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- 01GMVB35JBTE11ARWQJZRWT9H4 classification C3.
- 01GMVB35JBTE11ARWQJZRWT9H4 date "2022".
- 01GMVB35JBTE11ARWQJZRWT9H4 language "eng".
- 01GMVB35JBTE11ARWQJZRWT9H4 type conference.
- 01GMVB35JBTE11ARWQJZRWT9H4 hasPart 01GMXFPST5S95P2KBK0WPJM15H.pdf.
- 01GMVB35JBTE11ARWQJZRWT9H4 subject "Technology and Engineering".
- 01GMVB35JBTE11ARWQJZRWT9H4 doi "10.5281/zenodo.7405481".
- 01GMVB35JBTE11ARWQJZRWT9H4 presentedAt urn:uuid:50b258d4-0a8e-4b63-b42d-0cde7c5dbfb0.
- 01GMVB35JBTE11ARWQJZRWT9H4 abstract "The `oxygen paradox' can be explained as two opposing biological processes with oxygen (O2) as a reactant. On the one hand, oxygen is essential to aerobic metabolism, being used by mitochondria to fuel oxidative phosphorylation. On the other hand, an excess supply of oxygen will generate reactive species which are harmful for the cell. To maintain oxygen homeostasis, the first process should be maximized compared to the second one. We have hypothesized that curved and cholesterol-enriched membrane invaginations called caveolae help maintain the proper oxygen level by taking up oxygen and attenuating its release to the mitochondria. The mechanism by which caveolae may help to buffer the oxygen level in cells is still unclear. Here, we aim to assess how structural aspects of caveolae---namely the curvature and the cholesterol content of the membrane---influence the local oxygen abundance and the membrane permeability. We have modelled liposomes with varying size (curvature) and with varying ratios of phosphatidylcholine (POPC) and cholesterol, using molecular dynamics simulation. Associated changes in the oxygen free energy profile and permeability will be presented.".
- 01GMVB35JBTE11ARWQJZRWT9H4 author 26929427-1621-11ea-82de-f6c25dc23e21.
- 01GMVB35JBTE11ARWQJZRWT9H4 author F7F4F4A2-F0ED-11E1-A9DE-61C894A0A6B4.
- 01GMVB35JBTE11ARWQJZRWT9H4 author urn:uuid:07413b88-bbc4-4775-9829-a40f8b6e61cf.
- 01GMVB35JBTE11ARWQJZRWT9H4 author urn:uuid:6500a26e-4f62-4e06-a20b-9fca60fc4c13.
- 01GMVB35JBTE11ARWQJZRWT9H4 author urn:uuid:f25a92f4-cb7c-4a07-9c52-3aec80bbb1d6.
- 01GMVB35JBTE11ARWQJZRWT9H4 dateCreated "2022-12-21T21:58:06Z".
- 01GMVB35JBTE11ARWQJZRWT9H4 dateModified "2024-10-29T08:50:44Z".
- 01GMVB35JBTE11ARWQJZRWT9H4 name "Investigating the caveolin protein role in mitochondrial oxygen consumption".
- 01GMVB35JBTE11ARWQJZRWT9H4 pagination urn:uuid:c5ce94df-ddae-41a3-8509-f015444507ef.
- 01GMVB35JBTE11ARWQJZRWT9H4 sameAs LU-01GMVB35JBTE11ARWQJZRWT9H4.
- 01GMVB35JBTE11ARWQJZRWT9H4 sourceOrganization urn:uuid:1e142300-3bb3-4c08-bc72-403f1d8f4f27.
- 01GMVB35JBTE11ARWQJZRWT9H4 type C3.