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- Tiospirone abstract "Tiospirone (BMY-13,859), also sometimes called tiaspirone or tiosperone, is an atypical antipsychotic of the azapirone class. It was investigated as a treatment for schizophrenia in the late 1980s and was found to have an effectiveness equivalent to those of typical antipsychotics in clinical trials but without causing extrapyramidal side effects. However, development was halted and it was not marketed. Perospirone, another azapirone derivative with antipsychotic properties, was synthesized and assayed several years after tiospirone. It was found to be both more potent and more selective in comparison and was commercialized instead.Tiospirone acts as a 5-HT1A receptor partial agonist, 5-HT2A, 5-HT2C, and 5-HT7 receptor inverse agonist, and D2, D4, and α1-adrenergic receptor antagonist.Binding profile".
- Tiospirone atcPrefix "none".
- Tiospirone casNumber "87691-91-6".
- Tiospirone fdaUniiCode "35C6UMO5SR".
- Tiospirone iupacName "8-[4-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]butyl]-8-azaspiro[4.5]decane-7,9-dione".
- Tiospirone pubchem "55752".
- Tiospirone thumbnail Tiospirone.png?width=300.
- Tiospirone wikiPageID "26160599".
- Tiospirone wikiPageRevisionID "606596934".
- Tiospirone atcPrefix "none".
- Tiospirone c "24".
- Tiospirone casNumber "87691".
- Tiospirone chembl "35057".
- Tiospirone chemspiderid "50348".
- Tiospirone eliminationHalfLife "5040.0".
- Tiospirone excretion "Urine".
- Tiospirone h "32".
- Tiospirone hasPhotoCollection Tiospirone.
- Tiospirone iupacName "8".
- Tiospirone iupharLigand "101".
- Tiospirone metabolism "Hepatic".
- Tiospirone molecularWeight "440.6".
- Tiospirone n "4".
- Tiospirone o "2".
- Tiospirone pubchem "55752".
- Tiospirone s "1".
- Tiospirone unii "35".
- Tiospirone subject Category:Antipsychotics.
- Tiospirone subject Category:Azapirones.
- Tiospirone subject Category:Benzothiazoles.
- Tiospirone subject Category:Piperazines.
- Tiospirone type Agent114778436.
- Tiospirone type CausalAgent100007347.
- Tiospirone type Drug103247620.
- Tiospirone type Matter100020827.
- Tiospirone type Medicine103740161.
- Tiospirone type PhysicalEntity100001930.
- Tiospirone type Piperazine103946814.
- Tiospirone type Piperazines.
- Tiospirone type Substance100020090.
- Tiospirone type Vermifuge104528630.
- Tiospirone type Drug.
- Tiospirone type DrugProduct.
- Tiospirone type FunctionalSubstance.
- Tiospirone comment "Tiospirone (BMY-13,859), also sometimes called tiaspirone or tiosperone, is an atypical antipsychotic of the azapirone class. It was investigated as a treatment for schizophrenia in the late 1980s and was found to have an effectiveness equivalent to those of typical antipsychotics in clinical trials but without causing extrapyramidal side effects. However, development was halted and it was not marketed.".
- Tiospirone label "Tiospirone".
- Tiospirone sameAs m.0b6nxn4.
- Tiospirone sameAs Q13415380.
- Tiospirone sameAs Q13415380.
- Tiospirone sameAs Tiospirone.
- Tiospirone wasDerivedFrom Tiospirone?oldid=606596934.
- Tiospirone depiction Tiospirone.png.
- Tiospirone isPrimaryTopicOf Tiospirone.