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- Pravadoline abstract "Pravadoline (WIN 48,098) is an antiinflammatory and analgesic drug with an IC50 of 4.9 µM, related in structure to non-steroidal antinflammtory drugs (NSAIDs) such as indometacin. It was developed in the 1980s as a new antiinflammatory and prostaglandin synthesis inhibitor, acting through inhibition of the enzyme cyclooxygenase (COX).However, pravadoline was found to exhibit unexpectedly strong analgesic effects, which appeared at doses ten times smaller than the effective anti-inflammatory dose and so could not be explained by its action as a COX inhibitor. These effects were not blocked by opioid antagonists such as naloxone, and it was eventually discovered that pravadoline represented the first compound from a novel class of cannabinoid agonists, the aminoalkylindoles.Pravadoline was never developed for use as an analgesic, partly due to toxicity concerns (although these were later shown to be a result of the salt form that the drug had been prepared in rather than from the pravadoline itself), however the discovery of cannabinoid activity in this structurally novel family of drugs led to the discovery of several new cannabinoid agonists, including the drug WIN 55,212-2, which is now widely used in scientific research.".
- Pravadoline atcPrefix "none".
- Pravadoline casNumber "92623-83-1".
- Pravadoline fdaUniiCode "P3JW662TWA".
- Pravadoline iupacName "(4-methoxyphenyl)-[2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]methanone".
- Pravadoline pubchem "56463".
- Pravadoline thumbnail Pravadoline.svg?width=300.
- Pravadoline wikiPageID "14758056".
- Pravadoline wikiPageRevisionID "586850007".
- Pravadoline atcPrefix "none".
- Pravadoline c "23".
- Pravadoline casNumber "92623".
- Pravadoline chembl "13178".
- Pravadoline chemspiderid "50942".
- Pravadoline h "26".
- Pravadoline hasPhotoCollection Pravadoline.
- Pravadoline inchi "1".
- Pravadoline inchikey "MEUQWHZOUDZXHH-UHFFFAOYAE".
- Pravadoline iupacName "-[2-methyl-1-indol-3-yl]methanone".
- Pravadoline legalStatus "Legal".
- Pravadoline molecularWeight "378.46".
- Pravadoline n "2".
- Pravadoline o "3".
- Pravadoline pubchem "56463".
- Pravadoline smiles "O=Cc2c4ccccc4nCCN3CCOCC3".
- Pravadoline stdinchi "1".
- Pravadoline stdinchikey "MEUQWHZOUDZXHH-UHFFFAOYSA-N".
- Pravadoline unii "P3JW662TWA".
- Pravadoline verifiedfields "changed".
- Pravadoline verifiedrevid "464213342".
- Pravadoline subject Category:Aminoalkylindoles.
- Pravadoline subject Category:Benzoylindoles.
- Pravadoline subject Category:Morpholines.
- Pravadoline subject Category:Phenol_ethers.
- Pravadoline subject Category:WIN_compounds.
- Pravadoline type Abstraction100002137.
- Pravadoline type Cognition100023271.
- Pravadoline type Compound105870180.
- Pravadoline type Concept105835747.
- Pravadoline type Content105809192.
- Pravadoline type Element114840755.
- Pravadoline type Idea105833840.
- Pravadoline type Matter100020827.
- Pravadoline type Part113809207.
- Pravadoline type PhenolEthers.
- Pravadoline type PhysicalEntity100001930.
- Pravadoline type PsychologicalFeature100023100.
- Pravadoline type Quintessence114847103.
- Pravadoline type Relation100031921.
- Pravadoline type Substance100019613.
- Pravadoline type WINCompounds.
- Pravadoline type Whole105869584.
- Pravadoline type Drug.
- Pravadoline type DrugProduct.
- Pravadoline type FunctionalSubstance.
- Pravadoline comment "Pravadoline (WIN 48,098) is an antiinflammatory and analgesic drug with an IC50 of 4.9 µM, related in structure to non-steroidal antinflammtory drugs (NSAIDs) such as indometacin.".
- Pravadoline label "Pravadoline".
- Pravadoline sameAs m.03gwy98.
- Pravadoline sameAs Q7238828.
- Pravadoline sameAs Q7238828.
- Pravadoline sameAs Pravadoline.
- Pravadoline wasDerivedFrom Pravadoline?oldid=586850007.
- Pravadoline depiction Pravadoline.svg.
- Pravadoline isPrimaryTopicOf Pravadoline.