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• 01GPE00TMXQC2VHY0QYQ4ZWJNR abstract "In this paper we present baseline results for Event Coreference Resolution (ECR) in Dutch using gold-standard (i.e non-predicted) event mentions. A newly developed benchmark dataset allows us to properly investigate the possibility of creating ECR systems for both within and cross-document coreference. We give an overview of the state of the art for ECR in other languages, as well as a detailed overview of existing ECR resources. Afterwards, we provide a comparative report on our own dataset. We apply a significant number of approaches that have been shown to attain good results for English ECR including feature-based models, monolingual transformer language models and multilingual language models. The best results were obtained using the monolingual BERTje model. Finally, results for all models are thoroughly analysed and visualised, as to provide insight into the inner workings of ECR and long-distance semantic NLP tasks in general.".
• 01GPE06XJKTV7AAJ0J8QJAJ7FH abstract "Biomaterials can control cell and nuclear morphology. Since the shape of the nucleus influences chromatin architecture, gene expression and cell identity, surface topography can control cell phenotype. This study provides fundamental insights into how surface topography influences nuclear morphology, histone modifications, and expression of histone-associated proteins through advanced histone mass spectrometry and microarray analysis. The authors find that nuclear confinement is associated with a loss of histone acetylation and nucleoli abundance, while pathway analysis reveals a substantial reduction in gene expression associated with chromosome organization. In light of previous observations where the authors found a decrease in proliferation and metabolism induced by micro-topographies, they connect these findings with a quiescent phenotype in mesenchymal stem cells, as further shown by a reduction of ribosomal proteins and the maintenance of multipotency on micro-topographies after long-term culture conditions. Also, this influence of micro-topographies on nuclear morphology and proliferation is reversible, as shown by a return of proliferation when re-cultured on a flat surface. The findings provide novel insights into how biophysical signaling influences the epigenetic landscape and subsequent cellular phenotype.".
• 01GPE0CVNATSTVHN7CV2NPRT50 abstract "The pandemic readiness toolbox needs to be extended, targeting different biomolecules, using orthogonal experimental setups. Here, we build on our Cov-MS effort using LC???MS, adding SISCAPA technology to enrich proteotypic peptides of the SARSCoV-2 nucleocapsid (N) protein from trypsin-digested patient samples. The Cov2MS assay is compatible with most matrices including nasopharyngeal swabs, saliva, and plasma and has increased sensitivity into the attomole range, a 1000-fold improvement compared to direct detection in a matrix. A strong positive correlation was observed with qPCR detection beyond a quantification cycle of 30???31, the level where no live virus can be cultured. The automatable sample preparation and reduced LC dependency allow analysis of up to 500 samples per day per instrument. Importantly, peptide enrichment allows detection of the N protein in pooled samples without sensitivity loss. Easily multiplexed, we detect variants and propose targets for Influenza A and B detection. Thus, the Cov2MS assay can be adapted to test for many different pathogens in pooled samples, providing longitudinal epidemiological monitoring of large numbers of pathogens within a population as an early warning system.".
• 01GPE173JYQWYTE2VDE3VRQ5N9 abstract "Development of new solutions for masonry mortars is heavily reliant on laboratory-based experimental procedures. This study provides insights into the properties of masonry mortars, prepared by four distinct compaction methods, based on existing standards: tamping, tapping, jolting and vibrating. The particular mortar mix under study has been designed in volumetric proportions of 1:1:6 with air lime, cement and sand, respectively. Evaluation of differences among compaction methods is based on bulk density, mechanical strength, porosity and water absorption measurements at 7 and 28 days. Density and strength testing results indicate statistically significant differences, where mechanically compacted mortars are denser and stronger than their manually compacted counterparts. Similar development is observed through assessment of mortar porosity. The variation is noticeable in gel and capillary pore range as shown by mercury intrusion, while open porosity evaluated by vacuum immersion also indicates some distinction between manual and mechanical compaction, with the latter producing less porous mortars. On the other hand, capillary water absorption results reveal higher coefficients for jolted and vibrated samples, hinting at different pore interconnectivity in mechanically and manually compacted mortar specimens.".
• 01GPE1JSRWF4SAQ1JZ0DW0HBW3 abstract "BackgroundCompensatory cleft speech disorders can severely impact speech understandability and speech acceptability. Speech intervention is necessary to eliminate these disorders. There is, however, currently no consensus on the most effective speech therapy approach to eliminate the different subtypes of compensatory cleft speech disorders. AimsTo compare the immediate, short- and long-term effects of three well-defined speech intervention approaches (i.e., a motor-phonetic approach, a linguistic-phonological approach and a combined phonetic-phonological approach) on the speech and health-related quality of life (HRQoL) in Belgian Dutch-speaking children with cleft palate with or without cleft lip (CP +/- L) and different subtypes of compensatory speech disorders (i.e., anterior oral cleft speech characteristics (CSCs), posterior oral CSCs or non-oral CSCs). Besides, the perceived acceptability of these three speech intervention approaches will be investigated from the perspectives of caregivers and children with a CP +/- L. Methods & ProceduresA two-centre longitudinal randomized sham-controlled trial was used. Children were randomly assigned to one of the three intervention programmes and received 10 h of speech intervention divided over 2 weeks. Block randomization was used, stratified by age and gender. Primary outcome measures included perceptual speech outcomes. Secondary outcome measures included patient-reported outcomes. Outcomes & ResultsThe results of this trial will provide speech-language pathologists evidence-based guidelines to better tailor intervention approaches to the specific needs of a child with a defined compensatory speech disorder. WHAT THIS PAPER ADDSWhat is already known on this subjectSpeech therapy approaches to address cleft palate speech disorders are broadly divided into two categories: motor-phonetic interventions and linguistic-phonological interventions. Some limited evidence demonstrated the positive effects of these approaches in eliminating compensatory cleft speech disorders. Different studies have reported inter-individual variation, suggesting that one child may benefit more from a particular intervention approach than the other child. Perhaps this variation can be attributed to the specific subtype of compensatory speech disorder (i.e., anterior oral CSC, posterior oral CSC or non-oral CSC). What this paper adds to existing knowledgeThis paper describes a randomized sham-controlled trial that compared the immediate, short- and long-term effects of three well-defined speech intervention approaches (i.e., a motor-phonetic approach, a linguistic-phonological approach and a combined phonetic-phonological approach) on the speech and HRQoL in Belgian Dutch-speaking children with CP +/- L and different subtypes of compensatory cleft speech disorders (i.e., anterior oral CSCs, posterior oral CSCs or non-oral CSCs) measured by perceptual and psychosocial outcome measures. Besides, the experienced acceptability of these three speech intervention approaches were investigated from the perspectives of caregivers and children. What are the potential or actual clinical implications of this work?This project provides evidence-based knowledge on patient-tailored cleft speech intervention considering both scientific evidence and the perspectives of caregivers and children. The results aid SLPs in better tailoring intervention approaches to the needs of a child with a specific type of compensatory cleft speech disorder.".
• 01GPE3CXP8D50YERZKH8SCZN3M abstract "The current kinetic models for polystyrene (PS) pyrolysis contain many simplifications to reduce their size and the corresponding simulation time. Moreover, they are often based on rate coefficients determined using non -ideal experimental data featuring ambiguous process conditions with respect to mixing and temperature uni-formity. The practical interest of PS pyrolysis is the production of styrene monomer to be reused as a feedstock in the polymerization of styrene. In the present work, a lab-scale tree-based kinetic Monte Carlo (kMC) model is presented that differentiates between 18 reaction families and 26 end-group pairs to study the product yield variations for thermal degradation of PS. Model parameters follow from Bayesian optimization to experimental data recorded with an in-house micro-pyrolysis unit coupled with comprehensive two-dimensional gas chro-matography. Low chain length (CL) anionic-made PS is specifically considered to gain an understanding of the role of specific end-groups. The experimental yields of the major products (monomer: 74.7-80.8 wt%, dimer: 5.1-5.5 wt%, trimer: 1.6-7.7 wt%) are well-predicted with the fine-tuned parameters. The main reaction pathway in the formation of styrene monomer is end-chain beta-scission, while mid-chain beta-scission is primarily involved in the formation of the styrene dimer and trimer. Our model shows that the pyrolysis of low CL anionic-made PS leads to better rate coefficients than those obtained from state-of-the-art pyrolysis of long CL PS, in which end-groups play a much smaller role.".
• 01GPE3MFDB3P1R14ZP61ER1F3T abstract "Sarcoids are the most common equine skin tumours Although they do not metastasize, they can be locally aggressive and cause significant clinical symptoms in affected horses. Despite being common, very little is known about the host immune response and the biological mechanisms underlying persistence and recurrence of equine sarcoids. The latter reflects the need for further research in this field. This in-vitro study used sarcoid explants from horses with naturally occurring sarcoids (n = 12) to evaluate the induction of a humoral immune response directed against equine sarcoid-derived bovine papilloma-virus (BPV)− 1 infected fibroblasts using a flow cytometric crossmatch assay. The presence of antibodies against exogenous bovine serum albumin (BSA) and fibroblast-like mesenchymal stromal cells (MSCs) was also evaluated by ELISA and flow cytometry, respectively. The viral load in the sarcoid explants, the corresponding cultured sarcoid fibroblasts, and matched peripheral blood mononuclear cells (PBMCs) from affected horses were determined by quantitative BPV-1/− 2 PCR analysis. Antibodies against autologous sarcoid cells were present in six out of twelve sarcoid-affected horses. Serum from all horses showed cross reactivity with allogeneic sarcoid cells, while only a part reacted with BSA or MSCs. Screening of host PBMCs demonstrated the absence of BPV E1 nucleic acids. Statistical analysis revealed a significantly higher mean viral load in the parental sarcoid tissue compared to the low passage fibroblasts (P < 0.001). These results support the hypothesis that sarcoid-affected horses may develop antibodies recognizing tumour-specific antigens. In contrast to sarcoid explants, equine PBMCs do not seem to contain complete BPV genomes. These results provide a basis for future investigations on the clinical relevance of these antibodies.".
• 01GPE4XWV2NTRN8QGVY4JMEQ6Q abstract "El presente estudio se centra en los cambios que ha experimentado rollo para comportarse como sustantivo comodín y como marcador pragmático en la conversación coloquial de los últimos cincuenta años. Para explicar este proceso, se ha recopilado un corpus de textos caracterizados por su coloquialidad y se ha procesado el análisis de los datos mediante la metodología del Perfil Comportamental. Una vez detectadas las relaciones dinámicas cambiantes entre los significados, se ha procedido a la explicación cualitativa de la ruta diacrónica de los significados abstractos teniendo en cuenta los factores socioculturales que los motivaron. Los resultados revelan que rollo experimentó cambios semánticos relevantes en el seno del movimiento sociocultural de la Contracultura de los años setenta. Su configuración como elemento vago en el sociolecto juvenil posibilitó que a finales de los noventa se pragmaticalizara como aproximador, que resulta ser el uso más frecuente en el lenguaje juvenil actual.".
• 01GPE4XWV2NTRN8QGVY4JMEQ6Q abstract "The present study focuses on the rise of 'rollo' as a catchall noun and as an approximator that developed in oral conversation through the 20th century. In order to explain this process, an oral corpus of colloquial Spanish has been compiled and the data has been analyzed by means of the Behavioral Profile methodology. After detecting the changing dynamic relationships between meanings, an in-depth qualitative explanation of the diachronic route of abstract meanings is presented, taking into account the sociocultural factors that motivate them. The results reveal that 'rollo' underwent significant semantic changes within the sociocultural Counterculture movement of the seventies. Its configuration as a vague element in the sociolect of young people made it possible to become pragmaticalized at the end of the nineties as an approximator, which turns out to be the most frequent use in current youth language.".
• 01GPEH63VJMD962GZ4FQV9MSSC abstract "During resting-state EEG recordings, alpha activity is more prominent over the posterior cortex in eyes-closed (EC) conditions compared to eyes-open (EO). In this study, we characterized the difference in spectra between EO and EC conditions using dynamic causal modelling. Specifically, we investigated the role of intrinsic and extrinsic connectivity-within the visual cortex-in generating EC-EO alpha power differences over posterior electrodes. The primary visual cortex (V1) and the bilateral middle temporal visual areas (V5) were equipped with bidirectional extrinsic connections using a canonical microcircuit. The states of four intrinsically coupled subpopulations-within each occipital source-were also modelled. Using Bayesian model selection, we tested whether modulations of the intrinsic connections in V1, V5 or extrinsic connections (or a combination thereof) provided the best evidence for the data. In addition, using parametric empirical Bayes (PEB), we estimated group averages under the winning model. Bayesian model selection showed that the winning model contained both extrinsic connectivity modulations, as well as intrinsic connectivity modulations in all sources. The PEB analysis revealed increased extrinsic connectivity during EC. Overall, we found a reduction in the inhibitory intrinsic connections during EC. The results suggest that the intrinsic modulations in V5 played the most important role in producing EC-EO alpha differences, suggesting an intrinsic disinhibition in higher order visual cortex, during EC resting state. Author summary One of the strongest signals that can be measured using EEG are so called alpha rhythms. These are neural oscillations that fall within the 8-12Hz frequency range. Alpha rhythms are most prominent when the eyes are closed and are seen at the electrodes placed at the back of the head. In this study, we studied the mechanism of alpha rhythms changes when going from eyes-open to an eyes-closed state. We used a biologically plausible model including different neural populations. We focused on modelling connections within and between different neural sources of the visual cortex and how they are modulated when going from eyes-open to an eyes closed state. We found evidence that inhibitory neurons play an important role in alpha rhythms.".
• 01GPEZTD034PKGTABFYAADJJY5 abstract "The availability of solar energy resource information in Ethiopia is limited due to the lack of ground measurement stations. The aim of this work was, therefore, to estimate the temporal variation and spatial distribution of solar radiation for Geba catchment located in the Northern part of Ethiopia based on four selected measurement sites. To achieve this, ground measurement data at ten-minute interval that has been recorded for five years was employed. Time series data and temporal variation analysis were done for all the sites. The spatial distribution analysis was carried out by interpolation of the data from the sites across the catchment using Inverse Distance Weight (IDW) method of the ArcGIS software. The temporal data analysis indicated higher solar radiation of greater than 5 kWh/m(2)/day during the dry months of September to May and in the range of 3-4 kWh/m(2)/day during the rainy season of June to August. The result of the analysis on spatial distribution of solar radiation showed 5%-7. 5% variation with daily average solar radiation of 5.6 kWh/m(2)/day across the catchment. Areas in central part around Mekelle and southern part around Mayderhu site have relatively higher solar radiation.".
• 01GPF0PFD1PANC0921Q8VB8E0N abstract "Less acceptance and penetration of solar concentrating technology due to its high cost has inspired the research for alternative low-tech technologies and reflecting-materials. This paper aims to model and experimentally investigate optical characteristics of cost effective reflecting-materials on low-tech concentrators, which are easily available in the local market for wide low to medium temperature applications. Ray-tracing methods were employed to model and adjust the solar-concentrator position and geometry of reflecting-material. From the ray-tracing simulation, optimum glass mirror sizes of 1.5cm, 3cm, 4.5cm, and 6cm were selected to be tested at the optimum tracking position. Validation of the model was done by artificial laser-beam and ground radiation tests. Results gathered from the simulation and experimental tests were in a number of rays received and reflected back as well as temperature level at the focal point. The study from the simulation and laser beam test yields intercept ratio varied from 56.06% to 51.4% and 51.21% to 45.61% respectively. The respective results from the thermal test range between 52% and 31%. These results together with the observed image sizes indicate that the use of small sized glass mirror reflector at 00 incidence angle best fits the curvature of low-tech off-axis concentrator and attains higher efficiency.".
• 01GPFCV195VRKCQJPRW43FD3W6 abstract "Introduction: People with tuberculosis experience long-term health effects beyond cure, including chronic respiratory diseases. We investigated whether tuberculosis is a risk factor for subsequent lung cancer. Methods: We searched PubMed, Scopus, Cochrane, Latin American and Caribbean Health Sciences Literature and the Scientific Electronic Library Online for cohort and case-control studies providing effect estimates for the association between tuberculosis and subsequent lung cancer. We pooled estimates through random-effects meta-analysis. The study was registered in PROSPERO (CDR42020178362). Results: Out of 6240 records, we included 29 cohort and 44 case-control studies. Pooled estimates adjusted for age and smoking (assessed quantitatively) were hazard ratio (HR) 1.51 (95% CI 1.30-1.76, I-2 =81%; five studies) and OR 1.74 (95% CI 1.42-2.13, I-2 =59%; 19 studies). The occurrence of lung cancer was increased for 2 years after tuberculosis diagnosis (HR 5.01, 95% CI 3.64-6.89; two studies), but decreased thereafter. Most studies were retrospective, had moderate to high risk of bias, and did not control for passive smoking, environmental exposure and socioeconomic status. Heterogeneity was high. Conclusion: We document an association between tuberculosis and lung cancer occurrence, particularly in, but not limited to, the first 2 years after tuberculosis diagnosis. Some cancer cases may have been present at the time of tuberculosis diagnosis and therefore causality cannot be ascertained. Prospective studies controlling for key confounding factors are needed to identify which tuberculosis patients are at the highest risk, as well as cost-effective approaches to mitigate such risk.".
• 01GPFD6SYWVCRPZS3WNDX89QAA abstract "Introduction Research on public health interventions to improve hypertension care and control in low-income and middle-income countries remains scarce. This study aims to evaluate the effectiveness and assess the process and fidelity of implementation of a multi-component intervention to reduce the gaps in hypertension care and control at a population level in low-income communes of Medellin, Colombia. Methods and analysis A multi-component intervention was designed based on international guidelines, cross-sectional population survey results and consultation with the community and institutional stakeholders. Three main intervention components integrate activities related to (1) health services redesign, (2) clinical staff training and (3) patient and community engagement. The effectiveness of the intervention will be evaluated in a controlled before-after quasi-experimental study, with two deprived communes of the city selected as intervention and control arms. We will conduct a baseline and an endline survey 2 years after the start of the intervention. The primary outcomes will be the gaps in hypertension diagnosis, treatment, follow-up and control. Effectiveness will be evaluated with the difference-in-difference measures. Generalised estimation equation models will be fitted considering the clustered nature of data and adjusting for potential confounding variables. The implementation process will be studied with mixed methods. Implementation fidelity will be documented to assess to which degree the intervention components were implemented as intended. Ethics and dissemination The study protocol has been approved by the Ethics Research Committee of Metrosalud in Colombia (reference 1400/5.2), the Medical Ethics Committee of the Antwerp University Hospital (reference 18/40/424) and the Institutional Review Board of the Antwerp Institute of Tropical Medicine (reference 1294/19). We will share and discuss the study results with the community, institutional stakeholders and national health policymakers. We will publish them in national and international peer-reviewed scientific journals.".
• 01GPFDQK7KDN0XT2GEA9W187X2 abstract "Background SOBERANA-02 is a COVID-19 conjugate vaccine (recombinant RBD conjugated to tetanus toxoid). Phases 1/2 clinical trials demonstrated high immunogenicity, promoting neutralising IgG and specific T-cell response. A third heterologous dose of SOBERANA-Plus (RBD-dimer) further increased neutralising antibodies. The aim of this study is to evaluate the safety and efficacy of two immunisation regimes: two doses of SOBERANA-02 and a heterologous three-dose combination with SOBERANA-Plus added to it. Methods From March 8th to June 24th, 2021 we conducted in Havana, Cuba a multicentre randomised, double-blind, placebo-controlled, phase-3 trial evaluating a two doses SOBERANA-02 scheme and a heterologous scheme with one dose SOBERANA-Plus added to it (RPCEC00000354). Participants 19-80 years were randomly assigned to receiving 28 days apart either the two or three dose scheme or placebo. The main endpoint was vaccine efficacy in preventing the occurrence of RT-PCR confirmed symptomatic COVID-19 at least 14 days after the second or third dose in the per-protocol population. We also assessed efficacy against severe disease and, in all participants receiving at least one vaccine/placebo dose, safety for 28 days after each dose.Findings We included 44,031 participants (52.0% female, 48.0% male; median age 50 years, range 19-80 years; 7.0% black, 24.0% mixed-race, 59.0% white) in a context of initial Beta VOC predominance, with this variant being partially replaced by Delta near the trial's end. Vaccine efficacy in the heterologous combination was 92.0% (95%CI 80.4-96.7) against symptomatic disease. There were no severe COVID-19 cases in the vaccine group against 6 in the placebo group. Two doses of SOBERANA-02 was 69.7% (95%CI 56.5-78.9) and 74.9% (95%CI 33.7-90.5) efficacious against symptomatic and severe COVID-19, respectively. The occurrence of serious and severe adverse events (AE) was very rare and equally distributed between placebo and vaccine groups. Solicited AEs were slightly more frequent in the vaccine group but predominantly local and mostly mild and transient. Interpretation Our results indicate that the straightforward to manufacture SOBERANA vaccines are efficacious in a context of Beta and Delta VOC circulation, have a favourable safety profile, and may represent an attractive option for use in COVID-19 vaccination programmes. Funding This study received funds from the National Fund for Science and Technology (FONCI-CITMA-Cuba, contract 2020-20) of the Ministry of Science, Technology and Environment of Cuba. Copyright (c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).".
• 01GPFHH4K0F79ADJ3BJCX976MV abstract "Occlusion is one of the most challenging problems in single-view pedestrian detection. To alleviate the occlusion problem, multi-view systems have been exploited to fully acquire and recognize blocked targets. Most often, methods from the literature exploit perspective transformation to aggregate different sensing view angles of the scene, but projection distortion issues cause spatial structure break and prevent these methods from fully exploring the projected features. In this paper, we propose a novel approach, Multi-view Target Transformation (MVTT), to address the distortion problem inherent in multi-view aggregation by encoding the full target features and limiting the area of interest of the projected features. Experiment results show that the performance of our proposed method compares favorably against recent relevant methods on public datasets. The ablation studies also confirm the effectiveness of the proposed components.".
• 01GPFSY2593EG90QT5JMJHQ9S5 abstract "Patients who take oral anticancer drugs (OACD) alternate between the hospital and the community setting. Little is known about how general practitioners (GPs) and community pharmacists (CPs) from primary care (PC) can be involved in providing seamless care. In an exploratory qualitative study, semi-structured interviews with healthcare professionals from primary and secondary care (SC) and (N = 26) were performed to investigate perceptions of seamless collaboration for patients on OACD. Seamless collaboration initiated by SC was restricted to informing GPs about treatment-initiation and delegating limited tasks to them in treatment monitoring. CPs are currently not informed by SC about the treatment. PC expressed willingness for seamless collaboration. However, collaboration is currently impeded due to an expressed lack of trust and desire for control by SC. Moreover, SC expressed unfamiliarity with the organization of PC. Findings suggest that healthcare professionals from SC and PC need to get to know each other and to discuss expectations in the seamless care for patients on OACD. A possible strategy is to elaborate a shared care model based on a partnership between PC and SC, in which the specific expertise of each partner contributes to patient-centered care and the qualitative and safe use of OACD.".
• 01GPFT317VK0BR9WDZA1R4PQPJ abstract "Although it is argued that organizational leaders’ perceptions of external shocks determine organizations’ willingness to prepare for future shocks, insights on the sensemaking processes leading local politicians to invest in adaptive capacity building after a crisis are scarce. Therefore, this study examines how politicians’ COVID-19 risk perceptions relate to their proclivity to invest in organizational adaptive capacity building. Results, based on data from 710 local Flemish politicians, confirm that perceived severity of COVID-19 relates to politicians’ willingness to invest in adaptive capacity building, while sociodemographic and event-related variables as well as socio-political attitudes are relevant predictors of politicians’ risk perceptions.".
• 01GPFXZBTSG35KKW1ZJPMB78DZ abstract "Damage to porous materials in heritage buildings caused by salt mixture crystallization is driven by the surrounding environmental conditions. To understand the crystallization behavior of a mixed salt solution as a function of changing climatic conditions (i.e., relative humidity and temperature), excluding factors such as the internal pore structure, the thermodynamic model ECOS/RUNSALT is the only freeware available that requires simple input and includes the most relevant ions for heritage buildings and solids. We suggest the use of specific terminology and describe how to use the model and how to interpret the output, with emphasis on key limitations for which solutions are provided. When used correctly, the model output can be trusted, specifically when it is used to inform preventive conservation (e.g., environmental conditions in which salt crystallization cycles should not occur). However, salt mixture kinetics and the internal pore structure remain crucial parameters that are not considered in the model. These aspects need further attention to develop a better understanding and correctly model salt damage in relation to climatic changes.".
• 01GPFYQG4ADTSJWS70KYJ4SNDS abstract "A large database of salt mixtures found in the built environment and a charge balance calculations toolkit. Output of the PREDICT project predominantly including measurements of Belgian historic sites collected by KIK-IRPA Monuments Lab. Contents: Full integrated database and charge balance calculation sheet, including raw ion concentrations and balanced outputs (.xlsx) Sample integrated database (25 mixtures) and charge balance calculation sheet, including raw ion concentrations and balanced outputs (.xlsx) R scripts for charge balance calculations (.R) Full set of raw ion concentrations for the R scripts (.txt) Sample of 25 raw ion concentrations for the R scripts (.txt) Full set of balanced outputs from the R script (.txt) Sample of 25 balanced outputs from the R script (.txt)".
• 01GPFYQG4ADTSJWS70KYJ4SNDS abstract "This research was funded in whole by the Belgium Science Policy (Belspo) within the framework of BRAIN-be 2.0, Belgian Research Action through Interdisciplinary Networks: project B2/191/P1/PREDICT (Research action B2); joint PhD project PREDICT, Phase Transitions of Salts under Changing Climatic Conditions. A CC BY license is applied to the AAM arising from this submission, in accordance with the grant's open access conditions.".
• 01GPG4CQRBH1ZKJD1G5WRHKC26 abstract "As a consequence of climate change, in some regions, more intense rain showers go hand in hand with longer dry periods. The subsequent more and more severe droughts can have devastating effects on many economic and social sectors. Therefore, its is necessary to be able to predict and assess the consequences of these droughts on a local scale, in order to develop policies to cope. Drought assessment needs a lot of detailed and accurate input-data, such as land use, land cover, soil moisture, vegetation, evapotranspiration, etc., often obtained by continuous earth monitoring by satellites. Satellite images are generally converted into indices, of which the Normalized Difference Vegetation Index (NDVI) is one of the most widely used. It was developed for use with Landsat imagery and allows for the classification of satellite images for land use and displaying the vitality of the vegetation. In this research, a new composite index is presented and compared to the NDVI to be used with Sentinel-2A imagery, having higher resolution and more spectral bands than Landsat. This new composite index can be used to detect water and vegetation. Additionally, this newly developed composite index achieves a better accuracy through Support Vector Machine (SVM) classification than the widely used NDVI. Although further validation is necessary, the results promise a possible amelioration of vegetation related input data for drought assessment and management.".
• 01GPG613D83T59MA8E3DSWH0WJ abstract "Hydrogen uptake in steel structures can cause a degradation in mechanical properties such as toughness, and can induce cracks. This phenomenon is widely known as hydrogen embrittlement. For structural steels subjected to cathodic protection or pipelines transporting high-pressure hydrogen gas, hydrogen embrittlement represents an important challenge. Charpy V-notch testing provides a fast and inexpensive method for quantifying the impact toughness of a steel. However, its validity for assessing hydrogen embrittlement is uncertain. In this work, the influence of hydrogen uptake on the impact toughness of an API 5L X70 pipeline steel is investigated. Charpy V-notch impact tests are performed in air, both uncharged and after electrochemical hydrogen pre-charging. Different charging times are used, and the influence of hydrogen-induced cracking is studied. The temperature range of the Charpy impact tests is between -80 degrees C and +20 degrees C. A rising upper shelf phenomenon is observed in the uncharged specimens and the ductile-to-brittle transition temperature (DBTT) is not reached for the tested temperatures. For this material, hydrogen uptake causes a reduction in Charpy impact energy at the higher test temperatures, with the highest reduction measured at room temperature. A post-mortem analysis of the fracture surfaces suggests that the presence of hydrogen in the lattice aids the formation of separations during fracture, lowering the absorbed energy. (c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of the scientific committee of the 23 European Conference on Fracture - ECF23".
• 01GPG8Q9HH044KN0S44K046VBN abstract "Dual-phase low-alloy steels combine a soft ferrite phase with a hard martensite phase to create desirable properties in terms of strength and ductility. Nickel additions to dual-phase low-alloy steels can increase the yield strength further and lower the transformation temperatures, allowing for microstructure refining. Determining the correct intercritical annealing temperature as a function of nickel content is paramount, as it defines the microstructure ratio between ferrite and martensite. Likewise, quantifying the influence of nickel on the intercritical temperature and its synergistic effect with the microstructure ratio on mechanical properties is vital to designing dual-phase steels suitable for corrosive oil and gas services as well as hydrogen transport and storage applications. In this work, we used a microstructural design to develop intercritical annealing heat treatments to obtain dual-phase ferritic-martensitic low-alloy steels. The intercritical annealing and tempering temperatures and times were targeted to achieve three different martensite volume fractions as a function of nickel content, with a nominal content varying between 0, 1, and 3-wt% Ni. Mechanical properties were characterized using tensile testing and microhardness measurements. Additionally, the microstructure was studied using scanning electron microscopy coupled with electron backscatter diffraction analysis. Tensile strength increased with increasing martensite ratio and nickel content, with a further grain refinement effect found in the 3-wt% Ni steel. The optimal heat treatment parameters for oil and gas and hydrogen transport applications are discussed.".
• 01GPG8ZC2ZRDKYCS6WZGJ9NZPM abstract "This paper investigates the inclusion of “Coptic-only” letters in the spelling of Egyptian personal names and toponyms in otherwise Greek documents. A diachronic analysis of eighty documentary texts (4th-8th c. CE), primarily on papyrus, shows an increase of evidence in the sixth century, in line with recent literature on the evolution of documentary Coptic. As opposed to earlier papyri, which were mainly everyday texts with highly problematic Greek and interference from Egyptian, many later documents were of higher legal value, penned by bilingual scribes who were proficient in Greek, who could incorporate Coptic characters into their Greek writing, proving that script-mixing could be unrelated to poor linguistic competence. The phenomenon seems to have arisen from an unconscious cognitive process of ad hoc phoneme-to-grapheme conversion, which offered different spelling variants, and was triggered by the Egyptian origin of names, the special phonemes that certain Coptic graphemes represented, and the lack of inflection amidst the Greek text.".
• 01GPG9B5C388B85QBZHPH8B8D8 abstract "Most research on the hydrogen embrittlement of steel dealt with the interaction of hydrogen with the metal bulk microstructural features, whereas the first contact with hydrogen-containing environments occurs at the metal surface. Steel (when un-polarized) is always covered with an oxide layer, varying in composition and thickness. The impact of the oxide layer on the hydrogen transport is, however, not fully understood. This study focused on the effect of controlled pre-formed thermal oxide layers at the exit side on the hydrogen transport through the surface of SEA 1010 steel, considering two distinct thermally produced oxide types as test cases. Results demonstrated that thermal oxides can greatly limit hydrogen diffusion, with bilayers (hematite/magnetite) having a greater effect compared to magnetite layers. Increased oxide thickness resulted also in greater limiting diffusion. The main objective of this manuscript is to provide experimental evidence concerning the effect of oxide layers on the hydrogen transport through steel. Model thermal oxide layers were used to emphasize the importance of considering the surface characteristics when investigating hydrogen transport through metallic components.".
• 01GPGC3JF7VJBCF70QCF620D8H abstract "The Arenig Fawr area of North Wales constitutes the type area for the British Lower to Middle Ordovician Arenig Series and is complemented by sections in the Carmarthen and Whitland areas of South Wales. We describe chitinozoan assemblages from both areas in order to aid correlation of the Arenig Series in its type region with the global Ordovician series and stages. Chitinozoans recorded from Arenig Fawr provide permissive rather than conclusive evidence but suggest that the Henllan Ash Member correlates with the upper Floian Stage Slice Fl3 or lower Dapingian Stage Slice Dp1. Better results were obtained from South Wales where six chitinozoan assemblages are distinguished, ranging in age from late Tremadocian to middle Darriwilian (early Llanvirn). Most species are known from South China, Gondwana and/or Baltica where there are controls on ranges. They show that much of the lower Arenig (Moridunian) succession in South Wales correlates with the upper Floian Stage (Fl3). Correlatives of the lower and middle Floian Stage (Fl1, Fl2), if present, must be represented by the Ogof Hen Formation and lowest Carmarthen Formation. Chitinozoan assemblages from the upper Arenig Series (Fennian Stage) are more readily correlated with Gondwanan biozones and indicate correlation of the Fennian Stage with the Dapingian and lower Darriwilian (Dw1) stages. The middle Arenig Whitlandian Stage is constrained in South Wales to an interval from the uppermost Floian Stage to the basal Dapingian Stage, resulting in an inferred increased rate of sediment accumulation.".
• 01GPGE4R2RABJ9ZXB9VXGEDDRQ abstract "Hip dysplasia is a common orthopaedic condition in dogs and stress radiography is the best diagnostic tool for early diagnosis. Objective force guidelines are lacking, leaving room for errors and fraud during screening. Our objective was to develop an accurate and validated measuring device that allows quantification of the applied force in vivo in real-time during stress radiographic imaging. A two-step approach was followed. First, four load cells were incorporated in the original Vezzoni Modified Badertscher Distension Device (VMBDD) and a dedi-cated computer program was developed. In vitro evaluations of the accuracy demonstrated a trueness of 0.19 N (0.1%FS) and precision of 0.26 N (0.2%FS) for the individual loadcells. The trueness and precision of the assembled VMBDmD were 0.02 N (0.02%FS) and 0.52 N (0.38%FS). Secondly, the modified device was tested on several cadavers. The device was similar in use as the VMBDD, did not interfere with radiographic acquisition, gave the operator real-time feedback, and linked the force with the radiograph. Altogether, we describe the accuracy of the VMBDmD and have evaluated its use in cadavers. We saw that the device successfully quantified and stored the applied force in real-time during stress radiography.".
• 01GPGG2NB59MQ9ZH3BXRKE96KQ abstract "Mechanical overload is considered the main cause of Achilles tendinopathy. In addition to tensile loads, it is believed that the Achilles tendon may also be exposed to compressive loads. However, data on intratendinous pressures are lacking, and consequently, their role in the pathophysiology of tendinopathy is still under debate. Therefore, we aimed to evaluate the intratendinous pressure changes in the Achilles tendon during stretching and eccentric loading. Twelve pairs of human cadaveric legs were mounted in a testing rig, and a miniature pressure catheter was placed through ultrasound-guided insertion in four different regions of the Achilles tendon: the insertion (superficial and deep layers), mid-portion, and proximal portion. Intratendinous pressure was measured during three simulated loading conditions: a bent-knee calf stretch, a straight-knee calf stretch, and an eccentric heel-drop. It was found that the intratendinous pressure increased exponentially in both the insertion and mid-portion regions of the Achilles tendon during each loading condition (p < 0.001). The highest pressures were consistently found in the deep insertion region (p < 0.001) and during the eccentric heel-drop (p < 0.001). Pressures in the mid-portion were also significantly higher than in the proximal portion (p < 0.001). These observations offer novel insights and support a role for compression in the pathophysiology of Achilles tendinopathy by demonstrating high intratendinous pressures at regions where Achilles tendinopathy typically occurs. To what extent managing intratendinous pressure might be successful in patients with Achilles tendinopathy by, for example, avoiding excessive stretching, modifying exercise therapy, and offering heel lifts requires further investigation.".
• 01GPGMKD5B4GV2DWR7SPYP3ZX4 abstract "Low-educated adults do not often engage in lifelong learning. The current study examines whether and how psychosocial beliefs about lifelong learning differ between adults with different levels of educational attainment. The Theory of Planned Behaviour, which focuses on three specific psychosocial beliefs (related to Perceived Behavioural Control, Perceived Social Norms, and Attitudes) is used as a theoretical framework. In total, 563 adults completed our survey. ANOVA-analyses were used to study between-groups differences. The results demonstrated that low- and medium-educated adults' experiences with psychosocial barriers are quite similar, except for power of control, since medium-educated adults experience more control over learning skills needed to participate. High-educated adults experience statistically significant more social pressure to engage in lifelong learning, especially from their work-related referents. In addition, high-educated adults experience statistically significant more control over their participation, specifically when it comes to control over skills necessary to participate in learning. Low-and medium-educated adults do show positive attitudes towards learning, but high-educated adults' attitudes are statistically significant more positive. Follow-up, qualitative studies could provide in-depth insight into these determinants. Additional understanding of the three psychosocial barriers could help educational institutions and policy makers to appropriately attract and support adult learners.".
• 01GPGN5SBMK5Y80P0MSHT5TJRN abstract "Composite materials offer significant performance advantages due to their lightweight, high-strength, and high stiffness. This led to their adoption in several industrial sectors with particular emphasis on the aerospace industry which has undergone a transformation towards a composite-dominated new standard. In order to respond to the increased demand, it is mandatory to focus on an efficient and well-controlled curing cycle of the resin, which will lead to a significant reduction of cost and an increase in production speed. We investigate, a photonic solution, able of measure key monitoring values that facilitate optimization of the curing process. Simulation and evaluation results on a bragg grating based photonic integrated sensor, developed in 220 nm Silicon-on-Insulator platform, are presented. A multi-sensor deployment is considered, enabling monitoring of the temperature and the refractive index of the resin. Serially coupled bragg grating photonic elements will enable concurrent monitoring of both temperature and refractive index. Several bragg configurations have been investigated and experimentally evaluated, specifically regular and phase-shifted ones. Both TE and TM polarization operation sensors that have been designed and fabricated, will be presented. Their sensitivity on resin temperature and refractive index variation will be discussed, resulting in a comparative study outlining the benefits and disadvantages of each solution. Refractive index sensors are realized by employing post-processing etching techniques on Multi-project-Wafer run fabricated silicon chips, on top of the periodic bragg grating element. The comparative study takes into consideration TE and TM polarization operation, regular and phase-shifted bragg grating configuration elements, while evaluating their sensitivity in temperature and refractive index variations. Temperatures considered are in the range of 27 °C to 200 °C, while refractive index values lay between 1.5 and 1.6. A Figure-of-Merit is proposed to facilitate the selection of multi-sensor deployment for specific temperature and refractive index ranges.".
• 01GPGNEKH4K9GHQ19CS7Q5BXKD abstract "Background Mutations of the endoplasmic reticulum (ER) stress transducer OASIS (encoded by CREB3L1), cause severe recessive osteogenesis imperfecta (OI) not compatible with surviving the neonatal period, as has been shown in two unrelated families through a whole gene deletion vs. a qualitative alteration of OASIS Heterozygous carriers in the described families have exhibited a mild phenotype. OASIS is a transcription factor highly expressed in osteoblasts, and OASIS(-/-) mice exhibit severe osteopenia and spontaneous fractures. Here, we expand the clinical spectrum by a detailed phenotypic characterization of the first case of OASIS-associated OI surviving the neonatal period, with heterozygous family members being unaffected. Methods: All OI-associated genes were sequenced. Primary human osteoblast-like cell (hOB) and fibroblast (FB) cultures were obtained for qPCR, and steady-state collagen biochemistry. FB, hOB and skin biopsies were ultrastructurally analyzed. Bone was analyzed by |mu CT, histomorphometry, quantitative backscattered electron imaging (qBEI), and Raman microspectroscopy. Results: The proband, a boy with severe OI, had blue sclera and tooth agenesis A homozygous CREB3L1 stop codon mutation was detected by sequencing, while several family members were heterozygotes Markedly low levels of CREB3L1 mRNA were confirmed by qPCR in hOBs (16%) and FB (21%), however, collagen I levels were only reduced in hOBs (5-10%) Electron microscopy of hOBs showed pronounced alterations, with numerous myelin figures and diminished RER vs. normal ultrastructure of FB. Bone histomorphometry and qBEI were similar to collagen I OI, with low trabecular thickness and mineral apposition rate, and increased bone matrix mineralization. Raman microspectroscopy revealed low level of glycosaminoglycans. Clinical response to lifelong bisphosphonate treatment was as expected in severe OI with steadily increasing bone mineral density, but despite this the boy suffered repeated childhood fractures. Conclusions: Deficiency of OASIS can cause severe OI compatible with surviving the neonatal period A marked decrease of collagen type I transcription was noted in bone tissue, but not in skin, and ultrastructure of hOBs was pathological. Results also suggested OASIS involvement in glycosaminoglycan secretion in bone.".
• 01GPGNJE8HTE15MV99P7DYJHDJ abstract "Handelen of niet? Op welke manier en in welke mate? Alle handhavers worden in hun dagelijks werk met deze vraag geconfronteerd. Politie, bijzondere inspectie-diensten, bijzondere opsporingsambtenaren en gemeenschapswachten. Handhavingswerk, en politiewerk in het bijzonder, gebeurt binnen een welomlijnd kader van wet- en regelgeving en – theoretisch gezien – zou de interactie met de burger ook vanuit dat kader verlopen. In de praktijk wordt het dagelijks handhavingswerk echter slechts gedeeltelijk door regels geleid en bestaat er zoiets als ‘discretionaire ruimte’. Dit is de handelingsmarge of beslissingsvrijheid die frontlijnwerkers bezitten om zinvol en professioneel te handelen. Discretionaire ruimte wordt niet altijd als positief ervaren: te weinig sturing op die ruimte zou zorgen voor te veel beslissingsmarge en leiden tot ongelijke behandeling van burgers, willekeur, rechtsongelijkheid en ten slotte rechtsonzekerheid. Toch heeft een ruime handelingsvrijheid ook positieve kanten. Op maat en oplossingsgericht werken, beide kenmerken van gemeenschapsgerichte politiezorg, wordt mogelijk en de ambtenaar neemt zelf zijn verantwoordelijkheid. Dit Cahier belicht verschillende facetten van het fenomeen.".
• 01GPGNYQE8XKPMYABKSJRS69SZ abstract "Background The quantification of mitochondrial DNA heteroplasmy for the diagnosis of mitochondrial disease or after mitochondrial donation, is performed mainly using next-generation sequencing strategies (NGS). Digital PCR (dPCR) has the potential to offer an accurate alternative for mutation load quantification. Methods We assessed the mutation load of 23 low-input human samples at the m.11778 locus, which is associated with Leber’s hereditary optic neuropathy (LHON) using 2 droplet digital PCR platforms (Stilla Naica and Bio-Rad QX200) and the standard NGS strategy. Assay validation was performed by analyzing a titration series with mutation loads ranging from 50% to 0.01%. Results A good concordance in mutation rates was observed between both dPCR techniques and NGS. dPCR established a distinctly lower level of background noise compared to NGS. Minor alleles with mutation loads lower than 1% could still be detected, with standard deviations of the technical replicates varying between 0.07% and 0.44% mutation load. Although no significant systematic bias was observed when comparing dPCR and NGS, a minor proportional bias was detected. A slight overestimation of the minor allele was observed for the NGS data, most probably due to amplification and sequencing errors in the NGS workflow. Conclusion dPCR has proven to be an accurate tool for the quantification of mitochondrial heteroplasmy, even for samples harboring a low mutation load (<1%). In addition, this alternative technique holds multiple benefits compared to NGS (e.g., less hands-on time, more straightforward data-analysis, and a lower up-front capital investment).".
• 01GPGP02EM78Q14YRSR7HQG4V6 abstract "Recent studies identified a missense mutation in the gene coding for G protein???coupled receptor kinase 6 (GRK6) that segregates with type 2 diabetes (T2D). To better understand how GRK6 might be involved in T2D, we used pharmacological inhibition and genetic knockdown in the mouse II-cell line, MIN6, to determine whether GRK6 regulates insulin dynamics. We show inhibition of GRK5 and GRK6 increased insulin secretion but reduced insulin processing while GRK6 knock-down revealed these same processing defects with reduced levels of cellular insulin. GRK6 knockdown cells also had attenuated insulin secretion but enhanced proinsulin secretion consistent with decreased processing. In support of these findings, we demonstrate GRK6 rescue experiments in knock-down cells restored insulin secretion after glucose treatment. The altered insulin profile appears to be caused by changes in the proprotein convertases, the enzymes responsible for pro -insulin to insulin conversion, as GRK6 knockdown resulted in significantly reduced convertase expression and activity. To identify how the GRK6-P384S mutation found in T2D patients might affect insulin processing, we performed biochemical and cell biological assays to study the properties of the mutant. We found that while GRK6-P384S was more active than WT GRK6, it displayed a cytosolic distribution in cells compared to the normal plasma membrane localization of GRK6. Additionally, GRK6 overexpression in MIN6 cells enhanced proinsulin pro-cessing, while GRK6-P384S expression had little effect. Taken together, our data show that GRK6 regulates insulin processing and secretion in a glucose-dependent manner and provide a foundation for understanding the contribution of GRK6 to T2D.".
• 01GPGSTNE19EKDF7YFEYJ2Z8ZD abstract "Understanding the responses of insect herbivores to plant chemical defences is pivotal for the management of crops and pests. However, the mechanisms of interaction are not entirely understood. In this study, we compared the whole transcriptome gene expression of the aphid Macrosiphum euphorbiae grown on two different varieties of tomato that differ in their inducible chemical defences. We used two isogenic lines of tomato with a shared genetic background that only differ in the presence of type IV glandular trichomes and their associated acylsucrose excretions. This works also reports a de novo transcriptome of the aphid M. euphorbiae. Subsequently, we identified a unique and distinct gene expression profile for the first time corresponding to aphid ' s exposure to type IV glandular trichomes and acylsugars. The analysis of the aphid transcriptome shows that tomato glandular trichomes and their associated secretions are highly efficient in triggering stress-related responses in the aphid, and demonstrating that their role in plant defence goes beyond the physical impediment of herbivore activity. Some of the differentially expressed genes were associated with carbohydrate, lipid and xenobiotic metabolisms, immune system, oxidative stress response and hormone biosynthesis pathways. Also, the observed responses are compatible with a starvation syndrome. The transcriptome analysis puts forward a wide range of genes involved in the synthesis and regulation of detoxification enzymes that reveal important underlying mechanisms in the interaction of the aphid with its host plant and provides a valuable genomic resource for future study of biological processes at the molecular level using this aphid.".
• 01GPGVEPGZ0R5GP9END9TBBA3D abstract "Over the past decade, the quality of machine translation (MT) output has improved significantly (Van Brussel et al., 2018). As a result, tools such as Google Translate and DeepL have become wildly popular among second language (L2) learners. For example, MT tools are commonly used by L2 learners to support their writing process (Alm and Watanabe, 2021). However, it is yet to be investigated how efficient and effective the MT-assisted writing process actually is, compared to support from more traditional tools such as online bilingual dictionaries. An efficient writing process is a fluent one, with as little cognitive load as possible. An effective writing process is one that generates a writing product of high quality. Moreover, little is known about how the L2 proficiency level of learners affects the process's efficiency and/or effectiveness. To address this gap, the first research objective of this study focuses on how MT access during writing compares to writing with access to a more traditional tool: 1. Does L2 learners' use of MT tools during the writing process differ from how they use dictionaries? 2. Does MT use affect learners' writing process differently than dictionary use? Does it result in a more efficient and/or effective writing process? 3. Do these differences in efficiency and effectiveness differ across L2 proficiency levels? The second research objective will zoom in on the variation in L2 learners' use of MT during writing. Our aim is to find out which MT use patterns result in the most efficient and/or effective writing processes for learners at different L2 proficiency levels. Hence, we will be addressing the following questions: 1. To what extent does MT use vary during the writing process? Does this differ across L2 proficiency levels? 2. How do various MT use-related process indicators (e.g., mean consultation duration, total number of words looked up) and MT use patterns (combinations of process indicators) affect the process's efficiency and/or effectiveness? Does this differ across L2 proficiency levels? Data will be gathered by means of collecting both process and product data from L1 Dutch learners of Swedish (n = 60). They will complete a number of writing tasks, of which two with access to an MT tool and two with access to an online bilingual dictionary. The writing process data will consist of keystroke logs, screen recordings, eye-tracking data, and stimulated recall interviews. In addition, data on the L2 proficiency level of the participants will be collected by means of a placement test and self-assessments. The research hypothesis related to the first objective is that the MT-assisted writing process is more efficient as well as effective, especially for learners with a lower proficiency level. With regard to the second research objective, the hypothesis is that certain patterns of MT use result in more efficient and effective writing processes than others.".
• 01GPH8AXWPRHCAS0J4SMJVQ4ZD abstract "Om de gedeeltelijke vrijstelling van doorstorting van bedrijfsvoorheffing voor ploegen- of nachtarbeid toe te passen, moeten uitzendbureaus sinds 1 oktober 2022 het akkoord hebben verkregen van de onderneming waarin de uitzendkrachten zijn tewerkgesteld. De wet van 21 december 2022 houdende diverse fiscale bepalingen (BS 29 december 2022) voorziet nu een machtiging aan de Koning om de kenmerken waaraan dit akkoord moet voldoen te verduidelijken. Mogelijks zal de Koning daarbij ook bepaalde (verplichte) clausules voorzien die deel moeten uitmaken van het akkoord.".
• 01GPH8HA2Z0BDS10D0DP757W1V abstract "Depuis le 1er octobre 2022, pour appliquer la dispense partielle de versement du précompte professionnel pour travail en équipe ou de nuit, les agences d’intérim doivent avoir obtenu l’accord de l’entreprise dans laquelle les intérimaires sont employés. La loi du 21 décembre 2022 portant des dispositions fiscales diverses (M.B., 29 décembre 2022) a habilité le Roi à préciser les caractéristiques auxquelles cet accord doit répondre. Il est donc possible que le Roi prévoie certaines clauses qui devront (obligatoirement) faire partie de l’accord.".
• 01GPJFGS6VAQTG6H3XJJQ01A0Y abstract "To what degree do individuals experience sufficiency in contemporary society? Although this question is highly relevant from an environmental sustainability point of view, empirical research on this topic is limited. In this article we conceptualize and measure sufficiency from a subjective perspective in a micro-economic context using two concepts: what level of personal monthly income is considered to be enough (sufficiency level) and to what degree do individuals evaluate their personal monthly income as being enough (sufficiency evaluation). The second concept is measured both directly and indirectly. Additionally, we perform an explorative investi-gation of the potential determinants of the concepts by regression analysis with a main focus on economic variables (income and homeownership) and personal values (materialism and environmental self-identity). Based on Belgian survey data (N = 1645) we find that, while the vast majority of individuals evaluate their income to be at least sufficient, there is substantial variation across individuals as to what level of income is considered to be enough. Furthermore, our regression results suggest that personal monthly income plays a primary role for subjective income sufficiency, albeit with contradicting effects for both concepts: having a higher income is associated with a higher income sufficiency evaluation, yet also pushes the quoted sufficiency level upwards. Homeownership is positively related to one of both concepts only: homeowners (whose property is fully paid off) directly evaluate their income as being more sufficient compared to non-homeowners, but they do not quote different sufficiency levels. On the other hand, our results show that materialism as well as envi-ronmental self-identity negatively contribute to subjective income sufficiency: being more materialistic is associated with both a lower income sufficiency evaluation as well as a higher quoted sufficiency level, while seeing oneself more as acting environmentally-friendly is found to push the quoted sufficiency level further upwards. We conclude that the high levels of subjective income sufficiency reported by the respondents are promising to the extent that this may suggest society is ready for environmental strategies that are focused on the demand-side.".
• 01GPJJ2AMGEYBE2DCDSMZRS169 abstract "Purpose: Exploring the persisting presence of underlying processes, dynamics, experienced barriers and facilitators of Advanced Practice Nurses (APN) in oncology and Oncology Nurse Navigators (ONN) during their role integration in an interprofessional team over a research period of seven years.Methods: A qualitative study based on the principles of Grounded Theory, in which individual semi-structured interviews and focus groups were conducted with 51 ONN and APN from 11 university and local hospitals in Belgium between 2011-2018. Data were analyzed to develop a framework that consists of different themes.Results: ONN and APN experienced a lonely journey during role integration. They were searching for partners, medical knowledge and acknowledgement from the interprofessional team. ONN and APN had a watchful attitude and tried to make themselves visible to ensure they were involved in the team and to preserve their role and responsibilities. An unclear role description to the interprofessional team, and a lack of coaching and guidance were influencing factors in the experience of ONN and APN.Conclusion: ONN and APN in oncology feel difficulties to integrate their role in existing interprofessional teams. A lack of role clarity, the interprofessional team environment and a desire for coaching and guidance are influencing factors to implement APN roles. Coaching and mentorship of novice ONN/APN and their interprofessional team and healthcare managers are needed to address these issues. These findings could form the basis for a mentorship program for ONN/APN and their interprofessional team to enhance role integration.".
• 01GPJJZWNXJ4273SVKG127SSA0 abstract "This article examines the available literature on engaging young audiences to visit libraries, museums and performing arts shows, and their strategies for developing permanent audiences. The recommendations drawn from the review serve as an input for the Latin American Library for Children and Youth that is currently in a planning stage. Ideas regarding program, partnerships, communication and promotion of libraries in the context of the 21st century are explained in accordance with an audience approach that emphasises the presentness of children and youth, the demands and motivation of cultural participants, and the need to enable cultural rights.".
• 01GPJK1FWZGM0SSFZYRJBYNAC2 abstract "Nowadays, the favela makes up part of the urban imagery of Rio de Janeiro, but it has not always characterized the city. It is the product of a whole set of transformations the city experienced during the last century, and which include political, geographic, economic, and social aspects. After presenting the geography, history and symbolism inherent in this city, the article briefly describes these transformations. The main objective is to develop an initial analysis of the setting for the Brazilian novels Ciudad de Dios and Infierno. Finally, the article attempts to sketch the role that the authors play in the logic of social exclusion. Exclusion, the main consequence -and simultaneously the main cause- of the favela, is addressed from the systems theory point of view, since it conceives society as a system that describes itself by its functionally differentiated character.".
• 01GPJK2S1W9DXPVAPZVBMV1G1C abstract "This article examines two Chilean contemporary novels for young adults and discusses the notion of modernity embedded in them. First, the article describes both texts with regard to their similarities and differences, and then it considers Stuart Hall's notion about the crisis of the individual. By doing this, I intend to show how representations of adolescence in young adult narratives written and published currently in Chile mesh with the topics of national history and cultural identity. National politics and human rights (to education, for instance) and Chile's history of colonialism and a class-differentiated society are brought up for discussion. The analysis shows that a crisis of identity often at the heart of these narratives gives rise to an incomplete notion of modernity.".
• 01GPJKKEQCXFWPKJ5W11092H4W abstract "This is, to our knowledge, the first case report with in-depth analysis of bone marrow and bone lesions with diffusion-weighted imaging and dynamic contrast-enhanced MRI in Erdheim-Chester disease to date. We present a case of a 70-year-old woman who was referred for an X-ray of the pelvis, right femur and right knee after complaints of migratory arthralgia in hip and knee five months after an initial hip and knee trauma. Bone lesions on X-ray were identified. This case report highlights the strength and complementary use of modern multimodality multiparametric imaging techniques in the clinical radiological manifestations of Erdheim-Chester disease, in the differential diagnosis and in treatment response assessment, which is classically performed using 18FDG PET-CT. Erdheim-Chester disease is a rare form of non-Langerhans' cell histiocytosis, mainly affecting individuals in their fifth-seventh decade of life and without sex predominance. Apart from the typical bilateral symmetric lesions in long bone diaphyseal and metaphyseal regions and classically sparing the epiphyses, this multisystemic disease causes significant morbidity by infiltrating critical organs (the central nervous system, cardiovascular system, retroperitoneum, lungs and skin). With non-traumatic bone pain being the most common complaint, Erdheim-Chester disease is diagnosed most often in an incidental setting on imaging. The imaging workup classically consists of a multimodality approach using conventional radiography, CT, MRI, bone scintigraphy and 18FDG PET-CT. This case report extends this evaluation with diffusion-weighted imaging and dynamic contrast-enhanced imaging techniques.".
• 01GPJN2K19T32MTA1THNVN91JZ abstract "Over the last few years, research in automatic sleep scoring has mainly focused on developing increasingly complex deep learning architectures. However, recently these approaches achieved only marginal improve-ments, often at the expense of requiring more data and more expensive training procedures. Despite all these efforts and their satisfactory performance, automatic sleep staging solutions are not widely adopted in a clinical context yet. We argue that most deep learning solutions for sleep scoring are limited in their real-world applicability as they are hard to train, deploy, and reproduce. Moreover, these solutions lack interpretability and transparency, which are often key to increase adoption rates. In this work, we revisit the problem of sleep stage classification using classical machine learning. Results show that competitive performance can be achieved with a conventional machine learning pipeline consisting of preprocessing, feature extraction, and a simple machine learning model. In particular, we analyze the performance of a linear model and a non-linear (gradient boosting) model. Our approach surpasses state-of-the-art (that uses the same data) on two public datasets: Sleep-EDF SC-20 (MF1 0.810) and Sleep-EDF ST (MF1 0.795), while achieving competitive results on Sleep-EDF SC-78 (MF1 0.775) and MASS SS3 (MF1 0.817). We show that, for the sleep stage scoring task, the expressiveness of an engineered feature vector is on par with the internally learned representations of deep learning models. This observation opens the door to clinical adoption, as a representative feature vector allows to leverage both the interpretability and successful track record of traditional machine learning models.".
• 01GPJP489RWMM4N3H4J1S95JHZ abstract "3D reconstruction is the computer vision task of reconstructing the 3D shape of an object from multiple 2D images. Most existing algorithms for this task are designed for offline settings, producing a single reconstruction from a batch of images taken from diverse viewpoints. Alongside reconstruction accuracy, additional considerations arise when 3D reconstructions are used in real-time processing pipelines for applications such as robot navigation or manipulation. In these cases, an accurate 3D reconstruction is already required while the data gathering is still in progress. In this paper, we demonstrate how existing batch-based reconstruction algorithms lead to suboptimal reconstruction quality when used for online, iterative 3D reconstruction and propose appropriate modifications to the existing Pix2Vox++ architecture. When additional viewpoints become available at a high rate, e.g., from a camera mounted on a drone, selecting the most informative viewpoints is important in order to mitigate long term memory loss and to reduce the computational footprint. We present qualitative and quantitative results on the optimal selection of viewpoints and show that state-of-the-art reconstruction quality is already obtained with elementary selection algorithms.".
• 01GPJPFE460QWQVYHVZ82RC9WZ abstract "This article focuses on the representation of female authors' lives in English-language literary biopics and how these representations relate to feminist contexts. Departing from previous research on biopics focusing on women (particularly women writers), this article identifies four categories of such films: the patriarchal literary biopic, in which the representation of an author's life is related to patriarchal values, the second-wave feminist literary biopic, which is related to second-wave feminism, the postfeminist literary biopic, which is related to postfeminism, and finally the #MeToo literary biopic, a new category of films that has recently begun to emerge. By analyzing the films Colette (Wash Westmoreland, 2018) and Wild Nights with Emily (Madeleine Olnek, 2019), this article shows how these films correspond to the #MeToo movement. The MeToo literary biopic is characterized by (a) excessive attention to difficult publication processes and the disclosure of women's words, (b) emphasizing the persistent censoring of women's words, (c) deconstructing the myths surrounding female authors, and (d) underscoring (female) solidarity and empowerment.".
• 01GPJQG9DGFRJ49CXYYS1RZJAJ abstract "In microwave design, Bayesian optimization (BO) techniques have been widely applied to the optimization of the frequency response of components and devices. The common approach in BO is to model and maximize an objective function over the design parameters, in order to find the optimal spectral response. Such an approach avoids the direct modeling of spectral responses, which is a challenging task for the typical data-efficient surrogate models used in BO. Simple objective functions may lead to a suboptimal solutions, while complicated objectives require more powerful and less data-efficient surrogate models. To resolve this issue, this article proposes to adopt a deep Gaussian process (DGP) to directly model all relevant $S$ coefficients over the frequency and the design parameter ranges of interest. Subsequently, an objective probability distribution is retrieved from the DGP model and maximized using a BO scheme. The proposed approach is tested on two suitable microwave examples and compared to the standard BO approach. Results show increased accuracy in identifying the optimal frequency response for the given design parameters and the desired objective, while maintaining high data efficiency.".
• 01GPJR621WDF37PKJV6P810N7Z abstract "Background: Early indications were of a major decline in specialist palliative care volunteer numbers during COVID-19. It is important that ongoing deployment and role of volunteers is understood, given the dependence of many palliative care services on volunteers for quality care provision. Aim: To understand the roles and deployment of volunteers in specialist palliative care services as they have adjusted to the impact of COVID-19. Design: Observational multi-national study, using a cross-sectional online survey with closed and free-text option questions. Disseminated via social media, palliative care networks and key collaborators from May to July 2021. Setting/participants: Any specialist palliative care setting in any country, including hospices, day hospices, hospital based or community teams. The person responsible for managing the deployment of volunteers was invited to complete the survey. Results: Valid responses were received from 304 organisations (35 countries, 80.3% Europe). Most cared for adults only (60.9%), provided in-patient care (62.2%) and were non-profit (62.5%). 47.0% had cared for people with COVID-19. 47.7% changed the way they deployed volunteers; the mean number of active volunteers dropped from 203 per organisation to 33, and 70.7% reported a decrease in volunteers in direct patient/family facing roles. There was a shift to younger volunteers. 50.6% said this drop impacted care provision, increasing staff workload and pressure, decreasing patient support, and increasing patient isolation and loneliness. Conclusion: The sustained reduction in volunteer deployment has impacted the provision of specialist palliative care. Urgent consideration must be given to the future of volunteering including virtual modes of delivery, micro-volunteering, and appealing to a younger demographic.".
• 01GPJREQD8C43V2AD63N05RGQS abstract "Background: Compassionate Communities have been put forward as a new model for community-based palliative care to positively impact the health and wellbeing of those experiencing challenges of serious illness, death, dying, and loss. Despite the growing international movement to develop these public health initiatives to end-of-life care, only a handful of initiatives have undergone some form of evaluation. Aim: To provide guidance on designing evaluation research by identifying theoretical frameworks to understand the development, implementation, and underlying mechanisms of Compassionate Communities. Methods: To identify suitable theoretical frameworks for the study of Compassionate Communities, we applied two steps. The first step examined the characteristics of Compassionate Communities and translated them into assessment criteria for the selection of theoretical frameworks. The second step consisted of applying the identified assessment criteria to a list of widely used and highly cited theoretical frameworks. Results: Three well-established theoretical frameworks were identified as being most suitable to study the development, implementation, and underlying mechanisms of Compassionate Communities: The Consolidated Framework for Implementation Research (CFIR), the integrated-Promoting Action on Research Implementation in Health Services framework (i-PARIHS), and the Extended Normalization Process Theory (ENPT). Conclusions: The article supports and encourages the use of theoretical frameworks to evaluate the complex processes behind public health palliative care initiatives. The complementary use of two determinant frameworks and an implementation theory provides theoretical grounding to gain rich insights into the emergent and shifting interplays between agency, social processes, and contextual factors that shape the development and implementation of Compassionate Communities. ".
• 01GPJRN041PGHJJ7MAH214P34F abstract "Background: Advance care planning supports patients to reflect on and discuss preferences for future treatment and care. Studies of the impact of advance care planning on healthcare use and healthcare costs are scarce. Aim: To determine the impact on healthcare use and costs of an advance care planning intervention across six European countries. Design: Cluster-randomised trial, registered as ISRCTN63110516, of advance care planning conversations supported by certified facilitators. Setting/participants: Patients with advanced lung or colorectal cancer from 23 hospitals in Belgium, Denmark, Italy, the Netherlands, Slovenia and the UK. Data on healthcare use were collected from hospital medical files during 12 months after inclusion. Results: Patients with a good performance status were underrepresented in the intervention group (p< 0.001). Intervention and control patients spent on average 9 versus 8 days in hospital (p = 0.07) and the average number of X-rays was 1.9 in both groups. Fewer intervention than control patients received systemic cancer treatment; 79% versus 89%, respectively (p< 0.001). Total average costs of hospital care during 12 months follow-up were euro32,700 for intervention versus euro40,700 for control patients (p = 0.04 with bootstrap analyses). Multivariable multilevel models showed that lower average costs of care in the intervention group related to differences between study groups in country, religion and WHO-status. No effect of the intervention on differences in costs between study groups was observed (p = 0.3). Conclusions: Lower care costs as observed in the intervention group were mainly related to patients' characteristics. A definite impact of the intervention itself could not be established.".
• 01GPJRY85QPH03DGKH4NJYNGAC abstract "Artificial photosynthesis of H2O2, an environmentally friendly oxidant and a clean fuel, holds great promise. However, improving its efficiency and stability for industrial implementation remains highly challenging. Here, we report the visible-light H2O2 artificial photosynthesis by digging pro-superoxide radical carbon vacancies in three-dimensional hierarchical porous g-C3N4 through a simple hydrolysis-freeze-drying-thermal treatment. A significant electronic structure change is revealed upon the implantation of carbon vacancies, broadening visible-light absorption and facilitating the photogenerated charge separation. The strong electron affinity of the carbon vacancies promotes superoxide radical (O-center dot(2)-) formation, significantly boosting the H2O2 photocatalytic production. The developed photocatalyst shows an H2O2 evolution rate of 6287.5 mM g(-1) h(-1) under visible-light irradiation with a long cycling stability being the best-performing photocatalyst among all reported g-C3N4-based systems. Our work provides fundamental insight into highly active and stable photocatalysts with great potential for safe industrial H2O2 production.".
• 01GPJSH4JE5VRQ7SM0E64A5TN6 abstract "Sediment connectivity is the ability of a system to transfer water and sediment within a catchment. It is controlled by driving forces (rainfall and land cover), static aspects (geomorphology and soil), and dynamic aspects (surface runoff) of the catchment. The connectivity index is commonly used to measure sediment connectivity, even though it usually only looks at structural landscape features. The aims of this study are 1) to assess flow and sediment connectivity using the Borselli's index (IC) and the modified index of connectivity (MIC) and 2) to compare flow and sediment connectivity between two catchments in the Lake Tana Basin. The modified connectivity index was calculated by adding soil erodibility, rainfall erosivity, roughness index, and surface runoff. Remote sensing data were used to estimate the driving forces of connectivity, structural aspects of connectivity, and also functional aspects of connectivity. Landsat 8 OLI was used to identify the land cover, and remotely sensed rainfall estimates (TAMSAT) were used to quantify the precipitation in the catchments, while the Shuttle Radar Topographic Mission (SRTM) was used to identify slope gradient and roughness index. The IC values were higher than the MIC values, whereas the MIC values have a wider range of values compared to the IC values. The MIC can represent functional connectivity within the catchment. The IC and MIC values in the Gumara were higher than those in the Rib.".
• 01GPJVQG8H9NR8EJVRYCYPVSWK abstract "In a dynamic business environment, all organizations must respond to changes by incorporating new ideas into their business processes. Such processes can be complex, dynamic, interactive, socially constructed, and focusing more on the people. Numerous studies on process innovation capability or structured business process (SBP) are extensive; however, the study on process innovation capability in the less-structured business process (PIC-LSBP) is still a point of discussion [1]. We elaborate our research agenda into [1] Literature Review, [2] Optimization of the finding and proposed framework, [3] Theory Building. Through the Systematic Literature Review (SLR)[2], one of the initial findings indicates that further validation is required to build an appropriate framework for PIC-LSBP. Using Delphi study, we aim to investigate the main differences between innovating SBP and LSBP and identify the main success factors for innovating LSBP by developing an instrument to provide step-by-step guidance or to offer a brainstorming tool to assist organizations in identifying the core elements of their current and desired capabilities for their LSBPs.".
• 01GPJVVW29AP9VA955FWA7KKYX abstract "Background and aims: Individuals with speech disorders are often judged more negatively than peers without speech disorders. A limited number of studies examined the attitudes of adolescents toward peers with speech disorders due to a cleft lip with or without a cleft of the palate (CL & PLUSMN; P). Therefore, the aim of the present study was to investigate the attitudes of peers toward the speech of adolescents with CL & PLUSMN; P.Method: Seventy-eight typically developing adolescents (15-18 years, 26 boys, 52 girls) judged audio and au-diovisual samples of two adolescents with CL & PLUSMN; P based on three attitude components, i.e., cognitive, affective, and behavioral. The degree of speech intelligibility was also scored by their peers. The study investigated whether the three attitudes were determined by speech intelligibility or appearance of an individual with CL & PLUSMN; P. Furthermore, the influence of knowing someone with a cleft, the age, and gender of the listeners on their atti-tudes were explored.Results: A significantly positive correlation was found between the speech intelligibility percentage and the three different attitude components: more positive attitudes were observed when the speech intelligibility of the speaker was higher. A different appearance due to a cleft lip does not lead to more negative attitudes. Furthermore, boys seem to have more negative attitudes toward individuals with CL & PLUSMN; P compared to girls.Conclusion: This study provided additional evidence that peers show more negative attitudes toward adolescents with less intelligible speech due to CL & PLUSMN; P. Intervention should focus on changing the cognitive, affective, and behavioral attitudes of peers in a more positive direction and remove the stigma of patients with a cleft. Further research is needed to verify these results.".
• 01GPJXP9DSZX9QRBTYW16K5M2F abstract "Personal radiative heat regulation by photonic engineered textiles can contribute to a decreased energy consumption in buildings by expanding the range of comfortable ambient conditions. Here, we propose dual-mode photonic designs (a static and a dynamic one), which modulate the emissivity to provide thermal regulation in both cold and hot environments. The first design is a Janus-yarn fabric that tunes statically via fabric flipping, while the second design is dynamic by utilizing a shape-memory polymer.".
• 01GPJZ2TRG7YKN6625NN31GR2V abstract "Book of Proceedings of the 2022 Faculty or Engineering and Architecture Research Symposium (FEARS) at Ghent University.".
• 01GPJZY6YJZ4FEDGFG3CYS1R86 abstract "Electrochemical treatments in (waste)water management show high potential in the global water resource crisis, but are often limited by the ion-exchange membrane (IEM) performance. Low chemical resistance and fouling are major issues in the development of next-generation IEMs. Sulfonated silica-based nanofiber cation-exchange membranes (CEMs) offer a promising solution to these issues due to their superior chemical resistance and self-cleaning properties. Via the direct electrospinning of a sol–gel solution starting from tetraethyl orthosilicate (TEOS) and 3-mercaptopropyl triethoxysilane (MPTES), nanofiber membranes with an ion-exchange capacity (IEC) of 1.3 mmol g−1 can be produced without the need of an additional matrix. The produced nanofiber CEM performs excellent in lab-scale electrochemical tests, with a resistance of 3.2 ± 0.4 *10-3 Ω m2 and a Coulombic efficiency of ± 70 % for the transport of Na+ using a current density of either 128 or 256 A/m−2. Furthermore, the nanofiber CEM shows outstanding resistance against strong acidic solutions and chlorine. After fouling of the membrane with CaCO3, the nanofiber CEM shows self-cleaning properties, eliminating the need for an additional cleaning step during usage. These results illustrate the excellent performance of the silica-based nanofiber CEM for industrial water treatment applications.".
• 01GPK2CQZBR04SCQP3TXEX6NMX abstract "The Eleventh International Conference on Data Analytics (DATA ANALYTICS 2022), held between November 13 and November 17, 2022, continued the series on fundamentals in supporting data analytics, special mechanisms and features of applying principles of data analytics, application-oriented analytics, and target-area analytics. Processing of terabytes to petabytes of data, or incorporating non-structural data and multistructured data sources and types require advanced analytics and data science mechanisms for both raw and partially-processed information. Despite considerable advancements on high performance, large storage, and high computation power, there are challenges in identifying, clustering, classifying, and interpreting of a large spectrum of information. The conference had the following tracks:  Application-oriented analytics  Big Data  Sentiment/opinion analysis  Data Analytics in Profiling and Service Design  Fundamentals  Mechanisms and features  Predictive Data Analytics  Transport and Traffic Analytics in Smart Cities".
• 01GPK3DB4VFNV32N75CTPK74JW abstract "Background There is a growing number of patients with ventricular paced rhythm, who present to the emergency department with chest pain. The diagnosis of ST-segment elevation myocardial infarction (STEMI) and subsequent percutaneous coronary intervention (PCI) is often postponed, as the 12 leads-electrocardiogram (ECG) is discarded as not interpretable. There is a growing body of literature that suggests that Smith-modified Sgarbossa criteria can be applied for the diagnosis of STEMI in patients with paced rhythms. These criteria were originally developed for the interpretation of ECGs in patients with a left bundle branch block (LBBB) and chest pain, but have been expanded to paced ECGs. Methodology We present three case reports with chest pain and right ventricular or biventricular pacing. Findings In all three cases, the Smith-modified Sgarbossa was positive and the diagnosis of STEMI could have been made early on. Implications It remains important to look for ST-segment deviations and to compare the symptomatic ECG with previous asymptomatic ECGs. As the number of patients with potential acute myocardial infarction (AMI) and paced rhythms is likely to rise in the future, these criteria should be known to emergency physicians and cardiologists.".
• 01GPK3S1V2TDBW3V0J38NC028N abstract "Aircraft path planning in urban air mobility context relates to finding of a continuous path/trajectory that will drive the aircraft from a start to an end location knowing the environment map. This map can be a 3D model, including semantic information (no fly zones, aerial corridors) that are constraints for the path planning algorithm. This paper investigates the aircraft path plan dealing with the flight pre-known obstacles in the 3D space, regardless of their static or dynamic characteristics, that syncs with the local path in cases when pre-flight unknown obstacles are detected along the global path by one of the aircraft’s sensors to ensure safe flight between flight origin and destination locations. To achieve this, we rely on a combination of A* and Visibility graphs approach.".
• 01GPK6TX7PPQ3H9Z1TWFCKFFNB abstract "Organizational culture plays a paramount role in the success and outcomes of Business Process Management (BPM) initiatives. So far, academic research has primarily focused on the cultural values supporting exploitative BPM, and to a greater extent in the private sector. In this study, we aim to uncover the cultural context in the international public sector, underpinning the explorative dimension of BPM, as well as the necessary capabilities to balance explorative and exploitative process management practices. The latter is defined as BPM ambidexterity. For this purpose, we have conducted case studies in European Union (EU) public sector organizations because this governmental level stimulates digital innovation and is quite varied while not being limited to a single country. Our main contribution is a model of cultural values supporting exploratory BPM, called FADE (i.e., values related to Failure allowance, Agility, Disruptiveness, and Ecosystems).".
• 01GPK981P2GVKJ7V47BJTGKHMC abstract "Purpose – Organizations invest in novel digital innovations to improve their business processes. These innovations, including Industry 4.0 technologies, enable full organizational integrationwith business processmanagement (BPM), thereby requiring interorganizational relationship (IOR) capabilities.Many organizations lack knowledge about areas of interorganizational (IO) capability for integrating digital innovations into their value chains. They therefore have difficulty understanding that, as a socio-technical concept, digitalization surpasses the intraorganizational level and requires tools to develop mandatory IOR capabilities. The authors’ systematic literature review (SLR) explores these capabilities within the discipline of BPM. The purpose of this paper is to address this issue. Design/methodology/approach – This SLR follows the standard methodology for structuring a broad research field. The authors assessed capabilities relevant to manufacturing organizations from 58 academic articles published between 2011 and 2021. Findings – Building on existing firm-centric capability frameworks, the authors developed individual capabilities into a novel framework of digital interorganizational value chain (DIOVC). The authors’ conceptual model provides a basis for researchers and practitioners to consider capabilities and the theoretical spectrum of IO value chains. Research limitations/implications – Future studies should validate these DIOVC capabilities as input for an updated model of BPM maturity aimed at improving business process performance through digital innovations. Practical implications – This study provides organizations with IOR knowledge, supports decision makers in governing digital innovations and develops IO capabilities to improve their value chain performance. Originality/value – The authors’ DIOVC capability framework is robust, with constructs and dimensions grounded in the literature, demonstrating theoretical and practical relevance.".
• 01GPK9PZ9F9HPFAJ24GCVDBZMF abstract "Mycotoxin contamination is a global food safety issue leading to major public health concerns. Repeated exposure to multiple mycotoxins not only has repercussions on human health but could theoretically also lead to interactions with other xenobiotic substances-such as drugs-in the body by altering their pharmacokinetics and/or pharmacodynamics. The combined effects of chronic drug use and mycotoxin exposure need to be well understood in order to draw valid conclusions and, in due course, to develop guidelines. The aim of this review is to focus on food contaminants, more precisely on mycotoxins, and drugs. First, a description of relevant mycotoxins and their effects on human health and metabolism is presented. The potential for interactions of mycotoxins with drugs using in vitro and in vivo animal experiments is summarized. Predictive software tools for unraveling mycotoxin-drug interactions are proposed and future perspectives on this emerging topic are highlighted with a view to evaluate associated risks and to focus on precision medicine. In vitro and in vivo animal studies have shown that mycotoxins affect CYP450 enzyme activity. An impact from drugs on mycotoxins mediated via CYP450-enzymes is plausible; however, an impact of mycotoxins on drugs is less likely considering the much smaller dose exposure to mycotoxins. Drugs that are CYP450 perpetrators and/or substrates potentially influence the metabolism of mycotoxins, metabolized via these CYP450 enzymes. To date, very little research has been conducted on this matter. The only statistically sound reports describe mycotoxins as victims and drugs as perpetrators in interactions; however, more analysis on mycotoxin-drug interactions needs to be performed.".
• 01GPK9PZ9XT8WNKBFRQ3DYRFZF abstract "Estrogen receptor 8 (ER8) and NOD-like receptor family pyrin domain containing 6 (NLRP6) are highly ex-pressed in intestinal tissues. Loss of ER8 and NLRP6 exacerbate colitis in mouse models; however, the un-derlying mechanisms are incompletely understood. Here, we report that ER8 directly activates the NLRP6 gene expression via binding to estrogen responsive element of Nlrp6 gene promoter. ER8 also physically in-teracts with the NLRP6 nucleotide-binding domain and promotes NLRP6 inflammasome assembly. The ER8-NLRP6 axis then interacts with multiple autophagy-related proteins, including ULK1, BECN1, ATG16L1, LC3B, and p62, and affects the autophagosome biogenesis and autophagic flux. Finally, NLRP6-mediated autophagy suppresses the inflammatory response by promoting the K48-linked poly-ubiquitination of ASC, Casp-1 p20, IL-18, TNF-o, and prohibitin-2. Thus, ER8-NLRP6 direct an anti-inflamma-tory response by promoting autophagy. Our work uncovers an ER8-NLRP6-autophagy pathway as a regula-tory mechanism that maintains intestinal epithelial cell homeostasis and facilitates tissue repair in colitis.".
• 01GPK9PZA2CDWAMX99KBCE81G1 abstract "Mycotoxins, fungal secondary metabolites, are ubiquitously present in food commodities. Acute exposure to high levels or chronic exposure to low levels has an impact on the human body. The phase I metabolism in the human liver, performed by cytochrome P450 (CYP450) enzymes, is accountable for more than 80% of the overall metabolism of exogenous and endogenous compounds. Mycotoxins are (partially) metabolized by CYP450 enzymes. In this study, in vitro research was performed on CYP450 probes and aflatoxin B1 (AFB1), a carcinogenic mycotoxin, to obtain pharmacokinetic data on AFB1, required for further experimental work. The CYP450 probes of choice were a CYP3A4 substrate, midazolam (MDZ) and a CYP1A2 substrate, phenacetin (PH) since these are the main metabolizing phase I enzymes of AFB1. Linearity experiments were performed on the three substrates indicating that linear conditions were achieved at a microsomal protein concentration and incubation time of 0.25 mg/ml and 5 min, 0.50 mg/ml and 20 min and 0.25 mg/ml and 5 min for MDZ, PH and AFB1, respectively. The K-m was determined in human liver microsomes and was estimated at 2.15 mu M for MDZ, 40.0 mu M for PH and 40.9 mu M for AFB1. The associated V-max values were 956 pmol/(mg.min) (MDZ), 856 pmol/(mg.min) (PH) and 11,536 pmol/(mg.min) (AFB1). Recombinant CYP systems were used to determine CYP450-specific Michaelis-Menten values for AFB1, leading to a CYP3A4 K-m of 49.6 mu M and an intersystem extrapolation factor (ISEF) corrected V-max of 43.6 pmol/min/pmol P450 and a CYP1A2 K-m of 58.2 mu M and an ISEF corrected V-max of 283 pmol/min/pmol P450. An activity adjustment factor (AAF) was calculated to account for differences between microsome batches and was used as a correction factor in the determination of the human in vivo hepatic clearance for MDZ, PH and AFB1. The hepatic blood clearance corrected for the AAF CLH,B,MDZ,AAF, CLH,B,PH,AAF CLH,B,AFB1,AAF(CYP3A4) and CLH,B,AFB1,AAF(CYP1A2) were determined in HLM at 44.1 L/h, 21.7 L/h, 40.0 L/h and 38.5 L/h. Finally, inhibition assays in HLM showed that 45% of the AFB1 metabolism was performed by CYP3A4/3A5 enzymes and 49% by CYP1A2 enzymes.".
• 01GPK9Q46MN8SK7HZMM1RKE0R2 abstract "Early-life exposure occurs during gestation through transfer to the fetus and later, during lactation. Recent monitoring data revealed that the Portuguese population is exposed to mycotoxins, including young children. This study aimed to develop a pilot study to assess the early-life exposure to mycotoxins through a mother-child cohort, and to identify the associated challenges. Participants were recruited during pregnancy (1st trimester) and followed-up in three moments of observation: 2nd trimester of pregnancy (mother), and 1st and 6th month of the child's life (mother and child), with the collection of biological samples and sociodemographic and food consumption data. The earlyMYCO pilot study enrolled 19 mother-child pairs. The analysis of biological samples from participants revealed the presence of 4 out of 15 and 5 out of 18 mycotoxins' biomarkers of exposure in urine and breast milk samples, respectively. The main aspects identified as contributors for the successful development of the cohort were the multidisciplinary and dedicated team members in healthcare units, reduced burden of participation, and the availability of healthcare units for the implementation of the fieldwork. Challenges faced, lessons learned, and suggestions were discussed as a contribution for the development of further studies in this area.".
• 01GPK9Q46SB3J4NVFFN3BQBW9W abstract "The sampling protocols for the official control of the levels of mycotoxins in foodstuffs are very costly and time-consuming. More efforts are needed to implement alternative sampling plans able to support official control, or to adapt the current ones. The aim of the research carried out within the European Horizon 2020 MycoKey project was to evaluate the applicability at industrial scale of the dust sampling approach to detect multiple mycotoxins in grains. To this end, two trials were performed on an EU industrial site: (i) control of the unloading of wheat from train wagons; (ii) control of the unloading of wheat from trucks. In line with previous studies, the MycoKey results indicated that dust sampling and mycotoxin analysis represent a fitness for purpose approach for non-destructive and rapid identification of wheat commodities compliant to the maximum permitted levels. Based on reviewed and newly generated results, this article discusses potential applications and limits of the dust sampling methodology, identifying future research needs.".
• 01GPK9VXACS74ZFQ5HQC9M9ABH abstract "Summary Background: The frequency of family meals has been suggested as a protective factor against obesity among children. Objective: This study aimed to investigate the cross-sectional and longitudinal associations between family meals frequency and children's overweight/obesity in families at high risk of type 2 diabetes (T2D) across six European countries. Methods: 989 parent–child dyads (52% girls and 72% mothers) were included. Participants completed validated measures to assess the frequency of family meals and anthropometrics. Multivariable regression models were applied to examine the longitudinal associations between family meals frequency and overweight/obesity in children. Logistic regression was performed to predict the odds of having overweight/ obesity depending on changes in family meals frequency over a two-year follow-up period. Analyses were stratified for children's sex. Results: High frequency of family breakfasts and/or dinners was inversely associated with children's BMI in boys and girls at T2. Results showed decreased odds of overweight/ obesity at follow-up among both boys (OR = 0.65; 95% CI 0.41, 0.96) and girls (OR = 0.53; 95% CI 0.31, 0.87) who consumed minimum of three times family breakfasts and/or family dinners a week at baseline. An increase in family breakfasts and/or dinners frequency was associated with lower odds of overweight/obesity in both boys and girls at follow-up. Conclusion: A high frequency of family breakfasts and/or dinners but not lunch during childhood is associated with lower odds of overweight/obesity development in children from families at high risk of T2D. The promotion of family meals could help in preventing the development of overweight/obesity among children.".
• 01GPKC1T86J1X987ZE991QDRCH abstract "It may be tempting for researchers to stick to incremental extensions of their current work to plan future research activities. Yet there is also merit in realizing the grand challenges in one’s field. This paper presents an overview of the nine major research problems for the Business Process Management discipline. These challenges have been collected by an open call to the community, discussed and refined in a workshop setting, and described here in detail, including a motivation why these problems are worth investigating. This overview may serve the purpose of inspiring both novice and advanced scholars who are interested in the radical new ideas for the analysis, design, and management of work processes using information technology.".
• 01GPKE8E4B81H3QKCECBF6M8TY abstract "Oleaginous yeasts are typically defined as those able to accumulate more than 20% of their cell dry weight as lipids or triacylglycerides. Research on these yeasts has increased lately fuelled by an interest to use biotechnology to produce lipids and oleochemicals that can substitute those coming from fossil fuels or offer sustainable alternatives to traditional extractions (e.g., palm oil). Some oleaginous yeasts are attracting attention both in research and industry, with Yarrowia lipolytica one of the best-known and studied ones. Oleaginous yeasts can be found across several clades and different metabolic adaptations have been found, affecting not only fatty acid and neutral lipid synthesis, but also lipid particle stability and degradation. Recently, many novel oleaginous yeasts are being discovered, including oleaginous strains of the traditionally considered non-oleaginous Saccharomyces cerevisiae. In the face of this boom, a closer analysis of the definition of "oleaginous yeast" reveals that this term has instrumental value for biotechnology, while it does not give information about distinct types of yeasts. Having this perspective in mind, we propose to expand the term "oleaginous yeast" to those able to produce either intracellular or extracellular lipids, not limited to triacylglycerides, in at least one growth condition (including ex novo lipid synthesis). Finally, a critical look at Y. lipolytica as a model for oleaginous yeasts shows that the term "oleaginous" should be reserved only for strains and not species and that in the case of Y. lipolytica, it is necessary to distinguish clearly between the lipophilic and oleaginous phenotype.".
• 01GPKE8E4KSHXZAZGPYZMFN95E abstract "Saccharomyces cerevisiae is the model organism to most yeast researchers, and information obtained from its physiology is generally extrapolated to other yeasts. Studies on fatty acid transport in S. cerevisiae are based on the expression of both native fatty acid export genes as well as heterologous proteins. Starmerella bombicola, on the other hand, is an oleaginous yeast of industrial relevance but its fatty acid transport mechanisms are unknown. In this study, we attempt to use existing knowledge from S. cerevisiae to study fatty acid transport in S. bombicola, but the obtained results differ from those observed in S. cerevisiae. First, we observed that deletion of SbPRY1 in S. bombicola leads to higher fatty acid export, the opposite effect to the one previously observed for the Pry homologues in S. cerevisiae. Second, following reports that human FATP1 could export fatty acids and alcohols in S. cerevisiae, we expressed FATP1 in a fatty acid-accumulating S. bombicola strain. However, FATP1 reduced fatty acid export in S. bombicola, most likely due to its acyl-CoA synthetase activity. These results not only advance knowledge on fatty acid physiology of S. bombicola, but also improve our understanding of S. cerevisiae and its limitations as a model organism.".
• 01GPKMDEKNGMMWWZXRZQPJ0EMK abstract "IMPORTANCE Early identification of cerebral palsy (CP) is important for early intervention, yet expert-based assessments do not permit widespread use, and conventional machine learning alternatives lack validity. OBJECTIVE To develop and assess the external validity of a novel deep learning-based method to predict CP based on videos of infants' spontaneous movements at 9 to 18 weeks' corrected age. DESIGN, SETTING, AND PARTICIPANTS This prognostic study of a deep learning-based method to predict CP at a corrected age of 12 to 89 months involved 557 infants with a high risk of perinatal brain injury who were enrolled in previous studies conducted at 13 hospitals in Belgium, India, Norway, and the US between September 10, 2001, and October 25, 2018. Analysis was performed between February 11, 2020, and September 23, 2021. Included infants had available video recorded during the fidgety movement period from 9 to 18 weeks' corrected age, available classifications of fidgety movements ascertained by the general movement assessment (GMA) tool, and available data on CP status at 12 months' corrected age or older. A total of 418 infants (75.0%) were randomly assigned to the model development (training and internal validation) sample, and 139 (25.0%) were randomly assigned to the external validation sample (1 test set). EXPOSURE Video recording of spontaneous movements. MAIN OUTCOMES AND MEASURES The primary outcome was prediction of CP. Deep learning-based prediction of CP was performed automatically from a single video. Secondary outcomes included prediction of associated functional level and CP subtype. Sensitivity, specificity, positive and negative predictive values, and accuracy were assessed. RESULTS Among 557 infants (310 [55.7%] male), the median (IQR) corrected age was 12 (11-13) weeks at assessment, and 84 infants (15.1%) were diagnosed with CP at a mean (SD) age of 3.4 (1.7) years. Data on race and ethnicity were not reported because previous studies (from which the infant samples were derived) used different study protocols with inconsistent collection of these data. On external validation, the deep learning-based CP prediction method had sensitivity of 71.4% (95% CI, 47.8%-88.7%), specificity of 94.1%(95% CI, 88.2%-97.6%), positive predictive value of 68.2% (95% CI, 45.1%-86.1%), and negative predictive value of 94.9% (95% CI, 89.2%-98.1%). In comparison, the GMA tool had sensitivity of 70.0% (95% CI, 45.7%-88.1%), specificity of 88.7% (95% CI, 81.5%-93.8%), positive predictive value of 51.9% (95% CI, 32.0%-71.3%), and negative predictive value of 94.4% (95% CI, 88.3%-97.9%). The deep learning method achieved higher accuracy than the conventional machine learning method (90.6% [95% CI, 84.5%-94.9%] vs 72.7% [95% CI, 64.5%-79.9%]; P < .001), but no significant improvement in accuracy was observed compared with the GMA tool (85.9%; 95% CI, 78.9%-91.3%; P = .11). The deep learning prediction model had higher sensitivity among infants with nonambulatory CP (100%; 95% CI, 63.1%-100%) vs ambulatory CP (58.3%; 95% CI, 27.7%-84.8%; P = .02) and spastic bilateral CP (92.3%; 95% CI, 64.0%-99.8%) vs spastic unilateral CP (42.9%; 95% CI, 9.9%-81.6%; P < .001). CONCLUSIONS AND RELEVANCE In this prognostic study, a deep learning-based method for predicting CP at 9 to 18 weeks' corrected age had predictive accuracy on external validation, which suggests possible avenues for using deep learning-based software to provide objective early detection of CP in clinical settings.".
• 01GPKMN2SE8NV0KWKAHQDPVHK7 abstract "Introduction: Due to the heterogeneous clinical presentation of spastic cerebral palsy (SCP), which makes spas-ticity treatment challenging, more insight into the complex interaction between spasticity and altered muscle morphology is warranted.Aims: We studied associations between spasticity and muscle morphology and compared muscle morphology between commonly observed spasticity patterns (i.e. different muscle activation patterns during passive stretches).Methods: Spasticity and muscle morphology of the medial gastrocnemius (MG) and semitendinosus (ST) were defined in 74 children with SCP (median age 8 years 2 months, GMFCS I/II/III: 31/25/18, bilateral/unilateral: 46/27). Using an instrumented assessment, spasticity was quantified as the difference in muscle activation recorded during passive stretches at low and high velocities and was classified in mixed length-/velocity-dependent or pure velocity-dependent activation patterns. Three-dimensional freehand ultrasound was used to assess muscle morphology (volume and length) and echogenicity intensity (as a proxy for muscle quality). Spearman correlations and Mann-Whitney-U tests defined associations and group differences, respectively.Results: A moderate negative association (r =-0.624, p < 0.001) was found between spasticity and MG muscle volume, while other significant associations between spasticity and muscle morphology parameters were weak. Smaller normalized muscle volume (MG p = 0.004, ST p=<0.001) and reduced muscle belly length (ST p = 0.015) were found in muscles with mixed length-/velocity-dependent patterns compared to muscles with pure velocity-dependent patterns.Discussion: Higher spasticity levels were associated with smaller MG and ST volumes and shorter MG muscles. These muscle morphology alterations were more pronounced in muscles that activated during low-velocity stretches compared to muscles that only activated during high-velocity stretches.".
• 01GPKN0YRNFPP3J3AW0DCZCW47 abstract "In this work, optimization-under-uncertainty (OUU) is treated by simultaneously minimizing the mean of the objective and its variance due to variability of design variables and/or parameters in a multi-objective setting, while simultaneously ensuring that the minimal probability of constraint failure is met. This allows the designer to choose its robustness level without the need to repeat the optimization as typically encountered when formulated as a single objective and ensuring that the system will not fail with a prescribed probability. To account for the computational cost that is often encountered in OUU problems, the problem is fitted in a Bayesian optimization framework. The use of surrogate modeling techniques to efficiently solve problems under uncertainty has effectively found its way in the optimization community leading to surrogate-assisted OUU schemes. The surrogates are often considered cheap-to-sample black-boxes and are sampled to obtain the desired quantities of interest. However, since the analytical formulation of the surrogates is known, the mean square predictive error of the quantities of interest can be derived. To obtain these quantities without sampling, an analytical uncertainty propagation and reliability analysis through the surrogate is presented. The multi-objective Bayesian optimization framework and the analytical uncertainty propagation and reliability analysis are linked together through the formulation of the reliability-based robust expected improvement. To further enhance the efficiency of the approach, the Bayesian optimization method is solved in an asynchronous manner. In doing so the novel Surrogate-assisted Asynchronous Multi-objective optimization under Uncertainty framework for Robust and reliable solutions to Applications in Industry (SAMURAI) scheme is defined. The method is applied to a number of case studies and the design of a low-Re airfoil for blended-wing-bodies, which proves the effectiveness of the novel methodology.".
• 01GPKN6NZ57M4CGK8AZQSE7YBH abstract "For Quasi-Newton methods, one of the most important challenges is to find an estimate of the Jacobian matrix as close as possible to the real matrix. While in root-finding problems multi-secant methods are regularly used, in optimization, it is the symmetric methods (in particular BFGS) that are popular. Combining multi-secant and symmetric methods in one single update formula would combine their benefits. However, it can be proved that the symmetry and multi-secant property are generally not compatible. In this paper, we try to work around this impossibility and approach the combination of both properties into a single update formula. The novelty of our method is to group secant equations based on their relative importance and to order those groups. This leads to a generic formulation of a symmetric Quasi-Newton method that is as close as possible to satisfying multiple secant equations. Our new update formula is modular and can be used in different applications where multiple secant equations, coming from different sources, are available. The formulation encompasses also different existing Quasi-Newton symmetric update formulas that try to approach the multi-secant property.".
• 01GPKVB8B6E9KAXJJ6WVMQJ34E abstract "Background and objective: (Patho)physiological changes in older people may infuence the pharmacokinetics (PK), and consequently the target attainment, of ß-lactam antibiotics using standard dosing regimens. This systematic review compiles the current knowledge on the PK and target attainment of ß-lactam antibiotics in older people, with the aim to identify priorities for dose optimization in this patient population. Methods: A systematic literature search of the PubMed and EMBASE databases was conducted. Relevant articles published prior to 1 December 2021 were identifed as eligible when they included data on the PK of ß-lactam antibiotics in adults ≥ 65 years of age. Extracted information included reported PK parameters (volume of distribution, clearance [CL], elimination rate constant, intercompartmental CL, elimination half-life, area under the concentration-time curve, maximum and trough concentration), covariates on PK parameters, target attainment rate, and dosing recommendations. Results: Ninety-one relevant articles were included in this review. Four main ß-lactam subclasses were represented: 59.3% on cephalosporins + cephamycins, 25.3% on penicillins, 15.4% on carbapenems, and 3.3% on monobactams; 65.9% of articles involved intravenous administration, 16.5% mixed administration routes, 12.1% oral administration, and 5.5% intramuscular administration. The majority of studies had a small sample size, often did not include detailed information on the study population and methods, and were fairly old. CL was, on average, decreased, while elimination half-life was prolonged in aged subjects compared with young subjects. Volume of distribution was generally similar between age groups. Most studies identifed renal function as the most important contributor to altered drug CL. In only 30.8% of the articles, target attainment was studied, and in 35.7% of these articles, target attainment was found to be suboptimal. Dosing recommendations were incorporated in 87.9% of articles. Conclusion: Studies frequently fail to provide an evidence-based dosing recommendation for this diverse patient population. Model-based PK studies that address both physiological and disease-related changes are urgently needed. This review identifed gaps of knowledge to set priorities for further research.".
• 01GPKW5Q3DA02Y8K1EWGR96VH5 abstract "During the last decades, the progressive diffusion and technological improvements of renal tumor imaging have played a pivotal role in changing the natural history of this disease. The widespread diffusion of ultrasound (US) and computed tomography (CT) scan increased the number of incidentally detected renal tumors and amenable to less invasive or conservative treatment has increased with a subsequent increase in overall and cancer-specific survival. Moreover, the more frequent application of contrast-enhanced ultrasound (CEUS) and magnetic resonance imaging (MRI) lets clinicians to progressively better characterize some type of masses and help the surgeon choose the better treatment option. In addition, a lot of imaging technologies have been adopted for intraoperative use. The intraoperative US and the indocyanine green guidance are two of the most diffused tools adopted to improve the surgical navigation. Finally, the recent advent of 3D virtual models has furtherly increased surgeons’ comprehension of anatomical details with a subsequently more accurate preoperative planning. These very promising technologies had a large variety of applications, from 3D printed models to mixed or augmented reality. In conclusion the state of the art in pre- and intraoperative imaging modalities for kidney tumors is rapidly evolving thanks to technological improvements. With the help of these new technologies, it is estimated to further increase the number of complex renal masses suitable for nephron-sparing surgery and to reduce the postoperative functional impairment thanks to more conservative resection techniques and more selective clamping procedures.".
• 01GPKW5Q4904AZ7FE3B9T4CX3R abstract "We describe the first five robot-assisted radical prostatectomies (RARPs) performed with the new Hugo RAS system (Medtronic, Minneapolis, MN, USA) in Europe. The five patients underwent RARP $\pm$ lymph node dissection at OLV Hospital (Aalst, Belgium). All procedures were completed, with no need for conversion or for placement of additional ports. No intraoperative complication or technical failure of the system was recorded. The median operative time was 170 min (interquartile range [IQR]: 140-180) and the median console time was 120 min (IQR: 110-150). Median length of stay was 3 d (IQR: 2-4). System start-up and docking of the robotic arms were straightforward and rapid processes for a properly trained surgical team. Awaiting future investigations in larger series, this study proves the safety and feasibility of RARP with the Hugo RAS system and provides relevant data that may be of help to early adopters of this surgical platform.".
• 01GPKW5Q4HMX9JHG6QZYYCE7XV abstract "Background: In robot-assisted partial nephrectomy (RAPN) renorrhaphy is used to achieve hemostatic control of the tumoral resection bed, with detrimental impact on renal function. Hemostatic agents are used to achieve rapid and optimal hemostasis. GATT-Patch is a new hemostatic sealant that has already demonstrated promising results. Objective: Compare GATT-Patch and standard renorrhaphy in terms of hemostatic capacity, ischemia time, and prevention of urinary leakage after RAPN in a porcine model. Design, Setting, and Participants: In this preclinical randomized controlled trial, four pigs underwent 32 RAPNs. After resection, GATT-Patch application and performance of classic renorrhaphy were randomized. After the procedure, the resection bed was reinspected. A necropsy study evaluated the adhesiveness of the patch, and retrograde pyelography was performed to determine the leakage burst pressure. Intervention: Application of GATT-Patch and performance of classic renorrhaphy were randomized and surgeons blinded to the hemostatic technique to be performed. Outcome Measurements and Statistical Analysis: Warm ischemia, hemostatic control, active bleeding during hemostatic control, total procedure time, bleeding at reinspection, and presence of urinary leakage on retrograde pyelography were recorded. Continuous variables were compared using the Student t-test. Categorical variables were compared using the Chi-square or Fisher's exact test. Results and Limitations: GATT-Patch reduced warm ischemia time (WIT), time to achieve hemostatic control, active bleeding time, and total procedure time, achieving hemostasis in 100\% of the cases. Rebleeding at reinspection occurred in 0\% of the GATT-Patch group. Renal parenchyma damage was observed in 100\% of renorrhaphy cases and in 0\% of GATT-Patch cases. Conclusions: GATT-Patch guaranteed optimal hemostasis and urine sealant effect after RAPN in porcine models. Compared to renorrhaphy, we observed a reduction in WIT, total procedure time, and potential reduction in healthy parenchyma loss. Patient Summary: GATT-Patch stops bleeding and provides hemostasis faster than suturing after resection of portions of the kidney in pigs. It might be tested in patients undergoing partial nephrectomy for kidney cancer.".
• 01GPMFJFMD79TQ8VPHW6CQ6K08 abstract "EEG electrodes currently on the market are not suitable for longterm monitoring or wearable applications. The introduction of textile electrodes would solve associated issues. As a result, this research looked into textrodes to track brain activity. Textile- based EEG electrode was constructed from a silver-plated hook fabric that collects good quality EEG signals comparable to Ag/AgCl dry comb electrodes. The hook fabric textrode avoids the use of adhesive conductive gel and no shaving of the hair is necessary. The skin-to-electrode impedance was lower than that of Ag/AgCl dry comb electrodes. A knitted net bridge EEG cap was also developed and compared against universal EEG caps. Both the hook fabric textrode and knitted net bridge EEG cap were validated at the clinical level via Brain Quick® Clinical EEEG Line. Overall, the Hook fabric EEG textrode gave comparable EEG signals and ITC, ERSP, and log power spectral density plots across all main EEG bandwidths.".
• 01GPMGPYV2BSSG5JSDQ3VJ775H abstract "In this work, we explored a long-lasting and lightweight head phantom that allows synthetic wave injection and measuring at a performance similar to the commonly used ballistic gelatin-based head phantoms. It was found to perform similarly and for some parameters like the SNR even better than the gelatin-based one. The result proved that the textile-based head phantom can accurately mimic body-electrode frequency responses which make it suitable for the controlled validation of new electrodes. While the textile-based phantom was designed for EEG, it can also be adapted to electrocardiogram, electromyogram, electrooculogram, and other related studies as well. The new textile-based head phantom has a much lighter weight than the gelatin-based i.e., 0.5 and 6 kg, respectively. Therefore, the weight reduction is 91.67% which makes it more suitable for handling and moving from place to place. In addition, it is not delicate like the ballistic gelatin-based one, where the shape of ballistic gelatin could be distorted and decays fast even when kept in a refrigerator. In our case, the gelatin-based head phantom began decaying after a week of its construction which may also depend on the weather where it is placed during testing. In contrast, the textile-based head phantom does not decay at all. All these will play an enormous role from an economic and sustainability point of view.".
• 01GPN8AE0Z7E5HXJGDEM3PB7RB abstract "Detailed observation techniques are needed to reveal the underlying eco-physiological mechanisms driving tree growth processes. Terrestrial laser scanning (TLS) has proven to be a feasible technique for characterizing trees, but it has still remained unclear whether TLS point clouds and the existing point cloud processing methods can be used for capturing even the smallest signs of the growth process of individual trees. The aim of this study was to investigate the capacity of TLS in observing seasonal radial growth of boreal trees. The experimental setup included 91 sample trees from 20 sample plots characterized with multi-scan TLS point clouds pre- and postgrowing season. The sample trees were equipped with dendrometers that provided reference measurements for the increment in diameter at the breast height (Delta dbh) that varied from -1.4 mm to 4.0 mm with a mean of 1.0 mm. The experiment confirmed challenges related to quantification of millimeter-level increments in dbh using TLS but cautiously highlighted its feasibility for radial tree growth monitoring when the magnitude of Delta dbh exceeds several millimeters and when the aim is to characterize sample plot mean rather than individual tree growth. While the capacity of TLS to characterize Delta dbh of individual trees remained rather low (r = 0.17, p = 0.07), the TLS-based estimates for sample plot mean Delta dbh were slightly better in line with dendrometer measurements (r = 0.46, p = 0.04). At an individual tree level, the capacity of TLS to determine the occurrence of radial tree growth seemed to be dependent on the magnitude of observed Delta dbh and benefit from the analysis of paired diameter measurements along the stem for determining individual tree growth. The results showed overall classification accuracies of a) 60.7 % and b) 70.6 % for the use of TLS in determining whether radial growth had occurred or not when the analysis was based on a) Delta dbh measurements only or b) statistically significant mean increment in paired diameter measurements along the stem, respectively. Using the Delta dbh-based method, the overall accuracy improved from 56.3 % to 73.0 % when the magnitude of observed Delta dbh increased from <= 1 mm to > 1 mm, as was expected. Altogether, this study contributes by demonstrating that with TLS data acquisition and existing point cloud processing methods, it is possible to observe seasonal increments in tree structures, which emphasizes the feasibility of TLS in regular monitoring of structural changes even in boreal forest ecosystems.".
• 01GPNA45K9H29WB9QC8AE26CW4 abstract "The aims of agricultural land management change continuously, reflecting shifts in wider societal priorities. Currently, these include addressing the climate crisis, promoting environmental sustainability, and supporting the livelihoods of rural communities while ensuring food security. Working toward these aims requires information on the character of agricultural land and how dynamic processes influence it. Remote and near-surface sensing data are important sources of information on the characteristics of soils, plants, water, topography, and related processes. Sensing data are collected, analysed, and used in decision-making by specialists in multiple domains connected to land management. While progress has been made to connect the use of sensing data across agricultural and environmental applications under the umbrella of integrated sustainable land management, archaeological and heritage uses of these data remain largely disconnected. This creates barriers to accounting for the impacts of past human activities on contemporary agricultural landscapes through the alteration of soils, topography, and plant communities. In parallel, it hinders the creation of knowledge about the archaeological features which form an essential part of the heritage of agricultural landscapes. The ipaast-czo project explores the potential of a coordinated approach across all these domains, which would reduce these barriers and provide benefits by better integrating information generated using sensing. To do so, both conceptual and practical barriers to developing shared practices and how these might be overcome were considered. In this study, a conceptual framework designed to create a shared understanding of how agricultural landscapes work and enable collaboration around their management was proposed. This framework treats present-day rural agricultural landscapes as Critical Zones: complex entities shaped by long-term human-environment interactions including contemporary farming. Practitioners in precision agriculture and archaeological remote and near-surface sensing, as well as users of these data, were engaged using workshops and interviews. The relationships between practitioners' objectives, data requirements for their applications, and their perceptions of the benefits and disadvantages of changing working practices were interrogated. The conceptual framework and assessment of practical benefits and challenges emerging from this work provide a foundation for leveraging shared sensing data and methods for long-term integrated sustainable land management.".
• 01GPNGAHYDA02JXGHWG7NCR4VT abstract "Simultaneous wireless information and power transfer can be achieved using an integrated receiver, where the incoming signal is rectified, and both the energy harvesting (EH) and the information detection (ID) operate on this rectified signal. Because phase information is lost at the input of the ID, commonly-used modulation techniques cannot be straightforwardly applied and biased M-ASK is used instead. We consider downstream communication over a Rician block-fading channel, from a multi-antenna hasestation to a number of single-antenna users. Multi-user interference is eliminated by applying zero-forcing preceding. Using a realistic rectifier model, we compare EH and ID performances of linear precoding (LP) and modified Tomlinson-Harashima preceding (THP). We add low-complexity algorithms to these precoders that optimize the user ordering and the constellation rotations. Moreover, we investigate the effect of the amplitude ratio rho(ASK) of' the constellation on the energy-rate trade-off. Compared to the same precoders without optimization, optimizing the user ordering, rotations and rho(ASK) considerably reduces the transmit power required to achieve a harvested power of -30 dBm or an average mutual information of (log(2) M)/2. Both with and without optimizations, THP outperforms LP in terms of EH and ID, but THP exhibits much larger gains when optimizations are applied.".
• 01GPNHCT1T4J26E3JQWW7E13K4 abstract "The presence of hydrogen in steel components affects their structural integrity through a phenomenon called hydrogen embrittlement. While it is known that hydrogen affects the mechanical damage development upon loading, the specific mechanisms are still unclear. An experimental study is presented that investigates the plastic anisotropy and ductile fracture behavior of API 5L X70 pipeline steel with and without hydrogen charging at multiple scales. Three different tensile test specimen geometries (smooth and notched axisymmetric) are employed to investigate the influence of stress triaxiality thereon. The macromechanical responses during tensile tests are analyzed, along with micromechanical features of the resulting damage obtained using High-Resolution X-ray Computed Tomography. For all stress triaxialities tested, the presence of hydrogen does not affect the macroscopic plastic anisotropy, but accelerates ductile damage development and fracture, which is in agreement with the plasticity dominated hydrogen embrittlement mechanisms HELP and HESIV. Increasing stress triaxiality leads to a larger susceptibility to hydrogen embrittlement. Hydrogen accelerated void nucleation and enhanced lateral void growth are observed and quantified. The presented results can aid the development of numerical models describing hydrogen embrittlement in high-strength low-alloy steel.".
• 01GPNHNKSR208R1CHWFM0M7760 abstract "Gliomas, the most frequent type of primary tumor of the central nervous system in adults, results in significant morbidity and mortality. Despite the development of novel, complex, multidisciplinary, and targeted therapies, glioma therapy has not progressed much over the last decades. Therefore, there is an urgent need to develop novel patient-adjusted immunotherapies that actively stimulate antitumor T cells, generate long-term memory, and result in significant clinical benefits. This work aimed to investigate the efficacy and molecular mechanism of dendritic cell (DC) vaccines loaded with glioma cells undergoing immunogenic cell death (ICD) induced by photosens-based photodynamic therapy (PS-PDT) and to identify reliable prognostic gene signatures for predicting the overall survival of patients. Analysis of the transcriptional program of the ICD-based DC vaccine led to the identification of robust induction of Th17 signature when used as a vaccine. These DCs demonstrate retinoic acid receptor-related orphan receptor-gamma t dependent efficacy in an orthotopic mouse model. Moreover, comparative analysis of the transcriptome program of the ICD-based DC vaccine with transcriptome data from the TCGA-LGG dataset identified a four-gene signature (CFH, GALNT3, SMC4, VAV3) associated with overall survival of glioma patients. This model was validated on overall survival of CGGA-LGG, TCGA-GBM, and CGGA-GBM datasets to determine whether it has a similar prognostic value. To that end, the sensitivity and specificity of the prognostic model for predicting overall survival were evaluated by calculating the area under the curve of the time-dependent receiver operating characteristic curve. The values of area under the curve for TCGA-LGG, CGGA-LGG, TCGA-GBM, and CGGA-GBM for predicting five-year survival rates were, respectively, 0.75, 0.73, 0.9, and 0.69. These data open attractive prospects for improving glioma therapy by employing ICD and PS-PDT-based DC vaccines to induce Th17 immunity and to use this prognostic model to predict the overall survival of glioma patients.".
• 01GPNHQFGMABMRG77TE11QTQY7 abstract "Fibroblast migration is an important aspect of wound healing. Different factors can influence migration and as such proper wound healing. In vitro scratch wound assays are used to examine cellular migration. However, the wide array of techniques available reduces reproducibility of findings. In this paper, we compare two techniques for wound creation; i.e. the exclusion method or scratching of cell monolayers. Furthermore, we investigate if analysis software influences experimental outcome by comparing both commercially and freely available analysis software. Besides, we examine the effect of cortisol on migration behavior of fibroblasts and identify possible caveats in experimental design. Results show a significantly reduced migration of fibroblasts when wounds are created using a cell exclusion method. Furthermore, addition of cortisol to the cell culture media only reduced migration of fibroblast monolayers that had been scratched but not in those where wounds were created using the exclusion method. A possible explanation related to cytokine expression is discussed.".
• 01GPNJE30X7PJWZFE4RP10248C abstract "Accompanying dataset to the paper submitted to Materials Science and Engineering: A".
• 01GPNPNS7P4ED1MPWPN37GAYBB abstract "A novel waterfall aeration biofilm reactor integrated with a constructed wetland (WABR-CW) system was developed to meet the challenge of decentralized wastewater treatment with a focus on nutrient removal. In a lab-scale experiment of 70 days, the WABR-CW showed a high removal efficiency for COD (85-98 %), NH4+-N (100 %), TN (60-90 %) and TP (85 %-95 %), even when different organic loading rates (OLR) were used. The CW was responsible for improving the overall performance in view of an increased nutrient removal. The CW offers denitrification capacity when the OLR is not optimal for the WABR. Based on the lab-scale experiment, a pilotscale WABR-CW was built and tested for aquaculture wastewater treatment and reuse. A total of 63 m3 wastewater was treated of which 56.7 m3 was reused. Furthermore, the microbial structure of the WABR-CW system was investigated. A metabolic analysis highlighted the N and C metabolic pathways and functional genes distribution in the WABR-CW system. Next generation sequencing not only linked the pollutants removal performance and microbial encoding genes but also disclosed the potential ability of WABR-CW to treat more polluted and more complex wastewater. The outcomes of this study provide scale-up results and a better understanding of the functioning of the WABR-CW.".
• 01GPNQK34XVPFFQNVY2J50D6GK abstract "Steel support structures of offshore wind turbines (jackets and monopiles) undergo both fatigue and corrosion damage, impacting their lifetime. Due to the time‐variant uncertainties associated with environmental and mechanical loads, having reliable models that allow to predict the degradation due to corrosion and fatigue is necessary to accurately assess the structural integrity and to support decision making. Three Belgian universities (UGent, ULiege and VUB) and a collective center (Sirris) work together in the context of the ETF-funded project MAXWind to enhance the corrosion-fatigue analysis of offshore wind turbine support structures. The following objectives have been assigned to UGent: 1. Development of an advanced corrosion-fatigue model to analyze the interactive effects of corrosion and fatigue load on the lifetime of offshore wind turbine sub-structures. 2. Development of smart S-N curves that take into account the level of corrosion damage to predict the remaining lifetime.".
• 01GPNRVPFWPEHG27DV0J17XRWS abstract "Inspired by the analytical shift toward understanding altruism from an institutional perspective, this article presents an empirical analysis of the impact of institutionalized solidarity on attitudes toward payment for blood or plasma donations, in terms of both the level of welfare provision and confidence in the welfare system. Postulating that institutionalized solidarity is intertwined with group-based solidarity, this article offers a more refined understanding of the relationship between institutional context and attitudes toward paid donation by incorporating measures of social cohesion in the analysis. Based on Eurobarometer data from 2014, the results indicate that support for cash payment for donation is lower in European countries where social spending is higher. Similarly, aggregated levels of trust in the social security system are associated with less support for payment for donation. These findings point to the importance of institutionalized solidarity for the manifestation of support for non-remunerated blood and plasma donation.".
• 01GPNSY13N177S591VK2P66K3V abstract "Pitting corrosion is a common cause of concern for steel structures in an offshore environment. As geometric stress concentrating features, corrosion pits can potentially act as fatigue crack initiation sites. The current study is a part of the MAXWind project which, amongst others, aims to develop numerical tools for a more accurate estimate of the remaining lifetime of in-service wind turbines. UGent is responsible for developing an advanced corrosion-fatigue model which will be used to build “smart S-N curves”. The smart S-N curve is a novel concept that takes the level of corrosion into account. To this end, the entire evolution of corrosion fatigue is divided into three major phases including pitting corrosion, short fatigue crack propagation, and long fatigue crack propagation, see Figure 1. The main focus of this work is on pitting corrosion and its transition to short fatigue crack propagation. A phase-field modelling approach [1],[2] is used to simulate the autonomous growth of a corrosion pit. The corrosion phenomenon - pitting corrosion in particular – is a complex electrochemical process that is influenced by various environmental factors such as temperature, dissolved oxygen, pH, salinity, etc. [3]. Phase-field modelling is a robust technique that is capable to incorporate a vast range of influential parameters. In essence, in a phase-field model, each phase (here, metal and electrolyte) possesses a constant value in the bulk (0 for Pitting corrosion model transition transition Integrated model Experimental validation Short fatigue crack model Long fatigue crack model Phase-field modeling approach NR model X-FEM 18 th EAWE PhD Seminar on Wind Energy 2 – 4 November 2022 Bruges, Belgium electrolyte and 1 for steel), with a continuous interpolation between the bulk values across the interface between phases. The evolution of the system is a result of constrained minimization of free energy for which the advective Cahn-Hilliard equation is used. The Nernst-Planck equation is used to describe the diffusion of ions within the electrolyte, and the Butler-Volmer-type kinetic expression is used to calculate the reaction current density throughout the process. For more information and formulations see [1]. First, an electrochemical characterization was performed for structural steel grade S355 in an environment that is representative of the North Sea. This study is crucial to evaluate the electrochemical behaviour of this steel grade and will support further studies towards predicting pit dimensions in offshore wind turbine support structures in the North Sea. To this end, potentiodynamic polarization tests were implemented for S355 steel. An Ag/AgCl electrode was used as reference electrode in the tests and potential values are obtained against this electrode. The corresponding corrosion potential and current density were obtained as -711 mV vs. Ag/AgCl and 0.1534 A/m2 , respectively. For a metal, the more negative the corrosion potential is, the more susceptible it will be to corrosion [4]. In practice, corrosion protection systems and coatings will be applied to the metal structure, which will increase the value of corrosion potential [5]. Using the output of the experiments as input to the phase-field model, a parametric study was performed to assess the effect of the applied potential on geometrical parameters (pit width and depth) and electrochemical parameters associated with pit growth rate (metal cation concentration and reaction current density), see Figure 2. It was found that for an applied potential of -600 mV vs. Ag/AgCl, the corrosion process stays in the activation-controlled regime throughout the simulation time (150 seconds). Applied potentials of -550 to -500 mV vs. Ag/AgCl take the system to the current-resistance-controlled regime where the metal cation concentration does not reach the saturation. The higher the applied potential is, the more pitting corrosion is accelerated until it reaches to the point where any additional increase in applied potential will not have any 18 th EAWE PhD Seminar on Wind Energy 2 – 4 November 2022 Bruges, Belgium additional influence on pit growth rate. As it is easier for the metal ions to diffuse into the bulk electrolyte near the pit mouth in bare steel, pit width increases with a higher velocity in comparison to the pit depth. All numerical results will be validated with dedicated experiments. Any changes in temperature will cause changes in electrochemical parameters such as ionic diffusivity, corrosion potential and corrosion current density. As future work, a parametric study will be conducted on the effect of temperature on the corrosion pit growth rate. Ultimately, pit dimensions extracted at every time step will serve as input to a short fatigue crack propagation model [7]. Once a corrosion pit nucleates, the local stress in the material increases at the discontinuity. Therefore, in parallel to the pitting corrosion study, a finite element analysis was performed to assess the stress concentration factor (SCF) of corrosion pits and to identify the effect of different normalized geometrical parameters on SCF, see Figure 3. According to [8], a crack will initiate from a pit under the following conditions: (a) the pit size must pass a critical value, and (b) the crack growth rate must be higher than the pit growth rate. The concept of SCF can assist to address the first criterion. A pit becomes susceptible to transit to a crack as soon as it causes a considerable increase in the local stress. Results show that an increase in a/2c or b/c leads to enhanced SCF when the loading is oriented parallel to the pit’s major axis (i.e., 𝜑 = 0), see Figure 4 (a) and (b).".
• 01GPNVBBGRRH3YXF3Y845S9TMP abstract "The norms or expectation values of infinite projected entangled-pair states (PEPS) cannot be computed exactly, and approximation algorithms have to be applied. In the last years, many efficient algorithms have been devised-the corner transfer matrix renormalization group (CTMRG) and variational uniform matrix product state (VUMPS) algorithm are the most common-but it remains unclear whether they always lead to the same results. In this paper, we identify a subclass of PEPS for which we can reformulate the contraction as a variational problem that is algorithm independent. We use this variational feature to assess and compare the accuracy of CTMRG and VUMPS contractions. Moreover, we devise a new variational contraction scheme, which we can extend to compute general N-point correlation functions.".
• 01GPNVV0F90Y0JYRA85DJZ205M abstract "Aegidius is a pivotal figure in the final transition of northern Gaul from a peripheral Imperial Roman region into a Merovingian Frankish bulwark. it is his fusion of the last remnants of the Gallic field army, with the various Frankish followings that after his death coalesced around Childeric, that created the core of the Merovingian strike force which ultimately enabled Clovis to achieve Merovingian supremacy in Gaul. Aegidius should thus be seen as one of the architects of Merovingian Gaul.".
• 01GPP14N9E07PH4RYQFKJ49BRK abstract "Circular economy (CE) aims to create a sustainable economy while keeping economic growth intact, by internalizing negative externalities, such as waste. Research on this subject has come far on the macro level (e.g., legislative recommendations) and the meso level (e.g., life cycle engineering (LCE), circular supply chain (CSC), and circular value chain (CVC)), but less so on the micro level (i.e., the level of the individual firm). The issue this creates is that the businesses (which are the very basis of the economy) do not have clear frameworks, guidelines, or tools to reshape their own business in such a way that they can participate in a circular economy, hence hampering the development of a circular economy. In this research, we have created a circular production chain (CPC) that takes into account the resources, production process, product, and waste a company produces, through three aspects: imput, design, and output, but also places the company in the bigger picture, that is, the economy, and shows how CE is achieved by multiple companies working together, highlighting the importance of tactical management. In the process we uncover three main influences that facilitate or inhibit the implementation of CE practices in a single business.".
• 01GPP1BB2HPR153HSDX7K5M7AK abstract "Middle managers are often operating in complex and fast-moving environments, resulting in having to deal with enormous challenges in a short span of time, maneuvering diverse and numerous “givens” and aiming to achieve specific goals. These challenges are very diverse and require support tailored to the needs and characteristics of middle management. Due to the lack of tailored tools, middle managers often use methods that were originally designed for strategic or operational management, which they then adapt as best as possible to fit their tactical management needs. We thus see middle managers as the prototype of managers that have tactical management responsibilities, even though tactical management issues are also faced by executive, operational, and project managers. In a fast-changing world, heavily impacted by globalization and digitization, adaptability is one of the most essential characteristics of a middle manager. However, because of the lack of methods and systems tailored specifically to the tactical management level, middle managers are often not sufficiently supported to be able to deal with numerous givens, unpredictability, and a dynamic, turbulent, and complex environment. Hence, they lack proper support for being adaptable.".
• 01GPP1F7F1YJY1183YG1DXB62T abstract "Inspired by EUvsVirus, this chapter focuses on the Academia Diffusion Experiment (ADE) with more than 40 scholars and practitioners around the globe, who transform practice into science through co-creating, co-evolving, and co-dreaming. The chapter first introduces EUvsVirus as the context of the ADE and then uncovers the Denica 2.0 managerial method deployed to facilitate it, its primary constituents, governing principles, participants, information, and risk management. Finally, the chapter reflects the learnings from the ADE by discussing its potentials, problems, and challenges.".
• 01GPP1J6PEP6HQ0F1BN1W6MC3Q abstract "Since its burst in early 2020, the Covid-19 pandemic has deeply affected every aspect of daily life, from international trade and travelling to restrictions on an individual level, becoming a complex multi-level and highly multi-faceted problem. Due to its overarching influence and deep impact, it can be seen as one of the most disruptive Grand Challenges of our time. Different from most other lasting Grand Challenges, such as Climate Change, the pandemic exerted its influence with little ramp-up, rapidly transforming health and health systems, human lives, goods and economic flows, decision-making mechanisms, research and innovation, and many other aspects of life in a very short span of time. Grand Challenges require extraordinary efforts from society as a whole since they need holistic, effective, collaborative endeavours to solve them. One such unique orchestrated effort can be observed in the subsequent series of virtual massive EUvsVirus (https://www.euvsvirus.org/) events and committed collaborations (‘hackathon’, ‘matchathon’, ‘launchathon’, ‘community’, ‘EIC Covid platform’, and the unparalleled ‘Academia Diffusion Experiment’ [ADE], analysed in chapter “Academia Diffusion Experiment: Trailblazing the Emergence from Co-Creation” of this book). While this chapter explains ‘what’ has been produced with the ADE, inspired by the EUvsVirus phenomenon, the ADE chapter describes ‘how’ it has been done. Both are extremely unique in terms of content, procedure, motivation, collaboration, effects—and they attempt to trailblaze at highest level co-creation, co-evolution, and co-dreaming. Hence, situated as the last chapters of this book. This chapter will shed light on the EUvsVirus events, where over 30,000 individuals from 40 countries came together and addressed the complexity of this massive challenge in a pioneering and groundbreaking way. The chapter is focused on analysing the EUvsVirus hackathon (alongside its mentioned unique spillovers) as a tool, method, and process capable of channelling and activating individuals’ and institutions’ concerns, wills, and commitments into a unique orchestrated open, collaborative response to an urgent Grand Challenge, the pandemic. We are producing a multi-vortex tornado model, resembling the EUvsVirus phenomenon, its components, mechanisms, behaviour and how to replicate it to achieve such disruptive, global organisational effort of co-creation. Especially, the emergence of such collaboration in the face of such urgency leads to the assumption that there are crucial lessons to be learned from this endeavour, quite fittingly encapsulated by these words: ‘We are learning That though we weren't ready for this, We have been readied by it’. Amanda Gorman’s New Year poem (https://amandagormanbooks.com/#the-hill-we-climb-and-other-poems or https://edition.cnn.com/videos/tv/2022/01/06/exp-amanda-gorman-nye-poem.cnn)".

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