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- 01GJ09EMHE31A7Z0RMY7TK6BKF classification A1.
- 01GJ09EMHE31A7Z0RMY7TK6BKF date "2022".
- 01GJ09EMHE31A7Z0RMY7TK6BKF language "eng".
- 01GJ09EMHE31A7Z0RMY7TK6BKF type journalArticle.
- 01GJ09EMHE31A7Z0RMY7TK6BKF hasPart 01GJ0A4A8P8NBKCR02T97KY5W9.pdf.
- 01GJ09EMHE31A7Z0RMY7TK6BKF subject "Medicine and Health Sciences".
- 01GJ09EMHE31A7Z0RMY7TK6BKF doi "10.3390/ijms23147749".
- 01GJ09EMHE31A7Z0RMY7TK6BKF issn "1422-0067".
- 01GJ09EMHE31A7Z0RMY7TK6BKF issue "14".
- 01GJ09EMHE31A7Z0RMY7TK6BKF volume "23".
- 01GJ09EMHE31A7Z0RMY7TK6BKF abstract "Airway mucociliary regeneration and function are key players for airway defense and are impaired in chronic obstructive pulmonary disease (COPD). Using transcriptome analysis in COPD-derived bronchial biopsies, we observed a positive correlation between cilia-related genes and microRNA-449 (miR449). In vitro, miR449 was strongly increased during airway epithelial mucociliary differentiation. In vivo, miR449 was upregulated during recovery from chemical or infective insults. miR0449(-/-) mice (both alleles are deleted) showed impaired ciliated epithelial regeneration after naphthalene and Haemophilus influenzae exposure, accompanied by more intense inflammation and emphysematous manifestations of COPD. The latter occurred spontaneously in aged miR449(-/-) mice. We identified Aurora kinase A and its effector target HDAC6 as key mediators in miR449-regulated ciliary homeostasis and epithelial regeneration. Aurora kinase A is downregulated upon miR449 overexpression in vitro and upregulated in miR449(-/-) mouse lungs. Accordingly, imaging studies showed profoundly altered cilia length and morphology accompanied by reduced mucociliary clearance. Pharmacological inhibition of HDAC6 rescued cilia length and coverage in miR449(-/-) cells, consistent with its tubulin-deacetylating function. Altogether, our study establishes a link between miR449, ciliary dysfunction, and COPD pathogenesis.".
- 01GJ09EMHE31A7Z0RMY7TK6BKF author F4E14CA2-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author F84B8E2A-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:0923e75d-338f-4f2e-97ec-71eac0fab449.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:112f3e80-863d-40e9-b934-7026d53c97d2.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:1dc12b8a-3c5d-4545-8e00-ae56185d5d68.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:26eb84ea-2b43-4a19-a9ba-92cdfc9c0940.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:2f3b6e3f-873f-4c00-b9a3-50d682e9b0c1.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:2fbdee35-8449-4d66-be63-6f00fd01227d.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:35ac3434-8eed-4c0a-a466-2af21a0271ed.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:4186cd60-a592-42cb-9692-f771978d74f3.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:4e2cb71b-dca0-4603-bde3-fe66c6cd24c8.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:7f7fbdd1-48c6-428c-b93e-0ebb56c1813c.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:8eca103b-927b-4133-83c0-fb2b0fdd8d8c.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:94281c8d-dec1-4f38-af6a-4cc3b21f0085.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:9d713fb4-ee2d-4638-b124-8af2eb5c8757.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:a8a58e20-5556-4d47-b201-421b900006b6.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:aa98b611-83df-4094-a15c-9c3856328b3b.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:ab5b5925-ecf6-4fe7-9238-2e936ca0ceae.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:b19f4cbf-460b-425f-a716-d0d21879ad6c.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:b1b07c6d-c881-4a4d-a769-6af5e4f795ac.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:b57e654a-8c62-4e90-84d1-5f51926ea106.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:b7fba1e2-2738-42c2-b937-c844911f2212.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:ba2ff833-a504-4038-891b-84b23068fa74.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:c0e0cd2e-dd27-46a4-894c-ea62f168891a.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:d171c958-bbd7-4ac8-a824-33a4cfb8b728.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:d2807ef4-c4ff-4a32-a907-6ed6b4ec8ced.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:efa44ab2-2a91-4498-9d0b-c24ff9c22ef7.
- 01GJ09EMHE31A7Z0RMY7TK6BKF author urn:uuid:febf2017-e78d-46dd-9be1-ab24ac355f80.
- 01GJ09EMHE31A7Z0RMY7TK6BKF dateCreated "2022-11-16T13:18:31Z".
- 01GJ09EMHE31A7Z0RMY7TK6BKF dateModified "2024-12-12T20:20:48Z".
- 01GJ09EMHE31A7Z0RMY7TK6BKF name "miR449 protects airway regeneration by controlling AURKA/HDAC6-mediated ciliary disassembly".
- 01GJ09EMHE31A7Z0RMY7TK6BKF pagination urn:uuid:808f5297-099e-4647-aaf7-199ccd27b9a8.
- 01GJ09EMHE31A7Z0RMY7TK6BKF sameAs LU-01GJ09EMHE31A7Z0RMY7TK6BKF.
- 01GJ09EMHE31A7Z0RMY7TK6BKF sourceOrganization urn:uuid:7fa711ea-8866-4abf-8a02-ef3c6e930f1b.
- 01GJ09EMHE31A7Z0RMY7TK6BKF sourceOrganization urn:uuid:f051bebe-4eb5-4815-b868-a81eb322ff23.
- 01GJ09EMHE31A7Z0RMY7TK6BKF type A1.