.png".
- Allopregnanolone imagesize "200".
- Allopregnanolone iupacname "1".
- Allopregnanolone othernames "3".
- Allopregnanolone verifiedfields "changed".
- Allopregnanolone verifiedrevid "477318018".
- Allopregnanolone subject Category:Alcohols.
- Allopregnanolone subject Category:Ketones.
- Allopregnanolone subject Category:Neurosteroids.
- Allopregnanolone type Abstraction100002137.
- Allopregnanolone type Agent114778436.
- Allopregnanolone type Alcohol107884567.
- Allopregnanolone type Alcohols.
- Allopregnanolone type Beverage107881800.
- Allopregnanolone type CausalAgent100007347.
- Allopregnanolone type Chemical114806838.
- Allopregnanolone type Compound114818238.
- Allopregnanolone type Drug103247620.
- Allopregnanolone type DrugOfAbuse103248958.
- Allopregnanolone type Fluid114939900.
- Allopregnanolone type Food100021265.
- Allopregnanolone type Ketone114926294.
- Allopregnanolone type Ketones.
- Allopregnanolone type Liquid114940386.
- Allopregnanolone type Material114580897.
- Allopregnanolone type Matter100020827.
- Allopregnanolone type OrganicCompound114727670.
- Allopregnanolone type Part113809207.
- Allopregnanolone type PhysicalEntity100001930.
- Allopregnanolone type Relation100031921.
- Allopregnanolone type Substance100019613.
- Allopregnanolone type Substance100020090.
- Allopregnanolone type ChemicalCompound.
- Allopregnanolone type ChemicalSubstance.
- Allopregnanolone type ChemicalSubstanceType.
- Allopregnanolone type ChemicalObject.
- Allopregnanolone type Thing.
- Allopregnanolone comment "Allopregnanolone (3α-hydroxy-5α-pregnan-20-one or 3α,5α-tetrahydroprogesterone; also abbreviated as THP or THPROG) is a prototypic neurosteroid present in the blood and also the brain. It is a metabolite of progesterone and potent modulator of GABAA receptors.".
- Allopregnanolone label "Allopregnanolone".
- Allopregnanolone label "Allopregnanolone".
- Allopregnanolone label "Alloprégnanolone".
- Allopregnanolone label "Аллопрегнанолон".
- Allopregnanolone sameAs Alloprégnanolone.
- Allopregnanolone sameAs Allopregnanolon.
- Allopregnanolone sameAs Allopregnanolone.
- Allopregnanolone sameAs m.02p_4k_.
- Allopregnanolone sameAs Q2482223.
- Allopregnanolone sameAs Q2482223.
- Allopregnanolone sameAs Allopregnanolone.
- Allopregnanolone wasDerivedFrom Allopregnanolone?oldid=601537977.
- Allopregnanolone depiction Allopregnanolone.png.
- Allopregnanolone isPrimaryTopicOf Allopregnanolone.