Matches in Ghent University Academic Bibliography for { <https://biblio.ugent.be/publication/01GP18ZC77FC3HDK7JNNM1H6HY> ?p ?o. }
Showing items 1 to 37 of
37
with 100 items per page.
- 01GP18ZC77FC3HDK7JNNM1H6HY classification A1.
- 01GP18ZC77FC3HDK7JNNM1H6HY date "2022".
- 01GP18ZC77FC3HDK7JNNM1H6HY language "eng".
- 01GP18ZC77FC3HDK7JNNM1H6HY type journalArticle.
- 01GP18ZC77FC3HDK7JNNM1H6HY hasPart 01GP190V7ZG3WHHYD6TCVNNXAA.pdf.
- 01GP18ZC77FC3HDK7JNNM1H6HY subject "Medicine and Health Sciences".
- 01GP18ZC77FC3HDK7JNNM1H6HY doi "10.1111/jth.15889".
- 01GP18ZC77FC3HDK7JNNM1H6HY issn "1538-7836".
- 01GP18ZC77FC3HDK7JNNM1H6HY issn "1538-7933".
- 01GP18ZC77FC3HDK7JNNM1H6HY issue "12".
- 01GP18ZC77FC3HDK7JNNM1H6HY volume "20".
- 01GP18ZC77FC3HDK7JNNM1H6HY abstract "Background Acquired von Willebrand syndrome (aVWS) is common in patients with mechanical circulatory support (MCS) devices. In these patients, the high shear stress in the device leads to increased shear-induced proteolysis of von Willebrand factor (VWF) by A Disintegrin And Metalloprotease with Thrombospondin type 1 repeats, number 13 (ADAMTS13). As a result, the high molecular weight (HMW) VWF multimers are lost, leading to a decreased VWF function and impaired hemostasis that could explain the bleeding complications that are frequently observed in these patients. To counteract this abnormal VWF degradation by ADAMTS13, we developed a novel targeted therapy, using an anti-ADAMTS13 monoclonal antibody (mAb) that inhibits the shear-induced proteolysis of VWF by ADAMTS13. Methods Human or bovine blood was circulated through in vitro MCS device systems with either inhibitory anti-ADAMTS13 mAb 3H9 or 17C7 (20 mu g/ml) or control anti-ADAMTS13 mAb 5C11 or phosphate buffered saline (PBS). VWF multimers and function (collagen binding activity) were determined at different time points. Next, Impella pumps were implanted in calves and the calves were injected with PBS and subsequently treated with mAb 17C7. VWF, ADAMTS13, and blood parameters were determined. Results We demonstrated that blocking ADAMTS13 could prevent the loss of HMW VWF multimers in in vitro MCS device systems. Importantly, our antibody could reverse aVWS in a preclinical Impella-induced aVWS calf model. Conclusion Hence, inhibition of ADAMTS13 could become a novel therapeutic strategy to manage aVWS in MCS device patients.".
- 01GP18ZC77FC3HDK7JNNM1H6HY author 5D63A376-A6F4-11E7-8878-09B7AD28A064.
- 01GP18ZC77FC3HDK7JNNM1H6HY author urn:uuid:0bd93ba5-b1db-497d-882a-77737c92b9e1.
- 01GP18ZC77FC3HDK7JNNM1H6HY author urn:uuid:1b625607-c462-496f-8ed5-e3ccc3e75997.
- 01GP18ZC77FC3HDK7JNNM1H6HY author urn:uuid:20ee070b-ef58-4da0-9eec-3868abb0a43d.
- 01GP18ZC77FC3HDK7JNNM1H6HY author urn:uuid:2b5a8680-af92-4ddc-b3cc-276252164c46.
- 01GP18ZC77FC3HDK7JNNM1H6HY author urn:uuid:2c1a4c7e-2bb2-44f1-8ed0-fb567f47c2c4.
- 01GP18ZC77FC3HDK7JNNM1H6HY author urn:uuid:2cb12abe-544d-41ad-a861-5ad243a46ee9.
- 01GP18ZC77FC3HDK7JNNM1H6HY author urn:uuid:57762c98-9bfc-466f-8cec-aad76456f6c6.
- 01GP18ZC77FC3HDK7JNNM1H6HY author urn:uuid:5e79177f-1b57-4c09-a79f-552fb4e3c928.
- 01GP18ZC77FC3HDK7JNNM1H6HY author urn:uuid:64dbc44a-5a78-415e-8312-6393f64b83fb.
- 01GP18ZC77FC3HDK7JNNM1H6HY author urn:uuid:9a001fd8-e024-402b-9cf1-9f512b1500be.
- 01GP18ZC77FC3HDK7JNNM1H6HY author urn:uuid:b0670e67-55a0-4c21-ad97-b25c2c35b014.
- 01GP18ZC77FC3HDK7JNNM1H6HY author urn:uuid:c8e53afc-4cb1-4968-a55f-bed790d90a27.
- 01GP18ZC77FC3HDK7JNNM1H6HY author urn:uuid:cca938ad-0272-4231-a8cd-757096bc724d.
- 01GP18ZC77FC3HDK7JNNM1H6HY author urn:uuid:cd13d7d4-91e7-4de6-a034-dae183d3de69.
- 01GP18ZC77FC3HDK7JNNM1H6HY author urn:uuid:d5510268-49b5-4ad7-9d5a-e3349f9c3519.
- 01GP18ZC77FC3HDK7JNNM1H6HY author urn:uuid:fc00b614-29b1-4527-84e6-4e6bd85f3767.
- 01GP18ZC77FC3HDK7JNNM1H6HY author urn:uuid:ff21eb44-8d3d-4418-b54d-e3baa3dda9ec.
- 01GP18ZC77FC3HDK7JNNM1H6HY dateCreated "2023-01-05T15:32:13Z".
- 01GP18ZC77FC3HDK7JNNM1H6HY dateModified "2024-10-29T16:22:42Z".
- 01GP18ZC77FC3HDK7JNNM1H6HY name "ADAMTS13 inhibition to treat acquired von Willebrand syndrome during mechanical circulatory support device implantation".
- 01GP18ZC77FC3HDK7JNNM1H6HY pagination urn:uuid:e7c56965-bc58-4f34-a46a-77aed04852de.
- 01GP18ZC77FC3HDK7JNNM1H6HY sameAs LU-01GP18ZC77FC3HDK7JNNM1H6HY.
- 01GP18ZC77FC3HDK7JNNM1H6HY sourceOrganization urn:uuid:1828377c-b5e8-4625-bf7e-1af8b6f87a51.
- 01GP18ZC77FC3HDK7JNNM1H6HY type A1.