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- 01GPDG28TGVRM2CXJRRGC2BHNN classification A1.
- 01GPDG28TGVRM2CXJRRGC2BHNN date "2022".
- 01GPDG28TGVRM2CXJRRGC2BHNN language "eng".
- 01GPDG28TGVRM2CXJRRGC2BHNN type journalArticle.
- 01GPDG28TGVRM2CXJRRGC2BHNN hasPart 01GPDGREHCB32NSDGWDKQNCRYH.pdf.
- 01GPDG28TGVRM2CXJRRGC2BHNN subject "Biology and Life Sciences".
- 01GPDG28TGVRM2CXJRRGC2BHNN subject "Medicine and Health Sciences".
- 01GPDG28TGVRM2CXJRRGC2BHNN doi "10.3389/fimmu.2022.1067164".
- 01GPDG28TGVRM2CXJRRGC2BHNN issn "1664-3224".
- 01GPDG28TGVRM2CXJRRGC2BHNN volume "13".
- 01GPDG28TGVRM2CXJRRGC2BHNN abstract "The Inhibitor of Kappa B Kinase (IKK) complex is a critical regulator of NF-kappa B activation. More recently, IKK has also been shown to repress RIPK1 dependent extrinsic cell death pathways by directly phosphorylating RIPK1 at serine 25. In T cells, IKK expression is essential for normal development in the thymus, by promoting survival of thymocytes independently of NF-kappa B activation. RIPK1 undergoes extensive phosphorylation following TNF stimulation in T cells, though which targets are required to repress RIPK1 has not been defined. Here, we show that TNF induced phosphorylation of RIPK1 at S25 is IKK dependent. We test the relevance of this phosphorylation event in T cells using mice with a RIPK1(S25D) phosphomimetic point mutation to endogenous RIPK1. We find that this mutation protects T cells from TNF induced cell death when IKK activity is inhibited in vitro, and can rescues development of IKK deficient thymocytes in vivo to a degree comparable with kinase dead RIPK1(D138N). Together, these data show that phosphorylation of RIPK1S25 by IKK represents a key regulatory event promoting survival of T cells by IKK.".
- 01GPDG28TGVRM2CXJRRGC2BHNN author 01661B60-F0EE-11E1-A9DE-61C894A0A6B4.
- 01GPDG28TGVRM2CXJRRGC2BHNN author 26848544-F0EE-11E1-A9DE-61C894A0A6B4.
- 01GPDG28TGVRM2CXJRRGC2BHNN author urn:uuid:31ff2cd0-6e1e-49c8-b82e-543fba2c9ada.
- 01GPDG28TGVRM2CXJRRGC2BHNN author urn:uuid:8f2404b5-d995-40fd-9c11-042a8149543b.
- 01GPDG28TGVRM2CXJRRGC2BHNN author urn:uuid:e98bba8e-54e6-42a0-8969-7d187c2b619d.
- 01GPDG28TGVRM2CXJRRGC2BHNN dateCreated "2023-01-10T09:27:01Z".
- 01GPDG28TGVRM2CXJRRGC2BHNN dateModified "2024-12-12T17:38:43Z".
- 01GPDG28TGVRM2CXJRRGC2BHNN name "Phosphorylation of RIPK1 serine 25 mediates IKK dependent control of extrinsic cell death in T cells".
- 01GPDG28TGVRM2CXJRRGC2BHNN pagination urn:uuid:4ce5bead-710d-479c-b4ca-efaa31f9b826.
- 01GPDG28TGVRM2CXJRRGC2BHNN sameAs LU-01GPDG28TGVRM2CXJRRGC2BHNN.
- 01GPDG28TGVRM2CXJRRGC2BHNN sourceOrganization urn:uuid:4be13de5-91b0-419e-84f0-d9704b6a3486.
- 01GPDG28TGVRM2CXJRRGC2BHNN sourceOrganization urn:uuid:511a2f0e-f5bc-4319-9d20-5cf04b68d3d1.
- 01GPDG28TGVRM2CXJRRGC2BHNN type A1.