Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Formins> ?p ?o. }
- Formins abstract "Formins (formin homology proteins) are a group of proteins that are involved in the polymerization of actin and associate with the fast-growing end (barbed end) of actin filaments. Most formins are Rho-GTPase effector proteins. Formins regulate the actin and microtubule cytoskeleton and are involved in various cellular functions such as cell polarity, cytokinesis, cell migration and SRF transcriptional activity. Formins are multidomain proteins that interact with diverse signalling molecules and cytoskeletal proteins, although some formins have been assigned functions within the nucleus. Formins are characterised by the presence of three FH domains (FH1, FH2 and FH3), although members of the formin family do not necessarily contain all three domains.The proline-rich FH1 domain mediates interactions with a variety of proteins, including the actin-binding protein profilin, SH3 (Src homology 3) domain proteins, and WW domain proteins. The actin nucleation-promoting activity of S. cerevisiae formins has been localized to the FH2 domain. The FH2 domain is required for the self-association of formin proteins through the ability of FH2 domains to directly bind each other, and may also act to inhibit actin polymerisation. The FH3 domain is less well conserved and is required for directing formins to the correct intracellular location, such the mitotic spindle, or the projection tip during conjugation. In addition, some formins can contain a GTPase-binding domain (GBD) required for binding to Rho small GTPases, and a C-terminal conserved DRF autoregulatory domain (Dia-autoregulatory domain) (DAD). The GBD domain is a bifunctional autoinhibitory domain that interacts with and is regulated by activated Rho family members. Mammalian Drf3 contains a CRIB-like motif within its GBD for binding to Cdc42, which is required for Cdc42 to activate and guide Drf3 towards the cell cortex where it remodels the actin skeleton. The DRF autoregulatory domain binds the N-terminal GTPase-binding domain; this link is broken when GTP-bound Rho binds to the GBD and activates the protein. The addition of the DAD to mammalian cells induces actin filament formation, stabilises microtubules, and activates serum-response mediated transcription. Another commonly found domain is an armadillo repeat region (ARR) located in the FH3 domain.The FH2 domain, has been shown by X-ray crystallography to have an elongated, crescent shape containing three helical subdomains.Formins also directly bind to microtubules via their FH2 domain. This interaction is important in promoting the capture and stabilization of a subset of microtubules oriented towards the leading edge of migrating cells. Formins also promote the capture of microtubules by the kinetochore during mitosis and for aligning microtubules along actin filaments.".
- Formins arm "q".
- Formins band "13".
- Formins band "43".
- Formins chromosome "1".
- Formins chromosome "15".
- Formins entrezgene "342184".
- Formins entrezgene "56776".
- Formins hgncid "14074".
- Formins hgncid "3768".
- Formins locusSupplementaryData "-q14".
- Formins omim "136535".
- Formins omim "606373".
- Formins refseq "NM_001103184".
- Formins refseq "XM_371352".
- Formins symbol "Drf_DAD".
- Formins symbol "Drf_FH1".
- Formins symbol "Drf_FH3".
- Formins symbol "Drf_GBD".
- Formins symbol "FH2".
- Formins symbol "FMN1".
- Formins symbol "FMN2".
- Formins symbol "LD, FMN".
- Formins thumbnail PDB_1ux4_EBI.jpg?width=300.
- Formins uniprot "Q68DA7".
- Formins uniprot "Q9NZ56".
- Formins wikiPageExternalLink PIIS0092867410007208.pdf?intermediate=true.
- Formins wikiPageExternalLink go-0070649.
- Formins wikiPageID "13138964".
- Formins wikiPageRevisionID "597925300".
- Formins altsymbols "LD, FMN".
- Formins arm "q".
- Formins band "13".
- Formins band "43".
- Formins caption "crystal structure of mdia1 gbd-fh3 in complex with rhoc-gmppnp".
- Formins caption "crystal structure of the n-terminal mdia1 armadillo repeat region and dimerisation domain in complex with the mdia1 autoregulatory domain".
- Formins caption "crystal structures of a formin homology-2 domain reveal a tethered-dimer architecture".
- Formins chromosome "1".
- Formins chromosome "15".
- Formins entrezgene "342184".
- Formins entrezgene "56776".
- Formins hasPhotoCollection Formins.
- Formins hgncid "14074".
- Formins hgncid "3768".
- Formins interpro "IPR009408".
- Formins interpro "IPR010465".
- Formins interpro "IPR010472".
- Formins interpro "IPR010473".
- Formins interpro "IPR015425".
- Formins locussupplementarydata "-q14".
- Formins name "DRF Autoregulatory Domain".
- Formins name "Diaphanous FH3 Domain".
- Formins name "Diaphanous GTPase-binding Domain".
- Formins name "Formin Homology 2 Domain".
- Formins name "Formin Homology Region 1".
- Formins name "formin 1".
- Formins name "formin 2".
- Formins omim "136535".
- Formins omim "606373".
- Formins pfam "PF02181".
- Formins pfam "PF06345".
- Formins pfam "PF06346".
- Formins pfam "PF06367".
- Formins pfam "PF06371".
- Formins pfamClan "CL0020".
- Formins refseq "NM_001103184".
- Formins refseq "XM_371352".
- Formins scop "1".
- Formins smart "FH2".
- Formins symbol "Drf_DAD".
- Formins symbol "Drf_FH1".
- Formins symbol "Drf_FH3".
- Formins symbol "Drf_GBD".
- Formins symbol "FH2".
- Formins symbol "FMN1".
- Formins symbol "FMN2".
- Formins uniprot "Q68DA7".
- Formins uniprot "Q9NZ56".
- Formins subject Category:Cell_biology.
- Formins subject Category:Cellular_processes.
- Formins subject Category:Protein_domains.
- Formins subject Category:Proteins.
- Formins type Abstraction100002137.
- Formins type Act100030358.
- Formins type Activity100407535.
- Formins type Attribute100024264.
- Formins type CellularProcesses.
- Formins type Chemical114806838.
- Formins type Compound114818238.
- Formins type Environment113934596.
- Formins type Event100029378.
- Formins type Macromolecule114944888.
- Formins type Material114580897.
- Formins type Matter100020827.
- Formins type Molecule114682133.
- Formins type OrganicCompound114727670.
- Formins type Part113809207.
- Formins type PhysicalEntity100001930.
- Formins type Procedure101023820.
- Formins type Protein114728724.