Matches in Ghent University Academic Bibliography for { <https://biblio.ugent.be/publication/01GJ31585CP0C9H6G5E30BRQRM> ?p ?o. }
Showing items 1 to 37 of
37
with 100 items per page.
- 01GJ31585CP0C9H6G5E30BRQRM classification A1.
- 01GJ31585CP0C9H6G5E30BRQRM date "2023".
- 01GJ31585CP0C9H6G5E30BRQRM language "eng".
- 01GJ31585CP0C9H6G5E30BRQRM type journalArticle.
- 01GJ31585CP0C9H6G5E30BRQRM hasPart 01HEWAG9F1BQEY5YG6C3X81FEQ.pdf.
- 01GJ31585CP0C9H6G5E30BRQRM hasPart urn:uuid:77584b58-f27f-473e-96c0-3d7dd997453e.
- 01GJ31585CP0C9H6G5E30BRQRM subject "Medicine and Health Sciences".
- 01GJ31585CP0C9H6G5E30BRQRM doi "10.1136/thoraxjnl-2021-217674".
- 01GJ31585CP0C9H6G5E30BRQRM issn "0040-6376".
- 01GJ31585CP0C9H6G5E30BRQRM issn "1468-3296".
- 01GJ31585CP0C9H6G5E30BRQRM issue "5".
- 01GJ31585CP0C9H6G5E30BRQRM volume "78".
- 01GJ31585CP0C9H6G5E30BRQRM abstract "Introduction Older adults have the greatest burden of asthma and poorest outcomes. The pharmacogenetics of inhaled corticosteroid (ICS) treatment response is not well studied in older adults. Methods A genome-wide association study of ICS response was performed in asthmatics of European ancestry in Genetic Epidemiology Research on Adult Health and Aging (GERA) by fitting Cox proportional hazards regression models, followed by validation in the Mass General Brigham (MGB) Biobank and Rotterdam Study. ICS response was measured using two definitions in asthmatics on ICS treatment: (1) absence of oral corticosteroid (OCS) bursts using prescription records and (2) absence of asthma-related exacerbations using diagnosis codes. A fixed-effect meta-analysis was performed for each outcome. The validated single-nucleotide polymorphisms (SNPs) were functionally annotated to standard databases. Results In 5710 subjects in GERA, 676 subjects in MGB Biobank, and 465 subjects in the Rotterdam Study, four novel SNPs on chromosome six near PTCHD4 validated across all cohorts and met genome-wide significance on meta-analysis for the OCS burst outcome. In 4541 subjects in GERA and 505 subjects in MGB Biobank, 152 SNPs with pCPED1, CRADD and DST for the OCS burst outcome and GM2A, SNW1, CACNA1C, DPH1, and RPS10 for the asthma-related exacerbation outcome. Conclusions Multiple novel SNPs associated with ICS response were identified in older adult asthmatics. Several SNPs annotated to genes previously associated with asthma and other airway or allergic diseases, including PTCHD4.".
- 01GJ31585CP0C9H6G5E30BRQRM author 04778CDA-F0EE-11E1-A9DE-61C894A0A6B4.
- 01GJ31585CP0C9H6G5E30BRQRM author 8CAE9266-C1D9-11E8-88C3-04155707D3EF.
- 01GJ31585CP0C9H6G5E30BRQRM author F497BC5E-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GJ31585CP0C9H6G5E30BRQRM author urn:uuid:039a60c5-7e3c-419b-b026-450167c987b7.
- 01GJ31585CP0C9H6G5E30BRQRM author urn:uuid:2287cd6f-155a-450e-b061-87abe98fcbfb.
- 01GJ31585CP0C9H6G5E30BRQRM author urn:uuid:495a0213-c27d-4570-b145-24cde43febe1.
- 01GJ31585CP0C9H6G5E30BRQRM author urn:uuid:697215d9-9236-4e24-8a9b-75e05d5f021b.
- 01GJ31585CP0C9H6G5E30BRQRM author urn:uuid:7f215395-5dfd-4add-a8b8-3b5aaf40cf08.
- 01GJ31585CP0C9H6G5E30BRQRM author urn:uuid:97c800ca-0d3e-4cc3-8fe8-1d60011d884a.
- 01GJ31585CP0C9H6G5E30BRQRM author urn:uuid:99d2acfc-8cbc-4f11-be72-c32a2807b925.
- 01GJ31585CP0C9H6G5E30BRQRM author urn:uuid:b051e34a-7029-4290-9b1f-d68a8562872c.
- 01GJ31585CP0C9H6G5E30BRQRM author urn:uuid:bcca2cb7-6e4e-4d9e-90ff-e73020aa3c8f.
- 01GJ31585CP0C9H6G5E30BRQRM author urn:uuid:d131b9d8-2fa2-4732-9703-df2d0cbcbfca.
- 01GJ31585CP0C9H6G5E30BRQRM author urn:uuid:efb0a2b0-35f7-4855-a14f-780dd16e5335.
- 01GJ31585CP0C9H6G5E30BRQRM dateCreated "2022-11-17T14:51:18Z".
- 01GJ31585CP0C9H6G5E30BRQRM dateModified "2024-12-12T18:02:25Z".
- 01GJ31585CP0C9H6G5E30BRQRM name "Novel genetic variants associated with inhaled corticosteroid treatment response in older adults with asthma".
- 01GJ31585CP0C9H6G5E30BRQRM pagination urn:uuid:ea368e86-7606-4b95-9833-ce166294869c.
- 01GJ31585CP0C9H6G5E30BRQRM sameAs LU-01GJ31585CP0C9H6G5E30BRQRM.
- 01GJ31585CP0C9H6G5E30BRQRM sourceOrganization urn:uuid:0c603202-48ab-4793-b47d-4b98804b9369.
- 01GJ31585CP0C9H6G5E30BRQRM sourceOrganization urn:uuid:1e3d7f0b-89a6-476d-8826-0d4fca2e1895.
- 01GJ31585CP0C9H6G5E30BRQRM sourceOrganization urn:uuid:1f8e3a52-3008-47fe-91fb-a15d0431ef73.
- 01GJ31585CP0C9H6G5E30BRQRM sourceOrganization urn:uuid:98670b91-c588-4b57-b575-07659d548117.
- 01GJ31585CP0C9H6G5E30BRQRM type A1.