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- Doxorubicin abstract "Doxorubicin /ˌdɒksəˈruːbəsɪn/ (INN, AAN, BAN, USAN; trade name Adriamycin; liposome-encapsulated trade name Doxil), also known as hydroxydaunorubicin, is a drug used in cancer chemotherapy and derived by chemical semisynthesis from a bacterial species. It is an anthracycline antibiotic (note: in this context, this does not mean it is used to treat bacterial infections) closely related to the natural product daunomycin and like all anthracyclines, it works by intercalating DNA, with the most serious adverse effect being life-threatening heart damage. It is commonly used in the treatment of a wide range of cancers, including hematological malignancies (blood cancers, like leukaemia and lymphoma), many types of carcinoma (solid tumours) and soft tissue sarcomas.Common adverse effects of doxorubicin include hair loss (seen in most of those treated with the drug), myelosuppression (a compromised ability of the body's bone marrow to produce new blood cells), nausea and vomiting (which are seen in roughly 30-90% of people treated with the drug), oral mucositis, oesophagitis, diarrhoea, skin reactions (including hand-foot syndrome) and localised swelling and redness along the vein in which the drug is delivered. Less common, yet serious reactions include hypersensitivity reactions (including anaphylaxis), radiation recall, heart damage and liver dysfunction.The drug is administered intravenously, as the hydrochloride salt. It is sold under a number of different brand names, including Adriamycin PFS, Adriamycin RDF, or Rubex. Doxorubicin is photosensitive, and containers are often covered by an aluminum bag and/or brown wax paper to prevent light from affecting it. Doxorubicin is also available in liposome-encapsulated forms (that is, pegylated forms) as Doxil (United States), Caelyx and Myocet, although these forms must also be given by intravenous injection.".
- Doxorubicin atcPrefix "L01".
- Doxorubicin atcSuffix "DB01".
- Doxorubicin bioavailability "5.0".
- Doxorubicin casNumber "23214-92-8".
- Doxorubicin chEBI "28748".
- Doxorubicin drugbank "DB00997".
- Doxorubicin fdaUniiCode "80168379AG".
- Doxorubicin iupacName "(7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione".
- Doxorubicin pubchem "31703".
- Doxorubicin thumbnail Doxorubicin2DCSD.svg?width=300.
- Doxorubicin wikiPageExternalLink dpdirect.jsp?name=Doxorubicin.
- Doxorubicin wikiPageExternalLink Doxorubicin.htm.
- Doxorubicin wikiPageExternalLink www.doxil.com.
- Doxorubicin wikiPageExternalLink doxil-supply-shortage.
- Doxorubicin wikiPageExternalLink 65.
- Doxorubicin wikiPageExternalLink www.yissum.co.il.
- Doxorubicin wikiPageID "1802881".
- Doxorubicin wikiPageRevisionID "606596552".
- Doxorubicin atcPrefix "L01".
- Doxorubicin atcSuffix "DB01".
- Doxorubicin bioavailability "5.0".
- Doxorubicin c "27".
- Doxorubicin casNumber "23214".
- Doxorubicin chebi "28748".
- Doxorubicin chembl "53463".
- Doxorubicin chemspiderid "29400".
- Doxorubicin drugbank "DB00997".
- Doxorubicin eliminationHalfLife "-10080.0".
- Doxorubicin excretion "Urine , faeces".
- Doxorubicin h "29".
- Doxorubicin hasPhotoCollection Doxorubicin.
- Doxorubicin image "Doxorubicin3Dan.gif".
- Doxorubicin inchi "1".
- Doxorubicin inchikey "AOJJSUZBOXZQNB-TZSSRYMLBG".
- Doxorubicin iupacName "-7".
- Doxorubicin kegg "D03899".
- Doxorubicin legalAu "S4".
- Doxorubicin legalCa "Rx-only".
- Doxorubicin legalUk "POM".
- Doxorubicin legalUs "Rx-only".
- Doxorubicin medlineplus "a682221".
- Doxorubicin metabolism "Hepatic".
- Doxorubicin molecularWeight "543.52".
- Doxorubicin n "1".
- Doxorubicin o "11".
- Doxorubicin pregnancyAu "D".
- Doxorubicin pregnancyUs "D".
- Doxorubicin proteinBound "75.0".
- Doxorubicin pubchem "31703".
- Doxorubicin routesOfAdministration "Intravenous, intravesical".
- Doxorubicin smiles "C[C@H]1[C@H]O".
- Doxorubicin stdinchi "1".
- Doxorubicin stdinchikey "AOJJSUZBOXZQNB-TZSSRYMLSA-N".
- Doxorubicin tradename "Adriamycin".
- Doxorubicin unii "80168379".
- Doxorubicin verifiedfields "changed".
- Doxorubicin verifiedrevid "458446335".
- Doxorubicin width "200".
- Doxorubicin width "250".
- Doxorubicin subject Category:Anthracyclines.
- Doxorubicin subject Category:Anthraquinone_glycosides.
- Doxorubicin subject Category:Embryotoxins.
- Doxorubicin subject Category:IARC_Group_2A_carcinogens.
- Doxorubicin subject Category:Teratogens.
- Doxorubicin subject Category:Topoisomerase_inhibitors.
- Doxorubicin type Drug.
- Doxorubicin type DrugProduct.
- Doxorubicin type FunctionalSubstance.
- Doxorubicin comment "Doxorubicin /ˌdɒksəˈruːbəsɪn/ (INN, AAN, BAN, USAN; trade name Adriamycin; liposome-encapsulated trade name Doxil), also known as hydroxydaunorubicin, is a drug used in cancer chemotherapy and derived by chemical semisynthesis from a bacterial species.".
- Doxorubicin label "Doksorubicyna".
- Doxorubicin label "Doxorrubicina".
- Doxorubicin label "Doxorrubicina".
- Doxorubicin label "Doxorubicin".
- Doxorubicin label "Doxorubicin".
- Doxorubicin label "Doxorubicina".
- Doxorubicin label "Doxorubicine".
- Doxorubicin label "Doxorubicine".
- Doxorubicin label "Доксорубицин".
- Doxorubicin label "دوكسوروبيسين".
- Doxorubicin label "ドキソルビシン".
- Doxorubicin label "阿黴素".
- Doxorubicin sameAs Doxorubicin.
- Doxorubicin sameAs Doxorrubicina.
- Doxorubicin sameAs Doxorubicine.
- Doxorubicin sameAs Doxorubicina.
- Doxorubicin sameAs ドキソルビシン.
- Doxorubicin sameAs Doxorubicine.
- Doxorubicin sameAs Doksorubicyna.
- Doxorubicin sameAs Doxorrubicina.
- Doxorubicin sameAs m.05y6n3.
- Doxorubicin sameAs Q18936.
- Doxorubicin sameAs Q18936.
- Doxorubicin sameAs Doxorubicin.
- Doxorubicin sameAs DB00997.
- Doxorubicin wasDerivedFrom Doxorubicin?oldid=606596552.
- Doxorubicin depiction Doxorubicin2DCSD.svg.
- Doxorubicin isPrimaryTopicOf Doxorubicin.