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- Clorotepine abstract "Clorotepine (INN; Clotepin, Clopiben), also known as octoclothepin or octoclothepine, is a very potent atypical neuroleptic and central depressant of the tricyclic series which was derived from perathiepin in 1965 and soon thereafter marketed in the Czech Republic by Spofa for the treatment of schizophrenic psychosis. It is known to have high affinity for the D1, D2, D3, D4, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6, 5-HT7, α1A-adrenergic, α1B-adrenergic, α1D-adrenergic, and H1 receptors, where it has been it has been confirmed to act as an antagonist (or inverse agonist) at most sites (and likely is as such at all of them based on structure-activity relationships), and it also blocks the reuptake of norepinephrine via inhibition of the norepinephrine transporter. Due to its very potent activity at the D2 receptor, along with tefludazine, clorotepine was used as the basis for developing a 3-dimensional (3D) pharmacophore for D2 receptor antagonists.".
- Clorotepine atcPrefix "None".
- Clorotepine casNumber "13448-22-1".
- Clorotepine casSupplemental "42505-79-3 (mesylate)".
- Clorotepine casSupplemental "4789-68-8 (maleate)".
- Clorotepine fdaUniiCode "E65W20MU7A".
- Clorotepine iupacName "1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)-4-methylpiperazine".
- Clorotepine pubchem "1238".
- Clorotepine thumbnail Octoclothepin.svg?width=300.
- Clorotepine wikiPageID "33877796".
- Clorotepine wikiPageRevisionID "593798375".
- Clorotepine atcPrefix "None".
- Clorotepine c "19".
- Clorotepine casNumber "13448".
- Clorotepine casSupplemental "42505".
- Clorotepine casSupplemental "4789".
- Clorotepine chembl "64249".
- Clorotepine chemspiderid "1201".
- Clorotepine cl "1".
- Clorotepine h "21".
- Clorotepine hasPhotoCollection Clorotepine.
- Clorotepine inchi "1".
- Clorotepine inchikey "XRYLGRGAWQSVQW-UHFFFAOYAA".
- Clorotepine iupacName "1".
- Clorotepine legalStatus "Rx-only".
- Clorotepine molecularWeight "344.901".
- Clorotepine n "2".
- Clorotepine pubchem "1238".
- Clorotepine routesOfAdministration "Oral".
- Clorotepine s "1".
- Clorotepine smiles "Clc4cc2ccc4".
- Clorotepine stdinchi "1".
- Clorotepine stdinchikey "XRYLGRGAWQSVQW-UHFFFAOYSA-N".
- Clorotepine synonyms "VUFB-6281; VUFB-10030".
- Clorotepine unii "E65W20MU7A".
- Clorotepine subject Category:Atypical_antipsychotics.
- Clorotepine subject Category:Dibenzothiepines.
- Clorotepine subject Category:Organochlorides.
- Clorotepine subject Category:Piperazines.
- Clorotepine subject Category:Sedatives.
- Clorotepine type Agent114778436.
- Clorotepine type AtypicalAntipsychotics.
- Clorotepine type CausalAgent100007347.
- Clorotepine type Drug103247620.
- Clorotepine type DrugOfAbuse103248958.
- Clorotepine type MajorTranquilizer103713736.
- Clorotepine type Matter100020827.
- Clorotepine type Medicine103740161.
- Clorotepine type PhysicalEntity100001930.
- Clorotepine type Piperazine103946814.
- Clorotepine type Piperazines.
- Clorotepine type PsychotropicAgent104017429.
- Clorotepine type Sedative-hypnotic104166841.
- Clorotepine type Sedative104166553.
- Clorotepine type Sedatives.
- Clorotepine type Substance100020090.
- Clorotepine type Tranquilizer104470232.
- Clorotepine type Vermifuge104528630.
- Clorotepine type Drug.
- Clorotepine type FunctionalSubstance.
- Clorotepine comment "Clorotepine (INN; Clotepin, Clopiben), also known as octoclothepin or octoclothepine, is a very potent atypical neuroleptic and central depressant of the tricyclic series which was derived from perathiepin in 1965 and soon thereafter marketed in the Czech Republic by Spofa for the treatment of schizophrenic psychosis.".
- Clorotepine label "Clorotepine".
- Clorotepine sameAs m.0hn9jcd.
- Clorotepine sameAs Q5135148.
- Clorotepine sameAs Q5135148.
- Clorotepine sameAs Clorotepine.
- Clorotepine wasDerivedFrom Clorotepine?oldid=593798375.
- Clorotepine depiction Octoclothepin.svg.
- Clorotepine isPrimaryTopicOf Clorotepine.