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- Antineoplastic_resistance abstract "Antineoplastic resistance is the multidrug resistance of neoplastic (cancerous) cells, rather than drug resistance involving microorganisms such as bacteria, fungi and viruses. Cancer cells have the ability to become resistant to multiple drugs by many mechanisms:Increased efflux of drug (as by P-glycoprotein (ABCB1), multidrug resistance-associated protein (ABCC1), and breast cancer resistance protein (also known as mitoxantrone resistance associated protein, MXR, or ABCG2)Enzymatic deactivation (i.e., glutathione conjugation)Decreased permeability (drugs cannot enter the cell)Altered binding-sitesAlternate metabolic pathways (the cancer compensates for the effect of the drug).Because efflux is a significant contributor for multidrug resistance in cancer cells, current research is aimed at blocking specific efflux mechanisms. Treatment of cancer is complicated by the fact that there is such a variety of different DNA mutations that cause or contribute to tumor formation, as well as myriad mechanisms by which cells resist drugs. Notable differences between antibiotic drugs and antineoplastic (anticancer) drugs that complicate their design are that cancer cells are altered human cells and thus more difficult to damage without damaging healthy cells.".
- Antineoplastic_resistance wikiPageExternalLink cancerdr.
- Antineoplastic_resistance wikiPageExternalLink srep01445.html.
- Antineoplastic_resistance wikiPageID "38828080".
- Antineoplastic_resistance wikiPageRevisionID "604273844".
- Antineoplastic_resistance hasPhotoCollection Antineoplastic_resistance.
- Antineoplastic_resistance subject Category:Oncology.
- Antineoplastic_resistance comment "Antineoplastic resistance is the multidrug resistance of neoplastic (cancerous) cells, rather than drug resistance involving microorganisms such as bacteria, fungi and viruses.".
- Antineoplastic_resistance label "Antineoplastic resistance".
- Antineoplastic_resistance label "Multiple Drug Resistance".
- Antineoplastic_resistance sameAs Multiple_Drug_Resistance.
- Antineoplastic_resistance sameAs m.0rpf_jt.
- Antineoplastic_resistance sameAs Q13416904.
- Antineoplastic_resistance sameAs Q13416904.
- Antineoplastic_resistance wasDerivedFrom Antineoplastic_resistance?oldid=604273844.
- Antineoplastic_resistance isPrimaryTopicOf Antineoplastic_resistance.