Matches in DBpedia 2014 for { <http://dbpedia.org/resource/Metofoline> ?p ?o. }
Showing items 1 to 48 of
48
with 100 items per page.
- Metofoline abstract "Methopholine is an opioid analgesic drug discovered in the 1950s by a team of Swiss researchers at Hoffmann-La Roche.Methopholine is an isoquinoline derivative which is not structurally related to most other opioids.It has around the same efficacy as an analgesic as codeine, and was evaluated for the treatment of postoperative pain. Methopholine tablets were marketed in the United States under the brand name of Versidyne, but the drug was withdrawn from the market in 1965 due to the occurrence of ophthalmic side-effects and the discovery that it could produce corneal opacities in dogs.Methopholine has two enantiomers, with the levo (R) enantiomer being the active form, around 3x the potency of codeine, and the (S) enantiomer being inactive.Analogues where the 4'-chloro group has been replaced by other groups have also been tested, the fluoro derivative being slightly more potent than chloro, and the nitro derivative being most potent of all, with the racemic 4'-nitromethopholine being around 20x the potency of codeine.".
- Metofoline atcPrefix "none".
- Metofoline casNumber "2154-02-1".
- Metofoline casSupplemental "63937-57-5 (4'-nitromethopholine)".
- Metofoline fdaUniiCode "72L4ZT2W1P".
- Metofoline iupacName "1-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline".
- Metofoline pubchem "16538".
- Metofoline thumbnail Methopholine.svg?width=300.
- Metofoline wikiPageID "13967330".
- Metofoline wikiPageRevisionID "602868541".
- Metofoline atcPrefix "none".
- Metofoline c "20".
- Metofoline casNumber "2154-02-01".
- Metofoline casSupplemental "63937".
- Metofoline chemspiderid "15678".
- Metofoline cl "1".
- Metofoline h "24".
- Metofoline hasPhotoCollection Metofoline.
- Metofoline inchi "1".
- Metofoline inchikey "YBCPYHQFUMNOJG-UHFFFAOYAD".
- Metofoline iupacName "1".
- Metofoline kegg "D04986".
- Metofoline legalStatus "Legal".
- Metofoline molecularWeight "345.87".
- Metofoline n "1".
- Metofoline o "2".
- Metofoline pubchem "16538".
- Metofoline smiles "ClC1=CC=CC=C1".
- Metofoline stdinchi "1".
- Metofoline stdinchikey "YBCPYHQFUMNOJG-UHFFFAOYSA-N".
- Metofoline unii "72".
- Metofoline verifiedrevid "450690409".
- Metofoline width "180".
- Metofoline subject Category:Mu-opioid_agonists.
- Metofoline subject Category:Organochlorides.
- Metofoline subject Category:Phenol_ethers.
- Metofoline subject Category:Synthetic_opioids.
- Metofoline subject Category:Tetrahydroisoquinolines.
- Metofoline type Drug.
- Metofoline type FunctionalSubstance.
- Metofoline comment "Methopholine is an opioid analgesic drug discovered in the 1950s by a team of Swiss researchers at Hoffmann-La Roche.Methopholine is an isoquinoline derivative which is not structurally related to most other opioids.It has around the same efficacy as an analgesic as codeine, and was evaluated for the treatment of postoperative pain.".
- Metofoline label "Metofoline".
- Metofoline sameAs m.03cpn3m.
- Metofoline sameAs Q6824210.
- Metofoline sameAs Q6824210.
- Metofoline wasDerivedFrom Metofoline?oldid=602868541.
- Metofoline depiction Methopholine.svg.
- Metofoline isPrimaryTopicOf Metofoline.