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2010937423 contributor B12095787.
2010937423 created "c2011.".
2010937423 date "2011".
2010937423 date "c2011.".
2010937423 dateCopyrighted "c2011.".
2010937423 description "Includes bibliographical references and index.".
2010937423 description "Part I. General toxicology. Developing combination drugs in preclinical studies / Alberto Lodola. Preclinical evaluation of juvenile toxicity / Paul C. Barrow, Stéphane Barbellion, and Jeanne Stadler -- Part II. Pathology. Necropsy and sampling procedures in rodents / Laurence Fiette and Mohamed Slaoui. Histopathology procedures : from tissue sampling to histopathological evaluation / Mohamed Slaoui and Laurence Fiette. Principles and methods of immunohistochemistry / José A. Ramos-Vara. Tissue microarrays and digital image analysis / Denise Ryan, Laoighse Mulrane, Elton Rexhepaj, and William M. Gallagher -- Part III. Genetic toxicology. Micronucleus assay and labeling of centromeres with FISH technique / Ilse Decordier, Raluca Mateuca, and Micheline Kirsch-Volders. The use of bacterial repair endonucleases in the comet assay / Andrew R. Collins -- Part IV. Safety pharmacology. Manual whole-cell patch-clamping of the HERG cardiac K⁺ channel / Xiao-Liang Chen, Jiesheng Kang, and David Rampe -- Part V. Investigative toxicology. Generation and analysis of transcriptomics data / Philip D. Glaves and Jonathan D. Tugwood. Protocols of two-dimensional difference gel electrophoresis to investigate mechanisms of toxicity / Emmanuelle Com, Albrecht Gruhler, Martine Courcol, and Jean-Charles Gautier. Protocols and applications of cellular metabolomics in safety studies using precision-cut tissue slices and carbon 13 NMR / Gabriel Baverel, Sophie Renault, Hassan Faiz, Maha El Hage, Catherine Gauthier, Agnès Duplany, Bernard Ferrier, and Guy Martin. Statistical analysis of quantitative RT-PCR results / Richard Khan-Malek and Ying Wang. Evaluation of mitochondrial respiration in cultured rat hepatocytes / Jean-Pierre Marchandeau and Gilles Labbe -- Part VI. Screening assays for developmental toxicity. FETAX assay for evaluation of developmental toxicity / Isabelle Mouche, Laure Malesic, and Olivier Gillardeaux. Evaluation of embryotoxicity using the zebrafish model / Lisa Truong, Stacey L. Harper, and Robert L. Tanguay -- Part VII. Chemical protein adducts. Protocols of in vitro protein covalent binding studies in liver / Jean-François Lévesque, Stephen H. Day, and Allen N. Jones. Utilization of MALDI-TOF to determine chemical-protein adduct formation in vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, and Serrine S. Lau. Utilization of LC-MS/MS analyses to identify site-specific chemical protein adducts in vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, and Serrine S. Lau. One-dimensional western blotting coupled to LC-MS/MS analysis to identify chemical-adducted proteins in rat urine / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, and Serrine S. Lau. Identification of chemical-adducted proteins in urine by multi-dimensional protein identification technology (LC/LC-MS/MS) / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, and Serrine S. Lau -- Part VIII. Safety biomarkers. Optimization of SELDI for biomarker detection in plasma / Jean-Francois Léonard, Martine Courcol, and Jean-Charles Gautier. Differential proteomics incorporating iTRAQ labeling and multi-dimensional separations / Ben C. Collins, Thomas Y.K. Lau, Stephen R. Pennington, and William M. Gallagher. NMR and MS methods for metabonomics / Frank Dieterle, Björn Riefke, Götz Schlotterbeck, Alfred Ross, Hans Senn, and Alexander Amberg. Absolute quantification of toxicological biomarkers by multiple reaction monitoring / Thomas Y. K. Lau, Ben C. Collins, Peter Stone, Ning Tang, William M. Gallagher, and Stephen R. Pennington.".
2010937423 extent "xiii, 431 p. :".
2010937423 identifier "1603271864 (alk. paper)".
2010937423 identifier "1607618494 (e-ISBN)".
2010937423 identifier "9781603271868 (alk. paper)".
2010937423 identifier "9781607618492 (e-ISBN)".
2010937423 identifier 978-1-60761-849-2.
2010937423 isPartOf "Methods in molecular biology (Clifton, N.J.) ; v. 691. 1064-3745".
2010937423 isPartOf "Methods in molecular biology, 1064-3745 ; 691".
2010937423 isPartOf "Spinger protocols".
2010937423 isPartOf "Springer protocols.".
2010937423 issued "2011".
2010937423 issued "c2011.".
2010937423 language "eng".
2010937423 publisher "New York, NY : Humana Press,".
2010937423 subject "Drug Evaluation, Preclinical methods.".
2010937423 subject "Drug Toxicity.".
2010937423 subject "Drugs Testing.".
2010937423 subject "Drugs Toxicology.".
2010937423 subject "QV 771".
2010937423 subject "RM301.25 .D7864 2011".
2010937423 subject "Toxicity Tests methods.".
2010937423 subject "W1 ME9616J v.691 2011".
2010937423 tableOfContents "Part I. General toxicology. Developing combination drugs in preclinical studies / Alberto Lodola. Preclinical evaluation of juvenile toxicity / Paul C. Barrow, Stéphane Barbellion, and Jeanne Stadler -- Part II. Pathology. Necropsy and sampling procedures in rodents / Laurence Fiette and Mohamed Slaoui. Histopathology procedures : from tissue sampling to histopathological evaluation / Mohamed Slaoui and Laurence Fiette. Principles and methods of immunohistochemistry / José A. Ramos-Vara. Tissue microarrays and digital image analysis / Denise Ryan, Laoighse Mulrane, Elton Rexhepaj, and William M. Gallagher -- Part III. Genetic toxicology. Micronucleus assay and labeling of centromeres with FISH technique / Ilse Decordier, Raluca Mateuca, and Micheline Kirsch-Volders. The use of bacterial repair endonucleases in the comet assay / Andrew R. Collins -- Part IV. Safety pharmacology. Manual whole-cell patch-clamping of the HERG cardiac K⁺ channel / Xiao-Liang Chen, Jiesheng Kang, and David Rampe -- Part V. Investigative toxicology. Generation and analysis of transcriptomics data / Philip D. Glaves and Jonathan D. Tugwood. Protocols of two-dimensional difference gel electrophoresis to investigate mechanisms of toxicity / Emmanuelle Com, Albrecht Gruhler, Martine Courcol, and Jean-Charles Gautier. Protocols and applications of cellular metabolomics in safety studies using precision-cut tissue slices and carbon 13 NMR / Gabriel Baverel, Sophie Renault, Hassan Faiz, Maha El Hage, Catherine Gauthier, Agnès Duplany, Bernard Ferrier, and Guy Martin. Statistical analysis of quantitative RT-PCR results / Richard Khan-Malek and Ying Wang. Evaluation of mitochondrial respiration in cultured rat hepatocytes / Jean-Pierre Marchandeau and Gilles Labbe -- Part VI. Screening assays for developmental toxicity. FETAX assay for evaluation of developmental toxicity / Isabelle Mouche, Laure Malesic, and Olivier Gillardeaux. Evaluation of embryotoxicity using the zebrafish model / Lisa Truong, Stacey L. Harper, and Robert L. Tanguay -- Part VII. Chemical protein adducts. Protocols of in vitro protein covalent binding studies in liver / Jean-François Lévesque, Stephen H. Day, and Allen N. Jones. Utilization of MALDI-TOF to determine chemical-protein adduct formation in vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, and Serrine S. Lau. Utilization of LC-MS/MS analyses to identify site-specific chemical protein adducts in vitro / Ashley A. Fisher, Matthew T. Labenski, Terrence J. Monks, and Serrine S. Lau. One-dimensional western blotting coupled to LC-MS/MS analysis to identify chemical-adducted proteins in rat urine / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, and Serrine S. Lau. Identification of chemical-adducted proteins in urine by multi-dimensional protein identification technology (LC/LC-MS/MS) / Matthew T. Labenski, Ashley A. Fisher, Terrence J. Monks, and Serrine S. Lau -- Part VIII. Safety biomarkers. Optimization of SELDI for biomarker detection in plasma / Jean-Francois Léonard, Martine Courcol, and Jean-Charles Gautier. Differential proteomics incorporating iTRAQ labeling and multi-dimensional separations / Ben C. Collins, Thomas Y.K. Lau, Stephen R. Pennington, and William M. Gallagher. NMR and MS methods for metabonomics / Frank Dieterle, Björn Riefke, Götz Schlotterbeck, Alfred Ross, Hans Senn, and Alexander Amberg. Absolute quantification of toxicological biomarkers by multiple reaction monitoring / Thomas Y. K. Lau, Ben C. Collins, Peter Stone, Ning Tang, William M. Gallagher, and Stephen R. Pennington.".
2010937423 title "Drug safety evaluation : methods and protocols / edited by Jean-Charles Gautier.".
2010937423 type "text".