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Matches in Ghent University Academic Bibliography for { ?s <http://schema.org/abstract> ?o. }

• 01GJT0A21JR8PBJMBPEANFAS9J abstract "Textiles and their production machines are increasingly designed using simulations of the textile production process. These simulations require reliable structural yarn models. In practice, these models are often based on simplifying assumptions concerning the underlying geometry. However, in recent years more realistic geometrical fiber models have been developed, but have not been used to estimate the structural properties of yarns. The current contribution presents a new methodology to obtain a structural yarn model through numerical simulations based on a high-fidelity geometrical yarn model. Starting from microcomputed tomography data of a real-life natural fiber yarn used in air-jet weaving, a geometrical yarn model is constructed by tracing the individual fibers. This geometry is then incorporated in a computational finite-element analysis framework to obtain the yarn tensile and bending behavior through a simulated tensile test and Peirce cantilever test. Finally, the results are validated by comparison with experimental data. It is shown that this new technique succeeds to estimate the tensile and bending behavior. The presented methodology allows one to gain fundamental insight into the internal deformations and stresses in the yarn. Moreover, it is an important first step toward statistical studies on the structural yarn behavior on the microscale level and toward homogenized macro-models originating from a fully digital workflow.".
• 01GJT0ZR2N9Z940GGMX8QP5EYK abstract "This dataset contains the original µCT scan data, the scripts and intermediate results for the generation of the geometrical fiber model, as well as the structural simulation files and their experimental validation data described in the paper "A novel technique to simulate and characterize a yarn’s mechanical behavior based on a geometrical fiber model extracted from micro-CT imaging", published in Textile Research Journal.".
• 01GJTSXDN07J43X203R7CT5N7P abstract "Drawing on in-depth interviews with representatives from 17 organisations, this paper focuses on patterns of collaboration between different actors involved in the pre- and post-adulthood trajectories of youngsters arriving in Belgium as unaccompanied refugee minors. First, we clarify that the Belgian support system for these minors is characterised by fragmentation. In order for this fragmented system to benefit minors, different actors need to collaborate closely. Our qualitative analysis reveals that there is room for progress, specifically when concerning information exchange, case transfer and case coordination among different organisations. We identify five different but interrelated factors that engender interprofessional collaboration: timely and adequate diagnoses; knowledge of all service providers; sufficient capacity; informal trust relationships between professionals; and cultural competence of social workers and other professionals. While some of these issues can be addressed at the level of individual organisations, many are also embedded in a structural context of time pressure, understaffing, increased stress levels and high personnel turnover.".
• 01GJVEX1BPFY4E5K9PG0YD3VBJ abstract "Het toegangsbeleid in de Lage Landen vergeleken Hoe kan het dat de Vlaamse en Nederlandse selectieprocedures in het hoger onderwijs zo anders zijn? Terwijl de stelsels zelf verder veel op elkaar lijken? Dylan Couck en Rens van Hoogdalem, beiden in eigen land actief als studentvertegenwoordiger, inventariseren de verschillen en brengen de knelpunten in kaart.".
• 01GJVFB4H02HQVCEGRD45T4MEB abstract "De onzin van onvoorspelbare maatregelen en gedwongen concurrentie Dylan Couck van de Vlaamse Vereniging van Studenten hekelt het beleid rond de financiering van het hoger onderwijs. Hij maakt zich zorgen over een dreigend verlies van kwaliteit. ‘Gelijke en voldoende middelen voor elke student: dat zou het uitgangspunt moeten zijn.’".
• 01GJW5FMEXJDQ5F8857PV9MTZS abstract " This article provides a preliminary overview of the species of wild birds that lived in the fourteenth-century County of Holland, now the Netherlands, on the basis of archaeological and historical sources. It argues that scholars should devote more attention to the Late Middle Ages (1300–1500) as a historical baseline for the study of biodiversity, and demonstrates the value of using medieval financial administration (accounts) as a source for such research. The article identifies 46 species of birds, most of which had substantial socio-economic value (birds of prey, wildfowl, herons and spoonbills). Because some bird populations were actively managed to secure a steady supply, it is possible to gain insight into historical population dynamics. This study can also serve as an example in designing similar research on other species and geographical regions. ".
• 01GJWDPZ8R4C5NE98RFVBPWZ5B abstract "This paper scrutinizes the use of employee advocacy—the voluntary promotion of an organization and its goods and services by its own workforce. Nowadays, organizations often rely on employee advocacy as a significant marketing asset. This is exemplified in employee advocacy programs and platforms and anonymous employee review sites becoming increasingly popular. Despite its popularity in today's business environment, the use of employee advocacy programs and platforms, and also the content/messages that should be shared on these platforms to gain traction, is still a rather underexplored academic topic. By means of a content analysis, we try to uncover features that render messages shared on employee advocacy platforms to be more effective. As such, this study adds to extant employee advocacy research, while at the same time offering valuable insights for organizations that (want to) make use of employee advocacy programs and platforms.".
• 01GJWFPT33Y0NH7YBWDWTYKGGR abstract "La traduction est couramment définie comme une opération qui relie deux cultures nationales monolingues. Mais qu’en est-il des traductions produites au sein de cultures nationales ou régionales plurilingues comme le Canada, la Belgique, la Suisse ou les Caraïbes ? Peut-on encore arguer à leur propos de « sources » et de « cibles » ou de relations de « symétrie » et d’« équivalence », sachant que les cultures diglossiques ou pluriglossiques instaurent plutôt des inégalités entre les langues et les littératures ? Si les cartographies qui représentent l’espace culturel ont longtemps cherché à minorer ou à occulter ces inégalités, il s’impose de reconsidérer la nature des relations intraculturelles à mesure que les cultures se reconnaissent de plus en plus ouvertement comme plurilingues. Les notions de frontière (linguistique) et d’espace (national) y sont aujourd’hui mises à mal, en faveur d’une hybridation des langues dont la traduction se ressent à son tour. Cet ouvrage réunit des contributions théoriques, historiques et analytiques sur les traductions dans les cultures plurilingues. Il s’attache plus précisément à la période qui va de la naissance des idéologies monolingues au XIXe siècle à leur questionnement radical à partir de la seconde moitié du XXe siècle.".
• 01GJWFS7QFWB3RFE6RDX0VZ2DM abstract "Background: The voice use of choir singers is understudied despite the imbalance of high vocal demands versus low vocal education, and consequently increased risk for voice problems. Also, there is a lack of information on the effects of a performance on choristers’ voices. Available studies included performances of at least one hour. To date, no studies investigated the effects of a choir performance with a duration resembling vocal warm-ups. Purpose: The first purpose of this study was to determine the voice quality, capacities, symptoms and voice-related quality of life of choir singers. Secondly, the effect of a short choir performance, resembling warm-up duration (15 minutes), on the choristers’ voices was investigated. Methods: A randomized controlled trial was used. Thirty adult choir singers (25 women, 5 men; mean age: 32 years) were assigned randomly to an experimental group or a control group. Participants in the experimental group sung in choir for 15 minutes immediately after their pre voice assessment, whereas the control group was instructed to have standard voice use (one-on-one conversation with the investigator, no singing) across that time span. A second voice assessment was repeated afterwards. Results: The choir singers showed excellent voice quality and capacities with mean scores on the Dysphonia Severity Index and Acoustic Voice Quality Index of 7.5 and 2.0, respectively. Auditory-perceptually, the mean grade score was 5/100 corresponding with a normal to mildly deviant voice quality. Patient-reported outcome measures showed mean deviant scores, indicating a considerable singing voice handicap. The choir singers seem vulnerable for stress with a high occurrence rate of 76.7% (23/30). Compared with the control group, the Dysphonia Severity Index significantly improved, whereas the self-perceived presence of vocal fatigue and complaints increased after 15 minutes of choir singing. Fundamental frequency increased in both groups, being more outspoken in the experimental group. Conclusions: Choir singers show excellent voice quality and capacities, that further improve after a short choir performance of 15 minutes. Vocal fatigue and complaints, on the other hand, already increased after that short time span. Realizing that vocal load is much higher in real-life rehearsals, competitions and performances, choristers deserve and need a qualitative voice training and a strict follow-up. Future research should focus on effective vocal warm-up and cool-down programs for this population.".
• 01GJWRNXRMTA66K7M0SG1AR6AR abstract "Background Taenia solium cysticercosis is a zoonotic disease that is endemic in many low- and middle-income countries where risk factors for disease transmission are present. The economic impact of cysticercosis on public health and on the pig production sector is not well known in many of those countries, including Burundi. This study aimed at estimating the burden of T. solium cysticercosis in Burundi including data on humans and pigs. Methods Epidemiological and economic data were collected from literature up to July 30, 2021 and governmental and non-governmental agencies. Direct and indirect costs for neurocysticercosis (NCC)-associated epilepsy and losses due to porcine cysticercosis were estimated to assess the economic burden, while the health burden was estimated using zoonotic disability-adjusted life years (zDALYs). Different probability distributions (Uniform, Beta, Dirichlet and Gamma) were applied depending on the type of epidemiological parameter. Monte Carlo simulations and 100,000 iterations were used to calculate the 95% uncertainty interval (UI) for each parameter and perform sensitivity analyses. Results In Burundi, 4.26 million USD (95% UI, 1,858,308-8,190,951) were estimated as economic impact due to T. solium cysticercosis in humans and pigs, of which 40.2% (95% UI, 10.3-75.1) of the total costs were due to NCC-associated epilepsy and 59.8% (95% UI, 24.9-89.7) of the losses due to porcine cysticercosis. The cost per NCC-associated epilepsy case was 72 USD (95% UI, 25-168), representing 30.8% of the GDP per capita in 2020. The probable incident cases and deaths for NCC-associated epilepsy were 9065 (95% UI, 2370-16,716) and 61 (95% UI, 16-114), respectively. More than 2 zDALYs (95% UI, 1.1-3.4) per thousand person-years was estimated, of which an average of 1.3 DALYs [0;0] (95% UI, 0.3-2.6) was due to NCC- associated epilepsy and 0.8 animal loss equivalents (ALEs) (95% UI, 0.3-1.5) due to porcine cysticercosis. Conclusions This study provides evidence of a significant burden of T. solium cysticercosis for Burundi's population. We urge policy makers to use these evidence-based results and put T. solium cysticercosis on the public health agenda of the country. This study recommends urgent action to find solutions for integrated control strategies for T. solium cysticercosis in Burundi.".
• 01GJWW791BGQ92BD1FS6Y3B63M abstract "Introduction/Background To decrease immunosuppression and enhance T-cell activation in the tumour microenvironment, we conducted an open-label, investigator-initiated, multicohort, phase II trial (NCT03192059) of pembrolizumab with multimodal immunomodulation. Methodology Chemotherapy-pretreated patients were recruited into two experimental cohorts (cervical carcinoma or endometrial carcinoma) and one exploratory cohort (uterine sarcoma). Patients received an immunomodulatory five-drug cocktail consisting of low-dose cyclophosphamide, aspirin, lansoprazole, vitamin D, and curcumin starting two weeks before radioimmunotherapy (figure 1). Pembrolizumab, 200 mg/dose, was administered on day 1 of each 21-day cycle from day 15 onwards; one of the tumour lesions was irradiated (8Gyx3) on days 15, 17, and 19. The primary endpoint was objective response rate (irORR) per immune-related response criteria (irRC) at week 26; a lower bound of its 90% confidence interval (CI) of >10% in either experimental cohort was considered successful. Results Fifty patients were enrolled and treated across the cohorts (cervical, n=18; endometrial, n=25; sarcoma=7). Pathology review revealed that 3/7 sarcoma patients had carcinosarcoma. At week 26, the irORR was 11.1% (90%CI, 2.0 to 31.0) in cervical cancer, 12.0% (90%CI, 3.4 to 28.2) in endometrial cancer, and 14.3% (90% CI, 0.7 to 52.1) in uterine (carcino)sarcoma. The best overall response rate per RECIST v1.1 was 22.2% (90%CI, 8.0 to 43.9), 12.0% (90%CI, 3.4 to 28.2), and 28.6 (90%CI, 5.3 to 65.9). Median PFS was 13.4 weeks (11.3 to 26.1), 13.1 weeks (13.1 to 19.4), and 34.3 weeks (95%CI, 5.6 to 77.9) (figure 2A-C). Grade≥3 treatment-related adverse events were reported in 10 (55.6%), 9 (36.0%), and 4 (57.1%) patients. Overall, there was one (2.0%) possible treatment-related death. Health-related quality of life was generally stable over time. Multi-parameter immune monitoring characterised the patients and revealed changes throughout study treatment. Conclusion PRIMMO did not show sufficient evidence of a positive risk-to-benefit ratio to recommend a confirmatory phase III trial.".
• 01GJX4EKJ7KF9W1QQ3ZN90N9Q2 abstract "Cet article porte sur l’histoire des oppositions de transitivité et sur l’évolution du système des verbes labiles (verbes qui admettent des changements dans la transitivité sans changement formel du verbe, cf. La clé tourna dans la serrure ~ Pierre tourna la clé dans la serrure). Il se concentre sur l’évolution des systèmes de verbes labiles dans quelques branches de la famille des langues indo-européennes, qui témoignent de changements cruciaux dans ce domaine du système morpho-syntaxique (germanique, slave, indo-iranien). En intégrant des données de ces groupes linguistiques à celles d’autres branches indo-européennes et non indo-européennes qui attestent de changements radicaux dans le système des verbes labiles (comme le sémitique ou le chinois), l’article met à jour les mécanismes responsables de l’émergence et la disparition de la labilité. L’hypothèse d’un haut degré de labilité dans l’ancienne syntaxe indo-européenne fait l’objet d’une analyse critique. Notre contribution clarifiera la position des langues indo-européennes du point de vue de l’histoire des types de transitivité et contribuera à notre compréhension de la syntaxe proto-indo-européenne. En outre, l’article visera à expliquer pourquoi, dans plusieurs langues, la classe des verbes labiles est en augmentation constante (comme en anglais ou en grec), alors que dans d’autres langues, cette classe diminue (comme en sanskrit) ou manque totalement (comme en turc). Il s’efforcera de découvrir, systématiser et expliquer les caractéristiques et les processus qui déterminent l’évolution de la transitivité et les modifications des caractéristiques syntaxiques des verbes.".
• 01GJX8V1GMM61TS3Y244QXQSAG abstract "Polarity reversal has recently been argued to be the defining characteristic of counterfactuality. Ancient Greek had a diverse set of constructions which bring about polarity reversal that is not the direct result of a negation marker nor do they all express a counterfactual meaning. It is the aim of this paper to detail the major differences between these constructions synchronically and especially diachronically, focusing on counterfactual mood forms, counterfactual modal verbs, avertives (almost+past (im)perfective), non-counterfactual rhetorical questions and non-standard wishes. As a historically varied constructional group, these constructions bring about polarity reversal in different ways with different implicatures (e.g., counterfactual, contradictory, undesirable), but they most importantly differ in their diachronic conventionalization of polarity reversal. Whereas counterfactuals conventionalize their polarity reversal in various ways (e.g., changing temporal reference, counterfactual implicature transfer), non-counterfactual polarity reversal constructions create polarity reversal as a synchronic implicature through pragmatic means (e.g., a rhetorical question identifying a contradictory presupposition in the common ground or a non-standard wish evaluating an undesirable outcome to the speaker).".
• 01GJX96V231709NVX3M9VYQYWP abstract "This article argues for a typology of conditionals in Ancient Greek based on pragmatic rather than formal (e.g., mood) or semantic (e.g., temporal reference) criteria. It does so by proposing a novel pragmatic typology of conditionals with past tenses for Archaic and Classical Greek based on a corpus analysis of 973 conditionals. This article distinguishes 6 different pragmatic usages which generalise over mood and temporal variations: predictive, direct inferential, indirect inferential, illocutionary, metalinguistic and generic. They are distinguished by the pragmatic relationship between conditional and matrix clause and its direction, the illocutionary force of the matrix clause (e.g., declarative vs. assertoric/rhetorical question: wh-, yes-no, open) and types of implicature (e.g., contradictory vs. counterfactual). Despite some correlations with the pragmatic types such as order of p and q, pragmatic types cover multiple possible world distinctions based on formal marking such as mood or temporal reference; for example past tenses are used counterfactually but have different pragmatic usages, e.g., predictive, direct and indirect inferential or illocutionary, and temporal references, e.g., past and present. The diachrony of these conditionals also cuts across the pragmatic types, since direct inferential conditionals are a starting point for the replacement of the counterfactual optative by the counterfactual indicative, and generic conditionals with a past tense start to replace the so-called “iterative” optative in Classical Greek and replace it in Postclassical Greek (both of which have been discussed in preceding publications of the author). The article concludes with suggestions for applying this typology to conditionals in Ancient Greek in general.".
• 01GJX9T7V4NC132BB9TKC08PSR abstract "Research on the modal particles in Ancient Greek has mostly focused on speculations on their prehistory based on Homeric Greek or generalizing about their synchronic distributions (esp. in Classical Greek). Instead, this article details the diachronic spread of the modal particles in different modal constructions from Archaic to Classical Greek. It highlights those cases where its obligatory presence resulted in a different modal meaning (e.g. counterfactual and habitual usages) and critically discusses those cases of optional presence in Archaic and Classical Greek that prescriptivist grammarians have discouraged (e.g. with the future indicative and potential optative). Focusing on innovations allows us to (re)construct a chronology of the modal particles and their diachronic role in the Ancient Greek mood system, e.g. the replacement of the counterfactual optative by the indicative and its subsequent syntactic spread, and the creation of the past habitual and generic indicative replacing the habitual and generic optative (commonly dubbed 'iterative'). Finally, it is suggested that a similar diachronic approach which distinguishes between obligatory and optional presence could clarify the distribution of the modal particles in more complex areas such as Homeric Greek or the Ancient Greek dialects.".
• 01GJXDEE6QYKPP1T31QH3X5GCR abstract "The Sanskrit -ya-presents normally inflected in the active in Vedic (activa (quasi-)tantum) start to be employed with middle inflection in the later language, as in the case of śudhyati/‑te ‘becomes pure’ or muhyati/-te ‘becomes confused’. For some roots such as śudh, middle forms become as frequent as their active counterparts in the Dharmaśāstras (Smr̥tis) and Epics. It will be demonstrated that, contrary to the widely spread opinion, such middle forms never show passive meaning and occur in the same usage as the corresponding active forms. Accordingly, such verbal forms should be translated as ‘becomes pure’, rather than *‘is purified’; ‘becomes confused’, rather than *‘is confused’. I will argue that the choice of the diathesis (active/middle) is determined by metrical reasons in many cases and depends on the position of the verbal form in the pāda. These developments in the post-Vedic verbal system may be partly due to the fact that the active/middle opposition was lost in contemporaneous Middle Indic vernaculars, where only active endings survive.".
• 01GJXFQTH65HGZSB7BNP9V2VMR abstract "Cet article se concentre sur l'origine de plusieurs mots étymologiquement obscurs des vocabulaires grec et indo-iranien (surtout sanskrit) (principalement des noms faisant référence à certaines divinités ou créatures de panthéons mythologiques inférieurs), tels que gr. κένταυρος / skr. gandharvá- et gr. Κέρβερος / skr. śábala- (l’un des deux chiens de l’enfer dans la mythologie indienne). Je suppose que ces formes ne peuvent être tracées à aucun étymon proto-indo-européen, mais, plutôt, sont empruntées à une ou plusieurs langues non indo-européennes du Proche-Orient, probablement membre(s) de la macro-famille du Caucase du Nord.".
• 01GJXG2A1CF303EZEW704R8ZE4 abstract "Understanding human perceptions of public transport (PT) travel is essential for improving PT provision/ operation and the travel experiences of PT users, as well as for encouraging more people to use green and sustainable travel to reduce the congestion, air pollution, and energy costs that many urban systems are facing. Based on behavioral experiments and surveys, existing research has revealed that the spatial and temporal characteristics of PT travel greatly influence human perceptions; however, neuroimaging evidence confirming these findings remains lacking. In this study, we conducted a functional magnetic resonance imaging-(fMRI-) based PT travel and recall experiment with 9 participants and collected 651 unique bus travel trajectories in Beijing City over 21 days. We extracted 22 spatial and temporal characteristics and derived brain activity pat-terns for each PT travel route. A representational similarity analysis (RSA) was performed to quantify the relationship between these spatial and temporal characteristics and brain activity patterns. Verbal descriptions were collected to cross-check the brain imaging results. We show that the participants' brain activity patterns were significantly correlated with seven spatial (i.e., circuity, turn, angular deviation, slope, point of interest (POI), and land use) and two temporal (i.e., travel time and waiting time) features, although individuals' per-ceptions of PT travel differed substantially. These findings are in line with the participants' verbal reports. Our findings offer new neuroimaging evidence from an interdisciplinary perspective on the perception of the spatial and temporal characteristics of PT travel, which not only lays an empirical basis but also provides a "neuro-urbanism" approach to improve travelers' subjective well-being during PT travel.".
• 01GJXGANDXG6SVNF87YJWGMNAA abstract "This paper focuses on the Indo-European myth of the primordial incest, foremost using evidence from Vedic (Ṛgveda and Atharvaveda) and, more broadly, Indo-Iranian. On the basis of a philological and linguistic analysis of the dialogue hymn RV 10.10 (Yama and Yamī), I argue that Yamī, notorious for her hyper-sexuality, can be considered as the central figure of this common Indo-Iranian myth, being the (potential) sexual partner of the first human, Yama, and yet retaining connection with the world of gods and half-gods (demons) and betraying a number of features of a female half-deity. I will also briefly discuss possible parallels from other Indo-European mythologies, in particular, from Celtic and Germanic (Norse) mythologies, paying special attention to the goddess of sexuality Freyja, comparable in several respects to Yamī.".
• 01GJXHB5K5XWY2Y808XJM38CB1 abstract "The article discusses the etymology of the Greek theonym Κρόνος (Cronus), qualified by all dictionaries as etymologically unclear. I argue that this name can be considered as a member of the small class of nouns in ‑ όνο‑ with agent‑instrumental semantics. Following an old proposal by H. D. Müller (later advocated by M. Janda), I adopt the analysis of this name as a derivative of the verbal root *κερ‑ (cf. κείρω ‘cut’, Arm. kʻerem ‘scratch, rub’, Old Norse skera ‘cut’, etc.), thus explaining the name of the harvest god Cronus as ‘the one who cuts; castrator’, referring to one of his main functions as well as to the myth of castration of his father Uranus by Cronus. The class of nouns in ‑ όνο‑ (/ f. ‑ονη) arguably includes such nouns as θρ‑όνο‑ς ‘seat, chair’ (analysable as a derivative of *θερ‑ < PIE *dʰer‑ ‘fix, hold’), κλ‑όνο‑ς ‘excitement, throng’, φθ‑όνο‑ς ‘malice, envy’ (PIE *dʰegʷʰ‑ ‘almost reach’), βελ‑όνη ‘needle’ (PIE *gʷel‑ ‘throw, pierce’); ἀκ‑όνη ‘whetstone’ (PIE *h₂eḱ‑ ‘sharp(en)’). Possible correspondences of this morphological type outside Greek may include the Celtic type in ‑ono/ā‑ (cf. Nechtan, Mātronā) and Indo‑Iranian formations in ‑āna‑ of the type yudhāna‑ ‘enemy’ (yudh ‘fight’) or budhāna‑ ‘sage, teacher’ (budh ‘awake; observe, perceive’), formally coinciding with the middle participles made from root stems and, probably, partly absorbed by them.".
• 01GJXQEG7GVD541YSCWSJT2AEJ abstract "De talenbewuste leraar zoekt – met alle inzichten en handvatten op zak – naar wat leerlingen nodig hebben, zodat ze zich goed voelen en zich blijven ontwikkelen tot trotse taalgebruikers. Talenbewust lesgeven komt alle leerlingen ten goede, maar is bij uitstek van belang voor leerlingen uit kwetsbare thuissituaties en leerlingen met een meertalige achtergrond, die in sommige gevallen minder goed presteren op school dan eentalige leerlingen. Talige diversiteit en de achtergrond van leerlingen worden vaak gezien als belangrijke oorzaken voor deze onderwijskloof. Uit onderzoek blijkt echter dat deze kloof door het aanbieden van geschikte vormen van taalonderwijs, zoals talenbewust lesgeven, kan worden overbrugd. Talenbewust lesgeven helpt (toekomstige) leraren in het basisonderwijs om aan de slag te gaan met talige diversiteit in de klas, om zo de gewenste taalleeromgeving te creëren.".
• 01GJYHWSC9N2FCK913D8GET7KZ abstract "Nitrogen is an essential element for the yield and quality of grain. In this study, the structural and physicochemical properties of two common buckwheat varieties under four nitrogen levels (0, 90, 180, 270 kg N ha(-1)) at one location in two years were investigated. With increasing nitrogen level, the contents of moisture and amylose decreased but the contents of ash and crude protein increased. Excessive nitrogen application significantly increased the granule size, but reduced the light transmittance, water solubility, swelling power, absorption of water and oil. All the samples showed a typical A - type pattern, while high relative crystallinity and low order degree were observed under high nitrogen level. The samples under high nitrogen level had lower textural properties, pasting properties and rheological properties but higher pasting temperature and gelatinization enthalpy. These results indicated that nitrogen fertilizer significantly affected the structural and physicochemical properties of common buckwheat starch.".
• 01GJYHWSD1P1AKM9HFY49BVNXQ abstract "Two pea varieties were used to investigate the changes in the structural and physicochemical properties of pea starch during germination. The results showed that there were more obvious crimples on the surface of the germinated pea starch granules than native starch. Germination treatment led to significant increases in the amylose content and granule size distribution, while volume proportion of germinated pea starch significantly decreased. All the pea starches showed a typical C-type crystalline structure but the relative crystallinity slightly decreased during germination. Compared with the native starches, the light transmittance and absorption capacities of water and oil all firstly increased and then decreased with the increase of germination time. Moreover, there were obvious increases in the peak viscosity, trough viscosity and final viscosity, while the pasting temperature significantly decreased as germination prolonged to 4 d. The gelatinization temperature of pea starch firstly decreased and then increased during germination, while germinated pea starch showed higher gelatinization enthalpy than that of native starch. In conclusion, the structural and physicochemical properties of pea starch could be significantly affected under germination treatment, which may provide a theoretical basis to promote the utilization of germinated pea starch in the food industry.".
• 01GJYPTWZ28MXH6R1CNP5ASS5X abstract "Warmtenetten bieden, als potentieel koolstofarm energiesysteem, een valabel antwoord op de door het algemeen streven naar duurzaamheid gevoede roep naar energietransitie. Zij doen echter ook juridische vraagstukken ontstaan. Een van die vraagstukken betreft de wijze waarop, naar huidig recht, de (onder)grond juridisch in gebruik kan worden gegeven voor de aanleg en exploitatie van warmtenet-infrastructuur én of die mogelijkheden voldoen. Op deze vraag formuleert het gevoerde onderzoek een antwoord door ten eerste de eigenheden van de wettelijke en contractuele instrumenten die het grondgebruik vorm kunnen geven, in beeld te brengen en ten tweede deze theoretische bevindingen af te toetsen aan twee concreet uitgewerkte warmtecases. Het gevoerde onderzoek noopt tot de conclusie dat de eigenheden van elke rechtsfiguur de bruikbaarheid ervan voor de aanleg en exploitatie van warmtenet-infrastructuur kunnen beperken of net versterken. De juridische optimalisering van het grondgebruik bij de uitrol van warmtenetten hangt af van het adequaat gebruik van de bestaande rechtsfiguren, gelet op onder meer de specifieke (technische) kenmerken van warmtenetten. Dit proefschrift biedt stakeholders concreet uitgewerkte voorstellen om het grondgebruik voor de aanleg en exploitatie van warmtenet-infrastructuur juridisch op efficiënte wijze te organiseren.".
• 01GJYPW244RNHJWN4HPV2WPF9M abstract "Vitrimers are a new category of polymers with a dynamic covalently cross-linked network. This gives to vitrimers the chemical resistance and high mechanical properties of thermosets as they have a cross-linked structure, and the re-processability of thermoplastics thanks to the dynamic character of their network bonds. Such a unique combination of features makes vitrimers interesting for composite applications. However, the research on manufacturing and reprocessing of vitrimer composites is limited. In this work, a new epoxy-based vitrimer was used for the production of fibre-reinforced composites. Glass-Fibre-Reinforced Vitrimers (GFRVs) were produced by Vacuum Assisted Resin Infusion (VARI) and their quality was visually evaluated. The re-processability of the composite was assessed by means of thermoforming after curing and the quality of the thermoformed specimens was evaluated by digital microscopy.".
• 01GJYQ0PCTSJD1JCXPY4B2KNQH abstract "Chemische recyclage van vast plastiek afval (SPW) biedt de maatschappij een uitgelezen kans om verdere vervuiling van oceanen en land tegen te gaan, en de circulaire economie te omarmen. Chemische recyclagetechnologieën op basis van pyrolyse zijn dominant door hun (economische) robuustheid. Desalniettemin zijn een beter inzicht in de achterliggende chemie en innovatievere reactorontwerpen vereist om de efficiëntie van de processen te verbeteren. Dit kan enkel verwezenlijkt worden door conversieprofielen en productdistributies te modelleren. Het hoofddoel van deze doctoraatsthesis is het ontwikkelen van geavanceerde, stochastische kinetische Monte Carlo simulatiemodellen voor de snelle pyrolyse van poly(styreenperoxide) en polystyreen. De ontwikkelde modellen verbeteren het inzicht in de kinetiek van pyrolyseprocessen. Ze zijn tevens cruciaal voor de verdere ontwikkeling en optimalisatie van pyrolysereactoren.".
• 01GJYQ295F2YG71Z196JXMK2MT abstract "Tissue-resident macrophages adapt to local signals within tissues to acquire specific functions. Neoplasia transforms the tissue, raising the question as to how the environmental perturbations contribute to tumor associated macrophage (TAM) identity and functions. Combining single-cell RNA sequencing (scRNA-seq) with spatial localization of distinct TAM subsets by imaging, we discover that TAM transcriptomic programs follow two main differentiation paths according to their localization in the stroma or in the neoplastic epithelium of the mammary duct. Furthermore, this diversity is exclusively detected in a spontaneous tumor model and tracks the different tissue territories as well as the type of tumor lesion. These TAM subsets harbor distinct capacity to activate CD8+ T cells and phagocyte tumor cells, supporting that specific tumor regions, rather than defined activation states, are the major drivers of TAM plasticity and heterogeneity. The distinctions created here provide a framework to design cancer treatment targeting specific TAM niches.".
• 01GJYQ295YF7JSH99TF8KFEN5W abstract "Wallerian degeneration (WD) is a process of autonomous distal degeneration of axons upon injury. Macrophages (MPs) of the peripheral nervous system (PNS) are the main cellular agent controlling this process. Some evidence suggests that resident PNS-MPs along with MPs of hematogenous origin may be involved, but whether these two subsets exert distinct functions is unknown. Combining MP-designed fluorescent reporter mice and coherent anti-Stokes Raman scattering (CARS) imaging of the sciatic nerve, we deciphered the spatiotemporal choreography of resident and recently recruited MPs after injury and unveiled distinct functions of these subsets, with recruited MPs being responsible for efficient myelin stripping and clearance and resident MPs being involved in axonal regrowth. This work provides clues to tackle selectively cellular processes involved in neurodegenerative diseases.".
• 01GJYQ2963965N44YFSSX9SBK9 abstract "Sepsis is characterized by a systemic inflammation that can cause an immune dysfunction, for which the underlying mechanisms are unclear. We investigated the impact of cecal ligature and puncture (CLP)-mediated polymicrobial sepsis on monocyte (Mo) mobilization and functions. Our results show that CLP led to two consecutive phases of Mo deployment. The first one occurred within the first 3 days after the induction of the peritonitis, while the second phase was of a larger amplitude and extended up to a month after apparent clinical recovery. The latter was associated with the expansion of Mo in the tissue reservoirs (bone marrow and spleen), their release in the blood and their accumulation in the vasculature of peripheral non-lymphoid tissues. It occurred even after antibiotic treatment but relied on inflammatory-dependent pathways and inversely correlated with increased susceptibility and severity to a secondary infection. The intravascular lung Mo displayed limited activation capacity, impaired phagocytic functions and failed to transfer efficient protection against a secondary infection into monocytopenic CCR2-deficient mice. In conclusion, our work unveiled key dysfunctions of intravascular inflammatory Mo during the recovery phase of sepsis and provided new insights to improve patient protection against secondary infections.".
• 01GJYQ2968E808ZK7Y80KJ0JXQ abstract "Tumor-associated macrophages (TAM) represent the main immune cell population of the tumor microenvironment in most cancer. For decades, TAM have been the focus of intense investigation to understand how they modulate the tumor microenvironment and their implication in therapy failure. One consensus is that TAM are considered to exclusively originate from circulating monocyte precursors released from the bone marrow, fitting the original dogma of tissue-resident macrophage ontogeny. A second consensus proposed that TAM harbor either a classically activated M1 or alternatively activated M2 polarization profile, with almost opposite anti- and pro-tumoral activity respectively. These fundamental pillars are now revised in face of the latest discoveries on macrophage biology. Embryonic-derived macrophages were recently characterized as major contributors to the pool of tissue-resident macrophages in many tissues. Their turnover with macrophages derived from precursors of adult hematopoiesis seems to follow a regulation at the subtissular level. This has shed light on an ever more complex macrophage diversity in the tumor microenvironment than once thought and raise the question of their respective implication in tumor development compared to classical monocyte-derived macrophages. These recent advances highlight that TAM have actually not fully revealed their usefulness and deserve to be reconsidered. Understanding the link between TAM ontogeny and their various functions in tumor growth and interaction with the immune system represents one of the future challenges for cancer therapy.".
• 01GJYQ296D128BXS7859E1R0VJ abstract "In most cancers, myeloid cells represent the major component of the immune microenvironment. Deciphering the impact of these cells on tumor growth and in response to various anti-tumor therapies is a key issue. Many studies have elucidated the role of tumor-associated monocytes and tumor-associated macrophages (TAM) in tumor development, angiogenesis, and therapeutic failure. In contrast, tumor dendritic cells (DC) are associated with tumor antigen uptake and T-cell priming. Myeloid subpopulations display differences in ontogeny, state of differentiation and distribution within the neoplastic tissue, making them difficult to study. The development of high-dimensional genomic and cytometric analyses has unveiled the large functional diversity of myeloid cells. Important fundamental insights on the biology of myeloid cells have also been provided by a boom in functional fluorescent imaging techniques, in particular for TAM. These approaches allow the tracking of cell behavior in native physiological environments, incorporating spatio-temporal dimensions in the study of their functional activity. Nevertheless, tracking myeloid cells within the TME remains a challenging process as many markers overlap between monocytes, macrophages, DC, and neutrophils. Therefore, perfect discrimination between myeloid subsets remains impossible to date. Herein we review the specific functions of myeloid cells in tumor development unveiled by image-based tracking, the limits of fluorescent reporters commonly used to accurately track specific myeloid cells, and novel combinations of myeloid-associated fluorescent reporters that better discriminate the relative contributions of these cells to tumor biology according to their origin and tissue localization.".
• 01GJYQ2E2XBP7KHV6BJTKBVW4G abstract "Radiotherapy (RT) represents one of the main anticancer approaches for the treatment of solid tumors. Beyond the expected direct effects of RT on tumor cells, evidence supporting the importance of an immune response to RT is growing. The balance between RT-mediated immunogenic and tolerogenic activity is ill-defined and deserves more attention. Herein, a murine model of head and neck squamous cell carcinoma was used to demonstrate that RT upregulated CCL2 chemokine production in tumor cells, leading to a CCR2-dependent accumulation of tumor necrosis factor alpha (TNF alpha)-producing monocytes and CCR2(+) regulatory T cells (Treg). This corecruitment was associated with a TNF alpha-dependent activation of Tregs, dampening the efficacy of RT. Our results highlight an unexpected cross-talk between innate and adaptive immune system components and indicate CCL2/CCR2 and TNFa as potential clinical candidates to counterbalance the radioprotective action of monocyte-derived cells and Tregs, paving the way for potent combined radioimmunotherapies.".
• 01GJYQ2E328XXD0WJMGZGTAQ56 abstract "Tissue-resident macrophages can self-maintain without contribution of adult hematopoiesis. Herein we show that tissue-resident interstitial macrophages (Res-TAMs) in mouse lungs contribute to the pool of tumor-associated macrophages (TAMs) together with CCR2-dependent recruited macrophages (MoD-TAMs). Res-TAMs largely correlated with tumor cell growth in vivo, while MoD-TAMs accumulation was associated with enhanced tumor spreading. Both cell subsets were depleted after chemotherapy, but MoD-TAMs rapidly recovered and performed phagocytosis-mediated tumor clearance. Interestingly, anti-VEGF treatment combined with chemotherapy inhibited both Res and Mod-TAM reconstitution without affecting monocyte infiltration and improved its efficacy. Our results reveal that the developmental origin of TAMs dictates their relative distribution, function, and response to cancer therapies in lung tumors.".
• 01GJYQ2JZMG20C726V2PY129NS abstract "Understanding the mechanisms of cellular differentiation is challenging because differentiation is initiated by signaling pathways that drive temporally dynamic processes, which are difficult to analyze in vivo. We establish a new tool, Timer of cell kinetics and activity (Tocky; or toki [time in Japanese]). Tocky uses the fluorescent Timer protein, which spontaneously shifts its emission spectrum from blue to red, in combination with computer algorithms to reveal the dynamics of differentiation in vivo. Using a transcriptional target of T cell receptor (TCR) signaling, we establish Nr4a3-Tocky to follow downstream effects of TCR signaling. Nr4a3-Tocky reveals the temporal sequence of events during regulatory T cell (Treg) differentiation and shows that persistent TCR signals occur during Treg generation. Remarkably, antigen-specific T cells at the site of autoimmune inflammation also show persistent TCR signaling. In addition, by generating Foxp3-Tocky, we reveal the in vivo dynamics of demethylation of the Foxp3 gene. Thus, Tocky is a tool for cell biologists to address previously inaccessible questions by directly revealing dynamic processes in vivo.".
• 01GJYQCRXWC8BXZJ9AK078EJ78 abstract "In this proof-of-concept study on food contaminated with norovirus, we investigated the feasibility of metagenomics as a new method to obtain the whole genome sequence of the virus and perform strain level characterization but also relate to human cases in order to resolve foodborne outbreaks. We tested several preparation methods to determine if a more open sequencing approach, i.e., shotgun metagenomics, or a more targeted approach, including hybrid capture, was the most appropriate. The genetic material was sequenced using Oxford Nanopore technologies with or without adaptive sampling, and the data were analyzed with an in-house bioinformatics workflow. We showed that a viral genome sequence could be obtained for phylogenetic analysis with shotgun metagenomics if the contamination load was sufficiently high or after hybrid capture for lower contamination. Relatedness to human cases goes well beyond the results obtained with the current qPCR methods. This workflow was also tested on a publicly available dataset of food spiked with norovirus and hepatitis A virus. This allowed us to prove that we could detect even fewer genome copies and two viruses present in a sample using shotgun metagenomics. We share the lessons learnt on the satisfactory and unsatisfactory results in an attempt to advance the field.".
• 01GJYQH85DSXVQG0C8F56Y8Z2T abstract "Air jet weaving, where the weft yarn is transported through the machine using air as propelling medium, is a popular weaving method due to its superior productivity, however at the cost of a high energy demand. The interactions between the weft yarn and the air jets are complex and not yet fully understood. Moreover, state-of-the-art techniques to simulate these interactions, are far from mature since the yarn is often simplified as a smooth and solid cylinder. Therefore, a novel multi-scale and multi-physics approach is proposed to simulate the interaction between weft yarns and air jets. Starting from microcomputed tomography (µCT) scans of a yarn used in air jet weaving, a high-fidelity microscale geometrical model is constructed, representing the yarn by its fibers. This geometrical model is used as input for microstructural simulations and will be used for flow simulations on microscale, where the aim is to extract local coefficients and as such characterize the yarn. These coefficients are then used as input for computationally cheap macroscale models, where the yarn is represented by its centerline containing the microscale properties. In a final stage, the macroscale structural and flow models will be coupled as to obtain a full FSI simulation of a weft insertion in an air jet loom. Current paper highlights the microscale geometry extraction of a fine wool fiber yarn of 28.8 tex. Consecutively, a computational framework is proposed to simulate the tensile behavior of this yarn, using the previously obtained microscale geometrical model. The resulting stress-strain curve of the yarn is compared to experiments and shows good correspondence.".
• 01GJYQMR1EKGQDDZH8XTXNK8CN abstract "Axial flows in tube bundle geometries are omnipresent in nuclear power plants, including fuel assemblies and heat exchangers. The tubes are often long and slender which makes them susceptible to flow-induced vibrations. Current reactor research investigates the use of wires helicoidally wound around each rod, to preserve their mutual distance. This poses new challenges for numerical simulations. The wire-wrapped geometry is complex, among other things due to small gaps, making the meshing process complicated and cumbersome. This research explores the use of overset grids for such wire-wrapped tube bundles. This meshing method allows grids to overlap and the flow solution is interpolated between the different grids, providing more freedom for meshing. In this case the approach consists of making one grid for a single tube with a wire, termed the component mesh, and placing this grid in a so-called background mesh that takes into account other geometrical features (e.g. the bundle duct). In the case of bundles, the same tube mesh can be repeated several times without additional meshing effort, regardless of the bundle size. The approach is verified using 4 cases found in literature, using the same component mesh either one or multiple times for each case, thus reducing the meshing effort to a minimum thanks to the freedom and re-usability overset offers. The first two cases involve a fluid-structure interaction simulation of a single wire-wrapped tube in a cylindrical domain, the first one simulating a steady deformation and the second one a free vibration of the tube. Good agreement with results in literature was found. The latter two cases are Computational Fluid Dynamics simulations of a 7-pin and 19-pin bundle in a hexagonal duct, and excellent agreement with literature results was obtained. The overset approach was proven beneficial for simulating wire-wrapped bundle geometries: with largely reduced effort the same predictive capabilities can be obtained and potentially even extended.".
• 01GJYQT88VYKVFVPNX5AJEJ6AP abstract "The holistic nature of omics studies makes them ideally suited to generate hypotheses on health and disease. Sequencing-based genomics and mass spectrometry (MS)-based proteomics are linked through epigenetic regulation mechanisms. However, epigenomics is currently mainly focused on DNA methylation status using sequencing technologies, while studying histone posttranslational modifications (hPTMs) using MS is lagging, partly because reuse of raw data is impractical. Yet, targeting hPTMs using epidrugs is an established promising research avenue in cancer treatment. Therefore, we here present the most comprehensive MS-based preprocessed hPTM atlas to date, including 21 T-cell acute lymphoblastic leukemia (T-ALL) cell lines. We present the data in an intuitive and browsable single licensed Progenesis QIP project and provide all essential quality metrics, allowing users to assess the quality of the data, edit individual peptides, try novel annotation algorithms and export both peptide and protein data for downstream analyses, exemplified by the PeptidoformViz tool. This data resource sets the stage for generalizing MS-based histone analysis and provides the first reusable histone dataset for epidrug development.".
• 01GJYR5ES45BSP8PK8Q1VA2GJ2 abstract "In recent years, the continuing growth of the network edge, along with increasing user demands, has led to the need for increasingly complex and responsive management strategies for edge services. Many of these strategies are cloudbased, offering near-perfect solutions at the cost of requiring massive computational power, or edge-based, offering reactive strategies to changing edge conditions. This paper presents a decentralized, pro-active Quality of Experience (QoE) based architecture designed to run on edge nodes, which allows nodes to predict optimal service providers (fog nodes) in advance and request their services. The concepts behind the components of the architecture are explained, as well as geometry-inspired design decisions to limit model size. Evaluations on an NVIDIA Jetson Nano show that the architecture can predict optimal service providers for an edge node in real-time for 5 to 20 QoS (Quality of Service) and QoE parameters, with at least 50 potential fog nodes, and that overall QoE resulting from its use is improved by 1% to 18% over previous work such as SoSwirly, depending on the scenario.".
• 01GJYSMWMAEH0FGKRTEJR0KNRB abstract "Physical reservoir computing, a paradigm bearing the promise of energy-efficient high-performance computing, has raised much attention in recent years. We argue though, that the effect of signal propagation delay on reservoir task performance, one of the most central aspects of physical reservoirs, is still insufficiently understood in a more general learning context. Such physically imposed delay has been found to play a crucial role in some specific physical realizations, such as integrated photonic reservoirs. While delays at the readout layer and input of Echo State Networks (ESNs) have been successfully exploited before to improve performance, to our knowledge this feature has not been studied in a more general setting. We introduce inter-node delays, based on physical distances, into ESNs as model systems for physical reservoir computing. We propose a novel ESN design that includes variable signal delays along the connections between neurons, comparable to varying axon lengths in biological neural networks or varying length delay lines in physical systems. We study the impact of the resulting variable inter-node delays in this setup in comparison with conventional ESNs and find that incorporating variable delays significantly improves reservoir performance on the NARMA-10 benchmark task.".
• 01GJYT97PQ08YCWR7ABXTEQJTR abstract "In six-degrees-of-freedom light-field (LF) experiences, the viewer's freedom is limited by the extent to which the plenoptic function was sampled. Existing LF datasets represent only small portions of the plenoptic function, such that they either cover a small volume, or they have limited field of view. Therefore, we propose a new LF image dataset "SILVR" that allows for six-degrees-of-freedom navigation in much larger volumes while maintaining full panoramic field of view. We rendered three different virtual scenes in various configurations, where the number of views ranges from 642 to 2226. One of these scenes (called Zen Garden) is a novel scene, and is made publicly available. We chose to position the virtual cameras closely together in large cuboid and spherical organisations (2.2m3 to 48m3), equipped with 180° fish-eye lenses. Every view is rendered to a color image and depth map of 2048px × 2048px. Additionally, we present the software used to automate the multiview rendering process, as well as a lens-reprojection tool that converts between images with panoramic or fish-eye projection to a standard rectilinear (i.e., perspective) projection. Finally, we demonstrate how the proposed dataset and software can be used to evaluate LF coding/rendering techniques (in this case for training NeRFs with instant-ngp). As such, we provide the first publicly-available LF dataset for large volumes of light with full panoramic field of view.".
• 01GJYTZRT6QZBC4VBEFJJH7DT3 abstract "The effect of Si/Al ratio on operating regime, activity and selectivity in methanol-to-olefins conversion has been assessed over H-ZSM-5 zeolites with high (Si/Al=25), moderate (Si/Al=40) and low (Si/Al=140) acid site concentration, in a wide temperature (325 - 450 degrees C) and space time range (0.44 -110.0 kg(cat )s mol(MeOH)(-1)). For Si/Al-25 no stable regime is achieved, shifting immediately from transition to deactivation, while Si/Al=140 always ensures stable operation. At lower Si/Al ratio and increasing temperature, reaction pathways shift to produce more C-3-C-5 olefins. Suppression of bimolecular methylation and hydride transfer in favour of monomolecular alkene cracking is at the origin of such behaviour, either by increased acid sites distance or due to reduced physisorbed concentrations and activation energy differences. The latter phenomena cause a peculiar conversion decrease with increasing temperature between 350 and 400 degrees C. Consistent, well-designed data acquisition allowed insights into the complex mechanism and the effect of catalyst properties and temperature thereon.".
• 01GJYVRX9H3HS97N2MEB8TRWAH abstract "More than half of the Flemish adolescents report mild to serious mental problems. Healthy lifestyle behaviors are protective factors for mental health, and a focus on modifiable health behaviors for the promotion of mental health can be both destigmatizing and empowering. Increasingly, mobile technology is being used to deliver health behavior change interventions, and mobile health (mHealth) interventions have been shown feasible in an adolescent population. The goal of the project within this doctoral thesis was to develop and evaluate a mobile healthy lifestyle intervention for the promotion of mental health in adolescents. Specifically, we aimed to develop a multicomponent mHealth intervention, to evaluate its effectiveness in promoting healthy lifestyles and mental health, to gain insight in the components or mechanisms that led to behavior change, and to investigate determinants and outcomes of different types of engagement with the intervention. In a first phase, the mHealth intervention #LIFEGOALS was created. The requirements for the technology were based on theory and evidence, and on an investigation of the context and the needs and expectations of stakeholders and end-users. The design took place in an interdisciplinary team and in close collaboration with adolescents and stakeholders. An iterative development process resulted in a self-regulation-based app, coupled with an activity tracker, which was complemented with gamification elements, a support chatbot, and narrative videos. The participatory development and final intervention are described. In a second phase, the #LIFEGOALS intervention was evaluated. First, to evaluate the effect of the narrative on automatic attitude change, we aimed to develop an implicit measure to assess automatic sleep-related attitudes. However, the findings from our validation study indicated that the developed implicit measures were not suited to assess automatic sleep-related attitudes. For that reason we did not pursue the use of implicit measures for evaluating the narrative component. The effectiveness of the #LIFEGOALS intervention as a whole, was evaluated in a cluster-controlled trial. Self-reports and accelerometers were used to assess the effect of the intervention on health behavior and mental health. Results were mixed. The mHealth intervention showed beneficial effects on physical activity, sedentary behavior, sleep quality, mood, and self-perception. Most of the effects, however, were moderated by pandemic-related measures and only present in a close-to-normal context. For participants who had to follow partially remote education due to the pandemic, negative intervention effects were found on health-related quality of life, mood, and perceived social 1 support. This quantitative trial was complemented with qualitative interviews with participants who had actively used the #LIFEGOALS app. Interviewed users experienced that the reward system and the self-regulation techniques had contributed to their behavior change, and that increased health-related awareness had motivated to change behavior. The findings furthermore pointed to social factors, quality of technology, and autonomy as important elements within mHealth for adolescent health promotion. As a final part of the evaluation, engagement with the intervention was investigated. Analyses of continuously logged usage data and self-reported experience of engagement with the intervention revealed overall low usage of the app. There was a clear drop in usage after the first week. After six weeks, only one third of the participants who had installed the intervention still used the app. Ratings of experience were neutral to positive and dropped only slightly over time. Non-usage attrition was lowest with the activity-tracker, and its usage showed the weakest correlation with other component use. The self-regulation techniques and gamification were the most used app-components, and their use was strongly interrelated. Experiential engagement and usage of the activity-tracker differed as a function of education type. Using cluster analysis, we identified four groups of engagement with the #LIFEGOALS intervention: no usage, initial usage, mainly use of the activity tracker, and mainly use of the narrative. Age, social support, and depressive symptoms predicted engagement group, but the engagement group did not differentially affect the change in health behavior outcomes from pre- to post-intervention. To conclude, despite the extensive participatory development of the #LIFEGOALS intervention, engagement with the app was low. This limited our ability to investigate intervention effects and engagement types. The mixed effects of the intervention on healthy lifestyles and mental health were moreover moderated by the COVID-19 pandemic-related context. The self-regulation and gamification components are likely to have contributed to behavior change. More research is needed to optimize and evaluate a support chatbot and narrative videos within mHealth. Tailoring the intervention to the context, leveraging positive social influence, and integrating implementation science in the development process, are discussed as possible ways to improve effective engagement with mHealth in a general adolescent population.".
• 01GJYWS3YKF20EHV5M64Z7YT76 abstract "For vegetation monitoring, it is crucial to understand which changes are caused by the measurement setup and which changes are true representations of vegetation dynamics. UAV–LiDAR offers great possibilities to measure vegetation structural parameters; however, UAV–LiDAR sensors are undergoing rapid developments, and the characteristics are expected to keep changing over the years, which will introduce data inter-operability issues. Therefore, it is important to determine whether datasets acquired by different UAV–LiDAR sensors can be interchanged and if changes through time can accurately be derived from UAV–LiDAR time series. With this study, we present insights into the magnitude of differences in derived forest metrics in savanna woodland when three different UAV–LiDAR systems are being used for data acquisition. Our findings show that all three systems can be used to derive plot characteristics such as canopy height, canopy cover, and gap fractions. However, there are clear differences between the metrics derived with different sensors, which are most apparent in the lower parts of the canopy. On an individual tree level, all UAV–LiDAR systems are able to accurately capture the tree height in a savanna woodland system, but significant differences occur when crown parameters are measured with different systems. Less precise systems result in underestimations of crown areas and crown volumes. When comparing UAV–LiDAR data of forest areas through time, it is important to be aware of these differences and ensure that data inter-operability issues do not influence the change analysis. In this paper, we want to stress that it is of utmost importance to realise this and take it into consideration when combining datasets obtained with different sensors.".
• 01GJYXJWD4BEMPT88EQ21CWKPY abstract "Most commercial dressings with moderate to high exudate uptake capacities are mechanically weaker and/or require a secondary dressing. The current research article focuses on the development of hydrogel-based wound dressings combining mechanical strength with high exudate absorption capacities using acrylate-endcapped urethane-based precursors (AUPs). AUPs with varying poly(ethylene glycol) backbone molar masses (10 and 20 kg mol(-1)) and endcap chemistries are successfully synthesized in toluene, subsequently processed into UV-cured hydrogel sheets and are benchmarked against several commercial wound dressings (Hydrosorb, Kaltostat, and Mepilex Ag). The AUP materials show high gel fractions (>90%) together with strong swelling degrees in water, phosphate buffered saline and simulated wound fluid (12.7-19.6 g g(-1)), as well as tunable mechanical properties (e.g., Young's modulus: 0.026-0.061 MPa). The AUPs have significantly (p < 0.05) higher swelling degrees than the tested commercial dressings, while also being mechanically resistant. The elasticity of the synthesized materials leads to an increased resistance against fatigue. The di- and hexa-acrylated AUPs show excellent in vitro biocompatibility against human foreskin fibroblasts, as evidenced by indirect MTS assays and live/dead cell assays. In conclusion, the processed AUP materials demonstrate high potential for wound healing application and can even compete with commercially available dressings.".
• 01GJYY19BDVCVSQR1P69BFN922 abstract "The effect of metabolic syndrome (MetS) and clusters of its components on central blood pressure (CBP) has not been well characterized. We aimed to describe the effect of MetS and clusters of its components on CBP in a large population and to identify whether this effect differs in men and women. We studied 15,609 volunteers (43% women) from 10 cohorts worldwide who participated in the Metabolic syndrome and Artery REsearch Consortium. MetS was defined according to the NCEP-ATP III criteria (GHTBW, glucose, high-density lipoprotein cholesterol, triglyceride, blood pressure, waist circumference). CBP was measured noninvasively and acquired from pulse wave analysis by applanation tonometry. MetS was associated with a 50% greater odds of having higher CSBP. After controlling for age, male sex, non HDL cholesterol, diabetes mellitus, and mean arterial pressure, only specific clusters of MetS components were associated with a higher CSBP; and some of them were significant in women but not in men. We identified "risky clusters" of MetS variables associated with high CSBP. Future studies are needed to confirm they identify subjects at high risk of accelerated arterial aging and, thus, need more intensive clinical management.".
• 01GJYY19BN1WB58NKXMQVNVS70 abstract "Background: Type 2 diabetes mellitus (T2DM) is associated with a high risk of vascular complications. Interestingly, cocoa flavanols (CF) can exert beneficial vascular effects in non-diabetic subjects. However, these effects have only been scarcely studied in T2DM. Therefore, we performed a study to assess the effects on vascular reactivity of a single dose of CF (790 mg) in T2DM and whether certain antihypertensive drugs may modulate these effects. Methods: 24 non-diabetic and 11 T2DM subjects were studied in a cross-over design. Fasting blood samples, blood pressure (BP), and arterial vasoreactivity (flow-mediated dilation) were assessed before and 70 min after capsule ingestion. Muscle microvascular reactivity was only assessed after capsule ingestion. Age, waist-to-hip ratio, BP at baseline, and the use of antihypertensive drugs were regarded as covariates in a mixed models analysis. Results: CF ingestion did not affect any parameter. However, independent of the type of capsules ingested, a decrease in diastolic BP by 3 mmHg (95% CI: -4.0; -2.0) and an increase in the change in brachial artery diameter (pre vs. post occlusion) by 0.06 mm (95% CI: 0.01; 0.12) were detected in the non-diabetic group, while they remained unchanged in the T2DM group. Conclusion: No beneficial effects of CF were detected on vascular reactivity parameters in T2DM and non-diabetic participants.".
• 01GJYY1E8QR735EQ6GRC0VP9J4 abstract "Background:The TOPCAT trial (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial) suggested clinical benefits of spironolactone treatment among patients with heart failure with preserved ejection fraction enrolled in the Americas. However, a comprehensive assessment of biologic pathways impacted by spironolactone therapy in heart failure with preserved ejection fraction has not been performed. Methods:We conducted aptamer-based proteomic analysis utilizing 5284 modified aptamers to 4928 unique proteins on plasma samples from TOPCAT participants from the Americas (n=164 subjects with paired samples at baseline and 1 year) to identify proteins and pathways impacted by spironolactone therapy in heart failure with preserved ejection fraction. Mean percentage change from baseline was calculated for each protein. Additionally, we conducted pathway analysis of proteins altered by spironolactone. Results:Spironolactone therapy was associated with proteome-wide significant changes in 7 proteins. Among these, CARD18 (caspase recruitment domain-containing protein 18), PKD2 (polycystin 2), and PSG2 (pregnancy-specific glycoprotein 2) were upregulated, whereas HGF (hepatic growth factor), PLTP (phospholipid transfer protein), IGF2R (insulin growth factor 2 receptor), and SWP70 (switch-associated protein 70) were downregulated. CARD18, a caspase-1 inhibitor, was the most upregulated protein by spironolactone (-0.5% with placebo versus +66.5% with spironolactone, P<0.0001). The top canonical pathways that were significantly associated with spironolactone were apelin signaling, stellate cell activation, glycoprotein 6 signaling, atherosclerosis signaling, liver X receptor activation, and farnesoid X receptor activation. Among the top pathways, collagens were a consistent theme that increased in patients receiving placebo but decreased in patients randomized to spironolactone. Conclusions:Proteomic analysis in the TOPCAT trial revealed proteins and pathways altered by spironolactone, including the caspase inhibitor CARD18 and multiple pathways that involved collagens. In addition to effects on fibrosis, our studies suggest potential antiapoptotic effects of spironolactone in heart failure with preserved ejection fraction, a hypothesis that merits further exploration.".
• 01GJYY1E93AB1BRH0KDVDBK4KQ abstract "Fibromuscular dysplasia is a cardiovascular disease affecting mostly women with a mostly unknown genetic basis. Here the authors have performed a genome-wide association meta-analysis of Fibromuscular dysplasia to identify genetic loci, some of which are shared with common cardiovascular disease and traits. Fibromuscular dysplasia (FMD) is an arteriopathy associated with hypertension, stroke and myocardial infarction, affecting mostly women. We report results from the first genome-wide association meta-analysis of six studies including 1556 FMD cases and 7100 controls. We find an estimate of SNP-based heritability compatible with FMD having a polygenic basis, and report four robustly associated loci (PHACTR1, LRP1, ATP2B1, and LIMA1). Transcriptome-wide association analysis in arteries identifies one additional locus (SLC24A3). We characterize open chromatin in arterial primary cells and find that FMD associated variants are located in arterial-specific regulatory elements. Target genes are broadly involved in mechanisms related to actin cytoskeleton and intracellular calcium homeostasis, central to vascular contraction. We find significant genetic overlap between FMD and more common cardiovascular diseases and traits including blood pressure, migraine, intracranial aneurysm, and coronary artery disease.".
• 01GJYY1K5M6TQ6W9C3B4ZZC63D abstract "Background and aims: Clinical practice before 2019 suggests a substantial proportion of high and very high CV risk patients taking lipid-lowering therapy (LLT) would not achieve the new LDL-C goals recommended in the 2019 ESC/EAS guidelines (<70 and < 55 mg/dL, respectively). To what extent practice has changed since the last ESC/EAS guideline update is uncertain, and quantification of remaining implementation gaps may inform health policy. Methods: The SANTORINI study is a multinational, multicentre, prospective, observational, non interventional study documenting patient data at baseline (enrolment) and at 12-month follow-up. The study recruited 9606 patients >18 years of age with high and very high CV risk (as assigned by the investigators) requiring LLT, with no formal patient or comparator groups. The primary objective is to document, in the real-world setting, the effectiveness of current treatment modalities in managing plasma levels of LDL-C in high-and very high-risk patients requiring LLT. Key secondary effectiveness objectives include documenting the relationship between LLT and levels of other plasma lipids, high sensitivity C-reactive protein (hsCRP) and overall predicted CV risk over one year. Health economics and patient-relevant parameters will also be assessed. Conclusions: The SANTORINI study, which commenced after the 2019 ESC/EAS guidelines were published, is ideally placed to provide important contemporary insights into the evolving management of LLT in Europe and highlight factors contributing to the low levels of LDL-C goal achievement among high and very high CV risk patients. It is hoped the findings will help enhance patient management and reduce the burden of ASCVD in Europe. ' (c) 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).".
• 01GJYY1R2PPH1SHAFHPF50B5XZ abstract "Diabetes mellitus (DM) is associated with a higher risk of heart failure hospitalization and mortality in patients with heart failure with preserved ejection fraction (HFpEF). Using SomaScan assays and proteomics analysis of plasma from participants in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial and the Penn Heart Failure Study, this study identified 10 proteins with significantly different expression in patients with HFpEF and DM. Of these, apolipoprotein M was found to mediate 72% (95% CI: 36% to 100%; p < 0.001) of the association between DM and the risk of cardiovascular death, aborted cardiac arrest, and heart failure hospitalization. (C) 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.".
• 01GJYY21W20Z7W7VEM2VRE768H abstract "Background Familial hypercholesterolaemia (FH) is underdiagnosed in most countries. We report our first experience from a national pilot project of cascade screening in relatives of FH patients. Methodology Participating specialists recruited consecutive index patients (IP) with Dutch Lipid Clinic Network (DLCN) score >= 6. After informed consent, the relatives were visited by the nurses to collect relevant clinical data and perform blood sampling for lipid profile measurement. FH diagnosis in the relatives was based on the DLCN and/or MEDPED FH (Make-Early-Diagnosis-to-Prevent-Early-Deaths-in-FH) criteria. Results In a period of 18 months, a total of 127 IP (90 with definite FH and 37 with probable FH) were enrolled in 15 centres. Out of the 270 relatives visited by the nurses, 105 were suspected of having FH: 31 with DCLN score >8, 33 with DLCN score 5-8 and 41 with MEDPED FH criteria. In a post-hoc analysis, another set of MEDPED FH criteria established in the Netherlands and adapted to Belgium allowed to detect FH in 51 additional relatives. Conclusion In a country with no national FH screening program, our pilot project demonstrated that implementing a simple phenotypical FH cascade screening strategy using the collaboration of motivated specialists and two nurses, allowed to diagnose FH in 127 index patients and an additional 105 of their relatives over the two-year period. Newly developed MEDPED FH cut-offs, easily applicable by a nurse with a single blood sample, might further improve the sensitivity of detecting FH within families.".
• 01GJYY2TC47EKQA5N01HBQ2TQK abstract "Objective: Arterial ageing is characterized by increasing arterial stiffness as measured by pulse wave velocity (PWV). This process is enhanced in participants with early vascular ageing (EVA), but slowed in participants with healthy vascular ageing (HVA). We aimed to describe characteristics of EVA and HVA in a transcontinental study including 11 cohorts. Methods: In all, 18 490 participants from the global MARE Consortium, free of cardiovascular disease, participated with data on PWV and cardiometabolic risk factors. We defined HVA as the lowest 10% and EVA as the highest 10% of the standardized PWV distribution, adjusted for age intervals. HVA individuals were compared with the 90% of non-HVA individuals with ANCOVA, adjusted for age, sex and hypertension. Results: The 1723 HVA participants were at the same age as the rest of the population, more likely women (59.4 vs 57.0%), and with significantly lower levels of established cardiovascular risk factors (blood pressure, lipids, glucose). Similarly, the prevalence rate of obesity, diabetes mellitus, hypertension and the metabolic syndrome was lower in the HVA participants. In the presence of similar levels of cardiovascular risk factors, HVA participants in the 50-64 years of age group presented lower PWV 5.8 (SD 0.5) vs. 7.4 (1.4) m/s (P<0.0001) than control individuals in the 35-49 years of age group, corresponding to an estimated difference in chronological age of 14 years. Conclusion: Participants with healthy vascular ageing (HVA), belonging to the lowest end of the PWV distribution, are in general characterized by an up to 14 years estimated younger biological (vascular) age than those with higher PWV values, and have lower levels of risk factors.".
• 01GJZ0D00G9TWV8A28NC31G0TQ abstract "We prove that, over an arbitrary field, pointwise finite-dimensional persistence modules indexed by S-1 decompose uniquely, up to isomorphism, into the direct sum of a bar code and finitely-many Jordan cells. In the language of representation theory, this is a direct sum of string modules and band modules. Persistence modules indexed on S-1 have also been called angle-valued or circular persistence modules. We allow either a cyclic order or partial order on S-1 and do not have additional finiteness requirements on the modules. We also show that a pointwise finite-dimensional S-1 persistence module is indecomposable if and only if it is a bar or Jordan cell. Along the way we classify the isomorphism classes of such indecomposable modules.".
• 01GJZ1XVEFAY1AN65W08NQ8DR5 abstract "During the last decades, under influence of globalization, the scope of ethnobiological research has expanded. Rapidly developing technology, telecommunication, the internet, and social media promote the occurrence and maintenance of ties within and between communities through multifaceted ways of digital communication. This often gives rise to digital or virtual communities in which knowledge, perspectives and ideas are shared. We want to highlight the significance of these virtual digital social ties and the associated exchange of ethnobiological knowledge among and between ethnic groups, which can lead or has led to an extension of the ethnobiological field of study to a digital or virtual environment. We propose the new term "Digital Ethnobiology" as "the scientific study of dynamic relationships between peoples, biota, and environments in a virtual or digital environment". We support our term with four case studies from the field of urban ethnobotany, sociology, and agribusiness development. We discuss opportunities, concerns, challenges, future perspectives, and raise some relevant questions on good research practices.".
• 01GJZ3BKAEGNJW4HVSXJZPS655 abstract "An important polymer processing technique is additive manufacturing (AM), which enables shape-free design of complex final parts with limited waste during the development change, at least if the impact of molecular degradation reactions is minimized. In the present work, polystyrene (PS) and acrylonitrile butadiene styrene (ABS) polymer have been processed via: (i) fused filament fabrication (FFF), separately accounting for the prior single screw extrusion (SSE) filament production; and (ii) pellet-based additive manufacturing (PBAM), which are two important AM techniques. The influence of printing temperature, layer thickness, printing velocity, and printing technique on the degradation of both polymeric materials is studied by means of thermogravimetric analysis (TGA), size exclusion chromatography (SEC), small amplitude oscillatory shearing tests (SAOS), Fourier-transform infrared spectroscopy (FTIR), and yellowness index (YI) measurements. For ABS, SSE-FF leads to more fission (higher mechanical loading) whereas PBAM results in more cross-linking (more thermal loading). For PS, fission is always dominant and this more evident under FFF conditions. ABS also exhibits yellowing upon processing, indicating thermo-oxidative degradation although below the FTIR sensitivity limit. The selected PBAM conditions with PS are already delivering printed specimens with good mechanical properties and lower degradation. For ABS, a further PBAM optimization is still desired compared to the FFF countercase, taking into account layer-by-layer adhesion.".
• 01GJZ3GF6G12X2GGMBPRDA1557 abstract "Reactive extrusion (REX) is an important processing and production technique with applications in the field of polymer synthesis, modification and recycling. A full REX design demands a multi-scale approach recognizing at the molecular scale a wide spectrum of elementary reactions, at the micro-scale viscosity variations influencing the observed kinetics, at the meso-scale multiphase and morphological variations, and at the macro-scale various screw configurations and designs. In the present contribution, an overview is given of the multi-scale modeling tools currently available to fundamentally understand REX processes, targeting a (average) chain length increase, preservation or decrease. Emphasis is on computational fluid dynamics, in general, flow oriented approaches, and classical chemical reaction engineering approaches, addressing both deterministic and stochastic solvers. To highlight the potential of the discussed modeling tools five case studies are included, considering functionalization of (bio)polymers, polymer recycling and circularity.".
• 01GJZ3Y0T7DR3KQDTSCHHRKCGA abstract "The unique nature of tunnels, their potential for high consequences, and the emergence of new technologies (such as new energy carriers, NEC) implies that a risk-based approach is often required for the fire safety assessment of tunnel structures. The relationship between societal requirements and private considerations is however not always clear. To clarify this, a risk acceptance framework is presented which provides a roadmap for identifying the preferred fire safety design alternative. To support practical implementation, (i) sources of uncertainty to be considered as part of the probabilistic assessment are discussed, notably with a view on the consideration of NEC; and (ii) two simplified state-of-practice case studies are presented. Together, the discussion of uncertainties and the presented case studies highlight the knowledge gap between the theoretical risk acceptance framework and practical implementation. Therefore, a research and development project, FIERCE (Fire Integrated Environment for Risk Comprehension and Evaluation), has been initiated with support of the Flemish government. The targets and conceptualization of FIERCE are presented at the end of the paper.".
• 01GJZ3YW65DGKD3BV1CZPJH436 abstract "A new combined chemical looping process makes use of any gas stream containing CO2 and fuel to produce carbon monoxide without external energy input. Carbon monoxide can be used for producing a variety of carbon-based products.".
• 01GJZ3YW65DGKD3BV1CZPJH436 abstract "The iron and steel industry is a carbon-intensive industry and one of the largest industrial sources of CO2 emissions. In this work, we show how the steel mill gases can be conditioned using three metal oxides to produce a CO/CO2 stream that can be used for the production of chemicals, thereby preventing the emission of carbon to the atmosphere as CO2. Abundant oxides of iron and manganese, characterised by their readiness to capture and release gaseous O2, and calcium oxide, characterised by its capacity to capture and release gaseous CO2 can be deployed in this process. Process analysis indicates that by fully utilising the chemical energy of the carbon-rich blast furnace gas (BFG) of the steel mill, 37% of the associated CO2 emissions can be eliminated. A techno-economic evaluation shows that further reduction of CO2 emissions is viable. Preliminary estimations indicate that the cost for processing BFG through the proposed process is 46 EUR2020 per tonneBFG. The sources of revenue are the product CO/CO2 stream (0.2 tonneproduct per tonneBFG) and electricity constituting 85% and 14% of the total revenue with the remaining 1% obtained by the sale of spent metal oxides used in the process. The technical feasibility of the process was experimentally proven in a fixed bed reactor to produce a CO/CO2 stream and an H2O-rich stream while the metal oxides were periodically regenerated in alternating redox conditions. Thirty executed cycles indicated stable performance of the process. The proposed process concept can be applied to any gas stream containing CO2 and fuel.".
• 01GJZ5KEXKP0FPXMJQ1RFMC8PK abstract "We present a compact, highly tolerant vertical coupling structure, which can be a generic design that bridges the gap between conventional resonant couplers and adiabatic couplers for heterogeneously integrated devices. We show insights on relaxing the coupler alignment tolerance and provide a detailed design methodology. By the use of a multisegmented inverse taper structure, our design allows a certain proportion of the odd supermode to be excited during the coupling process, which simultaneously facilitates high tolerance and compactness. With a total length of 87 mu m, our coupler is almost threefold shorter than the state-of-the-art alignment-tolerant adiabatic couplers and outperforms them by demonstrating a more than 94% coupling efficiency (for <0.3 dB coupling loss) with +/- 1 mu m misalignment tolerance, which, to our best knowledge, is a new record for III-V-on-silicon vertical couplers. Furthermore, our design has high tolerance to fabrication-induced structural deformation and ultrabroad bandwidth. These features make it particularly suitable for building densely integrated III-V-onsilicon photonic circuits with commercially available microtransfer printing assembly tools. The proposed design can be widely adopted in various integration platforms.".
• 01GJZ634P4XXP6QQEQMZ1FBRA2 abstract "Introduction: Certain trace elements are essential for life and affect immune system function, and their intake varies by region and population. Alterations in serum Se, Zn and Cu have been associated with COVID-19 mortality risk. We tested the hypothesis that a disease-specific decline occurs and correlates with mortality risk in different countries in Europe. Methods: Serum samples from 551 COVID-19 patients (including 87 nonsurvivors) who had participated in observational studies in Europe (Belgium, France, Germany, Ireland, Italy, and Poland) were analyzed for trace elements by total reflection X-ray fluorescence. A subset (n=2069) of the European EPIC study served as reference. Analyses were performed blinded to clinical data in one analytical laboratory. Results: Median levels of Se and Zn were lower than in EPIC, except for Zn in Italy. Non-survivors consistently had lower Se and Zn concentrations than survivors and displayed an elevated Cu/Zn ratio. Restricted cubic spline regression models revealed an inverse nonlinear association between Se or Zn and death, and a positive association between Cu/Zn ratio and death. With respect to patient age and sex, Se showed the highest predictive value for death (AUC=0.816), compared with Zn (0.782) or Cu (0.769). Discussion: The data support the potential relevance of a decrease in serum Se and Zn for survival in COVID-19 across Europe. The observational study design cannot account for residual confounding and reverse causation, but supports the need for intervention trials in COVID-19 patients with severe Se and Zn deficiency to test the potential benefit of correcting their deficits for survival and convalescence.".
• 01GJZ6W8B0C7MA8CJQXMQMEFVD abstract "Objective: To understand the concept of goal-oriented care (GOC) through the experiences of people with chronic conditions.Method: Interviews with people living with chronic conditions (n=50) were analyzed in two ways. A deductive approach based on GOC attributes generated in a concept analysis on GOC: goal-elicitation, goal-setting, goal - evaluation, patients' context, and patients' needs and preferences. An inductive approach based on a thematic analysis using descriptive phenomenology.Results: The phase of goal-elicitation was recognized by the participants, whereas goal-setting and goal - evaluation were experienced to a lesser extent. Regarding the underpinning attributes, mixed feelings were re- ported concerning the integration of the patient's context and the presence of their needs and preferences throughout the care process. The inductive analysis revealed specific attention to informing patients about their condition and treatment options and discussing goals in interprofessional collaboration.Conclusion: Goal-elicitation was already present and seems to be a good foundation for GOC. More attention should be given to goal-setting and goal-evaluation. Practice implications: Developing guidance by means of a workflow, tools, or questions might support people with chronic conditions and providers to underpin the entire care process with patients' personal goals.".
• 01GJZ6YXFXFBNPE7Z3WQFC12EA abstract "The fib Model Code offers pre-normative guidance based on the synthesis of international research, industry and engineering expertise. Its new edition (draft MC 2020) will bring together coherent knowledge and experience for both the design of new concrete structures and the assessment of existing concrete structures. This contribution presents an overview of the main developments related to the partial factors for materials. In the draft MC2020, the partial factors are presented in tables for clusters of cases depending on consequence classes and variability of basic variables. Furthermore, formulas and background information are provided to facilitate updating of the partial factors. This contribution discusses the different assumptions adopted in MC 2020 for design and assessment. Main changes with respect to the previous version are related to description of the difference between in-situ concrete strength and the material strength measured on control specimens, and to modelling of geometrical variables. The presented comparison of the requirements imposed by Eurocodes and MC 2020 for design reveals insignificant differences. The assessment requirements may be decreased by about 25% when the conditions specified in MC 2020 are satisfied. Hence, the revised MC 2020 will provide designers and code makers with wider possibilities to utilise actual data and long-term experience in assessments of existing structures.".
• 01GJZ7RW6Z42Y1KD5DHMGJRNKD abstract "Objective The objective of this study was to measure the appropriateness of end-of-life care for children who died with neurologic conditions. Study design Based on linked routinely collected databases, we conducted a population-level decedent retrospective cohort study of children with neurologic conditions who died in Belgium between 2010 and 2017. We measured a set of 22 face-validated quality indicators. The set concerns 12 indicators of potentially appropriate end-of-life care (eg, specialized comfort medication, physician contact, continuous care) and 10 indicators of potentially inappropriate end-of-life care (eg, diagnostic tests, phlebotomy). We performed ANOVA for predictors (age, sex, disease category, nationality, having siblings, year of death) for scales of appropriate and inappropriate care. Results Between 2010 and 2017, 139 children with neurologic conditions died in Belgium. For potentially appropriate care, in the last 30 days, 76% of children received clinical care, 55% had continuous care relationships, 17% had contact with a general physician, 8% of children received specialized comfort medication, and 14% received care from a palliative care team. For potentially inappropriate care, in the last 14 days, 45% had blood drawn and 27% were admitted to intensive care unit. Conclusions Our study found indications of appropriate as well as inappropriate end-of-life care for children who died with neurologic conditions. These findings reveal a substantial margin for potential quality improvement, in regard to palliative care provision, multidisciplinary care, financial support, specialized comfort medication, clinical follow-up, general physician contact, diagnostics, and blood drawing.".
• 01GJZ8HFN09JC3K4GNA0G7ZRK1 abstract "Background: Family carers have a prominent role in end-of-life care for seriously ill persons. However, most of the Advance Care Planning literature is focused on the role of healthcare professionals. Aims: To investigate (1) what proportion of family carers discussed advance care planning with their relative and associated socio-demographic and clinical characteristics (2) what proportion received support from healthcare professionals for these conversations, (3) what type of support they received and (4) to what extent the type of support received was considered sufficient. Design/participants: Population-based cross-sectional survey in Belgium of bereaved family carers of persons with a serious chronic illness (N = 3000) who died 2-6 months before the sample was drawn, identified through three sickness funds. The survey explored support from healthcare professionals for family carers during the last 3 months of the patient's life. Results: Response rate was 55%. The proportion of family carers that engaged in an advance care planning conversation with their relative was 46.9%. Of these family carers, 78.1% received support from a healthcare professional, mostly by doing the advance care planning conversation together (53.8%). Of family carers receiving support from a healthcare professional, 57.4% deemed the support sufficient. Conclusion: Many family carers engage in advance care planning conversations with their dying relative. Healthcare professionals often support them by performing the advance care planning conversations together. More insight into how family carers can be supported to conduct these advance care planning conversations, both with and without involvement of healthcare professionals, is necessary.".
• 01GJZ8HP52CQRZC70XDJYE48F7 abstract "Facing the aging building stock, challenging times can be expected with a sharp increase of reinforced concrete buildings requiring maintenance, repair and/or replacement. For the condition assessment of existing reinforced concrete structures an in-depth and reliable inspection strategy and evaluation is essential to come to a durable and service-life extending repair strategy. A stepwise protocol to evaluate the condition and remaining bearing capacity of cantilevered reinforced concrete (RC) balconies is presented in this paper. Corrosion causing the reduction of the steel section, incorrect positioning of the reinforcement and/or higher loads are the main reasons service life might not be reached or the failure of the balcony can occur. As mentioned in EN 1504-9 and NEN 8700, an adequate diagnosis prior to repair showing the cause and extent of the damage is important (i) to determine the actual bearing capacity, (ii) to make an estimation of the residual lifespan and (iii) to select a durable repair technique and/or define maintenance requirements. In this paper a newly developed protocol for the assessment of the condition and the bearing capacity of the cantilevered RC balconies of a high-rise residential building is demonstrated. A semi-probabilistic method is used by applying partial safety factors based on Eurocode guidelines and fib Bulletin 80. The condition of the structure is determined based on NEN2767 regulations. As corrosion is the main contributor to the degradation of existing concrete structures, a chloride contaminated building with damaged reinforced concrete balconies is selected as case study in order to demonstrate the applicability of the developed protocol and tools.".
• 01GJZ8NRV3DKP1YR87V9Z3RWRJ abstract "Objective To identify strategies and interventions used to improve interprofessional collaboration and integration (IPCI) in primary care. Design Scoping review Data sources Specific Medical Subject Headings terms were used, and a search strategy was developed for PubMed and afterwards adapted to Medline, Eric and Web of Science. Study selection In the first stage of the selection, two researchers screened the article abstracts to select eligible papers. When decisions conflicted, three other researchers joined the decision-making process. The same strategy was used with full-text screening. Articles were included if they: (1) were in English, (2) described an intervention to improve IPCI in primary care involving at least two different healthcare disciplines, (3) originated from a high-income country, (4) were peer-reviewed and (5) were published between 2001 and 2020. Data extraction and synthesis From each paper, eligible data were extracted, and the selected papers were analysed inductively. Studying the main focus of the papers, researchers searched for common patterns in answering the research question and exposing research gaps. The identified themes were discussed and adjusted until a consensus was reached among all authors. Results The literature search yielded a total of 1816 papers. After removing duplicates, screening titles and abstracts, and performing full-text readings, 34 papers were incorporated in this scoping review. The identified strategies and interventions were inductively categorised under five main themes: (1) Acceptance and team readiness towards collaboration, (2) acting as a team and not as an individual; (3) communication strategies and shared decision making, (4) coordination in primary care and (5) integration of caregivers and their skills and competences. Conclusions We identified a mix of strategies and interventions that can function as 'building blocks', for the development of a generic intervention to improve collaboration in different types of primary care settings and organisations.".
• 01GJZ9BBXKE68H9SAK6KDNXKVG abstract "Even though studies at the intersection of translation and media are a burgeoning subfield within Translation Studies, the integration of media theory into the scholarship on translation remains underdeveloped. Joining a recent surge of interest in adapting media theory to a broad analysis of the impacts of the technologies that organise and support translation, this article takes up the concept of cultural technique to argue that, just as technological revolutions have reshaped translation practices, translations have structured media systems. Following its exploration of a medial methodology in Translation Studies and the benefits of a historicist perspective, the article turns to a set of case studies, all sourced from the Romantic period, which was characterised by a complex attitude to mediality and translation prefigurative of the current digital turn. The case studies demonstrate the benefits of a medial view in the study of translation.".
• 01GJZ9NM26JA52AJGSYXT0FVSV abstract "Raman spectroscopy is one of the most favorable techniques applied in the art analysis field. Its unique characteristics, namely the organic and inorganic components identification, spatial resolution down to micrometers scale, control of the laser power and measuring conditions and fast identification are just some of the remarkable features of the technique. Moreover, Raman spectroscopy can be applied directly on the artefact and on the field, with mobile systems, without jeopardizing the integrity of the work of art. Other Raman approaches can be considered namely, microspatially offset Raman spectroscopy (micro-SORS) and surface-enhanced Raman spectroscopy (SERS) when it comes to the direct non-destructive stratigraphic analysis of art works and the characterization of organic compounds such as dyes.".
• 01GJZA2BN385JFREQQ8HEVD16A abstract "Hydrated aluminum-rich sulfates belong to less widespread secondary minerals on Mars, which are probably connected with hydrothermal alterations. On Earth, such sulfates result from acidic weathering of aluminosilicates, and their formation is controlled by factors such as pH, temperature, or water activity. Physical-chemical conditions can be reconstructed if specific sulfate phases are detected, and therefore, the investigation of sulfate assemblages in high-temperature settings is important for planetology and exobiology research. Raman spectroscopy is a powerful analytical tool for the discrimination of sulfates, and the degree of hydration, which is a sensitive marker of temperature conditions, can be tracked using this method. However, spectral similarities of sulfates and metastability and rapid transformations may hinder their correct identification. We take advantage of in situ and laboratory Raman spectroscopy to characterize uncommon anhydrous and hydrated Al-NH4 sulfate mineralogy which forms under elevated temperature at the Anna burning coal waste dump, Alsdorf, Germany, and can be considered as analogous to fumarolic environments. We detected a suite of hydrated Al sulfates (e.g. alunogen, khademite, and tschermigite) in the medium-temperature zones (similar to 50 degrees C). To minimize possible rehydration processes, we deployed two miniaturized Raman spectrometers (532 and 1064 nm) for field investigations in the high-temperature zone (similar to 130 degrees C to 150 degrees C). Mixtures of anhydrous (godovikovite and millosevichite) and hydrated phases along with intermediate phases were detected in the field as well as in the laboratory. Such observations are consistent with the premise that the degree hydration of sulfates increase with decreasing temperature. These results confirm that Raman spectroscopy is, despite several analytical challenges, capable of distinguishing Al sulfates, and their hydration states, within complex aggregates and crusts, and future applications in planetary research are promising.".
• 01GJZACHF22SKEYAR3C9MHMGQP abstract "Raman spectroscopy is frequently implemented in the analysis of art objects. Especially its non-destructive character and the advent of mobile instruments, often equipped with fibre optics probe heads, have opened the doors for many direct investigations of artworks. However, Raman spectroscopy usually requires stable positioning of the objective lens, close to the paint surface. Consequently, and despite the use of an extensive range of positioning equipment, it is not possible to reach every spot of a large artefact. Positioning, and as a consequence measuring, is becoming even more critical for 3D objects. Therefore, we examine the characteristics and explore the opportunities for the investigation of art objects that can be obtained by using a zoom lens, which is suitable for the Raman investigation at working distances between 6 and 60 cm.".
• 01GJZAG2B63VKR08WAS4RR7DP1 abstract "Transition-metal dichalcogenide (TMD) nano-sheets have become an intensively investigated topic in the field of 2D nanomaterials, especially due to the direct semiconductor nature, and the broken inversion symmetry in the odd-layer number, of some of their family members. These properties make TMDs attractive for different technological applications such as photovoltaics, optoelectronics, valleytronics, and hydrogen evolu-tion reactions. Among them, MoX2 (X = S and Se) are turned to direct gap when their thickness is thinned down to monolayer, and thus, efforts toward obtaining large-scale monolayer TMDs are crucial for technological applications. Colloidal synthesis of TMDs has been developed in recent years, as it provides a cost-efficient and scalable way to produce few-layer TMDs having homogeneous size and thickness, yet obtaining a monolayer has proven challenging. Here, we present a method for the colloidal synthesis of mono-and few-layer MoX2 (X = S and Se) using elemental chalcogenide and metal chloride as precursors. Using a synthesis with slow injection of the MoCl5 precursor under a nitrogen atmosphere, and optimizing the synthesis parameters with a design of experiments approach, we obtained a MoX2 sample with the semiconducting (1H) phase and optical band gaps of 1.96 eV for H-1-MoS2 and 1.67 eV for 1H-MoSe2, respectively, consistent with a large monolayer yield in the ensemble. Both display photoluminescence at cryogenic and room temperature, paving the way for optical spectroscopy studies and photonic applications of colloidal TMD nanosheets.".
• 01GJZB4819MGEHEG9MHMCNFAVV abstract "A typical oil painting stratigraphy consists of the canvas substrate, the ground layer, the layer of paint and eventually the varnish layer. The ground layer, a mixture of inorganic and organic material could be a very helpful tool for indirect dating. The present study presents preliminary luminescence measurements on the main inorganic constituents of the ground layers for paintings between the 15th and the 20th century. Eight different substances were selected, based on the most common materials applied throughout these centuries. Most among the materials subjected to the present study present TL glow curve with different, unique shape. Notable exceptions stand in the case of the most recently invented materials such as zinc white, titanium white and lead white. Towards direct dating purposes, a number of luminescence features, such as sensitivity, sensitization after repeated cycles of irradiation-measurement, bleaching ability as well as thermal stability were studied for both cases of TL as well as OSL. Preliminary results indicate that kaolinite and gypsum stand as very promising candidates towards luminescence dating of portable paintings. Further work is required in order to establish their usefulness.".
• 01GJZCXVN5FHAR2RWX5EPT3A4R abstract "During his long career as a writer and activist, Georges Eekhoud (1854- 1927) dedicated himself to adopting and defending several aesthetic and political positions. As a writer, he penned both regionalist literature and scandalous writings. As an activist, he defended nationalist positions, which he exchanged in 1916 for a left-wing internationalist commitment. What are the consequences of reading the literary work of Eekhoud, in particular the texts he published after 1916? In this contribution, I will tackle this question by means of a close reading of Dernières Kermesses (1920). The book is presented as a book with a “regionalist” mark (the book is the last part of the Kermesses trilogy) whereas it was published when the author already had embraced (political and literary) “internationalism”.".
• 01GJZCXVN5FHAR2RWX5EPT3A4R abstract "Pendant sa longue carrière d’écrivain et d’homme engagé, Georges Eekhoud (1854-1927) a adopté et défendu des positions esthétiques et politiques diverses. En tant qu’écrivain, il est tant le romancier de terroir que l’auteur d’écrits scandaleux. En tant qu’homme engagé, il a défendu des positions nationalistes, qu’il a échangées en 1916 contre un engagement internationaliste de gauche. Quelles en sont les conséquences pour la lecture de l’œuvre littéraire d’Eekhoud, et notamment des textes publiés après 1916 ? Dans cette contribution, j’aborde cette question à partir d’une (re)lecture détaillée des Dernières Kermesses (1920). Le recueil se présente comme un ouvrage de signature « régionaliste » (c’est la dernière partie de la trilogie des Kermesses) tandis qu’il a été publié au moment où l’auteur avait déjà embrassé l’« internationalisme » (politique et littéraire).".
• 01GJZD7CV0E26E4ZFSYYJS78MF abstract "Background The legalization of Medical Assistance in Dying in Canada in 2016 provided new impetus for improving palliative care. This commitment to improvement included the development of a National Palliative Care Framework and Action Plan. The purpose of this study was to understand the progress made in palliative care since 2016 from the perspective of persons working and volunteering in palliative care and compare geographic differences. Methods A digital survey was developed from goals identified in Canada's Palliative Care Framework and Action Plan and administered online using Qualtrics. Participants were recruited through national palliative care organizations. The survey included both quantitative survey items designed to evaluate improvements across 5 domains and 29 items and included open-ended questions about impacts, innovations, and ongoing challenges. Descriptive statistics were generated for survey domains, items, and demographic variables. Geographic differences were compared using Independent-Samples Kruskal-Wallis test. Qualitative data was analyzed inductively into themes. Results One hundred fifty surveys met inclusion criteria and were analysed. Overall, the most improvement was reported in palliative care education and the least improvement was reported in support for family caregivers. Items on which respondents reported the most improvement included healthcare provider education in palliative care, advance care planning, and use of technology. Items on which respondents reported the least improvement were respite for family caregivers, access to bereavement services, and in-home support for family caregivers. Notably, rural participants reported more statistically significant improvements in the domains of education, access, and research and data collection than their urban counterparts. However, rural participants reported less improvement in places to die when home is not preferable. The COVID-19 pandemic was a significant contributor to these perceived improvements and ongoing challenges. Conclusion Canada's Framework and Action Plan sets out a roadmap for improving palliative care in Canada. Participants in this survey noted significant improvements in key areas, a notable accomplishment amidst the effects of the COVID-19 pandemic. Some improvements were a result of greater use of distance technology. Further leveraging these improvements will make an important contribution to solving some of the rural and remote palliative care issues that have arisen from Canada's unique geography.".
• 01GJZDRKKA5JA80XDDKJ7M4A9J abstract "Background End-of-life decisions with potential life-shortening effect in neonates and infants are common. We aimed to evaluate how often and in what manner neonatologists consult with parents and other healthcare providers in these cases, and whether consultation is dependent on the type of end-of-life decision made. Methods Based on all deaths under the age of one that occurred between September 2016 and December 2017 in Flanders, Belgium, a nationwide mortality follow-back survey was performed. The survey asked about different types of end-of-life decisions, and whether and why parents and/or other healthcare providers had or had not been consulted. Results Response rate was 83% of the total population. End-of-life decisions in neonates and infants were consulted both with parents (92%) and other healthcare providers (90%), and agreement was reached between parents and healthcare providers in most cases (96%). When medication with an explicit life-shortening intent was administered parents were always consulted prior to the decision; however when medication without explicit life-shortening intention was administered parents were not consulted in 25% of the cases. Conclusions Shared decision-making between parents and physicians in case of neonatal or infant end-of-life decision-making is the norm in daily practice. All cases without parental consultation concerned non-treatment decisions or comfort medication without explicit life-shortening intention where physicians deemed the medical situation clear and unambiguous. However, we recommend to at least inform parents of medical options, and to explore other possibilities to engage parents in reaching a shared decision. Physicians consult other healthcare providers before making an end-of-life decision in most cases.".
• 01GJZECVWAP97PDKZWFQZPH2NQ abstract "The present study examined associations of self- and partner-reported psychopathic traits, as well as the level of agreement between these reports (perceptual accuracy), with relationship quality, and the moderating role of violent and non-violent conflict tactics. Participants were 259 heterosexual couples from the community. Results indicated that, despite moderate convergence between self- and partner-reports, the female partners tended to underreport the levels of psychopathic traits in their male partner. Relationship quality was negatively associated with partner-reported and, albeit to a lesser extent, self-reported psychopathic traits. Contrary to expectations, perceptual accuracy was barely associated with relationship quality. Whereas no evidence was found for the moderating role of aggressive conflict tactics, non-violent negotiation seemed to buffer the effect of psychopathic traits on relationship quality. The study highlights the importance of considering the partner's perceptions as well as constructive conflict tactics when examining psychopathic traits in intimate relationships.".
• 01GJZEJZGTBNKTF15GV6MSY988 abstract "Le point de départ de cet article est un constat problématique. Après la Première Guerre mondiale, la Belgique est divisée en deux camps : les « jusqu’au-boutistes » s’opposent aux « défaitistes », les « héros » se distinguent des « traîtres ». Or, dans une constellation tellement polarisée, il est étonnant que le discours alternatif des cercles internationalistes et pacifistes emprunte des notions fortement connotées, tel l’« héroïsme », au discours officiel et dominant. À partir d’une lecture sociocritique de textes de Paul Colin, rédacteur en chef de la revue bruxelloise L’Art libre, il s’agira donc de déterminer la sémantique et le statut renouvelé de cette « vertu de l’héroïsme ».".
• 01GJZEJZGTBNKTF15GV6MSY988 abstract "This article’s starting point consists in a problematical observation. Following World War I, Belgium was divided into two camps : the “jusqu’au-boutistes” were opposed to the “défaitistes”, the “heroes” contrasted sharply with the “traitors”. In such a polarised constellation, it is striking that the “secondary” discourse of pacifist and internationalist circles borrows highly connotated notions, such as “heroism”, from the official and dominant discourse. On the basis of a sociocritical lecture of texts by Paul Colin (the director of the periodical L’Art libre), we shall determine the semantics and the renewed status of this “virtue of heroism”.".
• 01GJZHNJC1NWN4XVWK9SQDMS06 abstract "Optical infrared thermography (IRT) has shown significant potential and advantages in defect detection in fiber reinforced polymers(FRPs) due to its capabilities of realizing non-contact and quasi real-time measurements over a large detection area. Simulation of optical IRT is of great importance as it provides support for model-based development, implementation and optimization of the experiment. To this end, the authors have developed and implemented a versatile and fast 3D simulator, based on finite element (FE) approach, for multi-layer anisotropic materials. In order to model defects, an interface element formulation has been developed which has several advantages over the standard volume element approach. The developed simulator has been benchmarked for different cases with commercial FE software. It is found that our simulator provides identical results, but more importantly, it is shown that the use of interface elements (instead of the standard volume elements) is computationally much more efficient. To better represent experiments, realistic non-uniform optical heating conditions are also implemented in the simulator. Besides, a stochastic defect modelling technique, on the basis of a morphological approach, is proposed to generate arbitrary, yet realistic, defect geometries. Finally, the fast simulator is programmed in a fully parametrized manner, which makes it suitable for generating large and diverse virtual databases which could be employed for deep learning purposes in thermography. A fully functional GUI module will be made available to the community.".
• 01GK00X5RDVHXZ8BE7QX7864M0 abstract "Transition metal dichalcogenides (TMDs) are a class of materials that have been extensively studied in the last decade, with molybdenum disulfide (MoS2) being the main protagonist. Typically, the interesting TMD properties, e.g. a direct band gap transition, or broken inversion symmetry, are only present in monolayer thick TMDs, and in the absence of strong lateral confinement, we require different materials or alloys thereof when we want to obtain TMDs with varying (direct) band gap energies. With this in mind, tungsten disulfide (WS2) is emerging as a direct competitor of MoS2 due to its similar properties but larger band gap energy. While several colloidal strategies have been reported for the synthesis of WS2, the synthesis of monolayer WS2 and detailed studies on the effect of synthesis parameters on the synthesis outcome have remained elusive. In this work we therefore focused on a colloidal synthesis method for monolayer WS2 using a design of experiment (DOE) approach. After optimization, we obtained nanosheets with a band gap transition consistent with the expected value for a monolayer. The thickness was further confirmed by Raman spectroscopy. While we could identify two temperature ranges where we could obtain a monolayer, sample characterization by XPS spectroscopy revealed the presence of different ratios of the metallic phase, with the sample synthesized at lower temperature displaying a lower concentration of the metallic phase.".
• 01GK023AECFN4T282RWXAH0CKQ abstract "Colloidal CdTe nanoplatelets featuring a large absorption coefficient and ultrafast tunable luminescence coupled with heavy-metal-based composition present themselves as highly desirable candidates for radiation detection technologies. Historically, however, these nanoplatelets have suffered from poor emission efficiency, hindering progress in exploring their technological potential. Here, we report the synthesis of CdTe nanoplatelets possessing a record emission efficiency of 9%. This enables us to investigate their fundamental photophysics using ultrafast transient absorption, temperature-controlled photoluminescence, and radioluminescence measurements, elucidating the origins of exciton-and defect-related phenomena under both optical and ionizing excitation. For the first time in CdTe nanoplatelets, we report the cumulative effects of a giant oscillator strength transition and exciton fine structure. Simultaneously, thermally stimulated luminescence measurements reveal the presence of both shallow and deep trap states and allow us to disclose the trapping and detrapping dynamics and their influence on the scintillation properties.".
• 01GK0ACY2DPYF0TK1A9GHBCES0 abstract "Background: Among critically ill patients with acute kidney injury (AKI), earlier initiation of renal replacement therapy (RRT) may mitigate fluid accumulation and confer better outcomes among individuals with greater fluid overload at randomization. Methods: We conducted a pre-planned post hoc analysis of the STandard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial. We evaluated the effect of accelerated RRT initiation on cumulative fluid balance over the course of 14 days following randomization using mixed models after censoring for death and ICU discharge. We assessed the modifying effect of baseline fluid balance on the impact of RRT initiation strategy on key clinical outcomes. Patients were categorized in quartiles of baseline fluid balance, and the effect of accelerated versus standard RRT initiation on clinical outcomes was assessed in each quartile using risk ratios (95% CI) for categorical variables and mean differences (95% CI) for continuous variables. Results: Among 2927 patients in the modified intention-to-treat analysis, 2738 had available data on baseline fluid balance and 2716 (92.8%) had at least one day of fluid balance data following randomization. Over the subsequent 14 days, participants allocated to the accelerated strategy had a lower cumulative fluid balance compared to those in the standard strategy (4509 (- 728 to 11,698) versus 5646 (0 to 13,151) mL, p = 0.03). Accelerated RRT initiation did not confer greater 90-day survival in any of the baseline fluid balance quartiles (quartile 1: RR 1.11 (95% CI 0.92 to 1.34), quartile 2: RR 1.03 (0.87 to 1.21); quartile 3: RR 1.08 (95% CI 0.91 to 1.27) and quartile 4: RR 0.87 (95% CI 0.73 to 1.03), p value for trend 0.08). Conclusions: Earlier RRT initiation in critically ill patients with AKI conferred a modest attenuation of cumulative fluid balance. Nonetheless, among patients with greater fluid accumulation at randomization, accelerated RRT initiation did not have an impact on all-cause mortality.".
• 01GK0AH8R5TF1P60EBPGYAF0EP abstract "INTRODUCTIONMODIFIER LETTER TRIANGULAR COLON We examined whether patients with acute kidney injury (AKI) have a higher risk of developing atrial fibrillation (AF), heart failure (HF), acute coronary syndrome (ACS) and major adverse cardiac events (MACE) in the short- and long-term compared to patients without AKI, and if that risk is related to the severity of AKI. Furthermore, we investigated the influence of a cardiac event following AKI on the risk of all-cause mortality, length of stay in the intensive care unit and in the hospital. METHODS: We included English and Dutch retrospective and prospective cohort studies on adults (& GE;15 years) with AKI. Studies lacking epidemiological data, studies not using the consensus definitions (RIFLE, AKIN, KDIGO), animal studies and studies on children were excluded. Studies were identified using the PubMed and Embase search engines. The last search was performed on the first of August 2021. For assessment of method quality, NOS (Newcastle-Ottawa Scale) for assessing risk of bias was used for cohort studies and heterogeneity was determined by the I-2-statistic. Statistical analysis was performed using the Cochrane Review Manager (RevMan 5.3). The risk ratio (RR) and 95% confidence interval (CI) were calculated using the Mantel-Haenszel test. Results were presented a summary caterpillar plot. RESULTSMODIFIER LETTER TRIANGULAR COLON We evaluated 14 studies comprising 736 210 patients. AKI was defined according to the RIFLE consensus in 1 article, to the AKIN criteria in 7 and to the KDIGO guidelines in 6. Of the 14 included studies, 4 were prospective and 10 were retrospective. In comparison to patients without AKI, we found that patients with AKI had a 94% increased risk of developing AF in the short term (RR: 1.94, 95% CI 1.35 to 2.79; P = 0.0004). In the long-term, patients with AKI stage 1 had a 59% increased risk of developing HF and a 77% risk of developing ACS. (RR: 1.59, 95% CI 1.07 to 2.34, P = 0.02 and RR: 1.77, 95% CI 1.68 to 1.88, P < 0.00001, respectively). Patients with AKI stage 2 had a 45% increased risk of ACS development (RR: 1.45, 95% CI 1.11 to 1.90, P = 0.006). AKI stage 3 was associated with a 164% increased risk of HF and a 95% increased risk of ACS development. (RR: 2.64, 95% CI 1.71 to 4.08, P < 0.00001 and RR: 1.95, 95% CI 1.35 to 2.82, P = 0.0004, respectively). Analysis of studies not subdividing AKI in groups showed a 74% increased risk of HF, a 12% increased risk of ACS and a 30% increased risk of developing MACE. (RR: 1.74, 95% CI 1.51 to 2.01, P < 0.00001, RR: 1.12, 95% CI 1.07 to 1.17, P < 0.00001 and RR: 1.30, 95% CI 1.25 to 1.35, P < 0.00001, respectively). CONCLUSIONSMODIFIER LETTER TRIANGULAR COLON Patients who developed AKI have an increased risk of developing AF at short-term follow-up and HF, ACS and MACE beyond 30 days.".
• 01GK0ANEDPCJS96PX2GRTA52DN abstract "Background Education in ECMO starts with basic theory and physiology. For this type of training, self-assessment e-learning modules may be beneficial. The aim of this study was to generate consensus on essential ECMO skills involving various professional groups involved in caring for ECMO patients. These skills can be used for educational purposes: development of an e-learning program and fine-tuning of ECMO-simulation programs. Methods Experts worldwide received an e-mail inviting them to participate in the modified Delphi questionnaire. A mixture of ECMO experts was contacted. The expert list was formed based on their scientific track record mainly in adult ECMO (research, publications, and invited presentations). This survey consisted of carefully designed questionnaires, organized into three categories, namely knowledge skills, technical skills, and attitudes. Each statement considered a skill and was rated on a 5-point Likert-scale and qualitative comments were made if needed. Based on the summarized information and feedback, the next round Delphi questionnaire was developed. A statement was considered as a key competency when at least 80% of the experts agreed or strongly agreed (rating 4/5 and 5/5) with the statement. Cronbach's Alpha score tested internal consistency. Intraclass correlation coefficient was used as reliability index for interrater consistency and agreement. Results Consensus was achieved in two rounds. Response rate in the first round was 45.3% (48/106) and 60.4% (29/48) completed the second round. Experts had respectively for the first and second round: a mean age of 43.7 years (8.2) and 43.4 (8.8), a median level of experience of 11.0 years [7.0-15.0] and 12.0 years [8.3-14.8]. Consensus was achieved with 29 experts from Australia (2), Belgium (16), France (1), Germany (1), Italy (1), Russia (2), Spain (1), Sweden, (1),The Netherlands (4). The consensus achieved in the first round was 90.9% for the statements about knowledge, 54.5% about technical skills and 75.0% about attitudes. Consensus increased in the second round: 94.6% about knowledge skills, 90.9% about technical skills and 75.0% about attitudes. Conclusion An expert consensus was accomplished about the content of "ad ult essential ECMO skills". This consensus was mainly created with participation of physicians, as the response rate for nurses and perfusion decreased in the second round.".
• 01GK13YAZRWX6DXRNN5CSE3XX7 abstract "When gambling, people tend to speed up after losses. This 'post-loss speeding' is in contrast with 'post-error slowing', which is often observed in behavioral tasks in experimental psychology. Importantly, participants can control the outcome in most behavioral tasks, but not in gambling tasks. To test whether perceived controllability over the outcome influences response speed after negative outcomes when gambling, we ran two online studies in which we created an illusion of control without changing the nature of the chance-determined gamble. Using the manipulation by Langer and Roth (1975), whose effect is replicated in Part I, we presented three groups of healthy participants (N = 600 per experiment, crowdsourced samples) with three different sequences of outcomes in a coin-tossing task. We replicated that participants presented with more wins at the beginning of a sequence estimated their ability to predict the outcome of a coin-toss higher than participants presented with more losses at the beginning, or those presented with a random sequence. Additionally, participants generally responded more quickly after a loss than after a win. However, the illusion of control did not influence post-loss speeding. This result is not consistent with several theoretical accounts for changes in response speed after sub-optimal outcomes.".
• 01GK14DD3KNMPCVBWPNGM240KX abstract "The illusion of control is an important feature of both problematic and nonproblematic gambling behavior. Crucially, this construct is incorporated in most cognitive models of problem gambling, and is also central in numerous approaches to gambling disorder treatment (e.g. psychological interventions using cognitive restructuring to mitigate the illusion of control). In this preregistered study, we tried to replicate the illusion-of-control effect, as defined and investigated in the seminal work by Langer and Roth, in an online context. Using the same trial procedure and a similar cover story as the original study, we presented three groups of healthy participants (N = 289; crowdsourced sample) with three different sequences of wins and losses in a coin-tossing task. Consistent with the original study, we found that participants presented with more wins at the beginning of a sequence estimated their ability to predict the outcome of a coin-toss higher than participants presented with more losses at the beginning, or those presented with a random sequence, although the effect sizes were small to medium (biggest Hedge's g_av = 0.49) compared to the original study which yielded larger effect sizes (biggest eta p(2) = 0.14). Thus, we replicated the findings in an online context, although the effect size was smaller than expected.".
• 01GK16JB2ERX1BJV09YC34X2EG abstract "The increasing interlinkage between humans and animals has led to the emergence of the ‘One Health’ and ‘One Welfare’ discourse. The covid-19 pandemic has proven the intersectionality between humans and animals and fueled these campaigns even more. The concept of One Health has in particular found its way into regulatory policy. A World Health Assembly resolution of 19 May 2020 includes a specific reference to One Health as an approach that could guide the research into the origin and transmission of covid-19 and the prevention of future pandemics. The EU also devotes attention to the One Health concept and approach, for instance with regard to its Action Plan against Antimicrobial Resistance and a study requested by the committee on the Environment, Public Health and Food Safety that examines the relation between different zoonotic pandemics and the livestock sector. While we acknowledge the interwoven connection between animal and human welfare and health, a similar approach regarding legal protection has been almost totally ignored. Hence, regarding the current momentum of animal-human integration and following the example of these movements, the time has come to consider a ‘One Right’ approach to address legal rights for (nonhuman) animals in Europe. This contribution will canvass two possibilities for legal animal rights within the framework of the European Convention for the Protection of Human Rights and Fundamental Freedoms (echr). Firstly, the umbrella of article 8 of the echr and the case for a human right to animal protection will be explored. Currently, it has been accepted that this right to respect for private and family life also entails the right to a healthy environment. It is contended that likewise simple animal rights can be created under Article 8 following a responsible anthropocentric angle. In contrast, a second entry-point which will be scrutinized concerns a biocentric viewpoint and departs from an extensive interpretation of Article 1 of the echr. Through a dynamic and (r)evolutionary interpretation the personal scope of the echr can be extended to include (certain) animals.".
• 01GK17A0VG0QB944VN283M9YZ8 abstract "Public concern about animal welfare has increased substantially in recent decades. This is mostly due to scientific findings that show that animals possess the ability to experience pain and suffering. Despite this growing public concern, the relations between humans and animals remain ambivalent. Although policy makers have taken important steps to promote animal welfare, when coming into conflict with other societal interests, the balancing of interests often turns out badly for the animals. This doctoral thesis explores what new key elements can be introduced in the legal order to give animals and their welfare a fair place in this balancing of interests. For this purpose a multi-level approach is applied, combined with interdisciplinary insights from the fields of constitutional law, environmental law and human rights law.".
• 01GK17T0R6A84EEZJKMMNZK4WA abstract "Extended version of the 'Cabinet conflicts in Belgium (1979-2018)' dataset (doi: 10.17632/2zt252t9gv.2). Data on conflicts in Belgian cabinets between 1979 and 2018 (central level), based on the manual coding of two data sources: political yearbooks (1979-2006; N=364 conflicts) and an extended coding of news agency articles (1995-2018; N=1090 conflicts). Includes an extensive description of each conflict and variables grasping their intensity, outcome (yearbook data), situations of doubt, and two variables grasping communal sides (absence/presence vs. detailed nature). The variables grasping the presence or absence of communal issues is now complemented with a new variable that distinguishes between different types of communal issues. Codebook and logbook available on demand.".
• 01GK18R97NGS8S3XM5CYZ3K3TJ abstract "News organizations increasingly tailor their news offering to the reader through personalized recommendation algorithms. However, automated recommendation algorithms reflect a commercial logic based on calculated relevance to the user, rather than aiming at a well-informed citizenry. In this paper, we introduce the EventDNA corpus, a dataset of 1773 Dutch-language news articles annotated with information on entities, news events and IPTC Media Topic codes, with the ultimate goal to outline a recommendation algorithm that uses news event diversity rather than previous reading behaviour as a key driver for personalized news recommendation. We describe the EventDNA annotation guidelines, which are inspired by the well-known ERE framework and conclude that it is not practical to apply a fixed event typology such as used in ERE to an unrestricted data context. The corpus and related source code is made available at haps://github.com/NewsDNA-LT3/.github.".
• 01GK1967PJQ4ZW0FA3RPBP5NY0 abstract "Objectives Only a few studies have investigated the quality of end-of-life care provided to nursing home residents with dementia as perceived by their relatives. We aim to investigate the quality of end-of-life care as perceived by relatives and to investigate which characteristics of nursing home residents with dementia, their relatives and the care they received are associated with the evaluation the quality of end-of-life care as perceived by the relatives. Methods Data used were from two cross-sectional studies performed in Flanders in 2010 and 2015. Questionnaires were sent to bereaved relatives of nursing home residents with dementia and 208 questionnaires were returned. The quality of end-of-life care as perceived by the relatives was measured with the End-of-Life with Dementia-Satisfaction With Care scale (scores ranging 10-40). Results In total, 208 (response rate(2010): 51.05%, response rate(2015)=60.65%) bereaved relatives responded to the questionnaire. The quality of end-of-life care as perceived by them was positively associated with the nursing home resident being male (b=1.78, p<0.05), relatives receiving information on palliative care (b=2.92, p<0.01) and relatives receiving information about medical care from care providers (b=2.22, p<0.01). Conclusion This study suggests that relatives need to be well informed about palliative and medical care. Future end-of-life care interventions in nursing homes should focus on how to increase the information exchange and communication between nursing home staff and relatives.".
• 01GK19TS3856YFCQF6GF6FMZS4 abstract "Objectives Facilitated advance care planning (ACP) helps family carers' to be aware of patient preferences. It can improve family carers' involvement in decision making and their overall experiences at the end of life, as well as, reduce psychological stress. We investigated the effects of the ACTION Respecting Choices (RC) ACP intervention on the family carers' involvement in decision making in the last 3 months of the patients' life and on the family carers' psychological distress after 3 months of bereavement. Methods Over six European countries, a sample of 162 bereaved family carers returned a bereavement questionnaire. Involvement in decision making was measured with a single item of the Views of Informal Carers-Evaluation of Services Short Form questionnaire. Psychological distress was measured with the Impact of Event Scale (IES). Results No significant effect was found on family carers involvement in decision making in the last 3 months of the patients' life (95% CI 0.449 to 4.097). However, the probability of involvement in decision making was slightly higher in the intervention arm of the study (89.6% vs 86.7%; OR=1.357). Overall, no statistical difference was found between intervention and control group regarding the IES (M=34.1 (1.7) vs 31.8 (1.5); (95% CI -2.2 to 6.8)). Conclusion The ACTION RC ACP intervention showed no significant effect on family carers' involvement in decision making or on subsequent psychological distress. More research is needed about (1) how family carers can be actively involved in ACP-conversations and (2) how to prepare family carers on their role in decision making.".
• 01GK19X4RR3BKX4AS1XPAZD5TZ abstract "Introduction Amyotrophic lateral sclerosis (ALS) is an incurable motor neuron degenerative disease that has rapid progression and is associated with cognitive impairment. For people with ALS (pALS) and their family carers, advance care planning (ACP) is beneficial, as it can lead to feelings of control/relief and refusal of unwanted treatments. However, evidence concerning the experiences and preferences regarding ACP of pALS and their family carers, especially when their symptoms progress, is scarce. This article describes the protocol for a qualitative longitudinal study that aims to explore: (1) the experiences with ACP and the preferences for future care and treatment of pALS and their family carers and (2) how these experiences and preferences change over time. Methods and analysis A qualitative, longitudinal, multiperspective design. A total of eight to nine dyads (pALS and their family carers) will be recruited, and semistructured interviews administered every 3 months over a 9-month period. Qualitative longitudinal analysis involves content analysis via in-depth reading, followed by a two-step timeline method to describe changes in experiences and preferences within and across participants. Ethics and dissemination This protocol has been approved by the central ethical committee of the University Hospital of Brussels, and local ethical committees of the other participating hospitals (B.U.N. B1432020000128). The results will be disseminated via the research group's (endoflifecare.be) website, social media and newsletter and via presentations at national and international scientific conferences.".
• 01GK1A8SW2N3K7521ZJ5C8F8NH abstract "Introduction: Echinoderm microtubule-associated protein-like 4 (EML4)-Anaplastic Lymphoma Kinase (ALK) rearrangements occur in 3% to 7% of lung adenocarcinomas and are targets for treatment with tyrosine kinase inhibitors (TKIs). Here we have developed three novel EML4-ALK-positive patient-derived Non-Small-Cell-Lung-Cancer (NSCLC) cancer cell lines, CUTO8 (variant 1), CUTO9 (variant 1) and CUTO29 (variant 3) and included a fourth ALK-positive cell line YU1077 (variant 3) to study ALK-positive signaling and responses. Variants 1 and 3 are the most common EML4-ALK variants expressed in ALK-positive NSCLC, and currently cell lines representing these EML4-ALK variants are limited. Materials and methods: Resazurin assay was performed to evaluate cell viability. Protein levels were determined using western blotting. RNA sequencing was performed in all four cell lines to identify differentially expressed genes. Whole-genome sequencing was performed to determine the presence of EML4-ALK fusion and ALK tyrosine kinase inhibitor resistance mutations. Results: In this study, we have confirmed expression of the corresponding ALK fusion protein and assessed their sensitivity to a range of ALK tyrosine kinase inhibitors. These patient derived cell lines exhibit differential sensitivity to lorlatinib, brigatinib and alectinib, with EML4-ALK variant 3 containing cell lines exhibiting increased sensitivity to lorlatinib and brigatinib as compared to alectinib. These cell lines were further characterized by whole genome sequencing and RNA-seq analysis that identified the ribonucleotide reductase regulatory subunit 2 (RRM2) as a downstream and potential therapeutic target in ALK-positive NSCLC. Conclusion: We provide a characterization of four novel EML4-ALK-positive NSCLC cell lines, highlighting genomic heterogeneity and differential responses to ALK TKI treatment. The RNA-Seq characterization of ALK-positive NSCLC CUTO8, CUTO9, CUTO29 and YU1077 cell lines reported here, has been compiled in an interactive ShinyApp resource for public data exploration (https://ccgg.ugent.be/shiny/nsclc_rrm2_2022/).".
• 01GK1BNPK6FR87W5JXADF3979H abstract "Composite materials are subjected to an increasing importance in critical components commonly used for automotive, aerospace and other modern industrial sectors. Yet, these composites are quite susceptible to damages and defects which can be introduced during the manufacturing and/or operational life. Reconstruction Algorithm for the Probabilistic Inspection of Damage (RAPID) and Delay and Sum (DAS) are well-known guided wave imaging techniques capable to reveal the presence of damage in a sparse ultrasonic sensor network. In this study, several factors in RAPID are investigated to understand their influence on the quality of the reconstructed damage map for a composite laminate with an inter-ply defect. A critical comparison between RAPID and DAS is performed in terms of their accuracy and calculation cost. Finally, results are presented on a baseline-free probabilistic imaging modality by exploiting nonlinear wave/defect interactions.".
• 01GK1CQ7R6DZSEAZ9T46W40Q4S abstract "According to the dialetheist argument from the inconsistency of informal mathematics, the informal version of the Godelian argument leads us to a true contradiction. On one hand, the dialetheist argues, we can prove that there is a mathematical claim that is neither provable nor refutable in informal mathematics. On the other, the proof of its unprovability is given in informal mathematics and proves that very sentence. We argue that the argument fails, because it relies on the unjustified and unlikely assumption that the informal Godel sentence is informally provable.".
• 01GK1D67C82TTSEAZSPYJ4B173 abstract "Assessing the structural quality of metallic turbine blades is a challenging task due to their complex geometry and wide range of possible defect features. Process Compensated Resonance Testing (PCRT) is an effective quality assessment tool that uses a broadband sinusoidal swept input to excite the resonant modes of the component and employs a supervised learning algorithm to interpret the resonant modes and as such to determine the structural quality of the component. Our previous work has mostly centered on the exploitation of classifiers that are based on Mahalanobis distance. However, in practice, the measurement uncertainty may lead to bias in the trained classifier, potentially resulting in misclassification of the turbine blade. In this study, the concept of interval Mahalanobis space is introduced in the classifier in order to cope with measurement uncertainty. The resulting Integrated Interval Mahalanobis Classification System (IIMCS) classifier employs BPSO to screen those resonant frequencies that contribute favorably to the system and analyzes the sensitivity of resonant frequencies to measurement uncertainty under a Monte Carlo simulation scheme. The developed classifier was applied to an experimental case study of equiaxed nickel alloy first-stage turbine blades with a range of defect features, showing a good and robust classification performance.".

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