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- 01GM2Y0FFGRDCQZCD0YKVHYC0X classification A1.
- 01GM2Y0FFGRDCQZCD0YKVHYC0X date "2022".
- 01GM2Y0FFGRDCQZCD0YKVHYC0X language "eng".
- 01GM2Y0FFGRDCQZCD0YKVHYC0X type journalArticle.
- 01GM2Y0FFGRDCQZCD0YKVHYC0X hasPart 01GM301XQHE626SAVZWGQXKPYQ.pdf.
- 01GM2Y0FFGRDCQZCD0YKVHYC0X subject "Biology and Life Sciences".
- 01GM2Y0FFGRDCQZCD0YKVHYC0X doi "10.1111/1751-7915.14160".
- 01GM2Y0FFGRDCQZCD0YKVHYC0X issn "1751-7915".
- 01GM2Y0FFGRDCQZCD0YKVHYC0X issue "12".
- 01GM2Y0FFGRDCQZCD0YKVHYC0X volume "15".
- 01GM2Y0FFGRDCQZCD0YKVHYC0X abstract "Indole signalling has been proposed as a potential target for the development of novel virulence inhibitors to control bacterial infections. However, the major structural features of indole analogues that govern antivirulence activity remain unexplored. Therefore, we investigated the impact of 26 indole analogues on indole-regulated virulence phenotypes in Vibrio campbellii and on the virulence of the bacterium in a gnotobiotic brine shrimp model. The results demonstrated that 10 indole analogues significantly increased the fluorescence of indole reporter strain Vibrio cholerae S9149, 21 of them decreased the swimming motility of V. campbellii, and 13 of them significantly decreased the biofilm formation of V. campbellii. Further, we found that 1-methylindole, indene, 2,3-benzofuran, thianaphthene, indole-3-acetonitrile, methyl indole-3-carboxylate, 3-methylindole, and indole-2-carboxaldehyde exhibited a significant protective effect on brine shrimp larvae against V. campbellii infection, resulting in survival rates of challenged brine shrimp above 80%. The highest survival of shrimp larvae (98%) was obtained with indole-3-acetonitrile, even at a relatively low concentration of 20 mu M. Importantly, the indole analogues did not affect bacterial growth, both in vitro and in vivo. These results indicate the potential of indole analogues in applications aiming at the protection of shrimp from vibriosis.".
- 01GM2Y0FFGRDCQZCD0YKVHYC0X author 3BC3AAC0-F0EE-11E1-A9DE-61C894A0A6B4.
- 01GM2Y0FFGRDCQZCD0YKVHYC0X author 7FC36910-C5CA-11E8-8987-A2685607D3EF.
- 01GM2Y0FFGRDCQZCD0YKVHYC0X author F6F08698-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GM2Y0FFGRDCQZCD0YKVHYC0X dateCreated "2022-12-12T10:27:40Z".
- 01GM2Y0FFGRDCQZCD0YKVHYC0X dateModified "2024-10-29T15:56:40Z".
- 01GM2Y0FFGRDCQZCD0YKVHYC0X name "Indole analogues decreasing the virulence of Vibrio campbellii towards brine shrimp larvae".
- 01GM2Y0FFGRDCQZCD0YKVHYC0X pagination urn:uuid:3a161ffb-2495-4ca8-8f8d-da067dd1d03a.
- 01GM2Y0FFGRDCQZCD0YKVHYC0X sameAs LU-01GM2Y0FFGRDCQZCD0YKVHYC0X.
- 01GM2Y0FFGRDCQZCD0YKVHYC0X sourceOrganization urn:uuid:e49b0cec-995f-45e0-833a-4ff63342e6e9.
- 01GM2Y0FFGRDCQZCD0YKVHYC0X type A1.