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Matches in Ghent University Academic Bibliography for { <https://biblio.ugent.be/publication/01GJ30BWH3YY3WERBS9N8KD1DR> ?p ?o. }

• 01GJ30BWH3YY3WERBS9N8KD1DR classification A1.
• 01GJ30BWH3YY3WERBS9N8KD1DR date "2023".
• 01GJ30BWH3YY3WERBS9N8KD1DR language "eng".
• 01GJ30BWH3YY3WERBS9N8KD1DR type journalArticle.
• 01GJ30BWH3YY3WERBS9N8KD1DR hasPart 01GJ30DBPHF9EKDPQEP99161FY.pdf.
• 01GJ30BWH3YY3WERBS9N8KD1DR subject "Medicine and Health Sciences".
• 01GJ30BWH3YY3WERBS9N8KD1DR doi "10.1183/13993003.00606-2022".
• 01GJ30BWH3YY3WERBS9N8KD1DR issn "0903-1936".
• 01GJ30BWH3YY3WERBS9N8KD1DR issn "1399-3003".
• 01GJ30BWH3YY3WERBS9N8KD1DR issue "4".
• 01GJ30BWH3YY3WERBS9N8KD1DR volume "61".
• 01GJ30BWH3YY3WERBS9N8KD1DR abstract "BACKGROUND: Effectiveness studies with biological therapies for asthma lack standardised outcome measures. The COMSA (Core Outcome Measures sets for paediatric and adult Severe Asthma) working group sought to develop Core Outcome Measures (COM) sets to facilitate better synthesis of data and appraisal of biologics in paediatric and adult asthma clinical studies.; METHODS: COMSA utilised a multi-stakeholder consensus process among patients with severe asthma, adult, and paediatric clinicians, pharmaceutical representatives and health regulators from across Europe. Evidence included a systematic review of development, validity, and reliability of selected outcome measures plus a narrative review and a pan-European survey to better understand patients' and carers' views about outcome measures. It was discussed using a modified GRADE Evidence to Decision framework. Anonymous voting was conducted using predefined consensus criteria.; RESULTS: Both adult and paediatric COM sets include forced expiratory volume in 1 s (FEV1) as z scores, annual frequency of severe exacerbations and maintenance oral corticosteroid use. Additionally, the paediatric COM set includes the Paediatric Asthma Quality of Life Questionnaire, and Asthma Control Test (ACT) or Childhood-ACT while the adult COM includes the Severe Asthma Questionnaire and the Asthma Control Questionnaire-6 (symptoms and rescue medication use reported separately).; CONCLUSIONS: This patient-centred collaboration has produced two COM sets for paediatric and adult severe asthma. It is expected that they will inform the methodology of future clinical trials, enhance comparability of efficacy and effectiveness of biological therapies, and help assess their socioeconomic value. COMSA will inform definitions of non-response and response to biological therapy for severe asthma. Copyright ©The authors 2022. For reproduction rights and permissions contact permissions@ersnet.org.".
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• 01GJ30BWH3YY3WERBS9N8KD1DR dateCreated "2022-11-17T14:37:27Z".
• 01GJ30BWH3YY3WERBS9N8KD1DR dateModified "2024-12-12T17:57:35Z".
• 01GJ30BWH3YY3WERBS9N8KD1DR name "Development of core outcome measures sets for paediatric and adult Severe Asthma (COMSA)".
• 01GJ30BWH3YY3WERBS9N8KD1DR pagination urn:uuid:f90582fe-7bd2-4330-86c3-3e374df5e440.
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• 01GJ30BWH3YY3WERBS9N8KD1DR type A1.