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- 01GKV1VZZBF0SDKQFHGA7S5ZSB classification A1.
- 01GKV1VZZBF0SDKQFHGA7S5ZSB date "2022".
- 01GKV1VZZBF0SDKQFHGA7S5ZSB language "eng".
- 01GKV1VZZBF0SDKQFHGA7S5ZSB type journalArticle.
- 01GKV1VZZBF0SDKQFHGA7S5ZSB hasPart 01GKV1WKYJ20RP793Y3910GJ3Y.pdf.
- 01GKV1VZZBF0SDKQFHGA7S5ZSB subject "Medicine and Health Sciences".
- 01GKV1VZZBF0SDKQFHGA7S5ZSB doi "10.1002/cti2.1427".
- 01GKV1VZZBF0SDKQFHGA7S5ZSB issn "2050-0068".
- 01GKV1VZZBF0SDKQFHGA7S5ZSB issue "11".
- 01GKV1VZZBF0SDKQFHGA7S5ZSB volume "11".
- 01GKV1VZZBF0SDKQFHGA7S5ZSB abstract "Immunosenescence is a natural ageing phenomenon with alterations in innate and especially adaptive immunity and contributes to reduced antimicrobial defence and chronic low-grade inflammation. This is mostly reflected by an increase in organ-directed and/or circulating reactive and cytolytic terminally differentiated T cells that have lost their expression of the costimulatory receptor CD28. Apart from being induced by a genetic predisposition, ageing or viral infections (particularly cytomegalovirus infection), immunosenescence is accelerated in many inflammatory diseases and uraemia. This translates into an enhancement of vascular inflammation and cardiovascular disease varying from endothelial dysfunction to plaque rupture. Emerging data point to a mechanistic role of CD28(null) T cells in glomerulonephritis, where they initiate and propagate local inflammation in concordance with dendritic cells and macrophages. They are suitably equipped to escape immunological dampening by the absence of homing to lymph nodes, anti-apoptotic properties and resistance to suppression by regulatory T cells. Early accumulation of senescent CD28(null) T cells precedes glomerular or vascular injury, and targeting these cells could open avenues for early treatment interventions that aim at abrogating a detrimental vicious cycle.".
- 01GKV1VZZBF0SDKQFHGA7S5ZSB author 00875BD2-F0EE-11E1-A9DE-61C894A0A6B4.
- 01GKV1VZZBF0SDKQFHGA7S5ZSB author 2D6F1B76-F0EE-11E1-A9DE-61C894A0A6B4.
- 01GKV1VZZBF0SDKQFHGA7S5ZSB author FF0A8900-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GKV1VZZBF0SDKQFHGA7S5ZSB dateCreated "2022-12-09T09:01:12Z".
- 01GKV1VZZBF0SDKQFHGA7S5ZSB dateModified "2024-07-09T07:42:50Z".
- 01GKV1VZZBF0SDKQFHGA7S5ZSB name "Immunosenescence : an unexplored role in glomerulonephritis".
- 01GKV1VZZBF0SDKQFHGA7S5ZSB pagination urn:uuid:edd9e2de-c3cd-475d-9859-b73e6272209b.
- 01GKV1VZZBF0SDKQFHGA7S5ZSB sameAs LU-01GKV1VZZBF0SDKQFHGA7S5ZSB.
- 01GKV1VZZBF0SDKQFHGA7S5ZSB sourceOrganization urn:uuid:3b6cd5e6-4508-4e18-b827-98cde65e085b.
- 01GKV1VZZBF0SDKQFHGA7S5ZSB sourceOrganization urn:uuid:487a97c3-f530-4f96-9da3-becd7dd5fe09.
- 01GKV1VZZBF0SDKQFHGA7S5ZSB sourceOrganization urn:uuid:a7c1c025-b7d7-4ecb-af28-134c5f80bf2d.
- 01GKV1VZZBF0SDKQFHGA7S5ZSB sourceOrganization urn:uuid:c7c5c726-e48e-43be-9489-b14c63367be1.
- 01GKV1VZZBF0SDKQFHGA7S5ZSB type A1.