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- 01GJ30HERBN7NV1D65J9FCC7FP classification A1.
- 01GJ30HERBN7NV1D65J9FCC7FP date "2023".
- 01GJ30HERBN7NV1D65J9FCC7FP language "eng".
- 01GJ30HERBN7NV1D65J9FCC7FP type journalArticle.
- 01GJ30HERBN7NV1D65J9FCC7FP hasPart 01HEW7BE5V39091054R0S1CJEY.pdf.
- 01GJ30HERBN7NV1D65J9FCC7FP subject "Medicine and Health Sciences".
- 01GJ30HERBN7NV1D65J9FCC7FP doi "10.1093/gerona/glac202".
- 01GJ30HERBN7NV1D65J9FCC7FP issn "1079-5006".
- 01GJ30HERBN7NV1D65J9FCC7FP issn "1758-535X".
- 01GJ30HERBN7NV1D65J9FCC7FP issue "2".
- 01GJ30HERBN7NV1D65J9FCC7FP volume "78".
- 01GJ30HERBN7NV1D65J9FCC7FP abstract "BACKGROUND: The ageing population and its burden on health-care systems warrant early detection of patients at risk of functional decline and mortality. We aimed to assess frailty transitions and its accuracy for mortality prediction in subjects with impaired spirometry (Preserved Ratio Impaired Spirometry [PRISm] or Chronic Obstructive Pulmonary Disease [COPD]).; METHODS: In participants from the population-based Rotterdam Study (mean age 69.1±8.9 years), we examined whether PRISm (Forced Expiratory Volume in 1 second [FEV1]/Forced Vital Capacity [FVC]≥70% and FEV1<80%) or COPD (FEV1/FVC<70%) affected frailty transitions (progression/recovery between frailty states [robust, prefrailty and frailty], lost to follow-up or death) using age-, sex- and smoking state-adjusted multinomial regression models yielding odd's ratios (OR). Second, we assessed diagnostic accuracy of frailty score for predicting mortality in subjects with COPD using c-statistics.; RESULTS: Compared to subjects with normal spirometry, subjects with PRISm were more likely to transit from robust (OR 2.2[1.2-4.2], p<0.05) or prefrailty (OR 2.6[1.3-5.5], p<0.01) towards frailty. Subjects with PRISm (OR 0.4[0.2-0.8], p<0.05) and COPD (OR 0.6[0.4-1.0], NS) were less likely to recover from their frail state, and were more likely to progress from any frailty state towards death (OR between 1.1 and 2.8, p<0.01). Accuracy for predicting mortality in subjects with COPD significantly improved when adding frailty score to age, sex and smoking status (90.5[82.3-89.8] vs 77.9[67.2-88.6], p<0.05).; CONCLUSION: Participants with PRISm or COPD more often developed frailty with poor reversibility. Assessing physical frailty improved risk stratification for subjects with impaired spirometry for predicting increased life years. © The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America.".
- 01GJ30HERBN7NV1D65J9FCC7FP author 04778CDA-F0EE-11E1-A9DE-61C894A0A6B4.
- 01GJ30HERBN7NV1D65J9FCC7FP author BCC58358-1F47-11E4-ABD6-473CB5D1D7B1.
- 01GJ30HERBN7NV1D65J9FCC7FP author F497BC5E-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GJ30HERBN7NV1D65J9FCC7FP author urn:uuid:3a3fff3d-a4cd-422f-9cc7-a6214bb10153.
- 01GJ30HERBN7NV1D65J9FCC7FP author urn:uuid:41b71c4b-88ed-4fb7-8250-ca9144f9f3e7.
- 01GJ30HERBN7NV1D65J9FCC7FP author urn:uuid:5c32e877-8f56-4a84-a66a-a202a4460d87.
- 01GJ30HERBN7NV1D65J9FCC7FP author urn:uuid:ea9f74dc-5437-445a-ac2d-613ee8197ad3.
- 01GJ30HERBN7NV1D65J9FCC7FP dateCreated "2022-11-17T14:40:29Z".
- 01GJ30HERBN7NV1D65J9FCC7FP dateModified "2024-12-12T18:01:29Z".
- 01GJ30HERBN7NV1D65J9FCC7FP name "Frailty transitions in older persons with lung function impairment : a population-based study".
- 01GJ30HERBN7NV1D65J9FCC7FP pagination urn:uuid:b7b7b927-21b4-49ad-acd8-a0de57c49b74.
- 01GJ30HERBN7NV1D65J9FCC7FP sameAs LU-01GJ30HERBN7NV1D65J9FCC7FP.
- 01GJ30HERBN7NV1D65J9FCC7FP sourceOrganization urn:uuid:277ba785-1a57-45db-85e2-5c27fb67c78e.
- 01GJ30HERBN7NV1D65J9FCC7FP sourceOrganization urn:uuid:7c8f2a9b-2e1a-4bee-8fcc-810b4b0fb5c3.
- 01GJ30HERBN7NV1D65J9FCC7FP sourceOrganization urn:uuid:82ab0bee-0748-4854-8ca5-c96a0d623507.
- 01GJ30HERBN7NV1D65J9FCC7FP sourceOrganization urn:uuid:c3f0701e-1507-4a0f-b769-4f399948bfff.
- 01GJ30HERBN7NV1D65J9FCC7FP type A1.