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- 01GJYQT88VYKVFVPNX5AJEJ6AP classification A1.
- 01GJYQT88VYKVFVPNX5AJEJ6AP date "2022".
- 01GJYQT88VYKVFVPNX5AJEJ6AP language "eng".
- 01GJYQT88VYKVFVPNX5AJEJ6AP type journalArticle.
- 01GJYQT88VYKVFVPNX5AJEJ6AP hasPart 01GJYR0SGS5A3GJMGADAZS8N9F.pdf.
- 01GJYQT88VYKVFVPNX5AJEJ6AP subject "Medicine and Health Sciences".
- 01GJYQT88VYKVFVPNX5AJEJ6AP doi "10.1038/s41597-022-01736-1".
- 01GJYQT88VYKVFVPNX5AJEJ6AP issn "2052-4463".
- 01GJYQT88VYKVFVPNX5AJEJ6AP issue "1".
- 01GJYQT88VYKVFVPNX5AJEJ6AP volume "9".
- 01GJYQT88VYKVFVPNX5AJEJ6AP abstract "The holistic nature of omics studies makes them ideally suited to generate hypotheses on health and disease. Sequencing-based genomics and mass spectrometry (MS)-based proteomics are linked through epigenetic regulation mechanisms. However, epigenomics is currently mainly focused on DNA methylation status using sequencing technologies, while studying histone posttranslational modifications (hPTMs) using MS is lagging, partly because reuse of raw data is impractical. Yet, targeting hPTMs using epidrugs is an established promising research avenue in cancer treatment. Therefore, we here present the most comprehensive MS-based preprocessed hPTM atlas to date, including 21 T-cell acute lymphoblastic leukemia (T-ALL) cell lines. We present the data in an intuitive and browsable single licensed Progenesis QIP project and provide all essential quality metrics, allowing users to assess the quality of the data, edit individual peptides, try novel annotation algorithms and export both peptide and protein data for downstream analyses, exemplified by the PeptidoformViz tool. This data resource sets the stage for generalizing MS-based histone analysis and provides the first reusable histone dataset for epidrug development.".
- 01GJYQT88VYKVFVPNX5AJEJ6AP author 21800212-F0EE-11E1-A9DE-61C894A0A6B4.
- 01GJYQT88VYKVFVPNX5AJEJ6AP author 2D88F028-F0EE-11E1-A9DE-61C894A0A6B4.
- 01GJYQT88VYKVFVPNX5AJEJ6AP author 2EC22C3E-F0EE-11E1-A9DE-61C894A0A6B4.
- 01GJYQT88VYKVFVPNX5AJEJ6AP author 6B30F344-3548-11E4-8A59-3557B5D1D7B1.
- 01GJYQT88VYKVFVPNX5AJEJ6AP author 6F87950A-4399-11E5-997F-CA8CB5D1D7B1.
- 01GJYQT88VYKVFVPNX5AJEJ6AP author 9F804EC6-FDEE-11E1-B8C9-1EA810BDE39D.
- 01GJYQT88VYKVFVPNX5AJEJ6AP author CACD87A6-2D6C-11E4-A9C7-B2F1B4D1D7B1.
- 01GJYQT88VYKVFVPNX5AJEJ6AP author EDF6ADB6-2010-11E4-8BB4-A9F3B4D1D7B1.
- 01GJYQT88VYKVFVPNX5AJEJ6AP author F4D02620-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GJYQT88VYKVFVPNX5AJEJ6AP author F5F9DBEA-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GJYQT88VYKVFVPNX5AJEJ6AP author F7EE877A-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GJYQT88VYKVFVPNX5AJEJ6AP author F927748A-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GJYQT88VYKVFVPNX5AJEJ6AP author urn:uuid:cdcab04f-c1a2-4245-a661-51ecd930ddd0.
- 01GJYQT88VYKVFVPNX5AJEJ6AP dateCreated "2022-11-28T09:06:45Z".
- 01GJYQT88VYKVFVPNX5AJEJ6AP dateModified "2024-12-12T21:14:47Z".
- 01GJYQT88VYKVFVPNX5AJEJ6AP name "An interactive mass spectrometry atlas of histone posttranslational modifications in T-cell acute leukemia".
- 01GJYQT88VYKVFVPNX5AJEJ6AP pagination urn:uuid:85735148-7881-4986-b844-a013d0937594.
- 01GJYQT88VYKVFVPNX5AJEJ6AP publisher urn:uuid:29ee4c93-0b28-4834-a0c2-e38f756fd021.
- 01GJYQT88VYKVFVPNX5AJEJ6AP sameAs LU-01GJYQT88VYKVFVPNX5AJEJ6AP.
- 01GJYQT88VYKVFVPNX5AJEJ6AP sourceOrganization urn:uuid:527f2678-3276-4625-a0e9-f6f3cc3d5ce7.
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- 01GJYQT88VYKVFVPNX5AJEJ6AP sourceOrganization urn:uuid:bea55193-b4bc-42fd-8fd8-9f9897183b54.
- 01GJYQT88VYKVFVPNX5AJEJ6AP sourceOrganization urn:uuid:c391fb17-cd6e-4231-b8a9-6488a6f02fc2.
- 01GJYQT88VYKVFVPNX5AJEJ6AP type A1.