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- 01GKHPA0K5M1ZCKX0SZQ83DB3D classification A2.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D date "2022".
- 01GKHPA0K5M1ZCKX0SZQ83DB3D language "eng".
- 01GKHPA0K5M1ZCKX0SZQ83DB3D type journalArticle.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D hasPart 01GKHPJXAX0BH3WY95JARWQDY3.pdf.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D subject "Biology and Life Sciences".
- 01GKHPA0K5M1ZCKX0SZQ83DB3D subject "Medicine and Health Sciences".
- 01GKHPA0K5M1ZCKX0SZQ83DB3D doi "10.1093/narcan/zcac037".
- 01GKHPA0K5M1ZCKX0SZQ83DB3D issn "2632-8674".
- 01GKHPA0K5M1ZCKX0SZQ83DB3D issue "4".
- 01GKHPA0K5M1ZCKX0SZQ83DB3D volume "4".
- 01GKHPA0K5M1ZCKX0SZQ83DB3D abstract "While cell-free DNA (cfDNA) is widely being investigated, free circulating RNA (extracellular RNA, exRNA) has the potential to improve cancer therapy response monitoring and detection due to its dynamic nature. However, it remains unclear in which blood subcompartment tumour-derived exRNAs primarily reside. We developed a host-xenograft deconvolution framework, exRNAxeno, with mapping strategies to either a combined human-mouse reference genome or both species genomes in parallel, applicable to exRNA sequencing data from liquid biopsies of human xenograftmousemodels. The tool enables to distinguish (human) tumoural RNA from (murine) host RNA, to specifically analyse tumour-derived exRNA. We applied the combined pipeline to total exRNA sequencing data from 95 blood-derived liquid biopsy samples from 30 mice, xenografted with 11 different tumours. Tumoural exRNA concentrations are not determined by plasma platelet levels, while host exRNA concentrations increase with platelet content. Furthermore, a large variability in exRNA abundance and transcript content across individual mice is observed. The tumoural gene detectability in plasma is largely correlated with the RNA expression levels in the tumour tissue or cell line. These findings unravel new aspects of tumour-derived exRNA biology in xenograftmodels and open new avenues to further investigate the role of exRNA in cancer.".
- 01GKHPA0K5M1ZCKX0SZQ83DB3D author 042DC730-F0EE-11E1-A9DE-61C894A0A6B4.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D author 06C17FFE-F0EF-11E1-A197-91C894A0A6B4.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D author 0797DE42-F0EE-11E1-A9DE-61C894A0A6B4.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D author 094D8CB4-F0EE-11E1-A9DE-61C894A0A6B4.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D author 0D373960-F0EE-11E1-A9DE-61C894A0A6B4.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D author 0FFBBE0C-0464-11E3-AC31-8F7910BDE39D.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D author 29B996B4-F0EE-11E1-A9DE-61C894A0A6B4.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D author 3D91E92A-F0EE-11E1-A9DE-61C894A0A6B4.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D author 8863D352-9998-11E7-9FC9-587FAD28A064.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D author 9879B128-3611-11E4-8697-FC36B5D1D7B1.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D author F4388FA4-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D author F5540E9A-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D author F5CC824E-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D author F7234196-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D author F97EC6E0-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D author FB7AAD38-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D author urn:uuid:007ee585-b1ce-4df2-90bb-509a495569ae.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D author urn:uuid:1408febc-2c09-4955-a5fb-2fecb1240776.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D author urn:uuid:4b7c00fb-cce3-4699-a9eb-6c14f5822e7b.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D author urn:uuid:bbabd908-9de2-4e80-a7dd-29e44f8d4435.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D author urn:uuid:e6abad4d-3191-42af-8ef0-a49dc700d804.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D dateCreated "2022-12-05T17:45:58Z".
- 01GKHPA0K5M1ZCKX0SZQ83DB3D dateModified "2024-11-28T00:15:21Z".
- 01GKHPA0K5M1ZCKX0SZQ83DB3D name "Whole transcriptome profiling of liquid biopsies from tumour xenografted mouse models enables specific monitoring of tumour-derived extracellular RNA".
- 01GKHPA0K5M1ZCKX0SZQ83DB3D pagination urn:uuid:9be5836e-1a68-4fd9-8155-45555f140bdf.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D sameAs LU-01GKHPA0K5M1ZCKX0SZQ83DB3D.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D sourceOrganization urn:uuid:24dfae03-eb0b-4ddc-b1f9-e305a42f091a.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D sourceOrganization urn:uuid:5cf6865b-9451-4d78-8dba-40bfa1f32e0d.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D sourceOrganization urn:uuid:a426ebe7-369d-403f-814c-a888b2cb0829.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D sourceOrganization urn:uuid:ebff4e2e-5412-48a6-a383-1b697dad4d79.
- 01GKHPA0K5M1ZCKX0SZQ83DB3D type A2.