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- catalog abstract ""Providing a broad overview of basic and clinical aspects of alpha 1-antitrypsin ([alpha]1AT) deficiency, this up-to-date reference discusses the complex pathobiological processes underlying the pathogenesis of [alpha]1AT deficiency, describes the [alpha]1AT gene and its promoter, and details specific therapies to prevent the major clinical manifestations of the disorder." "Containing authoritative contributions from more than 35 leading experts in their respective fields, Alpha 1-Antitrypsin Deficiency considers the treatment of [alpha]1AT deficiency with [alpha]1AT replacement therapy ... reviews current literature on the expression and regulation of the [alpha]1AT gene in mononuclear phagocytes in normal and deficient individuals ... analyzes pulmonary function data supporting the development of premature emphysema in people with [alpha]1AT deficiency ... elucidates the theoretical and experimental basis for the modern conception of the role of proteases and anti-proteases in reactive airways disease ... examines the goals and design of the Registry for Patients with Severe Deficiency of Alpha 1-Antitrypsin sponsored by the National Heart, Lung and Blood Institute ... surveys the status of lung transplantation for antitrypsin-deficiency emphysema ... and more."--Jacket.".
- catalog alternative "Alpha one antitrypsin deficiency".
- catalog contributor b9023629.
- catalog created "c1996.".
- catalog date "1996".
- catalog date "c1996.".
- catalog dateCopyrighted "c1996.".
- catalog description ""Providing a broad overview of basic and clinical aspects of alpha 1-antitrypsin ([alpha]1AT) deficiency, this up-to-date reference discusses the complex pathobiological processes underlying the pathogenesis of [alpha]1AT deficiency, describes the [alpha]1AT gene and its promoter, and details specific therapies to prevent the major clinical manifestations of the disorder." "Containing authoritative contributions from more than 35 leading experts in their respective fields, Alpha 1-Antitrypsin Deficiency considers the treatment of [alpha]1AT deficiency with [alpha]1AT replacement therapy ... reviews current literature on the expression and regulation of the [alpha]1AT gene in mononuclear phagocytes in normal and deficient individuals ... analyzes pulmonary function data supporting the development of premature emphysema in people with [alpha]1AT deficiency ... elucidates the theoretical and experimental basis for the modern conception of the role of proteases and anti-proteases in reactive airways disease ... examines the goals and design of the Registry for Patients with Severe Deficiency of Alpha 1-Antitrypsin sponsored by the National Heart, Lung and Blood Institute ... surveys the status of lung transplantation for antitrypsin-deficiency emphysema ... and more."--Jacket.".
- catalog description "Includes bibliographical references and indexes.".
- catalog description "Introduction / Claude Lenfant -- 1. Alpha 1-Antitrypsin Deficiency: An Introduction / Andrea Mastrangeli and Ronald G. Crystal -- 2. Alpha 1-Antitrypsin Gene and Promoter / John G. Hay, Motoyoshi Suzuki and Ronald G. Crystal -- 3. Alpha 1-Antitrypsin Gene Evolution / Toshihiro Nukiwa, Fumitaka Ogushi and Ronald G. Crystal -- 4. Alpha 1-Antitrypsin Genotypes and Phenotypes / Mark Brantly -- 5. Structure and Expression of the Human Neutrophil Elastase Gene / Kunihiko Yoshimura -- 6. Three-Dimensional Structure of [alpha]1AT / Richard A. Engh and Wolfram Bode -- 7. Three-Dimensional Structure of Human Neutrophil Elastase / Wolfram Bode -- 8. Kinetics of Neutrophil Elastase Inhibition In Vivo / Joseph C. Bieth -- 9. Alpha 1-Antitrypsin Gene Expression in Neutrophils and Other Cells / Roland M. du Bois -- 10. Alpha 1-Antitrypsin Gene Expression in Hepatocytes / Alfredo Nicosia and Paolo Monaci -- 11. Alpha 1-Antitrypsin Gene Expression in Mononuclear Phagocytes / Gregg Joslin and David H. Perlmutter -- 12. Transgenic Animals with the [alpha]1AT Promoter / Wilfried Dalemans, Frederic Perraud, Dalila Ali-Hadji, Sophie Jallat and Andrea Pavirani -- 13. Chemistry and Biology of Secretory Leukoprotease Inhibitor / David F. Carmichael and Kjell Ohlsson -- 14. Laboratory Diagnosis of [alpha]1AT Deficiency / Mark Brantly -- 15. Clinical Manifestations of [alpha]1AT Deficiency / Noel G. McElvaney and Ronald G. Crystal -- 16. Lung Function and [alpha]1AT Deficiency / Alan F. Barker, Ray G. D'Silva and A. Sonia Buist -- 17. Reactive Airways Disease and [alpha]1AT Deficiency / Robert J. Fallat -- 18. Natural History of [alpha]1AT Deficiency / Janet Wittes and Margaret C. Wu -- 19. Prevalence of [alpha]1AT Deficiency Outside the United States and Europe / Toshihiro Nukiwa, Kuniaki Seyama and Shiro Kira.".
- catalog extent "xx, 449 p. :".
- catalog identifier "0824788486 (hc : alk. pbk.)".
- catalog isPartOf "Lung biology in health and disease ; 88".
- catalog isPartOf "Lung biology in health and disease ; v. 88.".
- catalog issued "1996".
- catalog issued "c1996.".
- catalog language "eng".
- catalog publisher "New York : Marcel Dekker,".
- catalog subject "616.2/4 20".
- catalog subject "Alpha 1-antitrypsin deficiency.".
- catalog subject "Lung Diseases, Obstructive physiopathology.".
- catalog subject "Lung Diseases, Obstructive therapy.".
- catalog subject "RC632.A43 A47 1996".
- catalog subject "W1 LU62 v.88 1996 WF 600 A456 1996".
- catalog subject "alpha 1-Antitrypsin Deficiency".
- catalog subject "alpha 1-Antitrypsin genetics.".
- catalog tableOfContents "Introduction / Claude Lenfant -- 1. Alpha 1-Antitrypsin Deficiency: An Introduction / Andrea Mastrangeli and Ronald G. Crystal -- 2. Alpha 1-Antitrypsin Gene and Promoter / John G. Hay, Motoyoshi Suzuki and Ronald G. Crystal -- 3. Alpha 1-Antitrypsin Gene Evolution / Toshihiro Nukiwa, Fumitaka Ogushi and Ronald G. Crystal -- 4. Alpha 1-Antitrypsin Genotypes and Phenotypes / Mark Brantly -- 5. Structure and Expression of the Human Neutrophil Elastase Gene / Kunihiko Yoshimura -- 6. Three-Dimensional Structure of [alpha]1AT / Richard A. Engh and Wolfram Bode -- 7. Three-Dimensional Structure of Human Neutrophil Elastase / Wolfram Bode -- 8. Kinetics of Neutrophil Elastase Inhibition In Vivo / Joseph C. Bieth -- 9. Alpha 1-Antitrypsin Gene Expression in Neutrophils and Other Cells / Roland M. du Bois -- 10. Alpha 1-Antitrypsin Gene Expression in Hepatocytes / Alfredo Nicosia and Paolo Monaci -- 11. Alpha 1-Antitrypsin Gene Expression in Mononuclear Phagocytes / Gregg Joslin and David H. Perlmutter -- 12. Transgenic Animals with the [alpha]1AT Promoter / Wilfried Dalemans, Frederic Perraud, Dalila Ali-Hadji, Sophie Jallat and Andrea Pavirani -- 13. Chemistry and Biology of Secretory Leukoprotease Inhibitor / David F. Carmichael and Kjell Ohlsson -- 14. Laboratory Diagnosis of [alpha]1AT Deficiency / Mark Brantly -- 15. Clinical Manifestations of [alpha]1AT Deficiency / Noel G. McElvaney and Ronald G. Crystal -- 16. Lung Function and [alpha]1AT Deficiency / Alan F. Barker, Ray G. D'Silva and A. Sonia Buist -- 17. Reactive Airways Disease and [alpha]1AT Deficiency / Robert J. Fallat -- 18. Natural History of [alpha]1AT Deficiency / Janet Wittes and Margaret C. Wu -- 19. Prevalence of [alpha]1AT Deficiency Outside the United States and Europe / Toshihiro Nukiwa, Kuniaki Seyama and Shiro Kira.".
- catalog title "Alpha 1-Antitrypsin deficiency : biology, pathogenesis, clinical manifestations, therapy / edited by Ronald G. Crystal.".
- catalog title "Alpha one antitrypsin deficiency".
- catalog type "text".