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- Tolvaptan abstract "Tolvaptan (INN), also known as OPC-41061, is a selective, competitive vasopressin receptor 2 antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH). Tolvaptan was approved by the U.S. Food and Drug Administration (FDA) on May 19, 2009, and is sold by Otsuka Pharmaceutical Co. under the trade name Samsca and in India is manufactured & sold by MSN laboratories Ltd. under the trade name Tolsama & Tolvat and by Lupin under the brand name Resodim.Tolvaptan was also in fast-track clinical trials for polycystic kidney disease. In a 2004 trial, tolvaptan, when administered with traditional diuretics, was noted to increase excretion of excess fluids and improve blood sodium levels in patients with heart failure without producing side effects such as hypotension (low blood pressure) or hypokalemia (decreased blood levels of potassium) and without having an adverse effect on kidney function. In a recently published trial (TEMPO 3:4 ClinicalTrials.gov number, NCT00428948) the study met its primary and secondary end points. Tolvaptan, when given at an average dose of 95 mg per day over a 3-year period, slowed the usual increase in kidney volume by 50% compared to placebo (2.80% per year versus 5.51% per year, respectively, p<0.001) and reduced the decline in kidney function when compared with that of placebo-treated patients by approximately 30% (reciprocal serum creatinine, -2.61 versus -3.81 (mg/mL)-1 per year, p <0.001)".
- Tolvaptan atcPrefix "C03".
- Tolvaptan atcSuffix "XA01".
- Tolvaptan casNumber "150683-30-0".
- Tolvaptan fdaUniiCode "21G72T1950".
- Tolvaptan iupacName "N-(4-{[(5R)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide".
- Tolvaptan pubchem "216237".
- Tolvaptan thumbnail Tolvaptan.svg?width=300.
- Tolvaptan wikiPageID "7960459".
- Tolvaptan wikiPageRevisionID "604447924".
- Tolvaptan atcPrefix "3.0".
- Tolvaptan atcSuffix "XA01".
- Tolvaptan bioavailability "Unknown".
- Tolvaptan c "26".
- Tolvaptan caption "and enantiomer".
- Tolvaptan casNumber "150683".
- Tolvaptan chembl "344159".
- Tolvaptan chemspiderid "187438".
- Tolvaptan cl "1".
- Tolvaptan eliminationHalfLife "43200.0".
- Tolvaptan h "25".
- Tolvaptan hasPhotoCollection Tolvaptan.
- Tolvaptan inchi "1".
- Tolvaptan inchikey "GYHCTFXIZSNGJT-UHFFFAOYAH".
- Tolvaptan iupacName "N--2-methylbenzamide".
- Tolvaptan iupharLigand "2226".
- Tolvaptan legalUs "Rx-only".
- Tolvaptan licenceUs "Tolvaptan".
- Tolvaptan medlineplus "a609033".
- Tolvaptan metabolism "Hepatic".
- Tolvaptan molecularWeight "448.941".
- Tolvaptan n "2".
- Tolvaptan o "3".
- Tolvaptan pregnancyUs "C".
- Tolvaptan proteinBound "99.0".
- Tolvaptan pubchem "216237".
- Tolvaptan routesOfAdministration "Oral".
- Tolvaptan smiles "O=CNc2cccCN4c3ccccc3CCCC4".
- Tolvaptan stdinchi "1".
- Tolvaptan stdinchikey "GYHCTFXIZSNGJT-UHFFFAOYSA-N".
- Tolvaptan synonyms "N-{4-[-9-chloro-6-hydroxy-2-azabicyclo[5.4.0]undeca-8,10,12-triene-2-carbonyl]-3-methyl-phenyl}-2-methyl-benzamide".
- Tolvaptan tradename "Samsca".
- Tolvaptan unii "21".
- Tolvaptan verifiedfields "changed".
- Tolvaptan verifiedrevid "470611744".
- Tolvaptan watchedfields "changed".
- Tolvaptan subject Category:Alcohols.
- Tolvaptan subject Category:Amides.
- Tolvaptan subject Category:Benzanilides.
- Tolvaptan subject Category:Benzazepines.
- Tolvaptan subject Category:Diuretics.
- Tolvaptan subject Category:Hormonal_agents.
- Tolvaptan subject Category:Organochlorides.
- Tolvaptan type Abstraction100002137.
- Tolvaptan type Agent114778436.
- Tolvaptan type Alcohol107884567.
- Tolvaptan type Alcohols.
- Tolvaptan type Amide114724264.
- Tolvaptan type Amides.
- Tolvaptan type Beverage107881800.
- Tolvaptan type CausalAgent100007347.
- Tolvaptan type Chemical114806838.
- Tolvaptan type Compound114818238.
- Tolvaptan type Drug103247620.
- Tolvaptan type DrugOfAbuse103248958.
- Tolvaptan type Fluid114939900.
- Tolvaptan type Food100021265.
- Tolvaptan type Liquid114940386.
- Tolvaptan type Material114580897.
- Tolvaptan type Matter100020827.
- Tolvaptan type OrganicCompound114727670.
- Tolvaptan type Part113809207.
- Tolvaptan type PhysicalEntity100001930.
- Tolvaptan type Relation100031921.
- Tolvaptan type Substance100019613.
- Tolvaptan type Substance100020090.
- Tolvaptan type Drug.
- Tolvaptan type DrugProduct.
- Tolvaptan type FunctionalSubstance.
- Tolvaptan comment "Tolvaptan (INN), also known as OPC-41061, is a selective, competitive vasopressin receptor 2 antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH). Tolvaptan was approved by the U.S. Food and Drug Administration (FDA) on May 19, 2009, and is sold by Otsuka Pharmaceutical Co. under the trade name Samsca and in India is manufactured & sold by MSN laboratories Ltd.".
- Tolvaptan label "Tolvaptan".
- Tolvaptan label "Tolvaptan".
- Tolvaptan label "Tolvaptan".
- Tolvaptan sameAs Tolvaptan.
- Tolvaptan sameAs Tolvaptan.
- Tolvaptan sameAs m.026ljpf.
- Tolvaptan sameAs Q426132.
- Tolvaptan sameAs Q426132.
- Tolvaptan sameAs Tolvaptan.
- Tolvaptan wasDerivedFrom Tolvaptan?oldid=604447924.
- Tolvaptan depiction Tolvaptan.svg.
- Tolvaptan isPrimaryTopicOf Tolvaptan.