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- 01GKGSDR6F8ZX3SZKXRQ1HR82P classification D1.
- 01GKGSDR6F8ZX3SZKXRQ1HR82P promoter 2D6554C4-F0EE-11E1-A9DE-61C894A0A6B4.
- 01GKGSDR6F8ZX3SZKXRQ1HR82P promoter urn:uuid:ec17de1b-f4b7-4986-82ea-9b1ca1a4b8ed.
- 01GKGSDR6F8ZX3SZKXRQ1HR82P date "2022".
- 01GKGSDR6F8ZX3SZKXRQ1HR82P language "eng".
- 01GKGSDR6F8ZX3SZKXRQ1HR82P type dissertation.
- 01GKGSDR6F8ZX3SZKXRQ1HR82P hasPart 01GKGSKH05J4184VGHW3W3EM0K.pdf.
- 01GKGSDR6F8ZX3SZKXRQ1HR82P subject "Biology and Life Sciences".
- 01GKGSDR6F8ZX3SZKXRQ1HR82P isbn "9789463575614".
- 01GKGSDR6F8ZX3SZKXRQ1HR82P abstract "In this work, an in vitro model of the simulated spaceflight environment was developed and applied to investigate the contribution of dermal fibroblasts in the wound healing process after exposure to simulated microgravity, ionizing radiation, and psychological stress. Besides, fibroblasts have been exposed to hypergravity and gravitational alterations between simulated microgravity and hypergravity, with or without stress hormones. After exposure to a combination of the aforementioned simulated spaceflight stressors, fibroblasts’ expression of cytokines and growth factors as well as dermal matrix proteins were measured. Additionally, measures of migration capacity and cytoskeletal remodeling were obtained as well. Finally, the effect of different radiation qualities on DNA damage and repair with or without the addition of stress hormones was investigated. The results show that the wound healing capacity of dermal fibroblasts is sensitive for exposure to simulated spaceflight stressors. Moreover, it was shown that the different spaceflight stressors can interfere with the wound healing process at any stage. Additionally, several interaction effects between the different spaceflight stressors have been identified. Taken together, the insights of this work highlight the need of investigating the combined effect of simulated spaceflight stressors on the wound healing capacity of the skin.".
- 01GKGSDR6F8ZX3SZKXRQ1HR82P author 14ABFF1C-2677-11E9-B3C7-45AB5607D3EF.
- 01GKGSDR6F8ZX3SZKXRQ1HR82P dateCreated "2022-12-05T09:21:12Z".
- 01GKGSDR6F8ZX3SZKXRQ1HR82P dateModified "2024-10-29T09:20:53Z".
- 01GKGSDR6F8ZX3SZKXRQ1HR82P name "Unravelling the effect of the interplay of spaceflight stressors on the in vitro wound healing process".
- 01GKGSDR6F8ZX3SZKXRQ1HR82P pagination urn:uuid:74c866b3-49e1-4467-a9ec-72a346c97df2.
- 01GKGSDR6F8ZX3SZKXRQ1HR82P publisher urn:uuid:b2687416-54e9-449f-b7d3-f958a2106180.
- 01GKGSDR6F8ZX3SZKXRQ1HR82P sameAs LU-01GKGSDR6F8ZX3SZKXRQ1HR82P.
- 01GKGSDR6F8ZX3SZKXRQ1HR82P sourceOrganization urn:uuid:c18808ea-270a-4ac1-b300-c16b733a97b6.
- 01GKGSDR6F8ZX3SZKXRQ1HR82P type D1.