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- Befiradol abstract "Befiradol (F-13,640) is a very potent and highly selective 5-HT1A receptor full agonist. It has powerful analgesic and antiallodynic effects comparable to those of high doses of opioid painkillers, but with fewer and less prominent side effects, as well as little or no development of tolerance with repeated use. A SAR study revealed that replacement of the dihalophenyl moiety by 3-benzothienyl increases maximal efficacy from 84% to 124% (Ki=2.7 nM).Befiradol was discovered and developed by Pierre Fabre Médicament, a French pharmaceuticals company. In September 2013, befiradol was out-licensed to Neurolixis Inc, a California-based biotechnology company. Neurolixis announced that it intends to re-purpose befiradol for the treatment of Levodopa-induced dyskinesia in Parkinson's disease.".
- Befiradol atcPrefix "none".
- Befiradol casNumber "208110-64-9".
- Befiradol fdaUniiCode "RAT9OHA1YH".
- Befiradol iupacName "3-chloro-4-fluorophenyl-[4-fluoro-4-([(5-methylpyridin-2-yl)methylamino]methyl)piperidin-1-yl]methanone".
- Befiradol pubchem "9865384".
- Befiradol thumbnail F-13640_structure.png?width=300.
- Befiradol wikiPageExternalLink www.neurolixis.com.
- Befiradol wikiPageID "23555082".
- Befiradol wikiPageRevisionID "597945595".
- Befiradol atcPrefix "none".
- Befiradol c "20".
- Befiradol casNumber "208110".
- Befiradol chembl "45305".
- Befiradol chemspiderid "8041076".
- Befiradol cl "1".
- Befiradol f "2".
- Befiradol h "22".
- Befiradol hasPhotoCollection Befiradol.
- Befiradol inchi "1".
- Befiradol inchikey "PKZXLMVXBZICTF-UHFFFAOYAP".
- Befiradol iupacName "3".
- Befiradol legalStatus "Uncontrolled".
- Befiradol molecularWeight "393.857".
- Befiradol n "3".
- Befiradol o "1".
- Befiradol pubchem "9865384".
- Befiradol smiles "FC2CNCc3nccC".
- Befiradol smiles "n2ccccc2CNCCCCN3Ccccc1F".
- Befiradol stdinchi "1".
- Befiradol stdinchikey "PKZXLMVXBZICTF-UHFFFAOYSA-N".
- Befiradol unii "RAT9OHA1YH".
- Befiradol verifiedfields "changed".
- Befiradol verifiedrevid "461088268".
- Befiradol watchedfields "changed".
- Befiradol subject Category:Amides.
- Befiradol subject Category:Amines.
- Befiradol subject Category:Analgesics.
- Befiradol subject Category:Organochlorides.
- Befiradol subject Category:Organofluorides.
- Befiradol subject Category:Piperidines.
- Befiradol subject Category:Pyridines.
- Befiradol type Abstraction100002137.
- Befiradol type AliphaticCompound114601294.
- Befiradol type Amide114724264.
- Befiradol type Amides.
- Befiradol type Amine114739004.
- Befiradol type Amines.
- Befiradol type Base114618253.
- Befiradol type Chemical114806838.
- Befiradol type Compound114818238.
- Befiradol type Material114580897.
- Befiradol type Matter100020827.
- Befiradol type MethaneSeries114951377.
- Befiradol type OrganicCompound114727670.
- Befiradol type Part113809207.
- Befiradol type PhysicalEntity100001930.
- Befiradol type Pyridine114692510.
- Befiradol type Pyridines.
- Befiradol type Relation100031921.
- Befiradol type Substance100019613.
- Befiradol type Drug.
- Befiradol type DrugProduct.
- Befiradol type FunctionalSubstance.
- Befiradol comment "Befiradol (F-13,640) is a very potent and highly selective 5-HT1A receptor full agonist. It has powerful analgesic and antiallodynic effects comparable to those of high doses of opioid painkillers, but with fewer and less prominent side effects, as well as little or no development of tolerance with repeated use.".
- Befiradol label "Befiradol".
- Befiradol sameAs m.06w51b1.
- Befiradol sameAs Q4880242.
- Befiradol sameAs Q4880242.
- Befiradol sameAs Befiradol.
- Befiradol wasDerivedFrom Befiradol?oldid=597945595.
- Befiradol depiction F-13640_structure.png.
- Befiradol isPrimaryTopicOf Befiradol.